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    Health care workers

    This report considers only clinical trials that are associated with COVID-19 vaccines.

    Developed by Shray Alag, The Harker School
    Sections: Correlations, Clinical Trials, and HPO

    Correlations computed by analyzing all clinical trials.

    Navigate: Clinical Trials and HPO


    Correlated Drug Terms (4)


    Name (Synonyms) Correlation
    drug1923 MR or M-M-R II ® vaccine Wiki 0.71
    drug678 CVnCoV Vaccine Wiki 0.50
    drug366 BCG Vaccine Wiki 0.35
    Name (Synonyms) Correlation
    drug2490 Placebo Wiki 0.18

    Correlated MeSH Terms (2)


    Name (Synonyms) Correlation
    D045169 Severe Acute Respiratory Syndrome NIH 0.14
    D018352 Coronavirus Infections NIH 0.11

    Correlated HPO Terms (0)


    Name (Synonyms) Correlation

    Clinical Trials

    Navigate: Correlations   HPO

    There are 2 clinical trials


    1 Reducing Health Care Workers Absenteeism in COVID-19 Pandemic by Enhanced Trained Immune Responses Through Bacillus Calmette-Guérin Vaccination, a Randomized Controlled Trial.

    Rationale: Covid-19 spreads rapidly throughout the world. A large epidemic in the Netherlands would seriously challenge the available hospital capacity, and this would be augmented by absenteeism of healthcare workers (HCW). Strategies to prevent absenteeism of HCW are, therefore, desperately needed to safeguard continuous patient care. Bacille Calmette-Guérin (BCG) is a vaccine against tuberculosis, with protective non-specific effects against other respiratory tract infections in in vitro and in vivo studies, and reported significant reductions in morbidity and mortality. The hypothesis is that BCG vaccination can reduce HCW absenteeism during the epidemic phase of Covid-19. Objective: Primary objective: To reduce absenteeism among HCW with direct patient contacts during the epidemic phase of Covid-19. Secondary objective: To reduce hospital admission, ICU admission or death in HCW with direct patient contacts during the epidemic phase of Covid-19. Study design: A placebo-controlled adaptive multi-centre randomized controlled trial. Study population: HCW with direct patient contacts among which nurses and physicians working at emergency rooms and wards where Covid-19-infected patients are treated. Intervention: Participants will be randomized between intracutaneous administration of BCG vaccine or placebo in a 1:1 ratio. Main study parameters/endpoints: Primary endpoint: number of days of (unplanned) absenteeism for any reason. Secondary endpoints include the number of days of (unplanned) absenteeism because of documented Covid-19 infection, and the cumulative incidence of hospital admission, Intensive Care Admission, and death. Nature and extent of the burden and risks associated with participation, benefit and group relatedness: Based on previous experience and randomized controlled trials in adult and elderly individuals, the risks of BCG vaccination are considered low. The objective of this trial is to evaluate the beneficial effects of BCG vaccination through a lower work absenteeism rate of HCW and/or a mitigated clinical course of Covid-19 infection. The primary endpoint and the adaptive design with frequent interim analyses facilitate maximum efficiency of the trial, so that results can inform policy making during the ongoing epidemic.

    NCT04328441
    Conditions
    1. COVID-19
    Interventions
    1. Drug: BCG Vaccine
    2. Drug: Placebo

    Primary Outcomes

    Description: Number of days of unplanned absenteeism for any reason

    Measure: Health Care Workers absenteeism

    Time: Maximum of 365 days

    Secondary Outcomes

    Measure: the cumulative incidence of documented COVID-19

    Time: Maximum of 365 days

    Measure: the cumulative incidence of Hospital Admission due to documented COVID-19

    Time: Maximum of 365 days

    Measure: the number of days of unplanned absenteeism, because of documented COVID-19

    Time: Maximum of 365 days

    Measure: the cumulative incidence of self-reported acute respiratory symptoms or fever

    Time: Maximum of 365 days

    Measure: the cumulative incidence of death due to documented COVID-19

    Time: Maximum of 365 days

    Measure: the cumulative incidence of Intensive Care Admission due to documented COVID-19

    Time: Maximum of 365 days

    Description: Exploratory

    Measure: the number of days of absenteeism, because of imposed quarantine as a result of exposure to COVID-19

    Time: Maximum of 365 days

    Description: Exploratory

    Measure: the number of days of absenteeism, because of imposed quarantine as a result of having acute respiratory symptoms, fever or documented COVID-19

    Time: Maximum of 365 days

    Description: Exploratory

    Measure: the number of days of unplanned absenteeism because of self-reported acute respiratory symptoms

    Time: Maximum of 365 days

    Description: Exploratory

    Measure: the number of days of self-reported fever (≥38 gr C)

    Time: Maximum of 365 days

    Description: Exploratory

    Measure: the cumulative incidence of self-reported fever (≥38 gr C)

    Time: Maximum of 365 days

    Description: Exploratory

    Measure: the number of days of self-reported acute respiratory symptoms

    Time: Maximum of 365 days

    Description: Exploratory

    Measure: the cumulative incidence of self-reported acute respiratory symptoms

    Time: Maximum of 365 days

    Description: Exploratory

    Measure: the cumulative incidence of death for any reason

    Time: Maximum of 365 days

    Description: Exploratory

    Measure: the cumulative incidence of Intensive Care Admission for any reason

    Time: Maximum of 365 days

    Description: Exploratory

    Measure: the cumulative incidence of Hospital Admission for any reason

    Time: Maximum of 365 days

    Description: Exploratory

    Measure: the cumulative incidence and magnitude of plasma/serum antibodies (IgA,M,G) and SARS-CoV-2-specific antibodies at 12 weeks after vaccination and at the end of the study period

    Time: Maximum of 365 days

    Description: Exploratory

    Measure: the cumulative incidence and magnitude of plasma/serum antibodies (IgA,M,G) and SARS-CoV-2-specific antibodies at 12 weeks after vaccination and at the end of the study period

    Time: 3-6 months after inclusion
    2 An International, Multi-site, Bayesian Platform Adaptive, Randomized, Placebo-controlled Trial Assessing the Effectiveness of Candidate Agents in Mitigating COVID-19 Disease in Healthcare Workers

    The objective of CROWN CORONATION is the prevention of symptomatic COVID-19 by using combinations of approved and safe repurposed interventions, with complementary mechanisms of action.

    NCT04333732
    Conditions
    1. COVID 19
    Interventions
    1. Drug: MR or M-M-R II ® vaccine
    2. Drug: Placebo

    Primary Outcomes

    Description: To determine the incidence of the trial intervention(s) in preventing laboratory test-confirmed, symptomatic COVID19 (i.e. any of the following: cough, shortness of breath or difficulty breathing, fever, chills, muscle pain, sore throat, new loss of taste or smell, nausea, vomiting, or diarrhea), in healthcare workers with repeated exposures to SARS-CoV-2 by day 60 after enrollment.

    Measure: Symptomatic COVID-19

    Time: 60 days

    Secondary Outcomes

    Description: Severity of COVID-19 will be graded on a simplified version of the ordinal World Health Organization COVID-19 severity scale (WHO COVID-19 severity scale).

    Measure: Severity of COVID-19 over the study period

    Time: 60 days

    Description: SARS-CoV-2 infection (by serology) over up to 5 months of follow-up

    Measure: Effectiveness of preventing/reducing SARS-CoV-2 infection

    Time: 5 months

    No related HPO nodes (Using clinical trials)


    HPO

    Alphabetical listing of all HPO terms. Navigate: Correlations   Clinical Trials


    No related HPO nodes (Using clinical trials)


    Reports

    Data processed on January 01, 2021.

    An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.

    Drug Reports   MeSH Reports   HPO Reports  

    Interventions

    4,818 reports on interventions/drugs

    MeSH

    706 reports on MeSH terms

    HPO

    306 reports on HPO terms

    All Terms

    Alphabetical index of all Terms

    Google Colab

    Python example via Google Colab Notebook