|drug2043||Microscopy of defined brain regions on autopsy specimens Wiki||1.00|
|drug1001||Data collection from lumbar puncture Wiki||1.00|
|drug1000||Data collection from blood draw Wiki||1.00|
There is one clinical trial.
This study is to analyze the microglia reaction or direct neurotropic effects of CNS COVID-19 in pathogenesis and brain stem dysfunction in critically ill patients. A microglia-focused, brain-specific 50+ marker CODEX panel is used to assess the neuroinflammatory microenvironment in specific brain regions of deceased COVID-19 patients. The peripheral (cerebrospinal fluid and peripheral blood) cytokine response to SARS-CoV-2 is investigated in regard to CNS affection and consecutive blood brain barrier disruption leading to braininherent neuroinflammatory reactions
Description: Comparison of lesions from patients that are neurologically affected to non-affected individuals in terms of CNS involvement to describe encephalitic changes due to COVID-19 infection.Measure: MRI imaging data Time: Project duration for each patient takes 1 hour for the MRI at baseline
Description: Description of proteomic biomarkers (CSF and Plasma) in comparison with control reference sample.Measure: Proteomic analysis Time: 10 minutes for blood draw at baseline
Description: Mass cytometry will be performed form peripheral blood mononuclear cells to count cell population frequency.Measure: Peripheral blood leukocyte Cytof Mass Cytometry Analysis for cell population frequency Time: 10 minutes for blood draw at baseline
Description: In situ distribution assessment of marker expression (CD147 protein, ACE2 protein, Transmembrane protease serine subtype 2 (TMPRSS2))Measure: CODEX (high dimensional microscopy) workflow analysis of defined regions on brain autopsy specimens Time: at baseline
Data processed on September 26, 2020.
An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.Drug Reports MeSH Reports HPO Reports