|drug1966||Maraviroc + Currently used therapy Wiki||1.00|
|drug950||Curently used therapy for COVID-19 non-critical patients Wiki||1.00|
|drug1190||Enhanced Chronic Disease Self-management program Wiki||1.00|
|D002908||Chronic Disease NIH||0.28|
There is one clinical trial.
Phase 2, randomized, open-label study to compare the safety and efficacy of maraviroc, favipiravir, and both drugs combined versus currently used therapy in hospitalized patients with pulmonary SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) infection (COVID-19)
Description: Percentage of patients free of mechanical ventilation or deathMeasure: Patients free of mechanical ventilation or death Time: 28 days post start
Description: Percentage of patients free of mechanical ventilation or deathMeasure: Patients free of mechanical ventilation or death Time: 5 days post start
Description: Time of improvement in at least 2 items of the 7-item World Health Organization (WHO) ordinal scale for COVID-19 in days.Measure: Time of clinical improvement Time: 15 days post start
Description: Rate of change (Delta) in lymphocytes, monocytes and neutrophils with phosphorilated CCR5 as per measured by parameters of flow cytometry.Measure: Rate of change in phosphorilated CCR5 Time: Day 10-1
Description: Rate of change (Delta) in peripheral blood levels of proinflammatory cytokines and chemokynes [IL-6, IL-1b, TNF, IFNa, IFNg, VEGF, GM-CSF (granulocyte-macrophage colony stimulating factor), CCL2, CCL3, CCL4, CCL5, CXCL10 and CCL7], as per measured by parameters of flow cytometryMeasure: Rate of change in peripheral blood levels of proinflammatory cytokines and chemokynes Time: Day 10-1
Description: Statistically significant change in the expression of activation [phosphorylated CCR5,CD38, CD126, CD127, CD25, CD86, CD83, CD40 (cluters of differentiation 38, 126, 127, 25, 86 and 40), HLA-DR (Human Leukocyte Antigen-DR isotype), Granzyme B, Perforin, CD107A, CD123, gp130, CD95], trafficking [CCR5, CCR2, CCR6, CCR7, CXCR1, CXCR3 , CXCR5, (CXC chemokine receptors 1, 3 and 5), CX3CR1 (CX3C chemokine receptor] and exhaustion (PD1, programmed death-1 receptor) markers in peripheral blood lymphocytes, neutrophils and monocytes, as per measured by parameters of flow cytometry.Measure: Change in the trafficking and activation pattern of peripheral leukocytes Time: Day 10-1
Data processed on September 26, 2020.
An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.Drug Reports MeSH Reports HPO Reports