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    AZD1222 vaccine for COVID-19 Prevention

    This report considers only clinical trials that are associated with COVID-19 vaccines.

    Developed by Shray Alag, The Harker School
    Sections: Correlations, Clinical Trials, and HPO

    Correlations computed by analyzing all clinical trials.

    Navigate: Clinical Trials and HPO


    Correlated Drug Terms (3)


    Name (Synonyms) Correlation
    drug369 BCG-10 vaccine Wiki 1.00
    drug16 0.9% saline Wiki 1.00
    drug128 AZD1222 Wiki 0.45

    Correlated MeSH Terms (4)


    Name (Synonyms) Correlation
    D003141 Communicable Diseases NIH 0.41
    D007239 Infection NIH 0.24
    D045169 Severe Acute Respiratory Syndrome NIH 0.20
    Name (Synonyms) Correlation
    D018352 Coronavirus Infections NIH 0.16

    Correlated HPO Terms (0)


    Name (Synonyms) Correlation

    Clinical Trials

    Navigate: Correlations   HPO

    There is one clinical trial.


    1 A Phase III Open-label Study in Adults to Determine the Safety and Immunogenicity of AZD1222, a Non-replicating ChAdOx1 Vector Vaccine, for the Prevention of COVID-19

    The purpose of this study is to evaluate safety and immunogenicity of AZD1222 for COVID-19 prevention in the Russian Federation

    NCT04540393
    Conditions
    1. COVID-19
    Interventions
    1. Biological: AZD1222

    Primary Outcomes

    Description: Occurrence of SAEs following the first vaccination and throughout the study duration (Day 180).

    Measure: Incidence of SAEs following the first vaccination and throughout the study duration (Day 180) [Safety and Tolerability].

    Time: 180 days

    Secondary Outcomes

    Description: Local and systemic solicited AEs for 7 days following each vaccination. Unsolicited AEs for 28 days following each vaccination. Occurrence of AESIs following the first vaccination and throughout the study duration (Day 180).

    Measure: Incidence of Solicited AEs for 7 following each vaccination [Safety and Tolerability].

    Time: 180 days

    Description: immunogenicity / serologic responses to AZD1222

    Measure: SARS-CoV-2 antigen-specific antibody levels

    Time: 180 days

    Description: immunogenicity / serologic responses to AZD1222

    Measure: The rate of participants seroconverting from negative to positive SARS-CoV-2 S antigen

    Time: 180 days

    Description: immunogenicity / serologic responses to AZD1222

    Measure: The rate of participants seroconverting from negative to positive SARS-CoV-2 N

    Time: 180 days

    Description: immunogenicity / serologic responses to AZD1222

    Measure: Quantity of SARS-CoV-2 neutralizing antibodies

    Time: 180 days

    Description: immunogenicity / serologic responses to AZD1222

    Measure: Count of peripheral blood mononuclear cells (PBMCs)

    Time: 180 days

    Description: immunogenicity / serologic responses to AZD1222

    Measure: Quantity of seasonal coronavirus antigens

    Time: 180 days

    Description: immunogenicity / serologic responses to AZD1222

    Measure: Quantity of antibodies to the ChAdOx1vector and the persistence of these antibodies over time

    Time: 180 days

    No related HPO nodes (Using clinical trials)


    HPO

    Alphabetical listing of all HPO terms. Navigate: Correlations   Clinical Trials


    No related HPO nodes (Using clinical trials)


    Reports

    Data processed on January 01, 2021.

    An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.

    Drug Reports   MeSH Reports   HPO Reports  

    Interventions

    4,818 reports on interventions/drugs

    MeSH

    706 reports on MeSH terms

    HPO

    306 reports on HPO terms

    All Terms

    Alphabetical index of all Terms

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