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Sections: Correlations,
Clinical Trials, and HPO
Navigate: Clinical Trials and HPO
| Name (Synonyms) | Correlation | |
|---|---|---|
| drug2402 | Mobile Enhanced Prevention Support Wiki | 0.71 |
| drug4170 | Usual Care plus Customized Referrals Wiki | 0.71 |
| drug3177 | Quality Improvement Wiki | 0.71 |
Navigate: Correlations HPO
There are 2 clinical trials
This study will provide HIV prevention and related support services to men who have sex with men and transgender women who have substance use disorders and are either leaving jail or recently released from jail, living in a residential facility providing substance use services or supportive housing . The researchers will compare the utilization of HIV prevention and other support services between individuals who receive routine case management provided following enrollment to those who have access to GeoPassport, a global position service (GPS)-based mobile app, incentives, and peer mentor support.
Description: Defined as the participant identifying and completing an appointment with a primary care provider who is willing and able to prescribe HIV pre-exposure prophylaxis. Provide documentation of the appointment.
Measure: Number of participants establishing a primary care provider who can prescribe PrEP (pre-exposure prophylaxis) Time: 9 monthsDescription: Defined as the participant completing the screening process for PrEP with an eligible provider or PrEP navigator. Provide documentation of the appointment.
Measure: Number of participants obtaining screening for PrEP Time: 9 monthsDescription: Defined as the participant obtaining a prescription for PrEP, providing documentation, reporting taking the medication
Measure: Number of participants who initiate PrEP regimen Time: 9 monthsDescription: Defined as the participant self-reporting taking prescribed PrEP at least 4 days per week over the prior 30 days
Measure: Number of participants who demonstrate minimal adherence to PrEP Time: 30 daysDescription: The participant will provide documentation of filled PrEP prescriptions for 3 or more months
Measure: Number of participants who remain on PrEP for at least 3 months. Time: 3 monthsDescription: Defined as the participant self-reporting having obtained HIV testing every 3 months over the 12 month follow-up period
Measure: Number of participants who undergo a HIV test every 3 months Time: 9 monthsDescription: Defined by the participant self-reporting having obtained testing for these 3 bacterial sexually transmitted diseases (STDs) every 6 months over the 12 month follow-up period
Measure: Number of participants who undergo a test for gonorrhea, syphilis, and chlamydia every 6 months Time: 9 monthsDescription: Defined by the participant self-reporting having obtained at least one test for Hepatitis C
Measure: Number of participants who undergo a test for hepatitis C Time: 9 monthsDescription: Defined by the participant self-report of completing initial recommended SUD appointments within 3 months of jail release, consistent with each participant's recommended American Society of Addiction Medicine (ASAM) level of care
Measure: Number of participants obtaining treatment for substance use disorders (SUDs) in the community Time: 3 monthsDescription: Defined by the participant self-reporting remaining engaged in treatment (i.e., continuing to attend meetings, counseling or other treatment activities) as defined by the recommended ASAM level of care in the 3 months prior to each follow-up interview.
Measure: Number of participants who remain engaged in treatment for substance use disorders (SUDs) in the community, Time: 3 monthsDescription: Self-report of whether or not participants received follow-up care and treatment for HIV, STD, and hepatitis C infections diagnosed during study follow-up (n=300)
Measure: Number of participants in each arm receiving care and treatment for newly diagnosed HIV or STD infections. Time: 9 monthsDescription: Measure the comparative effectiveness of each intervention arm on reducing recidivism (n=300), quantified as the number of respondents who are reincarcerated and the total number of reincarcerations per arm over the study period.
Measure: Number of participants in each arm experiencing recidivism Time: 9 monthsDescription: Describe the temporal distribution of PrEP uptake and supportive social service utilization patterns of the participants in the MEPS intervention arm using data collected via the GeoPassport mobile app (n=150).
Measure: Temporal service utilization patterns of intervention arm participants Time: 9 monthsDescription: Report the geographic distribution of PrEP uptake and supportive social service utilization patterns of the participants in the MEPS intervention arm using data collected via the GeoPassport mobile app (n=150).
Measure: Geographic service utilization patterns of intervention arm participants Time: 9 monthsCurrently, there is a lack of literature on programs evaluating rapid screening methods to traditional venipuncture methods for sample collection during screening for viral hepatitis. Due to the relatively low diagnosis and linkage to care rate, screening programs that provide same day results for viral hepatitis infection may improve both diagnosis and enable providers to engage patients shortly after diagnosis. This stands in contrast to the multi-visit, weeks long process that normally accompanies serum testing for hepatitis C virus (HCV) and hepatitis B virus (HBV). A few American studies have examined the implementation of HCV inpatient screening programs; however, they are focused specifically on high-risk patient populations, the barriers to accessing care experienced by study participants are not relevant to the Canadian healthcare system context, and do not use rapid testing. Furthermore, there are few, if any, data on HBV inpatient screening programs and the diagnosis rate remains low. This project will provide key data on a rapid inpatient screening and linkage to care strategy as well as the prevalence of these viruses across different age bands within the population. Finally, the study will help determine whether rapid inpatient screening is a feasible and acceptable approach for screening and linkage to care.
Description: To determine the proportion of HCV antibody positive participants who complete HCV RNA PCR in each arm. Participants will be contacted at 90 days and 1 year post-enrolment to self-report progress.
Measure: Number of HCV antibody positive participants who complete an HCV RNA PCR. Time: 2 yearDescription: To determine the proportion of HCV RNA positive participants successfully linked to care from each arm. Participants will be contacted at 90 days and 1 year post-enrolment to self-report.
Measure: Number of HCV RNA positive participants who attend their first hepatology appointment. Time: 2 yearDescription: To determine the proportion of HCV RNA positive participants who successfully achieved a sustained virological response at 12 weeks (SVR12) after treatment completion. Participants will be contacted at 90 days and 1 year post-enrolment to self-report.
Measure: Number of HCV RNA positive participants who achieve a Sustained Virological Response at 12 weeks (SVR12) after treatment completion. Time: 2 yearDescription: Proportion of screened participants who are positive and chronically infected in general internal medicine inpatient units.
Measure: Number of chronic hepatitis C and hepatitis B infection in the general internal medicine inpatient units. Time: 1 yearDescription: To determine acceptability of implementing hepatitis C and hepatitis B screening in general internal medicine inpatient units.
Measure: Number of patients willing to participate in hepatitis C and hepatitis B screening in general internal medicine inpatient units. Time: 1 yearDescription: To determine the effect of hepatitis C and hepatitis B screening on hospital staff workflow in general internal medicine inpatient units.
Measure: Percentage of physicians, residents, and nurses who believe that hepatitis C and hepatitis B screening can be incorporated into the general internal medicine inpatient units' workflow. Time: 1 yearDescription: To determine whether results of the Cepheid Xpert® HCV Viral Load assay are valid when compared to the standard commercial assay for HCV RNA PCR.
Measure: Proportion of Cepheid Xpert® HCV Viral Load test results matching test results from the standard commercial assay for HCV RNA PCR. Time: 1 yearDescription: To determine the historical rate of HCV screening and chronic HCV infection in general internal medicine inpatient units.
Measure: Retrospective rates of HCV testing, HCV antibody positive results, and HCV RNA positive results in general internal medicine inpatient units. Time: 1 yearAlphabetical listing of all HPO terms. Navigate: Correlations Clinical Trials
Data processed on September 26, 2020.
An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.
Drug Reports MeSH Reports HPO Reports