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    This report considers only clinical trials that are associated with COVID-19 vaccines.

    Developed by Shray Alag, The Harker School
    Sections: Correlations, Clinical Trials, and HPO

    Correlations computed by analyzing all clinical trials.

    Navigate: Clinical Trials and HPO

    Correlated Drug Terms (5)

    Name (Synonyms) Correlation
    drug2994 Saline-sodium citrate (SSC) buffer Wiki 1.00
    drug365 BCG GROUP Wiki 1.00
    drug2382 PLACEBO GROUP Wiki 1.00
    Name (Synonyms) Correlation
    drug1592 INO-4800 Wiki 0.58
    drug557 CELLECTRA® 2000 Wiki 0.50

    Correlated MeSH Terms (2)

    Name (Synonyms) Correlation
    D045169 Severe Acute Respiratory Syndrome NIH 0.20
    D018352 Coronavirus Infections NIH 0.16

    Correlated HPO Terms (0)

    Name (Synonyms) Correlation

    Clinical Trials

    Navigate: Correlations   HPO

    There is one clinical trial.

    1 Randomized Controlled Trial Evaluating the Efficacy of Vaccination With Bacillus Calmette and Guérin (BCG) in the Prevention of COVID-19 Via the Strengthening of Innate Immunity in Health Care Workers

    Healthcare Workers (HCW) are at high risk for COVID-19. In addition to the risk of serious forms among HCW, significant absenteeism due to illness would have dramatic consequences in our ability to fight COVID-19. No coronavirus vaccine is available today and drug treatments are only at the start of clinical evaluation. Available since 1921, the bacillus Calmette and Guérin (BCG) is the most widely used vaccine in the world (> 3 billion doses administered) with an extremely low rate of adverse effects. BCG is indicated for the prevention of tuberculosis (TB), but more recent studies have shown that it also has nonspecific immune properties which may be interesting in the current COVID-19 epidemic. Data in mice and in humans have demonstrated protection conferred by BCG against viral respiratory infections such as influenza. In countries with high endemic TB, BCG decreases the incidence of acute respiratory infections by up to 80%, neonatal BCG vaccination has been shown to greatly reduce the risk of sepsis and of hospitalization of children for reasons other than TB. A recent study conducted in South Africa showed that re-vaccination with BCG in adults reduced the incidence of respiratory infections by 70% compared to unvaccinated controls. Beyond respiratory infections, BCG has also shown protective effects against inflammatory diseases. These non-specific beneficial effects are likely linked to the induction of "trained innate immunity", implying epigenetic and metabolic re-programming of innate immune cells. It is therefore possible that revaccination with BCG could significantly reduce the incidence and severity of COVID-19. Very recent ecological observations indeed suggest an inverse correlation between BCG vaccination coverage and the morbidity and mortality of COVID-19. In this context several trials began in Europe and Australia to evaluate the efficacy of BCG vaccination in populations at risk of exposure (HCW) or severe disease (elderly). This study is aligned with studies carried out in Australia, The Netherlands and Spain. In contrast to these latter studies, virtually all French study participants have been vaccinated in their childhood, since BCG vaccination was mandatory in France in neonates until 2007, and in HCW until recently. Therefore, the French study will be in a unique situation to evaluate the effect of re-vaccination with BCG in the context of BCG priming decades before revaccination.

    1. Infection
    2. Viral, Agent as Cause of Disease Classified Elsewhere
    1. Biological: BCG GROUP
    2. Other: PLACEBO GROUP

    Primary Outcomes

    Description: Documented COVID-19, i.e. symptomatic COVID-19 confirmed by either positive nasopharyngeal tests for SARS CoV2 and/or by thoracic tomodensitometry compatible with the diagnosis. and/or SARS CoV2 seroconversion

    Measure: Incidence of documented COVID-19 among health care workers exposed to SARS CoV2 and vaccinated with BCG compared to placebo.

    Time: during the study period of 6 months

    Secondary Outcomes

    Description: Participants having developed a severe form of COVID-19, as defined by the necessity for hospitalization in ICU and O2 or artificial ventilation, or extracorporeal membrane oxygenation, or death

    Measure: Numbers of COVID-19 patients requiring hospitalization in ICU and O2, artificial ventilation or extracorporal membrane oxygenation, or deaths in BCG-vaccinated health care workers compared to placebo

    Time: during the study period of 6 months.

    Description: Participants with seroconversion during the study, without symptoms related to COVID-19

    Measure: Incidence of asymptomatic SARS CoV2 seropositive subjects among BCG-vaccinated health care workers compared to placebo.

    Time: during the study period of 6 months.

    Description: Participants presenting any kind of respiratory infection due to any cause

    Measure: Incidence of subjects with any respiratory infection among BCG-vaccinated health care workers compared to placebo.

    Time: during the study period of 6 months.

    Description: Numbers of sick days and number of sick leaves

    Measure: Numbers of sick days and numbers of sick leaves among BCG-vaccinated health care workers compared to placebo.

    Time: during the study period of 6 months

    Description: Local and general events following BCG revaccination after BCG revaccination

    Measure: Numbers of subjects with BCG-related advers events among BCG-vaccinated health care workers compared to placebo.

    Time: 30 days after BCG revaccination

    Description: Potentially modified markers of innate immunity upon SARS CoV-2 infection to be identified

    Measure: Numbers and intensity of changes in innate immune markers after SARS CoV2 infection among BCG-vaccinated health care workers compared to placebo.

    Time: during the study period of 6 months.

    No related HPO nodes (Using clinical trials)


    Alphabetical listing of all HPO terms. Navigate: Correlations   Clinical Trials

    No related HPO nodes (Using clinical trials)


    Data processed on January 01, 2021.

    An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.

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    4,818 reports on interventions/drugs


    706 reports on MeSH terms


    306 reports on HPO terms

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