SNPMiner Trials by Shray Alag
rs12979860 (38) rs6971 (31) rs9939609 (11) rs6265 (11) rs738409 (11) rs7903146 (8) rs4680 (8) rs8099917 (8) rs11200638 (6) rs429358 (6) rs10490924 (6) rs7412 (6) rs16969968 (5) rs25531 (5) rs1801133 (5) rs1800497 (5) rs1799971 (4) rs4244285 (4) rs2832407 (4) rs1045642 (4) rs1544410 (4) rs10033464 (3) rs1761667 (3) rs6166 (3) rs1042713 (3) rs2023239 (3) rs1051730 (3) rs174537 (3) rs1006737 (3) rs2230199 (3) rs1128503 (3) rs2231142 (3) rs10455872 (3) rs6313 (3) rs1061170 (3) rs776746 (3) rs4588 (3) rs2069514 (2) rs1799963 (2) rs9332739 (2) rs2032582 (2) rs3745274 (2) rs6295 (2) rs12936231 (2) rs6280 (2) rs7103572 (2) rs35599367 (2) rs13266634 (2) rs1410996 (2) rs6025 (2) rs4129267 (2) rs70991108 (2) rs174547 (2) rs1127354 (2) rs362331 (2) rs53576 (2) rs35705950 (2) rs641153 (2) rs1695 (2) rs2234246 (2) rs10741657 (2) rs1800955 (2) rs2106261 (2) rs4149056 (2) rs2234237 (2) rs362307 (2) rs3808607 (2) rs1828591 (2) rs1800470 (2) rs1024611 (2) rs12785878 (2) rs3751143 (2) rs762551 (2) rs165599 (2) rs2200733 (2) rs1150226 (2) rs4646 (2) rs3798220 (2) rs3813929 (2) rs25487 (2) rs10830963 (2) rs2472677 (2) rs2281135 (2) rs4986893 (2) rs3211938 (2) rs8050136 (2) rs1801131 (2) rs855791 (2) rs5219 (2) rs4646437 (2) rs2228570 (2) rs2070744 (1) rs1017783 (1) rs4986938 (1) rs2297201 (1) rs377637047 (1) rs2298771 (1) rs1799724 (1) rs7799039 (1) rs7041 (1) rs7586970 (1) rs8175347 (1) rs1799853 (1) rs1799732 (1) rs6190 (1) rs9344 (1) rs3918242 (1) rs7549785 (1) rs3796529 (1) rs10835211 (1) rs3570920 (1) rs1998199 (1) rs2274333 (1) rs78408340 (1) rs28363170 (1) rs2987983 (1) rs833069rs (1) rs41524547 (1) rs12529 (1) rs1042522 (1) rs11958940 (1) rs34743033 (1) rs13058338 (1) rs2043211 (1) rs5082 (1) rs6739405 (1) rs4958351 (1) rs6296 (1) rs3761624 (1) rs13333226 (1) rs179008 (1) rs4802703 (1) rs547154 (1) rs7521902 (1) rs867186 (1) rs641738 (1) rs2540923 (1) rs2297480 (1) rs1672717 (1) rs4869676 (1) rs10163409 (1) rs4869675 (1) rs236114 (1) rs6165 (1) rs700518 (1) rs11615 (1) rs3025039 (1) rs11795404 (1) rs3816527 (1) rs999737 (1) rs10836235 (1) rs1256049 (1) rs27072 (1) rs614367 (1) rs12434438 (1) rs137852620 (1) rs3853445 (1) rs35874116 (1) rs3747158 (1) rs1799930 (1) rs20432111 (1) rs5068 (1) rs1310182 (1) rs7604448 (1) rs20455 (1) rs1042714 (1) rs3114018 (1) rs2269273 (1) rs6269 (1) rs1042711 (1) rs2269272 (1) rs861529 (1) rs18011131 (1) rs9340799 (1) rs2235046 (1) rs316019 (1) rs10995190 (1) rs1260326 (1) rs4570625 (1) rs1042718 (1) rs2250656 (1) rs731236 (1) rs2307227 (1) rs41524745 (1) rs6841581 (1) rs1049353 (1) rs244072 (1) rs13208321 (1) rs35463555 (1) rs1052533 (1) rs3918226 (1) rs61747728 (1) rs4073 (1) rs904627 (1) rs2295190 (1) rs2053044 (1) rs10153820 (1) rs754203 (1) rs547987105 (1) rs2562582 (1) rs2494732 (1) rs619824 (1) rs8176528 (1) rs1360780 (1) rs833061 (1) rs16147 (1) rs72552763 (1) rs9679162 (1) rs2280964 (1) rs7975232 (1) rs1726866 (1) rs10813831 (1) rs6504950 (1) rs806380 (1) rs6856901 (1) rs45511401 (1) rs573562920 (1) rs3210140 (1) rs887829 (1) rs7221412 (1) rs628031 (1) rs20417 (1) rs2687133 (1) rs7579240 (1) rs174535 (1) rs679620 (1) rs2060793 (1) rs806377 (1) rs1800629 (1) rs66554220 (1) rs1800624 (1) rs3750920 (1) rs1042522s (1) rs10246939 (1) rs2550946 (1) rs2279744 (1) rs909253 (1) rs2071559 (1) rs1024582 (1) rs10930214 (1) rs13387042 (1) rs17601696 (1) rs2046210 (1) rs8065080 (1) rs4604006 (1) rs2002555 (1) rs757110 (1) rs2910164 (1) rs1061325 (1) rs4950928 (1) rs10994336 (1) rs11548193 (1) rs73049 (1) rs9457827 (1) rs1883112 (1) rs17782313 (1) rs12459419 (1) rs150018775 (1) rs708272 (1) rs2275163 (1) rs12762549 (1) rs10941679 (1) rs699947 (1) rs2895795 (1) rs2697153 (1) rs45500792 (1) rs30461 (1) rs550842646 (1) rs2067085 (1) rs1051931 (1) rs333 (1) rs3853839 (1) rs956572 (1) rs4900442 (1) rs3755166 (1) rs324015 (1) rs271924 (1) rs3758673 (1) rs3758674 (1) rs11572080 (1) rs4151667 (1) rs894278 (1) rs10859871 (1) rs2294918 (1) rs933226 (1) rs9657182 (1) rs571312 (1) rs20715592 (1) rs12201199 (1) rs1786378374 (1) rs13376333 (1) rs17070145 (1) rs17561 (1) rs34489327 (1) rs7571842 (1) rs11133360 (1) rs2235321 (1) rs678849 (1) rs8069645 (1) rs35059413 (1) rs6454674 (1) rs2853884 (1) rs737865 (1) rs183489969 (1) rs7333181 (1) rs1143623 (1) rs71647871 (1) rs4149032 (1) rs17037122 (1) rs1062613 (1) rs2516513 (1) rs1048661 (1) rs11126727 (1) rs11568821 (1) rs1049524 (1) rs11568820 (1) rs1049522 (1) rs172378 (1) rs10994133 (1) rs924607 (1) rs2488457 (1) rs1143633 (1) rs11039155 (1) rs1143634 (1) rs2464266 (1) rs396991 (1) rs562696473 (1) rs11126731 (1) rs8105790 (1) rs10509681 (1) rs12041331 (1) rs1805010 (1) rs6013897 (1) rs16139 (1) rs2234693 (1) rs35652124 (1) rs4693608 (1) rs961360700 (1) rs2305948 (1) rs4343 (1) rs5743844 (1) rs4883263 (1) rs10033900 (1) rs4883264 (1) rs2243250 (1) rs2241193 (1) rs17614942 (1) rs2383206 (1) rs1800592 (1) rs613872 (1) rs4803217 (1) rs11031006 (1) rs1047768 (1) rs12208357 (1) rs4488809 (1) rs1800588 (1) rs2227902 (1) rs1549339 (1) rs3184504 (1) rs2248949 (1) rs222797 (1) rs1643649 (1) rs4803455 (1) rs2853564 (1) rs780094 (1) rs2231137 (1) rs6434222 (1) rs3825942 (1) rs112735431 (1) rs751402 (1) rs9701796 (1) rs1202167 (1) rs1202168 (1) rs1202169 (1) rs12472215 (1) rs4311 (1) rs2279238 (1) rs3766404 (1) rs7349683 (1) rs3781727 (1) rs1800450 (1) rs7157609 (1) rs529802001 (1) rs2257401 (1) rs3817198 (1) rs1217414 (1) rs1045485 (1) rs2278392 (1) rs2476601 (1) rs7993418 (1) rs13181 (1) rs4673 (1) rs2097432 (1) rs324011 (1) rs1079598 (1) rs1800566 (1) rs1800682 (1) rs603965 (1) rs993607 (1) rs1790349 (1) rs1044396 (1) rs3742376 (1) rs6592052 (1) rs9332377 (1) rs16111115 (1) rs11559024 (1) rs1149222 (1) rs11870474 (1) rs25331 (1) rs2929116 (1) rs2929115 (1) rs7961953 (1) rs2242480 (1) rs4532 (1) rs222747 (1) rs105173 (1) rs2165241 (1) rs1800795 (1) rs2075606 (1) rs11648486 (1) rs35874116rs (1) rs4795541 (1) rs2282679 (1) rs7853758 (1) rs1504982 (1) rs1176713 (1) rs11249433 (1) rs12467815 (1) rs10524523 (1) rs4880 (1) rs12760457 (1) rs2062305 (1) rs3828057 (1) rs3790515 (1) rs11687951 (1) rs1800896 (1) rs254093 (1) rs4994 (1) rs4633 (1) rs1885988 (1) rs11099592 (1) rs6843082 (1) rs17611 (1) rs2228171 (1) rs1042173 (1) rs41432149 (1) rs926198 (1) rs12992677 (1) rs2305619 (1) rs1800888 (1) rs61729512 (1) rs2266782 (1) rs1653624 (1) rs664393 (1) rs2246704 (1) rs11959427 (1) rs4848306 (1) rs3765467 (1) rs2246709 (1) rs2089760 (1) rs2180439 (1) rs2242447 (1) rs2981582 (1) rs12654788 (1) rs5275 (1) rs1053230 (1) rs1906591 (1) rs2010963 (1) rs11102930 (1) rs2601126 (1) rs2854116 (1) rs2854117 (1) rs16944 (1) rs17778257 (1) rs16942 (1) rs1801282 (1) rs5751876 (1) rs762251 (1) rs3803662 (1) rs10264272 (1) rs28399433 (1) rs230561 (1) rs12654778 (1) rs4364254 (1) rs10177833 (1) rs2238071 (1) rs1801275 (1) rs10766197 (1) rs704010 (1) rs10937405 (1) rs2228480 (1) rs9526240 (1) rs17570669 (1) rs10407022 (1) rs4612666 (1) rs6746030 (1) rs889312 (1) rs243866 (1) rs2740565 (1) rs1558902 (1) rs8192620 (1) rs10865801 (1) rs58542926 (1) rs3789604 (1) rs1801260 (1) rs2273773 (1) rs10757274 (1) rs573112 (1) rs2244613 (1) rs10757278 (1) rs6330 (1) rs1056892 (1) rs11931074 (1) rs2075252 (1) rs1297860 (1) rs28459296 (1) rs2380205 (1) rs780094s (1) rs9557195 (1) rs11045585 (1) rs1801253 (1) rs1801132 (1) rs11569562 (1) rs2104772 (1) rs15524 (1) rs2854275 (1) rs2066842 (1) rs12255372 (1) rs6323 (1) rs1057910 (1) rs1051375 (1) rs544684689 (1) rs2234237r25r (1) rs6318 (1) rs9826 (1) rs7120118 (1) rs12356193 (1) rs8111699 (1) rs7270101 (1) rs17042171 (1) rs1062033 (1) rs553668 (1) rs185670819 (1) rs1405655 (1) rs6311 (1) rs518147 (1) rs10401969 (1) rs4516035 (1) rs33996649 (1) rs10276036 (1) rs1465952 (1) rs2232618 (1) rs549927573 (1) rs41308230 (1) rs2293152 (1) rs2237060 (1) rs5215 (1) rs4820059 (1) rs12329760 (1) rs12676 (1) rs11083519 (1) rs16874954 (1) rs35597368 (1) rs1799983 (1) rs5573 (1) rs2229774 (1) rs2731886 (1) rs5574 (1) rs2302616 (1) rs12221497 (1) rs4973768 (1) rs5569 (1) rs2032892 (1) rs13281615 (1) rs4820268 (1) rs10079250 (1) rs1799750 (1) rs9366637 (1) rs4148738 (1) rs10456542 (1) rs25648 (1) rs9984723 (1) rs766996587 (1) rs2398162 (1) rs7291050 (1) rs1011970 (1) rs4253728 (1) rs12143842 (1)
SNPMiner Trials (Home Page)
Report for SNP rs2275163
Developed by Shray Alag, 2020-2021.
SNP Clinical Trial Gene
There is one clinical trial.
Clinical Trials
1 A Study on Genetic Alterations (Polymorphism) in Key Genes in the Kynurenine Pathway on Suicidal Behavior
Current research has shown that an imbalance in the Kinurenine pathway plays a role in the physiopathology of neurogenerative and mental disorders (with a decrease in neuroprotective metabolites and an increase in neurotoxic products). So far the research has concentrated on the enzymes IDO, KAT, KMO, 3HAO and QPRT which are the key players in this pathway. Several polymorphisms affecting these enzymes have been associated with certain disorders characterized by a deregulation of the inflammation and immune response (McCauley et al 2009,Tardito et al 2013, Lee et al 2014), but no studies have ever tried to find a link between these enzymes and suicidal behavior. The investigators hypothesize that people who have attempted to commit suicide will have pro-inflammatory genetic variations affecting the kynurenine pathway.
NCT04565834 Conditions
- Kynureninase
- Polymorphism
- Suicidal Behavior
Interventions
- Genetic: Analysis of Single nucleotide polymorphisms in each group.
A. Frequency of single nucleotide polymorphism rs2275163 of KMO in the Suicide group.
A. Frequency of single nucleotide polymorphism rs2275163 of KMO in the Emotion Control group.
Frequency of rs2275163 of KMO involved in the kynurenine pathway in the Suicide group.
The frequency of rs2275163 of KMO involved in the kynurenine pathway in the suicide group will be measured as a percentage.
Frequency of rs2275163 of KMO involved in the kynurenine pathway in the Healthy Controls group.
The frequency of rs2275163 of KMO involved in the kynurenine pathway in the healthy controls group will be measured as a percentage.
Primary Outcomes
Description: The presence of this genetic variation will be measured as a percentage
Measure: Presence of single nucleotide polymorphism rs9657182 of Enzyme IDO1 in the Suicide group Time: 24 monthsDescription: The presence of this genetic variation will be measured as a percentage
Measure: Presence of single nucleotide polymorphism rs9657182 of Enzyme IDO1 in the Emotion Control group Time: 24 monthsSecondary Outcomes
Description: The frequency of this genetic variation will be measured as a percentage
Measure: A. Frequency of single nucleotide polymorphism rs35059413 of Enzyme IDO1 in the Suicide group Time: 24 monthsDescription: The frequency of this genetic variation will be measured as a percentage
Measure: A. Frequency of single nucleotide polymorphism rs35059413 of Enzyme IDO1 in the Emotion Control group Time: 24 monthsDescription: The frequency of this genetic variation will be measured as a percentage
Measure: A. Frequency of single nucleotide polymorphism rs2929115 of Enzyme IDO2 in the Suicide group Time: 24 monthsDescription: The frequency of this genetic variation will be measured as a percentage
Measure: A. Frequency of single nucleotide polymorphism rs2929115 of Enzyme IDO2 in the Emotion Control group Time: 24 monthsDescription: The frequency of this genetic variation will be measured as a percentage
Measure: A. Frequency of single nucleotide polymorphism rs2929116 of Enzyme IDO2 in the Suicide group Time: 24 monthsDescription: The frequency of this genetic variation will be measured as a percentage
Measure: A. Frequency of single nucleotide polymorphism rs2929116 of Enzyme IDO2 in the Emotion Control group Time: 24 monthsDescription: The frequency of this genetic variation will be measured as a percentage
Measure: A. Frequency of single nucleotide polymorphism rs1053230 of KMO in the Suicide group Time: 24 monthsDescription: The frequency of this genetic variation will be measured as a percentage
Measure: A. Frequency of single nucleotide polymorphism rs1053230 of KMO in the Emotion Control group Time: 24 monthsDescription: The frequency of this genetic variation will be measured as a percentage
Measure: A. Frequency of single nucleotide polymorphism rs2275163 of KMO in the Suicide group Time: 24 monthsDescription: The frequency of this genetic variation will be measured as a percentage
Measure: A. Frequency of single nucleotide polymorphism rs2275163 of KMO in the Emotion Control group Time: 24 monthsDescription: The numerical value of the polygenic risk score will be used to measure this criterion.
Measure: B. Simultaneous influence of the various single nucleotide polymorphisms on the functioning of the kynurenine pathway and suicidal behavior. Time: 24 monthsDescription: The frequency of single nucleotide polymorphisms, measured as a percentage, will be compared with the number of suicide attempts, the lethality, the method used and the intensity of suicidal ideation in the Suicide group. The polygenic risk score is calculated as a weighted sum of the risk alleles resulting from the study using GWAS (genome-wide association study) summary statistics data. This score is not calculated on a scale but as a relative risk compared to the unaffected population.
Measure: C. Percentage frequency of single nucleotide polymorphisms among patients in the Suicide group. Time: 24 monthsDescription: Inflammation will be measured according to the level of the main pro-inflammatory cytokines in the various samples : TGF-beta. The rate of anti-inflammatory cytokines IL-2 and IL-4 will also be measured in pg/ml and mg/ml
Measure: D. Correlation between negative life events triggering suicide attempts and the level of inflammation in the Suicide group. Time: 24 monthsDescription: Inflammation will be measured according to the level of the main pro-inflammatory cytokines in the various samples : TGF-beta. The rate of anti-inflammatory cytokines IL-2 and IL-4 will also be measured in pg/ml and mg/ml
Measure: D. Correlation between negative life events triggering suicide attempts and the level of inflammation in the Affective Controls group. Time: 24 monthsOther Outcomes
Description: The frequency of rs35059413 of IDO1 involved in the kynurenine pathway in the suicide group will be measured as a percentage.
Measure: Frequency of rs35059413 of IDO1 involved in the kynurenine pathway in the Suicide group Time: 24 monthsDescription: The frequency of rs35059413 of IDO1 involved in the kynurenine pathway in the healthy controls group will be measured as a percentage.
Measure: Frequency of rs35059413 of IDO1 involved in the kynurenine pathway in the Healthy Control group Time: 24 monthsDescription: The frequency of rs2929115 of IDO2 involved in the kynurenine pathway in the suicide group will be measured as a percentage
Measure: Frequency of rs2929115 of IDO2 involved in the kynurenine pathway in the Suicide group Time: 24 monthsDescription: The frequency of rs2929115 of IDO2 involved in the kynurenine pathway in the healthy controls group will be measured as a percentage
Measure: Frequency of rs2929115 of IDO2 involved in the kynurenine pathway in the Healthy Controls group Time: 24 monthsDescription: The frequency of rs2929116 of IDO2 involved in the kynurenine pathway in the suicide group will be measured as a percentage
Measure: Frequency of rs2929116 of IDO2 involved in the kynurenine pathway in the Suicide group Time: 24 monthsDescription: The frequency of rs2929116 of IDO2 involved in the kynurenine pathway in the Affective Control group will be measured as a percentage
Measure: Frequency of rs2929116 of IDO2 involved in the kynurenine pathway in the Healthy Controls group Time: 24 monthsDescription: The frequency of rs1053230 of KMO involved in the kynurenine pathway in the suicide group will be measured as a percentage
Measure: Frequency of rs1053230 of KMO involved in the kynurenine pathway in the Suicide group Time: 24 monthsDescription: The frequency of rs1053230 of KMO involved in the kynurenine pathway in the healthy controls group will be measured as a percentage
Measure: Frequency of rs1053230 of KMO involved in the kynurenine pathway in the Healthy Controls group Time: 24 monthsDescription: The frequency of rs2275163 of KMO involved in the kynurenine pathway in the suicide group will be measured as a percentage
Measure: Frequency of rs2275163 of KMO involved in the kynurenine pathway in the Suicide group Time: 24 monthsDescription: The frequency of rs2275163 of KMO involved in the kynurenine pathway in the healthy controls group will be measured as a percentage
Measure: Frequency of rs2275163 of KMO involved in the kynurenine pathway in the Healthy Controls group Time: 24 monthsDescription: The age of patients in the suicide group will be recorded for statistical purposes
Measure: Age of patients in the Suicide group Time: 24 monthsDescription: The age of patients in the healthy controls group will be recorded for statistical purposes
Measure: Age of patients in the Healthy Controls group Time: 24 monthsDescription: The weight of patients in the suicide group will be recorded in kg for statistical purposes
Measure: Weight of patients in the Suicide group Time: 24 monthsDescription: The weight of patients in the healthy controls group will be recorded in kg for statistical purposes
Measure: Weight of patients in the Healthy Controls group Time: 24 monthsDescription: The height of patients in the suicide group will be recorded in centimeters for statistical purposes
Measure: Height of patients in the Suicide group Time: 24 monthsDescription: The height of patients in the healthy controls group will be recorded in centimeters for statistical purposes
Measure: Height of patients in the Healthy Controls group Time: 24 monthsDescription: The gender of patients in the suicide group will be recorded for statistical purposes
Measure: Gender of patients in the Suicide group Time: 24 monthsDescription: The gender of patients in the healthy controls group will be recorded for statistical purposes
Measure: Gender of patients in the Healthy Controls group Time: 24 monthsDescription: The gene frequency of patients in the suicide group will be recorded as a percentage for statistical purposes
Measure: Gene frequency of patients in the Suicide group Time: 24 monthsDescription: The gene frequency of patients in the healthy controls group will be recorded as a percentage for statistical purposes
Measure: Gene frequency of patients in the Healthy Controls group Time: 24 monthsDescription: The cytokine concentration of patients in the suicide group will be recorded in pg/l
Measure: Cytokine concentration: patients in the Suicide group Time: 24 monthsDescription: The cytokine concentration of patients in the healthy controls group will be recorded in pg/l
Measure: Cytokine concentration: patients in the Healthy Controls group Time: 24 months