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    Non-specific effects of BCG

    This report considers only clinical trials that are associated with COVID-19 vaccines.

    Developed by Shray Alag, The Harker School
    Sections: Correlations, Clinical Trials, and HPO

    Correlations computed by analyzing all clinical trials.

    Navigate: Clinical Trials and HPO


    Correlated Drug Terms (4)


    Name (Synonyms) Correlation
    drug2710 QazCovid-in® - COVID-19 inactivated vaccine Wiki 1.00
    drug370 BCG-Denmark Wiki 0.58
    drug2985 Saline Wiki 0.45
    Name (Synonyms) Correlation
    drug2490 Placebo Wiki 0.13

    Correlated MeSH Terms (2)


    Name (Synonyms) Correlation
    D045169 Severe Acute Respiratory Syndrome NIH 0.20
    D018352 Coronavirus Infections NIH 0.16

    Correlated HPO Terms (0)


    Name (Synonyms) Correlation

    Clinical Trials

    Navigate: Correlations   HPO

    There is one clinical trial.


    1 BCG Vaccine to Reduce Unplanned Absenteeism Due to Illness of Health Care Workers During the COVID-19 Pandemic. A Multi-center Randomised Controlled Trial (BCG-COVID-RCT)

    The COVID-19 pandemic challenges available hospital capacity. Strategies to protect health care workers (HCW) are desperately needed. Bacille Calmette- Guérin (BCG) has protective non-specific effects against other infections; a plausible immunological mechanism has been identified in terms of "trained innate immunity". The primary objective of the study is to evaluate whether BCG can reduce unplanned absenteeism due to illness among HCW during the COVID-19 pandemic. Secondary objectives are to reduce the number of HCW that are infected with COVID-19, reduce hospital admissions for HCW and to improve the capacity for clinical research. Design: Single-blind, parallel-group placebo-controlled multi-centre block randomized trial including a total of 1050 HCW. The study sites will be the Manhiça hospital in Mozambique, Central Hospital Dr. Agostinho Neto and Central Hospital Dr. Baptista de Sousa in Cape Verde and Hospital Nacional Simão Mendes and other hospitals in the capital Bissau in Guinea-Bissau. Population: HCW (nurses/physicians/others) ≥18 years. Intervention: Block randomization 1:1 to intradermal standard dose (0.1 ml) of BCG vaccine or placebo (saline). Endpoints: Primary: Days of unplanned absenteeism due to illness. Secondary: Days of absenteeism because of documented COVID-19; cumulative incidence of infectious disease hospitalizations. Follow-up: mobile phone interviews every second week, regarding symptoms, absenteeism and causes, COVID-19 testing (if done) and their results. Perspectives: If BCG can reduce HCW absenteeism it has global implications. The intervention can quickly be scaled up all over the world.

    NCT04641858
    Conditions
    1. Covid19
    2. Morbidity
    3. Absenteeism
    Interventions
    1. Biological: BCG-Denmark
    2. Biological: Saline

    Primary Outcomes

    Description: Unplanned absenteeism is defined by being absent from work due to causes other than holidays, parental leave, and other planned leaves, family assistance (including mourning leave) and quarantine measures.

    Measure: Days of unplanned absenteeism due to illness

    Time: 6 months after inclusion

    Secondary Outcomes

    Description: Unplanned absenteeism is defined by being absent from work due to causes other than holidays, parental leave, and other planned leaves, family assistance (including mourning leave) and quarantine measures.

    Measure: Days of unplanned absenteeism due to documented COVID-19

    Time: 6 months after inclusion

    Description: Hospital admissions involves staying at a hospital for at least one night or more for medical reasons. It includes admissions to hospital wards and overnight stays in emergency departments.

    Measure: Cumulative incidence of hospital admissions due to illness (minus accidents).

    Time: 6 months after inclusion

    Description: Whether the participant died during follow-up

    Measure: Death

    Time: 6 months after inclusion

    Other Outcomes

    Description: Refers to the number of nights of hospitalisation due to COVID-19

    Measure: Hospitalisation for COVID-19

    Time: 6 months after inclusion

    Description: Refers to the number of nights of hospitalisation due to other reasons besides COVID-19

    Measure: Hospitalisation besides COVID-19

    Time: 6 months after inclusion

    Description: Time, in days, from enrolment to first night of hospitalisation

    Measure: Time to hospitalisation

    Time: 6 months after inclusion

    Description: Time, in days, from enrolment to first day absent from work due to ill-health and disease

    Measure: Time to absenteeism

    Time: 6 months after inclusion

    Description: Refers to the number of days since enrolment to first day absent from work due to suspected COVID-19

    Measure: Time to COVID-19 absenteeism

    Time: 6 months after inclusion

    Description: Describes if the participant is positive for SARS-CoV2 or has had COVID-19

    Measure: COVID-19 infection

    Time: 6 months after inclusion

    Description: Time, in days, from enrolment to positive test for SARS-CoV2

    Measure: Time to COVID-19

    Time: 6 months after inclusion

    No related HPO nodes (Using clinical trials)


    HPO

    Alphabetical listing of all HPO terms. Navigate: Correlations   Clinical Trials


    No related HPO nodes (Using clinical trials)


    Reports

    Data processed on January 01, 2021.

    An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.

    Drug Reports   MeSH Reports   HPO Reports  

    Interventions

    4,818 reports on interventions/drugs

    MeSH

    706 reports on MeSH terms

    HPO

    306 reports on HPO terms

    All Terms

    Alphabetical index of all Terms

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