Developed by Shray Alag, The Harker School
Sections: Correlations,
Clinical Trials, and HPO
Navigate: Clinical Trials and HPO
Name (Synonyms) | Correlation | |
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drug3802 | convalescent plasma Wiki | 1.00 |
drug2514 | Placebo Comparator Wiki | 1.00 |
drug394 | Bacille Calmette-Guérin (BCG) Wiki | 0.71 |
Name (Synonyms) | Correlation | |
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D045169 | Severe Acute Respiratory Syndrome NIH | 0.20 |
D018352 | Coronavirus Infections NIH | 0.16 |
Name (Synonyms) | Correlation |
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Navigate: Correlations HPO
There is one clinical trial.
A novel betacoronavirus, SARS-CoV-2, is spreading rapidly throughout the world. A large epidemic in South Africa may overwhelm available hospital capacity and healthcare resources which would be worsened by absenteeism of healthcare workers and other frontline staff (HCW). Strategies to prevent morbidity and mortality of HCW are desperately needed to safeguard continuous patient care. Bacillus Calmette-Guérin (BCG) is a vaccine against tuberculosis (TB), with protective non-specific effects against other respiratory tract infections in in vitro and in vivo studies, with reported morbidity and mortality reductions as high as 70%. We hypothesize that a BCG vaccination may reduce the morbidity and mortality of healthcare workers during the COVID-19 outbreak in South Africa.
Description: To compare the incidence of HCWs hospitalized due to COVID-19 per arm.
Measure: Incidence of HCWs hospitalized due to COVID-19 per arm Time: 52 weeksDescription: To determine the incidence of SARS-CoV-2 infection in HCW by molecular or serological testing (as available) at entry, 10, 26 and/or 52 weeks.
Measure: Incidence of SARS-CoV-2 infection per arm Time: 52 weeksDescription: To compare the incidence of symptoms of upper respiratory tract infection per arm.
Measure: Incidence of upper respiratory tract infections per arm Time: 52 weeksDescription: To compare the number of days of (unplanned) absenteeism because of documented SARS-CoV-2 infection, COVID-19 or any reason per arm.
Measure: Days of unplanned absenteeism due to COVID-19 or any reason per arm Time: 52 weeksDescription: To compare the incidence of hospitalization of HCW for any reason per arm.
Measure: Incidence of hospitalization for any reason per arm Time: 52 weeksDescription: To compare the incidence of intensive care admission of HCW due to COVID-19 or any reason per arm.
Measure: Incidence of intensive care unit admission per arm Time: 52 weeksDescription: To compare the incidence of death of HCW due to COVID-19 or any reason per arm.
Measure: Incidence of death per arm Time: 52 weeksDescription: To describe the prevalence of latent TB infection as determined by interferon gamma release assay (IGRA) at enrolment and at week 52.
Measure: Prevalence of latent TB infection Time: 52 weeksDescription: To compare the incidence of active TB of HCW per arm.
Measure: Incidence of active TB per arm Time: 52 weeksDescription: To compare the effect of latent TB infection on morbidity and mortality of HCW due to COVID-19 per arm. The risk of morbidity and mortality of latent TB infected individuals is not known, we will examine whether there is a higher risk of disease severity and poor outcomes in this group.
Measure: Compare the effect of latent TB on morbidity and mortality due to COVID-19 per arm Time: 52 weeksDescription: To compare the incidence of grade 2 or higher adverse events and vaccination site reactions per arm.
Measure: Incidence of treatment related adverse events Time: 52 weeksAlphabetical listing of all HPO terms. Navigate: Correlations Clinical Trials
Data processed on January 01, 2021.
An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.
Drug Reports MeSH Reports HPO Reports