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    Sars-Cov-2 Virus Infection

    This report considers only clinical trials that are associated with COVID-19 vaccines.

    Developed by Shray Alag, The Harker School
    Sections: Correlations, Clinical Trials, and HPO

    Correlations computed by analyzing all clinical trials.

    Navigate: Clinical Trials and HPO


    Correlated Drug Terms (5)


    Name (Synonyms) Correlation
    drug3573 VLA2001 Wiki 1.00
    drug1916 MF59 adjuvanted SARS-CoV-2 Sclamp vaccine 45mcg Wiki 1.00
    drug1917 MF59 adjuvanted SARS-CoV-2 Sclamp vaccine 5mcg Wiki 1.00
    Name (Synonyms) Correlation
    drug1915 MF59 adjuvanted SARS-CoV-2 Sclamp vaccine 15mcg Wiki 1.00
    drug2490 Placebo Wiki 0.13

    Correlated MeSH Terms (1)


    Name (Synonyms) Correlation
    D014777 Virus Diseases NIH 0.41

    Correlated HPO Terms (0)


    Name (Synonyms) Correlation

    Clinical Trials

    Navigate: Correlations   HPO

    There is one clinical trial.


    1 A Phase I/II Randomized, Two Parts, Dose-Finding Study To Evaluate The Safety, Tolerability and Immunogenicity Of An Inactivated, Adjuvanted Sars-Cov-2 Virus Vaccine Candidate (VLA2001), Against Covid-19 In Healthy Subjects

    A multicenter, 3-arm randomized dose finding study in UK to evaluate safety, tolerability and immunogenicity of a vaccine candidate against Covid-19. 150 healthy volunteers will be enrolled and receive two shots of the vaccine candidate.

    NCT04671017
    Conditions
    1. Sars-Cov-2 Virus Infection
    Interventions
    1. Biological: VLA2001
    MeSH:Virus Diseases

    Primary Outcomes

    Measure: Frequency and severity of solicited AEs (local and systemic reactions) within 7 days after any vaccination

    Time: until Day 29

    Measure: Geometric mean titre (GMT) for neutralizing antibodies against SARS-CoV-2

    Time: Day 36

    Secondary Outcomes

    Measure: Frequency and severity of any unsolicited AE

    Time: until Day 36

    Measure: Frequency and severity of any vaccine-related AE

    Time: until Day 36

    Measure: Frequency and severity of any AE

    Time: until Day 208

    Measure: Frequency and severity of any vaccine-related AE

    Time: until Day 208

    Measure: Frequency and severity of any SAE

    Time: until Day 36

    Measure: Frequency and severity of any AESI

    Time: until Day 36

    Measure: Frequency and severity of any SAE

    Time: until Day 208

    Measure: Frequency and severity of an AESI

    Time: until Day 208

    Measure: Immune response as measured by neutralizing antibody titres against SARS-CoV-2

    Time: until Day 208

    Measure: Proportion of subjects with seroconversion in terms of neutralizing antibodies

    Time: until Day 208

    Measure: Fold increase of SARS-CoV-2 neutralizing antibody titres compared with baseline

    Time: until Day 208

    Measure: GMTs for IgG antibodies against SARS-CoV-2

    Time: until Day 208

    Measure: Proportion of subjects with seroconversion in terms of IgG antibodies against SARS-CoV-2 in subjects negative for SARS-CoV-2 at screening

    Time: until Day 208

    No related HPO nodes (Using clinical trials)


    HPO

    Alphabetical listing of all HPO terms. Navigate: Correlations   Clinical Trials


    No related HPO nodes (Using clinical trials)


    Reports

    Data processed on January 01, 2021.

    An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.

    Drug Reports   MeSH Reports   HPO Reports  

    Interventions

    4,818 reports on interventions/drugs

    MeSH

    706 reports on MeSH terms

    HPO

    306 reports on HPO terms

    All Terms

    Alphabetical index of all Terms

    Google Colab

    Python example via Google Colab Notebook