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    Healthcare workers

    This report considers only clinical trials that are associated with COVID-19 vaccines.

    Developed by Shray Alag, The Harker School
    Sections: Correlations, Clinical Trials, and HPO

    Correlations computed by analyzing all clinical trials.

    Navigate: Clinical Trials and HPO

    Correlated Drug Terms (2)

    Name (Synonyms) Correlation
    drug367 BCG vaccine Wiki 0.50
    drug2490 Placebo Wiki 0.13

    Correlated MeSH Terms (2)

    Name (Synonyms) Correlation
    D045169 Severe Acute Respiratory Syndrome NIH 0.20
    D018352 Coronavirus Infections NIH 0.16

    Correlated HPO Terms (0)

    Name (Synonyms) Correlation

    Clinical Trials

    Navigate: Correlations   HPO

    There is one clinical trial.

    1 Prevention, Efficacy and Safety of BCG Vaccine in COVID-19- Randomized Clinical Trial

    In Mexico the total number of confirmed cases of COVID-19 is 232, 000 and 28,510 deaths. Health workers are at high risk of COVID-19 infection. Their absence from work dramatically limits the ability to contain the disease. There is currently no vaccine to prevent the disease. Since the introduction to the vaccination schedule of the Bacillus Calmette-Guerin (BCG) live attenuated vaccine directed towards tuberculosis prevention, a decrease in infant mortality has been reported, not related only to tuberculosis. BCG vaccine has been hypothesized to have a non-specific role towards other unrelated pathogens such as viruses that cause airway disease, with reduced morbidity and mortality. In murine as well as in human models it has been shown to decrease the incidence of acute respiratory influenza infections. Likewise, in countries with a high endemicity for tuberculosis, the BCG vaccine reduces the incidence of respiratory infections by up to 80% . In healthy subjects, the BCG vaccine increases the production of proinflammatory cytokines in monocytes. Likewise, it increases the epigenetic response, causing an increase in the transcription of genes important in the antimicrobial response, as well as an improvement in cellular function. This is the first national clinical trial to evaluate prospectively the effect that the BCG vaccine offers towards the prevention and reduction of severity in cases of COVID-19.

    1. BCG
    2. COVID-19
    3. SARS-CoV2
    4. Corona Virus Infection
    1. Biological: BCG vaccine
    2. Other: Placebo
    MeSH:Coronavirus Infections Severe Acute Respiratory Syndrome

    Primary Outcomes

    Description: Cumulative incidence of infection in 6 months: disease defined as positive SARS-Cov-2 test (serology), plus fever (using self-reported questionnaire), or at least one sign or symptom of respiratory disease including cough, shortness of breath, respiratory distress/failure (using self-reported questionnaire)

    Measure: Demonstrate COVID- 19 disease incidence among Health care workers:

    Time: During the 6 months study period

    Description: Cumulative incidence of hospitalization for COVID-19

    Measure: Demonstrate cumulative incidence of hospitalization for COVID-19 among Health care workers:

    Time: During the 6 months study period

    Description: Incidence of specific Antibodies (IgG and IgM) against SARS-CoV-2 will be measured at 3 and 6 months

    Measure: Demonstrate the Incidence of specific Antibodies against SARS-CoV-2 at 3 and 6 months in health care workers

    Time: During the 6 months study period

    Description: Number of participants who needed hospitalization

    Measure: Hospitalization of severe disease COVID-19

    Time: During the 6 months study period

    Description: Number of participants who Need for oxygen supplementation (nasal cannulas, masks, high flow oxygen) in hospitalized patients

    Measure: Oxygen supplementation in severe disease COVID-19

    Time: During the 6 months study period

    Description: Number of participants who Need for intubation or non-invasive ventilation in hospitalized patients

    Measure: Need for intubation or non-invasive ventilation for the patient.

    Time: During the 6 months study period

    Description: Number of participants in Critical care admission with SARS-CoV2 in hospitalized patients

    Measure: Critical care admission with SARS-CoV2

    Time: During the 6 months study period

    Description: Mortality associated to progressive pulmonary disease in hospitalized patients

    Measure: Mortality associated to progressive pulmonary disease

    Time: During the 6 months study period

    Secondary Outcomes

    Measure: Evaluate the safety of the vaccine by measuring the incidence rates of local and systemic adverse effects that occur after one month its application.

    Time: 1 month after vaccine/placebo application

    Measure: Calculate the incidence of COVID-19 complications

    Time: During the 6 months study period

    Measure: Determine the mean days of hospitalization and days in intensive care unit by COIVD-19

    Time: During the 6 months study period

    Measure: Calculate the cost associated with in-hospital medical care

    Time: During the 6 months study period

    Description: SOFA score: PaO2/FIO2 (mm Hg), SaO2/FIO2, Platelets (×10³/µL), Bilirubin (mg/dL), Hypotension, Glasgow Coma Score and Creatinine (mg/dL) or urine output (mL/d).

    Measure: Determine the scores of the Clinical Prediction Rules associated with mortality using Sequential Organ Failure Assessment (SOFA score) at the patient's hospital admission:

    Time: During the 6 months study period

    Description: APACHE: History of severe organ failure or immunocompromise Heart Failure Class IV, cirrhosis, chronic lung disease, or dialysis-dependent, Age, Temperature (C°), Mean arterial pressure (mmHg), pH, Sodium (mEq/L), Potassium (mEq/L), Creatinine (mg/dL), Hematocrit (%), WBC (x 109/L)

    Measure: Determine the scores of the Clinical Prediction Rules associated with mortality using Acute Physiology and Chronic Health disease Classification System (APACHE) at the patient's hospital admission:

    Time: During the 6 months study period

    Description: CPR, ESR, Ferritin, D-dimer, LDH,Troponins, Procalcitonin, Interleukin-6, Hemoglobin, Hematocrit, Erythrocytes, Leukocytes, MCV, HCM, MCHC, Lymphocytes, Monocytes, Eosinophils, Basophils, Platelets, Glucose, Urea, Creatinine, BUN, Sodium, Potassium, Chlorine, Calcium, Serum albumin, Direct bilirubin, Indirect bilirubin, Alkaline phosphatase, AST, ALT, bleeding time, Prothrombin Time, Activated partial thromboplastin time, Arterial / Venous Blood Gasometry, pH, pCO2, HCO3, pO2, SaO2%, Lactate.

    Measure: Evaluate and determine the alteration profile in laboratory studies at the patient's hospital admission

    Time: During the 6 months study period

    Measure: Registration of chronic medications

    Time: During the 6 months study period

    Measure: Need for vasopressors

    Time: During the 6 months study period

    No related HPO nodes (Using clinical trials)


    Alphabetical listing of all HPO terms. Navigate: Correlations   Clinical Trials

    No related HPO nodes (Using clinical trials)


    Data processed on January 01, 2021.

    An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.

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    706 reports on MeSH terms


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