|drug2540||Placebo control (non-behavioral infographic) Wiki||1.00|
|D016171||Torsades de Pointes NIH||1.00|
|D054537||Atrioventricular Block NIH||1.00|
There is one clinical trial.
As the coronavirus disease 2019 (COVID-19) pandemic has continued to affect life in the United States, the important role of non-pharmaceutical preventive behaviors (such as wearing a face mask) in reducing harm has become clear. In parallel to the pandemic, researchers have observed an "infodemic" of misinformed or inconsistent narratives about COVID-19. There is growing evidence that misinformed COVID-19 narratives are associated with a wide variety of undesirable behavior (e.g., burning down cell towers). Further, individuals' adherence to recommended COVID-19 preventive guidelines has been inconsistent, and such mandates have engendered opposition and controversy. Recent research suggests the possibility that trust in science and scientists may be an important thread to weave throughout these seemingly disparate components of the modern public health landscape. Thus, this paper describes the protocol for a randomized trial of a brief, digital intervention to increase trust in science. The objective of this trial is to examine if exposure to a curated infographic can increase trust in science, reduce believability of misinformed narratives, and increase likelihood to engage in preventive behaviors.
Description: 21-item scale developed by Nadelson et al  called the Trust in Science Inventory. It is scored from 1 to 5, where 1 indicates low trust and 5 indicates high trust.Measure: Change in trust in science Time: Pre-intervention and immediately post-intervention
Description: Will be computed using latent profile analysis of believability measures. These measures were developed and first used in our recent study of COVID-19 narratives . Response options for these measures used well-established semantic differential responses for believability of different statements (e.g., as in Herzberg et al.)  ranging from [1: Extremely unbelievable] to [7: Extremely believable]. Exact measures used to generate profiles for this study will be available in the published protocol paper (to be submitted).Measure: Believability profiles Time: Immediately post-intervention
Description: A series of six questions based on the US Centers for Disease Control and Prevention's recommended COVID-19 preventive behaviors.  Questions will be written according to Azjen's guide to intention questionnaires .Measure: Preventive behavioral intentions Time: Immediately post-intervention
Description: Scale variable (0: Conservative to 10: Liberal) as in our prior work [2, 6]Measure: Political orientation (covariate 1) Time: Immediately post-intervention
Description: Scale variable (0: Low commitment to 10: High commitment) as in our prior work [2, 6]Measure: Religious commitment (covariate 2) Time: Immediately post-intervention
Description: Race/ethnicity, gender, age, and education level using standardized questionsMeasure: Sociodemographics (covariates 3 through 6) Time: Immediately post-intervention
Description: Two self report questions. The first asks whether the respondent has been diagnosed with COVID-19, and the second asks more broadly whether the respondent believes they have had COVID-19. Question wording will be per Bruine de Bruin (2020) .Measure: COVID-19 diagnosis (covariates 7 and 8) Time: Immediately post-intervention
Description: Based on the Health Belief Model as used in Yıldırıma & Gülerc .Measure: Perceived severity of COVID-19 (covariate 9) Time: Immediately post-intervention
Description: Based on the Health Belief Model as used in Yıldırıma & Gülerc .Measure: Self-efficacy to act regarding COVID-19 Time: Immediately post-intervention
Description: Single item from Chambon et al .Measure: Normative beliefs about friends' and family's COVID-19 behaviors Time: Immediately post-intervention
Data processed on September 26, 2020.
An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.Drug Reports MeSH Reports HPO Reports