Developed by Shray Alag, The Harker School
Sections: Correlations,
Clinical Trials, and HPO
Navigate: Clinical Trials and HPO
Name (Synonyms) | Correlation | |
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drug369 | BCG-10 vaccine Wiki | 1.00 |
drug16 | 0.9% saline Wiki | 1.00 |
drug128 | AZD1222 Wiki | 0.45 |
Name (Synonyms) | Correlation | |
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D003141 | Communicable Diseases NIH | 0.41 |
D007239 | Infection NIH | 0.24 |
D045169 | Severe Acute Respiratory Syndrome NIH | 0.20 |
Name (Synonyms) | Correlation |
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Navigate: Correlations HPO
There is one clinical trial.
Countries that have not carried out universal mass vaccination against tuberculosis (BCG) have been shown to have higher incidence and death rates due to COVID-19 than countries with mass, long-term BCG immunization programmes. The aim of the study is to answer the following questions: 1. Does BCG vaccination affect the course of COVID-19 (number of cases/deaths/severity of symptoms)? 2. Will the course of COVID-19 be milder among subjects with a negative TB skin test (PPD RT 23 SSI) after an additional dose of BCG than in case of non-vaccinated subjects? 3. Do people with a positive TB skin test have a milder course of COVID-19 infection than people with a negative test result? A multicenter, randomized, partially blinded, placebo-controlled study will be conducted in Rzeszow/Krakow/ Katowice/Warsaw on a group of 1000 volunteers, health care workers according to the following schedule: V 0-1: inclusion/informed consent/interview; V2: administration of TB skin test/anti-SARS-CoV-2 IgG test/serum banking*; V3: TB skin test (TST) interpretation and subjects' division into three groups: (I) positive TST - observation; (II) negative TST- BCG-10 vaccination; (III) negative TST - placebo. Division into groups II and III based on randomisation; V4: serum banking*. Parallel beginning from V3, weekly telephone monitoring participants' health status; In case of COVID-19 symptoms a nasopharyngeal swab to confirm SARS-CoV-2 infection + serum banking*. V5: 3 months after vaccination at the end of the study: history/anti-SARS-CoV-2 IgG test, serum banking*. Statistical analysis - comparison of the course of COVID-19 in groups: (I) with positive TST + observation, (II) with negative TST + BCG, (III) with negative TST + placebo - should demonstrate whether mass BCG vaccination has an impact on the incidence and course of COVID-19. * to measure the level of cytokines involved in cell-mediated immunity process
Description: shock - when catecholamines are required despite initial fluid resuscitation severe respiratory failure - the need for non-invasive or invasive ventilation severe renal failure - the need for renal replacement therapy (for undialysed individuals, i.e. with end-stage renal failure (ESRD)
Measure: death and life- or health-threatening condition (cardiac arrest with effective resuscitation, shock, severe respiratory failure, severe renal failure, stroke/transient cerebral ischaemia) Time: throughout the period of 18 months from inclusionDescription: Present symptoms (determined in the Telephone Contact Card) appear to indicate a possible SARS-CovV-2 infection
Measure: Onset of clinical symptoms of COVID-19 Time: 12 weeks from the date of the third visit - V3Description: based on anti SARS-CoV-2 IgG serological tests
Measure: asymptomatic SARS-CovV-2 infection Time: 12 weeks from the date of the third visit - V3Description: the need for hospitalisation and its duration
Measure: Hospitalisation Time: 12 weeks from the date of the third visit - V3Description: the need for hospitalisation in the ICU and its duration
Measure: ICU Hospitalisation Time: 12 weeks from the date of the third visit - V3Description: requiring passive oxygen therapy to eliminate the symptom or maintain saturation >92%
Measure: Dyspnoea Time: 12 weeks from the date of the third visit - V3Alphabetical listing of all HPO terms. Navigate: Correlations Clinical Trials
Data processed on January 01, 2021.
An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.
Drug Reports MeSH Reports HPO Reports