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    Adenovirus V

    This report considers only clinical trials that are associated with COVID-19 vaccines.

    Developed by Shray Alag, The Harker School
    Sections: Correlations, Clinical Trials, and HPO

    Correlations computed by analyzing all clinical trials.

    Navigate: Clinical Trials and HPO


    Correlated Drug Terms (2)


    Name (Synonyms) Correlation
    drug2806 Recombinant Novel Coronavirus Vaccine (Adenovirus Type 5 Vector) -placebo Wiki 1.00
    drug2805 Recombinant Novel Coronavirus Vaccine (Adenovirus Type 5 Vector) Wiki 0.45

    Correlated MeSH Terms (0)


    Name (Synonyms) Correlation

    Correlated HPO Terms (0)


    Name (Synonyms) Correlation

    Clinical Trials

    Navigate: Correlations   HPO

    There is one clinical trial.


    1 A Randomized, Double-blind, Placebo -Controlled Phase IIb Clinical Trial to Evaluate the Safety and Immunogenicity of Ad5-nCoV in Person 6 Years of Age and Older and Those Who Have Previously Been Vaccinated With Ad5-EBOV

    This study is a randomized, double-blind, placebo -controlled IIb clinical trial, in order to evaluate the safety and immunogenicity of Recombinant Novel Coronavirus Vaccine (Adenovirus Type 5 Vector) in people 6 years old and above and .

    NCT04566770
    Conditions
    1. COVID-19
    Interventions
    1. Biological: Recombinant Novel Coronavirus Vaccine (Adenovirus Type 5 Vector)
    2. Biological: Recombinant Novel Coronavirus Vaccine (Adenovirus Type 5 Vector) -placebo

    Primary Outcomes

    Description: Occurrence of adverse reactions post vaccination

    Measure: Safety indexes of adverse reactions

    Time: within 14 days post each vaccination

    Description: Evaluate the Geometric mean titer (GMT) of IgG antibody

    Measure: Immunogencity indexes of GMT

    Time: Day 28 post the second vaccination

    Description: Evaluate the Geometric mean titer (GMT) of neutralizing antibody

    Measure: Immunogencity indexes of neutralizing antibody

    Time: Day 28 post the second vaccination

    Secondary Outcomes

    Description: Occurrence of adverse reactions post-vaccination

    Measure: Safety indexes of adverse events

    Time: Day 0-7,0-14,0-28 post each vaccination

    Description: Occurrence of abnormal changes of Hematological examination indexes(only fit for MID and sentinel group)

    Measure: Safety indexes of Hematological examination measures(Hemoglobin, WBC)

    Time: pre-vaccination, day 4 post each vaccination

    Description: Occurrence of abnormal changes of lBlood routine indexes (only fit for MID and sentinel group)

    Measure: Safety indexes of Blood routine measures(ALT, AST)

    Time: pre-vaccination, day 4 post each vaccination

    Description: Occurrence of serious adverse events post-vaccination

    Measure: Safety indexes of SAE

    Time: Within 6 months post the second vaccination

    Description: Evaluate the Geometric mean titer of IgG antibody

    Measure: Immunogencity indexes of GMT

    Time: Day 28 post the first vaccination, pre the second vaccination ,Month 6 post the second vaccination

    Description: Evaluate the Geometric mean titer (GMT) of neutralizing antibody

    Measure: Immunogencity indexes of neutralizing antibody

    Time: Day 28 post the first vaccination, pre the second vaccination ,Month 6 post the second vaccination

    Description: Number of cell-mediated immune response against SARS-CoV-2(IL-2)

    Measure: Immunogencity indexes of cellular immune

    Time: Day 28 post the first vaccination, pre and day 28 post the second vaccination

    No related HPO nodes (Using clinical trials)


    HPO

    Alphabetical listing of all HPO terms. Navigate: Correlations   Clinical Trials


    No related HPO nodes (Using clinical trials)


    Reports

    Data processed on January 01, 2021.

    An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.

    Drug Reports   MeSH Reports   HPO Reports  

    Interventions

    4,818 reports on interventions/drugs

    MeSH

    706 reports on MeSH terms

    HPO

    306 reports on HPO terms

    All Terms

    Alphabetical index of all Terms

    Google Colab

    Python example via Google Colab Notebook