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    Ad5-nCoV

    This report considers only clinical trials that are associated with COVID-19 vaccines.

    Developed by Shray Alag, The Harker School
    Sections: Correlations, Clinical Trials, and HPO

    Correlations computed by analyzing all clinical trials.

    Navigate: Clinical Trials and HPO


    Correlated Drug Terms (6)


    Name (Synonyms) Correlation
    drug158 Ad5-nCoV Wiki 0.71
    drug12 0.9% (w/v) saline Wiki 0.71
    drug2812 Recombinant novel coronavirus vaccine (Adenovirus type 5 vector) Wiki 0.71
    Name (Synonyms) Correlation
    drug80 AG0301-COVID19 Wiki 0.50
    drug128 AZD1222 Wiki 0.32
    drug2490 Placebo Wiki 0.09

    Correlated MeSH Terms (1)


    Name (Synonyms) Correlation
    D000257 Adenoviridae Infections NIH 0.63

    Correlated HPO Terms (0)


    Name (Synonyms) Correlation

    Clinical Trials

    Navigate: Correlations   HPO

    There are 2 clinical trials


    1 A Clinical Trial to Evaluate the Safety and Immunogenicity of a Recombinant Adenovirus 5 Vectored COVID-19 Vaccine (Ad5-nCoV) With Two Doses in Healthy Adults Aged 18 Years and Older

    This is a clinical trial to evaluate the safety and immunogenicity of a recombinant adenovirus 5 vectored COVID-19 vaccine (Ad5-nCoV) with two doses and with different adminstration routes in healthy adults aged 18 years and older.

    NCT04552366
    Conditions
    1. COVID-19
    Interventions
    1. Biological: Ad5-nCoV
    MeSH:Adenoviridae Infections

    Primary Outcomes

    Description: The occurrence of AE in all groups within 0-7 days after each vaccination;

    Measure: Incidence of the AE in all groups

    Time: 0-7 days after each vaccination

    Description: Seroconversion rate the IgG antibody against SARS-CoV-2 measured on Day 28 after last vaccination

    Measure: Seroconversion rate of the IgG antibody against SARS-CoV-2

    Time: Day 28 after last vaccination

    Description: Geomean titers of the IgG antibody against SARS-CoV-2 measured on Day 28 after last vaccination

    Measure: Geomean titers of the IgG antibody against SARS-CoV-2

    Time: Day 28 after last vaccination

    Description: Seroconversion rate of the neutralizing antibody against SARS-CoV-2 measured on Day 28 after last vaccination

    Measure: Seroconversion rate of the neutralizing antibody against SARS-CoV-2

    Time: Day 28 after last vaccination

    Description: Geomean titers of the neutralizing antibody against SARS-CoV-2 measured on Day 28 after last vaccination

    Measure: Geomean titers of the neutralizing antibody against SARS-CoV-2

    Time: Day 28 after last vaccination

    Secondary Outcomes

    Description: The occurrence of AE in all groups within 0-30 minutes and 0-28 days after each vaccination.

    Measure: Incidence of the AE in all groups

    Time: 0-30 minutes, 0-28 days after each vaccination

    Description: The occurrence of Serious adverse events (SAE) in all groups within 6 months after the final vaccination.

    Measure: Incidence of Serious adverse events (SAE) in all groups

    Time: 6 months after the final vaccination

    Description: Geomean titers of the IgG antibody against SARS-CoV-2 measured on Day 0, 14, 28 and 56 after first vaccination and on Day 14 and Day168 after last vaccination.

    Measure: Geomean titers of the IgG antibody against SARS-CoV-2

    Time: Day 0, 14, 28 and 56 after first vaccination and Day 14 and Day168 after last vaccination.

    Description: Seroconversion rate of the IgG antibody against SARS-CoV-2 measured on Day 0, 14, 28 and 56 after first vaccination and on Day 14 and Day168 after last vaccination.

    Measure: Seroconversion rate of the IgG antibody against SARS-CoV-2

    Time: Day 0, 14, 28 and 56 after first vaccination and Day 14 and Day168 after last vaccination.

    Description: Geomean titers of the neutralizing antibody against SARS-CoV-2 measured on Day 0, 14, 28 and 56 after first vaccination and on Day 14 and Day168 after last vaccination.

    Measure: Geomean titers of the neutralizing antibody against SARS-CoV-2

    Time: Day 0, 14, 28 and 56 after first vaccination and Day 14 and Day168 after last vaccination.

    Description: Seroconversion rate of the neutralizing antibody against SARS-CoV-2 measured on Day 0, Day14, Day 28 or Day 56 after first vaccination and on day 14, day 28 and day168 after last vaccination.

    Measure: Seroconversion rate of the neutralizing antibody against SARS-CoV-2

    Time: Day 0, 14, 28 and 56 after first vaccination and on Day 14 and Day168 after last vaccination.

    Description: The positive rate of IFN-γ stimulated by S protein overlapping peptide library detected by ELISpot on Day 0 and Day 14 after each vaccination

    Measure: Cellular immune response by ELISpot

    Time: Day 0 and Day 14 after each vaccination

    Description: Geomean titers of neutralizing antibody response to Ad5-vector on Day 0, 14 and 28 after each vaccination.

    Measure: Geomean titers of neutralizing antibody response to Ad5-vector

    Time: Day 0, 14 and 28 after each vaccination.

    Description: The positive rate of the specific cytokines expressed by CD4+ and CD8+ T lymphocytes stimulated by S protein overlapping peptide library detected by intracellular cytokine staining on Day 0 and Day 14 after each vaccination

    Measure: Cellular immune response by ICS

    Time: Day 0 and Day 14 after each vaccination

    Description: Geomean titers of the IgA antibody against SARS-CoV-2 on Day 0, 14 and 28 after each vaccination.

    Measure: Geomean titers of the IgA antibody against SARS-CoV-2

    Time: Day 0, 14 and 28 after each vaccination
    2 A Randomized, Double-blind, Placebo-controlled Phase II Clinical Trial to Evaluate the Safety and Immunogenicity of the Recombinant Novel Coronavirus Vaccine (Adenovirus Vector) in Healthy Adults Aged Above 18 Years

    This is a phase II, randomised, double-blinded and placebo-controlled clinical trial in healthy adults above 18 years of age. This clinical trial is designed to evaluate the immunogenicity and safety of Ad5-nCoV which encodes for a full-length spike (S) protein of SARS-CoV-2.

    NCT04341389
    Conditions
    1. COVID-19
    Interventions
    1. Biological: Recombinant novel coronavirus vaccine (Adenovirus type 5 vector)
    2. Other: Placebo
    MeSH:Adenoviridae Infections

    Primary Outcomes

    Measure: Occurrence of adverse reactions

    Time: 0-14 days post vaccination

    Measure: Anti SARS-CoV-2 S IgG antibody response(ELISA)

    Time: 28 days post vaccination

    Measure: Neutralizing antibody response to SARS-CoV-2

    Time: 28 days post vaccination

    Secondary Outcomes

    Measure: Occurrence of adverse events

    Time: 0-28 days post vaccination

    Measure: Occurrence of serious adverse reaction

    Time: 0-6 months post vaccination

    Measure: Anti SARS-CoV-2 S IgG antibody response(ELISA)

    Time: 0, 14 days and 6 months post vaccination

    Measure: Neutralizing antibody response to SARS-CoV-2

    Time: 0 and 6 months post vaccination

    Measure: Neutralizing antibody response to Ad5-vector

    Time: 0, 28 days and 6 months post vaccination

    Measure: IFN-γ ELISpot responses to SARS-CoV-2 spike protein

    Time: 0 and 28 days post vaccination

    No related HPO nodes (Using clinical trials)


    HPO

    Alphabetical listing of all HPO terms. Navigate: Correlations   Clinical Trials


    No related HPO nodes (Using clinical trials)


    Reports

    Data processed on January 01, 2021.

    An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.

    Drug Reports   MeSH Reports   HPO Reports  

    Interventions

    4,818 reports on interventions/drugs

    MeSH

    706 reports on MeSH terms

    HPO

    306 reports on HPO terms

    All Terms

    Alphabetical index of all Terms

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