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    Lentiviral vector, Covid-19/aAPC vaccine

    This report considers only clinical trials that are associated with COVID-19 vaccines.

    Developed by Shray Alag, The Harker School
    Sections: Correlations, Clinical Trials, and HPO

    Correlations computed by analyzing all clinical trials.

    Navigate: Clinical Trials and HPO

    Correlated Drug Terms (1)

    Name (Synonyms) Correlation
    drug2417 Pathogen-specific aAPC Wiki 1.00

    Correlated MeSH Terms (0)

    Name (Synonyms) Correlation

    Correlated HPO Terms (0)

    Name (Synonyms) Correlation

    Clinical Trials

    Navigate: Correlations   HPO

    There is one clinical trial.

    1 Safety and Immunity Evaluation of A Covid-19 Coronavirus Artificial Antigen Presenting Cell Vaccine

    In December 2019, viral pneumonia (Covid-19) caused by a novel beta-coronavirus (SARS-CoV-2) broke out in Wuhan, China. Some patients rapidly progressed and suffered severe acute respiratory failure and died, making it imperative to develop a safe and effective vaccine to treat and prevent severe Covid-19 pneumonia. Based on detailed analysis of the viral genome and search for potential immunogenic targets, a synthetic minigene has been engineered based on conserved domains of the viral structural proteins and a polyprotein protease. The infection of Covid-19 is mediated through binding of the Spike protein to the ACEII receptor, and the viral replication depends on molecular mechanisms of all of these viral proteins. This trial proposes to develop universal vaccine and test innovative Covid-19 minigenes engineered based on multiple viral genes, using an efficient lentiviral vector system (NHP/TYF) to express viral proteins and immune modulatory genes to modify artificial antigen presenting cells (aAPC) and to activate T cells. In this study, the safety and immune reactivity of this aAPC vaccine will be investigated.

    1. Treat and Prevent Covid-19 Infection
    1. Biological: Pathogen-specific aAPC

    Primary Outcomes

    Description: Frequency of vaccine events such as fever, rash, and abnormal heart function.

    Measure: Frequency of vaccine events

    Time: Measured from Day 0 through Day 28

    Description: Frequency of serious vaccine events

    Measure: Frequency of serious vaccine events

    Time: Measured from Day 0 through Day 28

    Measure: Proportion of subjects with positive T cell response

    Time: 14 and 28 days after randomization

    Secondary Outcomes

    Description: Number of deaths during study follow-up

    Measure: 28-day mortality

    Time: Measured from Day 0 through Day 28

    Description: Duration of mechanical ventilation use in days. Multiple mechanical ventilation durations are summed up

    Measure: Duration of mechanical ventilation if applicable

    Time: Measured from Day 0 through Day 28

    Description: Proportion of patients in each category of the 7-point scale, the 7-category ordinal scale that ranges from 1 (discharged with normal activity) to 7 (death)

    Measure: Proportion of patients in each category of the 7-point scale

    Time: 7,14 and 28 days after randomization

    Description: Proportion of patients with different inflammation factors in normalization range

    Measure: Proportion of patients with normalized inflammation factors

    Time: 7 and 14 days after randomization

    Description: A decline of 2 points on the 7-point scale from admission means better outcome. The 7-category ordinal scale that ranges from 1 (discharged with normal activity) to 7 (death)

    Measure: Clinical improvement based on the 7-point scale if applicable

    Time: 28 days after randomization

    Description: Murray lung injury score decrease more than one point means better outcome. The Murray scoring system range from 0 to 4 according to the severity of the condition

    Measure: Lower Murray lung injury score if applicable

    Time: 7 days after randomization

    No related HPO nodes (Using clinical trials)


    Alphabetical listing of all HPO terms. Navigate: Correlations   Clinical Trials

    No related HPO nodes (Using clinical trials)


    Data processed on January 01, 2021.

    An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.

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