SNPMiner Trials by Shray Alag

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SNPMiner SNPMiner Trials (Home Page)


Report for SNP rs12041331

Developed by Shray Alag, 2020-2021.
SNP Clinical Trial Gene

There is one clinical trial.

Clinical Trials


1 PHARMACOGENOMICS OF ANTI-PLATELET RESPONSE - I

This clinical trial is examining the role of genetic polymorphism on the effect of clopidogrel (with or without aspirin) on platelet response in persons at high-risk for myocardial infarction or stroke due to family history of early-onset coronary artery disease.

NCT01815008
Conditions
  1. Platelet Aggregation
  2. Platelet Transcriptome
  3. Coronary Artery Disease
Interventions
  1. Drug: Clopidogrel
  2. Drug: Aspirin
MeSH:Coronary Artery Disease
HPO:Coronary artery atherosclerosis

Platelet Aggregation Platelet Transcriptome Coronary Artery Disease Coronary Artery Disease The main goal of this study is to explore the impact of the PEAR1 genetic variant (rs12041331) on responsiveness to clopidogrel.

Primary Outcomes

Description: ADP-induced platelet aggregation will be measured using impedance aggregometry in whole blood before and after 1-week of clopidogrel. The difference between the baseline and after clopidogrel therapy will be determined. Higher impedance represent higher platelet aggregation.

Measure: Difference in ADP-induced Platelet Aggregation

Time: at baseline and at 1 week

Secondary Outcomes

Description: Arachidonic Acid-induced platelet aggregation will be measured using impedance aggregometry in whole blood before and after 1-week of clopidogrel. The difference between the baseline and after clopidogrel therapy will be determined

Measure: Difference in Arachidonic Acid-induced Platelet Aggregation

Time: At baseline and after 1-week

Description: Collagen-induced platelet aggregation will be measured using impedance aggregometry in whole blood before and after 1-week of clopidogrel. The difference between the baseline and after clopidogrel therapy will be determined

Measure: Difference in Collagen-induced Platelet Aggregation

Time: At Baseline and at 1 week

Description: Platelet transcriptome will be examined before and after 1 week of therapy with clopidogrel and differences will be determined

Measure: Changes in Platelet Transcriptome With Clopidogrel

Time: At baseline and at 1 week


HPO Nodes