|drug1571||Hyperbaric Chamber Wiki||0.71|
|drug1460||Helmet Continuous Positive Airway Pressure (CPAP) Wiki||0.71|
|drug1474||High Flow Nasal Oxygen (HFNO) Wiki||0.71|
|D011024||Pneumonia, Viral NIH||0.08|
|D018352||Coronavirus Infections NIH||0.05|
There are 2 clinical trials
This is a randomized double-blind placebo-controlled Phase II trial of recombinant human deoxyribonuclease I (rhDNase I) - Pulmozyme - in mechanically ventilated patients with COVID-19 pneumonia. Patients admitted to the ICU with severe COVID-19 pneumonia who require mechanical ventilation will be invited to participate in this study. Potential subjects will be identified from medical record review or from direct contact with physicians. Investigators will check medical history and confirm eligibility. Informed consent will be obtained from either the patient or designated healthcare proxy. 60 subjects will be enrolled. After obtaining informed consent, patients will be randomized 2:1 to Pulmozyme 2.5 mg BID for up to 28 days or until they are no longer receiving mechanical ventilation, whichever is sooner plus standard of care vs. placebo normal saline 2.5 ml plus standard of care.
Description: Primary outcomeMeasure: Ventilator-free days at 28 days Time: 28 days
Description: change in airway resistanceMeasure: change in airway resistance Time: 28 days
Description: Change in lung complianceMeasure: change in lung compliance Time: 28 days
Description: oxygenationMeasure: oxygenation (PaO2/FiO2 ratio) Time: 28 days
Description: length of stayMeasure: length of stay (ICU and hospital) Time: 28 days
Description: rate of batotraumaMeasure: rate of barotrauma Time: 28 days
Description: mortalityMeasure: mortality. Time: 28 days
In this study, the effectiveness of the Dornase Alpha treatment, which is known to reduce the viscosity of respiratory secretions, will be investigated in new diagnosed and severe COVID-19 patients separately.
Description: i. The patient has no complaints (cough and dyspnea completely disappear, the number of breaths are in the age-appropriate range, oxygen saturation is in the normal range), inflammatory markers in blood improve (CRP, LDH, Ferritin and D-Dimer regression to the reference range). ii. Extubation (for mechanically ventilated group) iii. Intubated (for newly diagnosed group)Measure: Response Time: 3 months
Description: DeathMeasure: Survival Time: 3 months
Data processed on September 26, 2020.
An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.Drug Reports MeSH Reports HPO Reports