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    intravenous immunogloulin therapy

    This report considers only clinical trials that are associated with COVID-19 vaccines.

    Developed by Shray Alag, The Harker School
    Sections: Correlations, Clinical Trials, and HPO

    Correlations computed by analyzing all clinical trials.

    Navigate: Clinical Trials and HPO


    Correlated Drug Terms (1)


    Name (Synonyms) Correlation
    drug3901 intravenous immunoglobulin therapy Wiki 1.00

    Correlated MeSH Terms (0)


    Name (Synonyms) Correlation

    Correlated HPO Terms (0)


    Name (Synonyms) Correlation

    Clinical Trials

    Navigate: Correlations   HPO

    There is one clinical trial.


    1 Intravenous Immunoglobulins for the Treatment of Covid-19 Patients: a Clinical Trial

    The current project is based on the immunological studies covering the potential of disease induced immunoglobulins as treatment regime. We would be able to generate the concentrated antibodies specific against coronavirus (Covid-19). These antibodies can be used as serum therapy. Aside from a Covid-19 vaccine, antibodies from recovered patients could provide a short-term "passive immunization" to the disease. Those antibodies can be extracted from the blood serum of surviving patients and then injected into infected people. Passive immunization usually lasts for a few weeks or months, after which those borrowed or donated antibodies, get broken down by the host body within about 30 days. While drugs to treat patients with covid-19, and vaccines to prevent infection are being developed, a fast acting, stopgap serum therapy could be useful as a first aid for high-risk patients.

    NCT04548557
    Conditions
    1. Covid19
    Interventions
    1. Biological: intravenous immunoglobulin therapy

    Primary Outcomes

    Description: total number of days the patient remain in hospital

    Measure: In hospital days

    Time: 14 days or discharge

    Description: mortality if any in the study duration of 14 days

    Measure: 14 day mortality

    Time: 14 days

    Secondary Outcomes

    Description: reduction in D-dimers (< 250 ng/mL)

    Measure: D-dimers

    Time: 7 days

    Description: reduction in C-Reactive protein (less than 10 mg/L)

    Measure: C-reactive protein

    Time: 7 days

    Description: improvement in oxygen saturation (pulse oximeter readings within range of 95 to 100%)

    Measure: Oxygen saturation

    Time: 7 days

    Description: reduction in TNF alpha after IVIG treatment (upto 8.1 pg/mL)

    Measure: TNF alpha

    Time: 7 days

    Description: reduction in IL-6 after IVIG treatment

    Measure: IL-6

    Time: 7 days

    Description: reduction in ferritin levels after IVIG treatment

    Measure: Ferritin

    Time: 7 days

    Description: safety and tolerability

    Measure: Number of participants with treatment-related adverse events as assessed by CTCAE v4.0

    Time: 14 days

    No related HPO nodes (Using clinical trials)


    HPO

    Alphabetical listing of all HPO terms. Navigate: Correlations   Clinical Trials


    No related HPO nodes (Using clinical trials)


    Reports

    Data processed on January 01, 2021.

    An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.

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    Interventions

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    MeSH

    706 reports on MeSH terms

    HPO

    306 reports on HPO terms

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    Alphabetical index of all Terms

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