Developed by Shray Alag, The Harker School
Sections: Correlations,
Clinical Trials, and HPO
Navigate: Clinical Trials and HPO
Name (Synonyms) | Correlation | |
---|---|---|
drug84 | AKS-452 Wiki | 0.71 |
drug899 | Convalescent plasma Wiki | 0.50 |
drug4042 | rAd26-S Wiki | 0.50 |
Name (Synonyms) | Correlation | |
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D000257 | Adenoviridae Infections NIH | 0.32 |
D007239 | Infection NIH | 0.17 |
D045169 | Severe Acute Respiratory Syndrome NIH | 0.14 |
Name (Synonyms) | Correlation |
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Navigate: Correlations HPO
There are 2 clinical trials
The objective is to evaluate the safety and immunogenicity of AZD1222 given in combination with (either before or after) rAd26-S, for the prevention of COVID 19 in adults ≥ 18 years of age.
Description: Incidence of local and systemic solicited AEs for 7 days post each dose Incidence of unsolicited AEs for 28 days post each dose Incidence of SAEs and AESIs to 28 days post second dose
Measure: Incidence of local and systemic solicited AEs for 7 days post each dose Incidence of unsolicited AEs for 28 days post each dose Incidence of SAEs and AESIs to 28 days post second dose Time: 180 daysDescription: Safety
Measure: Incidence of SAEs and AE of Special Interest until study end Time: 180 daysDescription: immunogenicity
Measure: SARS-CoV-2 antigen-specific antibody levels Time: 57 daysDescription: immunogenicity
Measure: To assess antibody responses Time: Up to 180 daysDescription: immunogenicity
Measure: Quantity of SARS-CoV-2 neutralizing antibodies Time: Up to 180 daysThis study is randomized, double-blind (blinded for the trial subject and the study physician), placebo-controlled trial in the parallel assignment of the immunogenicity, and safety of the Gam-COVID-Vac combined vector vaccine against the SARS-CoV-2-induced coronavirus infection in adults in the SARS-СoV-2 infection prophylactic treatment.
Description: The geometric mean titer of the SARS-CoV-2 glycoprotein-specific antibodies in trial subjects on the drug administration day before injecting the first dose of the study vaccine/placebo and 42±4 , 120±14 and 180±14 days after the first dose
Measure: SARS-CoV-2 glycoprotein-specific antibodies titer Time: 42±4 , 120±14 and 180±14 daysDescription: Percentage of trial subjects with fourfold or more increase in the titer of SARS-CoV-2 glycoprotein-specific antibodies in trial subjects on the drug administration day before injecting the first dose of the study vaccine/placebo and 42±4, 120±14 and 180±14 days after the first dose
Measure: Seroconversion rate Time: 42±4, 120±14 and 180±14 daysDescription: Interferon gamma concentration in response to S protein after re-stimulation with the SARS-CoV-2 glycoprotein in trial subjects on the drug administration day before injecting the first dose of the study vaccine/placebo and 28±4 days after the first dose
Measure: IFN-gamma antigen-specific release Time: 28±4 daysDescription: The number of proliferating CD4 and CD8 cells in response to antigen stimulation in trial subjects on the drug administration day before injecting the first dose of the study vaccine/placebo and 28±4 days after the first dose
Measure: CD4+/CD8+ proliferating cells Time: 28±4 daysDescription: Geometric mean virus-neutralizing antibodies titer in trial subjects on the drug administration day before injecting the first dose of the study vaccine/placebo and 42±4 and 120±14 days after the first dose
Measure: Virus-neutralizing antibodies titer Time: 42±4 and 120±14 daysDescription: Incidence and severity of adverse events in trial subjects within 4 & 6 months after injecting the first dose of the study vaccine/placebo.
Measure: Incidence and severity of adverse events Time: within 4 & 6 monthsAlphabetical listing of all HPO terms. Navigate: Correlations Clinical Trials
Data processed on January 01, 2021.
An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.
Drug Reports MeSH Reports HPO Reports