Developed by Shray Alag, The Harker School
Sections: Correlations,
Clinical Trials, and HPO
Navigate: Clinical Trials and HPO
| Name (Synonyms) | Correlation | |
|---|---|---|
| drug1695 | Health Enhancement Program Wiki | 0.45 |
| drug1810 | Hydroxychloroquine and azithromycin treatment Wiki | 0.45 |
| drug3140 | Psychological stress and adaptation at work score (PSAS) Wiki | 0.45 |
| Name (Synonyms) | Correlation | |
|---|---|---|
| drug949 | Co-mestring (co-coping) Wiki | 0.45 |
| drug3801 | Sudarshan Kriya Yoga (SKY) Wiki | 0.45 |
| drug4444 | conventional management of patients Wiki | 0.45 |
| drug4064 | Transcendental meditation Wiki | 0.45 |
| drug4108 | Two doses of low dosage inactivated SARS-CoV-2 vaccine at the schedule of day 0,28 Wiki | 0.32 |
| drug369 | Assessment of work-related stress Wiki | 0.32 |
| drug3518 | Saliva sample collection Wiki | 0.32 |
| drug850 | Cardiac and electrodermal recordings Wiki | 0.32 |
| drug4111 | Two doses of medium dosage inactivated SARS-CoV-2 vaccine at the schedule of day 0,28 Wiki | 0.32 |
| drug364 | Assessment of behavioral response to emotional stimulation Wiki | 0.32 |
| drug3525 | Sample collection Wiki | 0.32 |
| drug4119 | Two doses of placebo at the schedule of day 0,28 Wiki | 0.32 |
| drug963 | Colchicine Wiki | 0.13 |
| drug2916 | Placebo Wiki | 0.02 |
| Name (Synonyms) | Correlation | |
|---|---|---|
| D000068376 | Compassion Fatigue NIH | 0.32 |
| D002055 | Burnout, Professional NIH | 0.30 |
| D000067073 | Psychological Trauma NIH | 0.26 |
| Name (Synonyms) | Correlation |
|---|
Navigate: Correlations HPO
There are 5 clinical trials
This study is aiming at investigating whether professional burnout in people involved in the mobile intensive care unit (in French: Element Mobile de Réanimation, EMR) in Mulhouse (France) can be predicted upstream by a low mindfulness level (as a protective factor) or by a dysregulation of stress pathways with a high level of perceived stress towards an emotional event (psychological index of allostatic load), i.e. an early and silent dysfunctional physiological response (measured by the electrophysiological and biological measurements of allostasis load and parasympathetic brake). It is part of a global approach aiming at identifying levers to prevent the allostatic load of occupational stress related to large-scale health crises.
Description: Professional burnout is measured at D21 by the Burnout Measure Short Version (BMS) questionnaire It is a 10-item questionnaire used to assess burnout regardless of the occupational category. Each item is rated from 0 to 6 ("never" to "always"). An average score (sum/10) below 2.4 indicates a very low degree of burnout exposure; a score between 2.5 and 3.4 indicates a low degree of burnout exposure; a score between 3.5 and 4.4 indicates the presence of burnout; a score between 4.5 and 5.4 indicates a high degree of burnout exposure; a score above 5.5 indicates a very high degree of burnout exposure.
Measure: Professional burnout Time: 21 days after enrollment (Day 21)Description: Mindfulness level is assessed at D0 thanks to the Freiburg Mindfulness Inventory. It is a 14 item scale. Each item is rated from 1 to 4 ("almost never" to "almost always"). The total score is between 14 and 56. The mean value in a population of young adults under 36 years of age is 38.5 (+/- 5.1 standard deviation).
Measure: Mindfulness level Time: Day 1Description: Perceived stress level is assessed with the Perceived Stress Scale (PSS). It is a 14 item scale. Each item is rated from 0 to 5 ("never" to "very often"). The total score ranges from 0 to 56 with higher scores indicating greater perceived stress.
Measure: Perceived stress level following the emotional stimulation Time: Day 1Description: Parasympathetic flexibility is assessed through dynamic electro-physiological analysis of cardiac and electrodermal conductance recordings. Physiological and cognitive reserve of emotional regulation is assessed through the analysis of the spectral power of the 0.1 Hz frequency band at emotional recall.
Measure: Parasympathetic flexibility evolution during emotional recall Time: Day 1Description: The activity of the sympathetic tone is assessed by the measurement of the resting state salivary Chromogranin A. Physiological and cognitive reserve of emotional regulation is assessed through the analysis of the spectral power of the 0.1 Hz frequency band at emotional recall. The activity of the sympathetic tone is assessed by the measurement of the resting salivary Chromogranin A.
Measure: Sympathetic tone at rest Time: Day 1Description: Corticotropic activation at rest is assessed through the DHEA/cortisol level ratio
Measure: Corticotropic activation at rest Time: Day 1Description: The Hospital Anxiety and Depression Scale (HAD-s32) is used to assess mood disorders in the general non-psychiatric population. It is used to discriminate between anxiety and depression. Scores greater than 11 are indicative of charcaterized anxiety/depression.
Measure: Mood disorders (anxiety / depression) Time: Day 1Description: Post-traumatic disorder is assessed with the PCL-5. It is a 20-item self-administered questionnaire representing DSM-5 PTSD diagnosis symptoms rated by the subject on a scale from 0 ("not at all") to 4 ("extremely") during the past month. Scores range from 0 to 80. A score greater than of 33 evokes the presence of post-traumatic stress disorder.
Measure: Post-traumatic stress disorder Time: Day 1Description: Sleep quality is assesses thanks to the Leeds Sleep Evaluation questionnaire (LEEDS). It consists of ten visual analogue scales assessing four aspects of sleep: (i) quality of falling asleep and degree of drowsiness, (ii) quality of sleep, (iii) quality of wakefulness, and (iv) quality of post-wakefulness and performance.
Measure: Sleep quality Time: Day 1This study will examine the feasibility of conducting an online Randomized Controlled Trial (RCT) in frontline hospital and long term care healthcare staff in managing COVID-19 patients in London, ON. The study will randomize participants to Sudarshan Kriya Yoga (SKY) or a Health Enhancement Program (HEP).
Description: The number of participants recruited per month will be calculated as a feasibility measure.
Measure: Rate of participant recruitment Time: 1 yearDescription: The retention rate of participants will be calculated as a feasibility measure.
Measure: Rate of retention Time: 1 yearDescription: The completeness of study assessments will be assessed as a feasibility measure by calculating the missing percentage of data in case report forms.
Measure: Completeness of data entry Time: 1 yearDescription: The cost of both study interventions will be calculated to assess the total study cost for interventions and the cost per participant. This information will be used as a feasibility measure.
Measure: Cost of interventions Time: 1 yearDescription: The total of unexpected costs will be calculated as a feasibility measure.
Measure: Unexpected costs Time: 1 yearDescription: The Athens Insomnia Scale will be used to assess insomnia. This scale is an 8-item, self-rated measure of the extent of sleep difficulties over the last 30 days with each item representing a different aspect of sleep (e.g. "Overall Quality of Sleep"). Ratings are from 0 to 4, with 0 being no difficulty with the item and 4 being the most difficulty with the item. Higher overall scores on this scale indicate higher difficulties with sleep.
Measure: Change in Athens Insomnia Scale Time: Change from Week 0 to week 3 and to week 5Description: The Generalized Anxiety Disorder 7-item scale (each scored 0-3) is a self-rated measure of anxiety and has been validated for the diagnosis of Generalized Anxiety Disorder in the adult population. Scores range from 0 to 21. Higher scores indicate greater anxiety symptoms (5-9, mild anxiety; 10-14, moderate anxiety; 15-21 severe anxiety).
Measure: Change in Generalized Anxiety Disorder 7-item scale Time: Change from Week 0 to week 3 and to week 5Description: The Patient Health Questionnaire (PHQ-9) is a 9-item, self-rated measure of depression which has been validated for screening a major depressive episode in adults. Total scores indicate various levels of depression: 0-4, no depression; 5-9, mild depression; 10-14, moderate depression; 15-19, moderately severe depression; 20-27, severe depression.
Measure: Change in Patient Health Questionnaire 9 Time: Change from Week 0 to week 3 and to week 5Description: The Connor-Davidson Resilience Scale (CD-RISC) is a brief self-rated assessment tool that comprises of 10 items, each rated on a 5-point Likert scale (0 = not true at all to 4 = true nearly all the time). Higher scores reflect greater resilience, which is a measure of one's ability to cope with stress. The scale demonstrated strong reliability and validity and has been studied in a variety of populations including medical personnel, nurses, social workers and physicians).
Measure: Change in Connor-Davidson Resilience Scale Time: Change from Week 0 to week 3 and to week 5Background. The current coronavirus disease (COVID-19) has a great impact worldwide. Healthcare workers play an essential role and are one of the most exposed groups.Information about the psychosocial impact on healthcare workers is limited. Methods. 3109 healthcare workers completed a national, internet-based, cross-sectional 45-item survey between 9 and 19 April 2020. The objective is to assess the psychological impact of the COVID-19 pandemic in Spanish healthcare workers. A Psychological Stress and Adaptation at work Score (PSAS) was defined combining four modified versions of validated psychological assessment tests (A) Healthcare Stressful Test, (B) Coping Strategies Inventory,(C) Font-Roja Questionnaire and (D) Trait Meta-Mood Scale.
Description: evaluate the severity of psychological impact of the pandemic in Spain in healthcare workers
Measure: PSAS (Psychological Stress and Adaptation at work Score) during the crisis Time: during the pandemic (April 9, 2020 to April 19, 2020)Description: evaluate the psychological stress in Spain in healthcare workers
Measure: PSAS (Psychological Stress and Adaptation at work Score) in basal conditions Time: After the pandemic (back to regular activity to be considered in the future as we do not know it yet. It expected to be in less than one year.This proposal aims to optimize resident physician and fellow wellness and performance at Banner University Medical Center through an evidence-based stress reduction program, Transcendental Meditation (TM). It is particularly timely due to the enormous pressure and stress that residents face as front-line workers during the current 2019 novel coronavirus (COVID-19) pandemic. Participants will be randomly assigned to the TM training (group 1), or delayed TM training (group 2). Study outcomes will be assessed at baseline and at 1 and 3 months post-training. Participants who are assigned to group 2 , will receive the TM training following the three month assessment, and then complete assessments at 1 and 3 months post-training. These assessment tools look at anxiety (Generalized Anxiety Disorder Scale-GAD-7), depression (Patient Health Questionnaire (PHQ-9), insomnia (Pittsburgh Sleep Quality Index PSQI), psychological distress (Brief Symptom Inventory BSI18), burnout (Maslach Burnout Inventory-MBI), resilience (Conner-Davidson Resilience Scale- RISC), and alcohol use (Alcohol Use Disorder Identification Test - AUDIT).
Description: Maslach Burnout Inventory- Participants respond to each prompt 0-6, high score in first 2 sections, low score in third may indicate risk of burnout.
Measure: Burnout Time: baselineDescription: Maslach Burnout Inventory- Participants respond to each prompt 0-6, high score in first 2 sections, low score in third may indicate risk of burnout.
Measure: Burnout Time: 1 monthDescription: Maslach Burnout Inventory- Participants respond to each prompt 0-6, high score in first 2 sections, low score in third may indicate risk of burnout.
Measure: Burnout Time: 3 monthDescription: Connor-Davidson Resilience Scale- Participants respond to each prompt 0-5 x 25 items, low score indicates poor resilience.
Measure: Resilience Time: baselineDescription: Connor-Davidson Resilience Scale- Participants respond to each prompt 0-5 x 25 items, low score indicates poor resilience.
Measure: Resilience Time: 1 monthDescription: Connor-Davidson Resilience Scale- Participants respond to each prompt 0-5 x 25 items, low score indicates poor resilience.
Measure: Resilience Time: 3 monthsDescription: AUDIT: Alcohol Use Disorders Identification Test- Participants respond to 10 items with 0-4, higher score more concerning for alcohol use disorder.
Measure: Alcohol use Time: baselineDescription: AUDIT: Alcohol Use Disorders Identification Test- Participants respond to 10 items with 0-4, higher score more concerning for alcohol use disorder.
Measure: Alcohol use Time: 1 monthDescription: AUDIT: Alcohol Use Disorders Identification Test- Participants respond to 10 items with 0-4, higher score more concerning for alcohol use disorder.
Measure: Alcohol use Time: 3 monthsDescription: PHQ-9: Patient Health Questionnaire- Participants answer each prompt (not all all, some days, most days, nearly every day) higher numbers indicate greater depressive symptoms.
Measure: Depression Time: baselineDescription: PHQ-9: Patient Health Questionnaire- Participants answer each prompt (not all all, some days, most days, nearly every day) higher numbers indicate greater depressive symptoms.
Measure: Depression Time: 1 monthDescription: PHQ-9: Patient Health Questionnaire- Participants answer each prompt (not all all, some days, most days, nearly every day) higher numbers indicate greater depressive symptoms.
Measure: Depression Time: 3 monthsDescription: PSQI: Pittsburgh Sleep Quality Index- Participant answers 19 questions in 7 sections, Seven sections are combined for global score of 0-21 where ) is no problems and 21 is problems in all areas.
Measure: Sleep Quality Time: baselineDescription: PSQI: Pittsburgh Sleep Quality Index- Participant answers 19 questions in 7 sections, Seven sections are combined for global score of 0-21 where ) is no problems and 21 is problems in all areas.
Measure: Sleep Quality Time: 1 monthDescription: PSQI: Pittsburgh Sleep Quality Index- Participant answers 19 questions in 7 sections, Seven sections are combined for global score of 0-21 where ) is no problems and 21 is problems in all areas.
Measure: Sleep Quality Time: 3 monthsDescription: BSI18: Brief Symptom Inventory 18- Participants answer 18 questions on 0-4 scale. Higher numbers indicate more distress.
Measure: Distress Time: baselineDescription: BSI18: Brief Symptom Inventory 18
Measure: Distress Time: 1 monthDescription: BSI18: Brief Symptom Inventory 18
Measure: Distress Time: 3 monthsDescription: GAD7: Generalized Anxiety Disorder 7- Participants answer 7 questions 0-3. Higher scores indicate greater anxiety,
Measure: Anxiety Time: baselineDescription: GAD7: Generalized Anxiety Disorder 7- Participants answer 7 questions 0-3. Higher scores indicate greater anxiety,
Measure: Anxiety Time: 1 monthDescription: GAD7: Generalized Anxiety Disorder 7- Participants answer 7 questions 0-3. Higher scores indicate greater anxiety,
Measure: Anxiety Time: 3 monthsThe objective of this study is to compare psychological distress and needs of nurses in ICU before and during coronavirus pandemic.
Description: Job Content Questionnaire (Karasek, 1979)
Measure: stress at work Time: change from baseline at one yearDescription: Nursing Stress Questionnaire (Gray-Toft, 1981)
Measure: stress in a medical unit Time: change from baseline at one yearDescription: We will ask if they are used to do activities like hypnosis, yoga, mediation, sport, etc. This factor could help us to know if these activities can help and if we have to promote them in the hospital.
Measure: hobby activities Time: change from baseline at one yearAlphabetical listing of all HPO terms. Navigate: Correlations Clinical Trials
Data processed on September 26, 2020.
An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.
Drug Reports MeSH Reports HPO Reports