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    adenoviral vector

    This report considers only clinical trials that are associated with COVID-19 vaccines.

    Developed by Shray Alag, The Harker School
    Sections: Correlations, Clinical Trials, and HPO

    Correlations computed by analyzing all clinical trials.

    Navigate: Clinical Trials and HPO


    Correlated Drug Terms (6)


    Name (Synonyms) Correlation
    drug1366 Gam-COVID-Vac Wiki 0.65
    drug3947 multipeptide cocktail Wiki 0.58
    drug2936 SARS-CoV-2 vaccine (inactivated) Wiki 0.58
    Name (Synonyms) Correlation
    drug2777 RUTI® vaccine Wiki 0.58
    drug4004 placebo Wiki 0.33
    drug2490 Placebo Wiki 0.22

    Correlated MeSH Terms (1)


    Name (Synonyms) Correlation
    D007239 Infection NIH 0.42

    Correlated HPO Terms (0)


    Name (Synonyms) Correlation

    Clinical Trials

    Navigate: Correlations   HPO

    There are 3 clinical trials


    1 Randomized, Double-blind, Placebo Controlled, Clinical Trial of the Immunogenicity, Safety, and Efficacy of the Gam-COVID-Vac Combined Vector Vaccine in Prophylactic Treatment for SARS-СoV-2 Infection

    Randomized, double-blind, placebo controlled clinical trial of immunogenicity, safety and efficacy of the Gam-COVID-Vac combined vector vaccine against the SARS-CoV-2-induced coronavirus infection in adults.

    NCT04642339
    Conditions
    1. Covid19
    Interventions
    1. Biological: Gam-COVID-Vac
    2. Biological: Placebo

    Primary Outcomes

    Description: Percentage of trial subjects with fourfold or more increase in the titer of SARS-CoV-2 glycoprotein-specific antibodies in 2,000 trial subjects on the drug administration day before injecting the first dose of the study drug/placebo and 42±2 and 180±14 days after the first dose

    Measure: Seroconversion rate

    Time: 42 day, 180 day

    Secondary Outcomes

    Description: Incidence and severity of adverse events in trial subjects within 6 months after injecting the first dose of the study drug/placebo

    Measure: Incidence and severity of adverse events

    Time: through the study (till day 180)

    Description: Geometric mean virus-neutralizing antibodies titer in 500 trial subjects on the drug administration day before injecting the first dose of the study drug/placebo and 42±2 days after the first dose

    Measure: Virus-neutralizing antibody levels against the SARS-CoV-2

    Time: 42 day

    Description: Geometric mean titer of the SARS-CoV-2 glycoprotein-specific antibodies in 2,000 trial subjects on the drug administration day before injecting the first dose of the study drug/placebo and 42±2 and 180±14 days after the first dose

    Measure: Antibody levels against the SARS-CoV-2 glycoprotein

    Time: 42 day, 180 day

    Description: Percentage of trial subjects with coronavirus disease 2019 (COVID-19) developed within 6 months, as confirmed with the method of polymerase chain reaction (PCR)

    Measure: Percentage of trial subjects with coronavirus disease 2019 (COVID-19)

    Time: through the study (till day 180)
    2 Сlinical Trial of Efficacy, Safety and Immunogenicity of Combined Vector Vaccine Gam-COVID-Vac in SARS-СoV-2 Infection Prophylactic Treatment in Republic of Belarus

    Randomized, double-blind (blinded for the trial subject and the study physician), placebo controlled, multi-center clinical trial in parallel assignment of efficacy, immunogenicity, and safety of the Gam-COVID-Vac combined vector vaccine against the SARS-CoV-2-induced coronavirus infection in adults in the SARS-СoV-2 infection prophylactic treatment.

    NCT04564716
    Conditions
    1. Covid19
    Interventions
    1. Biological: Gam-COVID-Vac
    2. Other: Placebo

    Primary Outcomes

    Description: Demonstrate the superiority of Gam-COVID-Vac combined vector vaccine against the SARS-CoV-2-induced coronavirus infection compared to placebo, based on the percentage of trial subjects with coronavirus disease 2019 (COVID-19) developed within 6 months after the second dose of the study drug/placebo, as confirmed with the method of polymerase chain reaction (PCR)

    Measure: percentage of trial subjects with coronavirus disease 2019 (COVID-19) developed within 6 months after the first dose

    Time: through the whole study, an average of 180 days

    Secondary Outcomes

    Description: Assess the efficacy of the Gam-COVID-Vac combined vector vaccine against the SARS-CoV-2-induced coronavirus compared to placebo, based on the severity of the clinical course of COVID-19

    Measure: the severity of the clinical course of COVID-19

    Time: through the whole study, an average of 180 days

    Description: Assess the immunogenicity of the Gam-COVID-Vac combined vector vaccine against the SARS-CoV-2-induced coronavirus infection compared to placebo, based on the geometric mean titer of SARS-CoV-2 glycoprotein-specific antibodies

    Measure: Changing of antibody levels against the SARS-CoV-2 glycoprotein S

    Time: day before injecting the first dose of the study drug/placebo and 42±2 and 180±14 days after the first dose

    Description: Incidence of adverse events in trial subjects compared to placebo

    Measure: Incidence of adverse events in trial subjects

    Time: through the whole study, an average of 180 days

    Description: Severity of adverse events in trial subjects compared to placebo

    Measure: Severity of adverse events in trial subjects

    Time: through the whole study, an average of 180 days
    3 Randomized Double-blind Placebo-controlled Multi-center Clinical Trial in Parallel Assignment of Efficacy, Safety, and Immunogenicity of Gam-COVID-Vac Combined Vector Vaccine in SARS-СoV-2 Infection Prophylactic Treatment

    Randomized, double-blind (blinded for the trial subject and the study physician), placebo controlled, multi-center clinical trial in parallel assignment of efficacy, immunogenicity, and safety of the Gam-COVID-Vac combined vector vaccine against the SARS-CoV-2-induced coronavirus infection in adults in the SARS-СoV-2 infection prophylactic treatment.

    NCT04530396
    Conditions
    1. Covid19 Prevention
    Interventions
    1. Biological: Gam-COVID-Vac
    2. Other: placebo

    Primary Outcomes

    Description: Demonstrate the superiority of Gam-COVID-Vac combined vector vaccine against the SARS-CoV-2-induced coronavirus infection compared to placebo, based on the percentage of trial subjects with coronavirus disease 2019 (COVID-19) developed within 6 months after the second dose of the study drug/placebo, as confirmed with the method of polymerase chain reaction (PCR)

    Measure: percentage of trial subjects with coronavirus disease 2019 (COVID-19) developed within 6 months after the first dose

    Time: through the whole study, an average of 180 days

    Secondary Outcomes

    Description: Assess the efficacy of the Gam-COVID-Vac combined vector vaccine against the SARS-CoV-2-induced coronavirus compared to placebo, based on the severity of the clinical course of COVID-19

    Measure: the severity of the clinical course of COVID-19

    Time: through the whole study, an average of 180 days

    Description: Assess the immunogenicity of the Gam-COVID-Vac combined vector vaccine against the SARS-CoV-2-induced coronavirus infection compared to placebo, based on the geometric mean titer of SARS-CoV-2 glycoprotein-specific antibodies

    Measure: Changing of antibody levels against the SARS-CoV-2 glycoprotein S

    Time: day before injecting the first dose of the study drug/placebo and 42±2 and 180±14 days after the first dose

    Description: Describe the strength of cell-mediated immune response induced by the use of the Gam-COVID-Vac combined vector vaccine against the SARS-CoV-2-induced coronavirus infection compared to placebo

    Measure: Changing of antigen-specific cellular immunity level

    Time: the drug administration day before injecting the first dose of the study drug/placebo and 28±2 days after the first dose

    Description: Geometric mean virus-neutralizing antibodies titer

    Measure: Changing of of virus neutralizing antibody titer

    Time: the drug administration day before injecting the first dose of the study drug/placebo and 42±2 days after the first dose

    Description: Incidence of adverse events in trial subjects compared to placebo

    Measure: Incidence of adverse events in trial subjects

    Time: through the whole study, an average of 180 days

    Description: Severity of adverse events in trial subjects compared to placebo

    Measure: Severity of adverse events in trial subjects

    Time: through the whole study, an average of 180 days

    Description: Percentage of study subjects with antibodies to the N-protein of the SARS - CoV-2 virus that appeared after vaccination

    Measure: estimation of the proportion of study subjects with antibodies to the N-protein of the virus SARS-CoV-2

    Time: day before injecting the first dose of the study drug/placebo and 42±2 and 180±14 days after the first dose

    No related HPO nodes (Using clinical trials)


    HPO

    Alphabetical listing of all HPO terms. Navigate: Correlations   Clinical Trials


    No related HPO nodes (Using clinical trials)


    Reports

    Data processed on January 01, 2021.

    An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.

    Drug Reports   MeSH Reports   HPO Reports  

    Interventions

    4,818 reports on interventions/drugs

    MeSH

    706 reports on MeSH terms

    HPO

    306 reports on HPO terms

    All Terms

    Alphabetical index of all Terms

    Google Colab

    Python example via Google Colab Notebook