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    efficacy

    This report considers only clinical trials that are associated with COVID-19 vaccines.

    Developed by Shray Alag, The Harker School
    Sections: Correlations, Clinical Trials, and HPO

    Correlations computed by analyzing all clinical trials.

    Navigate: Clinical Trials and HPO


    Correlated Drug Terms (2)


    Name (Synonyms) Correlation
    drug2805 Recombinant Novel Coronavirus Vaccine (Adenovirus Type 5 Vector) Wiki 0.45
    drug2490 Placebo Wiki 0.13

    Correlated MeSH Terms (0)


    Name (Synonyms) Correlation

    Correlated HPO Terms (0)


    Name (Synonyms) Correlation

    Clinical Trials

    Navigate: Correlations   HPO

    There is one clinical trial.


    1 A Global Multicenter, Randomized, Double-blind, Placebo -Controlled, Adaptive Designed Phase Ⅲ Clinical Trial to Evaluate the Efficacy, Safety and Immunogenicity of Ad5-nCoV in Adults 18 Years of Age and Older

    This study is a global multicenter, randomized, double-blind, placebo -controlled, adaptive designed phase Ⅲ clinical trial, in order to evaluate the efficacy, safety and immunogenicity of Recombinant Novel Coronavirus Vaccine (Adenovirus Type 5 Vector) in adults 18 years old and above.

    NCT04526990
    Conditions
    1. COVID-19
    Interventions
    1. Biological: Recombinant Novel Coronavirus Vaccine (Adenovirus Type 5 Vector)
    2. Biological: Placebo

    Primary Outcomes

    Description: The efficacy of Ad5-nCoV in preventing virologically confirmed (PCR positive) COVID-19 disease

    Measure: Incidence of COVID-19 cases

    Time: day 28 to 12 months post vaccination

    Description: Evaluate the incidence of severe adverse events (SAE)

    Measure: Incidence of SAE

    Time: Within 12 months

    Secondary Outcomes

    Description: Evaluate the efficacy of Ad5-nCoV in preventing severe COVID-19 disease caused by SARS-CoV-2 infection

    Measure: Incidence of severe COVID-19 cases

    Time: Day 14 to 12 months post vaccination

    Description: Incidence of solicited adverse reactions within 7 days after vaccination, in a subset

    Measure: Incidence of solicited adverse reactions

    Time: Day 0-7 post vaccination

    Description: Incidence of unsolicited adverse events within 28 days after vaccination in a subset

    Measure: Incidence of unsolicited adverse events

    Time: Day 0-28 post vaccination

    Description: The seroconversion rate of S-RBD IgG antibody post vaccination

    Measure: Immunogencity of S-RBD IgG antibody (ELISA method)

    Time: Day 28 post vaccination

    Description: The seroconversion rate of neutralizing antibody

    Measure: Immunogencity of neutralizing antibody

    Time: Day 28 post vaccination

    Description: Number of cell-mediated immune response against SARS-CoV-2

    Measure: Cell-mediated immune profile

    Time: Day 28 post vaccination

    No related HPO nodes (Using clinical trials)


    HPO

    Alphabetical listing of all HPO terms. Navigate: Correlations   Clinical Trials


    No related HPO nodes (Using clinical trials)


    Reports

    Data processed on January 01, 2021.

    An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.

    Drug Reports   MeSH Reports   HPO Reports  

    Interventions

    4,818 reports on interventions/drugs

    MeSH

    706 reports on MeSH terms

    HPO

    306 reports on HPO terms

    All Terms

    Alphabetical index of all Terms

    Google Colab

    Python example via Google Colab Notebook