Developed by Shray Alag, The Harker School
Sections: Correlations,
Clinical Trials, and HPO
Navigate: Clinical Trials and HPO
Name (Synonyms) | Correlation | |
---|---|---|
drug97 | ARCT-021 Dose 1 Wiki | 0.50 |
drug4131 | vaccine BCG Wiki | 0.50 |
drug99 | ARCT-021 Dose 3 Wiki | 0.50 |
Name (Synonyms) | Correlation | |
---|---|---|
drug3562 | V-SARS Wiki | 0.50 |
drug98 | ARCT-021 Dose 2 Wiki | 0.50 |
drug102 | ARCT-021 Dose Regimen 2 Wiki | 0.50 |
drug653 | COVID19 vaccine Wiki | 0.50 |
drug101 | ARCT-021 Dose Regimen 1 Wiki | 0.50 |
drug100 | ARCT-021 Dose 4 Wiki | 0.50 |
drug1364 | GX-19 Wiki | 0.50 |
drug2985 | Saline Wiki | 0.45 |
drug4042 | rAd26-S Wiki | 0.35 |
drug367 | BCG vaccine Wiki | 0.25 |
drug128 | AZD1222 Wiki | 0.22 |
drug2490 | Placebo Wiki | 0.19 |
Name (Synonyms) | Correlation | |
---|---|---|
D000257 | Adenoviridae Infections NIH | 0.22 |
D007239 | Infection NIH | 0.12 |
D045169 | Severe Acute Respiratory Syndrome NIH | 0.10 |
Name (Synonyms) | Correlation |
---|
Navigate: Correlations HPO
There are 4 clinical trials
The primary objective of this study is to describe the safety and tolerability of one IM dose of AZD1222 followed by one IM dose of rAd26-S in adults ≥ 18 years of age
Description: Incidence of Serious Adverse Events (SAEs) post first dose until the study end
Measure: Incidence of Serious Adverse Events (SAEs) post first dose until the study end Time: from Day 1 until Day 180Description: Incidence of unsolicited AEs for 28 days post each dose
Measure: Incidence of unsolicited Adverse Events (AEs) for 28 days post each dose Time: from Day 1 to Day 28 and from Day 29 to Day 57Description: Incidence of local and systemic solicited AEs for 7 days post each dose
Measure: Incidence of local and systemic solicited AEs for 7 days post each dose Time: from Day 1 to Day 8 and From Day 29 to Day 36Description: Incidence of AESIs post first dose until study end (Day 180)
Measure: Incidence of Adverse events of special interest (AESIs) post first dose until study end Time: from Day 1 to Day 180Description: assessment of time course of antibody to Spike protein of one IM dose of AZD1222 followed by one IM dose of rAd26-S
Measure: assessment of time course of antibody to Spike protein of one IM dose of AZD1222 followed by one IM dose of rAd26-S Time: On Day 1 and on Day 29Description: Determination of anti-SARS-CoV-2 neutralising antibody levels in serum following one IM dose of AZD1222 followed by one IM dose of rAd26-S
Measure: Determination of anti-SARS-CoV-2 neutralising antibody levels in serum following one IM dose of AZD1222 followed by one IM dose of rAd26-S Time: On Day 1 and on day 29Description: Proportion of participants who have a post treatment seroresponse (≥ 4-fold rise in titers from day of dosing baseline value to 28 days post each dose) as measured by SARS-CoV-2 antibodies to Spike protein
Measure: Proportion of participants who have a post treatment seroresponse Time: from Day 1 (before dose) to Day 28 and from Day 29 (before dose) to Day 57This is a study to test a new vaccine (Covax-19) against COVID-19. COVID-19 is a potentially deadly disease that is caused by a new strain of coronavirus called SARS-CoV-2. To date, SARS-CoV-2 has infected over 4 million people worldwide resulted in the deaths of over three hundred thousand people.
Description: Incidence of Adverse Events 1 week post immunisation
Measure: Incidence of Adverse Events Time: 1 weeks post immunisationDescription: COVID19 neutralizing antibody titers post immunisation
Measure: COVID19 neutralizing antibody titers Time: 2 weeks post second immunisationDescription: Frequency of COVID19 spike specific T cells 3 weeks post second immunisation
Measure: COVID19 T cell immunogenicity Time: 3 weeks post second immunisationDescription: COVID19 spike specific antibody titers 6 months post second immunisation
Measure: Durability of antibody response Time: 6 months post immunisationUntil the first half of April, Colombia has more than 2,800 infected cases and a hundred deaths as a result of COVID-19, with Antioquia being the third department with the highest number of cases. Official records indicate that, in Colombia, the first case was diagnosed on March 6, 2020, corresponding to a patient from Italy. However, in conversations with several infectologists and intensivists from Medellín, it was agreed that clinical cases similar to the clinical presentation that is now recognized as COVID-19 had arisen since the end of 2019 when it was still unknown to everyone. The previous suggests that the virus was already circulating in the country since before March 6, 2020. But at that moment, there were no tools to make a clinical identification, nor to diagnose it from the laboratory's point of view. Considering as real the hypothesis that the infection has been circulating in the country since before the first official diagnosis, the question arises: Why does not the country still has the same healthcare and humanitarian chaos that countries such as Italy and Spain are suffering at this time? To answer this question may be that there are differences in vaccination rates with BCG (Bacille Calmette-Guérin or tuberculosis vaccine), which is significantly higher in Latin America compared to those in Europe. This finding could explain to some extent the situation in the country, since previous studies have shown the influence that this vaccine can have on the immune response against various other pathogens, including viruses. Among the population at risk of infection, health-care workers due to their permanent contact with patients are the population group with the highest risk of contracting SARS-Cov-2 and developing COVID-19 in any of its clinical manifestations, and currently there are no vaccines or proven preventive interventions available to protect them. For this reason, this research study aims to demonstrate whether the centennial vaccine against tuberculosis (BCG), a bacterial disease, can activate the human immune system in a broad way, allowing it to better combat the coronavirus that causes COVID-19 and, perhaps, prevents the complications that lead the patient to the intensive care unit and death. In the future, and if these results are as expected, they may be the basis for undertaking a population vaccination campaign that improves clinical outcomes in the general population.
Description: Incidence of COVID-19 cases confirmed or probable in the study population
Measure: Primary outcome Time: From date of randomization to 360 day of the studyDescription: Incidence of severe or critical infection in COVID-19 cases
Measure: Secondary outcome Time: From date to diagnosis to 1 month afterDescription: Lethality of the infection in both groups
Measure: Secondary outcome Time: From date to diagnosis to 1 month afterDescription: Assess the safety (frequency, seriousness, and severity of adverse events) of BCG vaccination
Measure: Secondary outcome Time: From date of randomization to 7 day of the studyDescription: Prevalence of SARS-Cov-2 infection
Measure: Secondary outcome Time: At baseline evaluationSafety and immunogenicity one-month study in healthy individuals administered once-daily pill of therapeutic vaccine made from heat-inactivated plasma from donors with COVID-19. Healthy, at least 20, volunteers will be monitored for signs of adverse events. Their PBMC will be collected at baseline and one month later to analyze which type of immune response vaccine has induced.
Description: Routine laboratory complete blood cell count at pre- and post-treatment periods by automated CBC counter Routine laboratory complete blood count Routine clinical laboratory CBC parameters at pre- and post-treatment periods
Measure: Effect on CBC as per CTCAE v4.0 Time: 15 DaysDescription: Routine clinical laboratory blood biochemistry parameters at pre- and post-treatment periods by automated biochemistry analyzer
Measure: Effect on biochemistry parameters as per CTCAE v4.0 Time: 15 DaysDescription: Clinical well-being assessed by CTCAE v4.0
Measure: Lack of adverse events as per CTCAE v4.0 Time: 15 daysAlphabetical listing of all HPO terms. Navigate: Correlations Clinical Trials
Data processed on January 01, 2021.
An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.
Drug Reports MeSH Reports HPO Reports