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    Critically ill COVID-19 patients

    This report considers only clinical trials that are associated with COVID-19 vaccines.

    Developed by Shray Alag, The Harker School
    Sections: Correlations, Clinical Trials, and HPO

    Correlations computed by analyzing all clinical trials.

    Navigate: Clinical Trials and HPO


    Correlated Drug Terms (3)


    Name (Synonyms) Correlation
    drug2912 SARS-CoV-2 antibody based IVIG therapy Wiki 1.00
    drug1642 Inactivated SARS-CoV-2 Vaccine (Vero cell) Wiki 0.58
    drug2490 Placebo Wiki 0.13

    Correlated MeSH Terms (1)


    Name (Synonyms) Correlation
    D045169 Severe Acute Respiratory Syndrome NIH 0.20

    Correlated HPO Terms (0)


    Name (Synonyms) Correlation

    Clinical Trials

    Navigate: Correlations   HPO

    There is one clinical trial.


    1 Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-2) Antibodies Based Intravenous Immunoglobulin (IVIG) Therapy for Severe and Critically Ill COVID-19 Patients

    Severe and critically ill patients will be enrolled in the study (50 patients) after duly filled consent forms. Recipients shall be divided in to 5 groups with 10 patients per group to compare clinical efficacy and safety of patients in clinical phase I study. Each group shall receive particular single dose of Intravenously administered Immunoglobulins (IVIG) developed from convalescent plasma of recovered COVID-19 individual , an experimental drug along with standard treatment except for control group which will receive standard treatment only.

    NCT04521309
    Conditions
    1. COVID-19
    Interventions
    1. Biological: SARS-CoV-2 antibody based IVIG therapy
    MeSH:Severe Acute Respiratory Syndrome

    Primary Outcomes

    Description: All cause mortality of participants will be monitored for 28 days to assess the safety and efficacy of IVIG treatment.

    Measure: 28 Days mortality

    Time: 28 days

    Description: Number of days required for invasive or non-invasive oxygen supply during hospital stay as per oxygen saturation status of patient

    Measure: Requirement of supplemental oxygen support

    Time: 28 days

    Description: Number of days a participant will be requiring assisted ventilation both invasive and noninvasive

    Measure: Number of days on assisted ventilation

    Time: 28 days

    Description: Shifting from ICU to ward

    Measure: Days to step down

    Time: 28 days

    Description: Duration from day of enrollment in study to Day of hospital discharge

    Measure: Days to Hospital Discharge

    Time: 28 days

    Description: Kidney failure, hypersensitivity with cutaneous or hemodynamic manifestations, aseptic meningitis, hemolytic anemia, leuko-neutropenia, transfusion related acute lung injury (TRALI)

    Measure: Adverse events during hospital stay

    Time: 28 days

    Description: Change in C-Reactive Protein (CRP) levels from baseline will be used to monitor inflammation

    Measure: Change in C-Reactive Protein (CRP) levels

    Time: 28 days

    Description: change in neutrophil lymphocyte ratio from baseline will be used to monitor inflammation

    Measure: Change in neutrophil lymphocyte ratio

    Time: 28 days

    Secondary Outcomes

    Description: change in Ferritin level from baseline will be used to monitor inflammation and immune dysregulation

    Measure: Change in Ferritin levels

    Time: 28 days

    Description: change in LDH from baseline will be used to monitor infections and tissue health

    Measure: Change in lactate dehydrogenase (LDH) levels

    Time: 28 days

    Description: Any change seen in radiological chest X-ray findings

    Measure: Change in radiological (X-ray) findings

    Time: 28 days

    Description: Time taken for participant to receive negative COVID-19 PCR test

    Measure: Days to negative SARS-CoV-2 Polymerase Chain Reaction (PCR) test

    Time: 28 days

    Description: Anti-SARS-CoV-2 antibody titre from blood measured by semi-qualitative method

    Measure: Anti-SARS-CoV-2 Antibody

    Time: 28 days

    Description: Change in body temperature from baseline will be used to monitor safety and efficacy

    Measure: Change in fever

    Time: 28 days

    Description: Change in electrolytes (Sodium) seen in participants

    Measure: Change in Sodium levels

    Time: 28 days

    Description: Change in electrolytes (Potassium) seen in participants

    Measure: Change in Potassium levels

    Time: 28 days

    Description: Change in electrolytes (Chloride) seen in participants

    Measure: Change in Chloride levels

    Time: 28 days

    Description: Change in electrolytes (Bicarbonate) seen in participants

    Measure: Change in Bicarbonate levels

    Time: 28 days

    No related HPO nodes (Using clinical trials)


    HPO

    Alphabetical listing of all HPO terms. Navigate: Correlations   Clinical Trials


    No related HPO nodes (Using clinical trials)


    Reports

    Data processed on January 01, 2021.

    An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.

    Drug Reports   MeSH Reports   HPO Reports  

    Interventions

    4,818 reports on interventions/drugs

    MeSH

    706 reports on MeSH terms

    HPO

    306 reports on HPO terms

    All Terms

    Alphabetical index of all Terms

    Google Colab

    Python example via Google Colab Notebook