1. The polycystic ovary syndrome is the major cause of infertility in the United States. Metformin has been shown to increase frequency of ovulations in PCOS, and is used in clinical practice to treat infertility, but some women with PCOS do not respond to metformin treatment. 2. Knowing that a specific gene predicts the effect of metformin on ovulation would facilitate more efficient and effective treatment of infertility in PCOS.

NCT00703508

Conditions

1. Polycystic Ovary Syndrome

Interventions

1. Drug: Metformin 500 mg tablet

MeSH:Polycystic Ovary Syndrome

HPO:Polycystic ovaries

Number of Responders/Non-responders for Each STK11 rs8111699 Genotype (C/G, C/C, G/G).

We hypothesize that women with the polycystic ovary syndrome (PCOS) who have the G/G genotype of single nucleotide polymorphism (SNP)_ rs8111699 in STK11 will exhibit a significantly greater response to metformin, in terms of ovulation, compared with women with either the C/G or C/C genotype.