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    2019 novel coronavirus

    This report considers only clinical trials that are associated with COVID-19 vaccines.

    Developed by Shray Alag, The Harker School
    Sections: Correlations, Clinical Trials, and HPO

    Correlations computed by analyzing all clinical trials.

    Navigate: Clinical Trials and HPO


    Correlated Drug Terms (9)


    Name (Synonyms) Correlation
    drug97 ARCT-021 Dose 1 Wiki 1.00
    drug99 ARCT-021 Dose 3 Wiki 1.00
    drug98 ARCT-021 Dose 2 Wiki 1.00
    Name (Synonyms) Correlation
    drug102 ARCT-021 Dose Regimen 2 Wiki 1.00
    drug101 ARCT-021 Dose Regimen 1 Wiki 1.00
    drug100 ARCT-021 Dose 4 Wiki 1.00
    drug4042 rAd26-S Wiki 0.71
    drug128 AZD1222 Wiki 0.45
    drug2490 Placebo Wiki 0.13

    Correlated MeSH Terms (1)


    Name (Synonyms) Correlation
    D000257 Adenoviridae Infections NIH 0.45

    Correlated HPO Terms (0)


    Name (Synonyms) Correlation

    Clinical Trials

    Navigate: Correlations   HPO

    There is one clinical trial.


    1 A Phase II Open-label Study in Adults to Determine the Safety and Immunogenicity of AZD1222, a Non-replicating ChAdOx1 Vector Vaccine, Given in Combination With rAd26-S, Recombinant Adenovirus Type 26 Component of Gam-COVID-Vac Vaccine, for the Prevention of COVID 19

    The primary objective of this study is to describe the safety and tolerability of one IM dose of AZD1222 followed by one IM dose of rAd26-S in adults ≥ 18 years of age

    NCT04686773
    Conditions
    1. COVID-19
    Interventions
    1. Biological: AZD1222
    2. Biological: rAd26-S
    MeSH:Adenoviridae Infections

    Primary Outcomes

    Description: Incidence of Serious Adverse Events (SAEs) post first dose until the study end

    Measure: Incidence of Serious Adverse Events (SAEs) post first dose until the study end

    Time: from Day 1 until Day 180

    Secondary Outcomes

    Description: Incidence of unsolicited AEs for 28 days post each dose

    Measure: Incidence of unsolicited Adverse Events (AEs) for 28 days post each dose

    Time: from Day 1 to Day 28 and from Day 29 to Day 57

    Description: Incidence of local and systemic solicited AEs for 7 days post each dose

    Measure: Incidence of local and systemic solicited AEs for 7 days post each dose

    Time: from Day 1 to Day 8 and From Day 29 to Day 36

    Description: Incidence of AESIs post first dose until study end (Day 180)

    Measure: Incidence of Adverse events of special interest (AESIs) post first dose until study end

    Time: from Day 1 to Day 180

    Description: assessment of time course of antibody to Spike protein of one IM dose of AZD1222 followed by one IM dose of rAd26-S

    Measure: assessment of time course of antibody to Spike protein of one IM dose of AZD1222 followed by one IM dose of rAd26-S

    Time: On Day 1 and on Day 29

    Description: Determination of anti-SARS-CoV-2 neutralising antibody levels in serum following one IM dose of AZD1222 followed by one IM dose of rAd26-S

    Measure: Determination of anti-SARS-CoV-2 neutralising antibody levels in serum following one IM dose of AZD1222 followed by one IM dose of rAd26-S

    Time: On Day 1 and on day 29

    Description: Proportion of participants who have a post treatment seroresponse (≥ 4-fold rise in titers from day of dosing baseline value to 28 days post each dose) as measured by SARS-CoV-2 antibodies to Spike protein

    Measure: Proportion of participants who have a post treatment seroresponse

    Time: from Day 1 (before dose) to Day 28 and from Day 29 (before dose) to Day 57

    No related HPO nodes (Using clinical trials)


    HPO

    Alphabetical listing of all HPO terms. Navigate: Correlations   Clinical Trials


    No related HPO nodes (Using clinical trials)


    Reports

    Data processed on January 01, 2021.

    An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.

    Drug Reports   MeSH Reports   HPO Reports  

    Interventions

    4,818 reports on interventions/drugs

    MeSH

    706 reports on MeSH terms

    HPO

    306 reports on HPO terms

    All Terms

    Alphabetical index of all Terms

    Google Colab

    Python example via Google Colab Notebook