|drug616||Blood test for IgG antibodies against SARS-CoV-2 Wiki||0.50|
|drug2153||Lock-down and social distancing Wiki||0.50|
|drug4547||laparoscopic or open appendicectomy Wiki||0.50|
|drug3770||Standardised questionnaires Wiki||0.50|
|drug625||Bovine Lactoferrin Wiki||0.50|
|drug615||Blood test Wiki||0.35|
|drug614||Blood sampling Wiki||0.20|
There are 4 clinical trials
The study aims to examine whether a nationwide lock-down with an entire population subjugated to social distancing reduces the incidence of appendicitis. If a reduction is detected it supports the hypothesis that infectious disease may play a role in the etiology of appendicitis.
Description: Appendectomy or other surgery for appendicitisMeasure: Appendectomy Time: 5 weeks
Description: Postoperative length of stayMeasure: Postoperative length of stay Time: 30 days
Description: Overall mortalityMeasure: Mortality Time: 30 days
Description: Perforated appendicitis or periappendicular abscessMeasure: Incidence of complicated appendicitis Time: 5 weeks
Appendectomy is the most effective treatment option for acute appendisitis, which is the most commen emergent surgical pathology. However with in time period, surgical treatment borders are narrowed. Especially in uncomplicated acute appendicitis cases, nonoperative management (NOM) with antibiotherapies becomes primary treatment option. The COVID-19 pandemic, which is caused by 2019 novel coronavirus (2019-nCoV) and we encountered in the current process, has led to the re-questioning of surgical elective and emergency cases. Serious complications and increased mortality rates of the 2019-nCoV creates a novel problems of patient selection for emergent surgery and health care workers faced with potential health problems. As the same as the other surgical procedures, in the uncomplicated acute appendisitis cases NOM become more mandantory. NOM of uncomplicated acute appendisitis doen't increase perforation risk and general practice for decreasing surgical complications in the COVID-19 pandemic period. Additionally complicated acute appendicitis accounts for 20 to 30% of the patients undergoing appendectomy and lead to increased risk of postoperative complications, delayed recovery and longer hospital stay. Therefore, early diagnosis of complicated acute appendicitis is important; however, the most appropriate and inexpensive diagnostic method to make this diagnosis has not been established yet. Although the use of imaging methods is widespread, these methods are not accessible in many rural hospitals due to the high costs and unavailability of specialists. Thus, the need for an inexpensive and effective diagnostic technique allowing to make a differential diagnosis has not been met yet. For this purpose, several inexpensive and easily accessible blood parameter tests have been proposed; including the white blood cell count, immature granulocyte (IG) percentage, C-reactive protein levels or the neutrophil-to-lymphocyte ratio. An increase in the IG count shows that the bone marrow is active. This parameter has been used as a prognostic factor in many infectious and non infectious diseases including sepsis, acute pancreatitis, and acute myocardial infarction. The Immature granulocyte (IG) fraction includes promyelocytes, myelocytes, and metamyelocytes but not band neutrophils or myeloblasts. The IG count and percentage has become an easy-to-use method, especially with the introduction of technological advances, as it can be easily determined using the results of a routine complete blood count. It is aimed to efficacy of IG count and percentage which are calculated automatically in CBC samples, to differatiate the complicated and uncomplicated acute appendicitis cases with a cheap, easily applicable and cost effective test, especially in rural areas without enough diagnostic tests in COVID-19 pandemy.
Description: Preoperative IG count of the patients to differentiate complicated and uncomplciated acute appendicitisMeasure: Preoperative IG count of the patients to differentiate complicated and uncomplciated acute appendicitis Time: Preoperative
Description: Preoperative IG count of the patients to select medically treatment patients of noncomplicated acute appendicitisMeasure: Preoperative IG count for selection of medical treatment patients of noncomplicated acute appendicitis Time: Preoperative
Description: Preoperative IG percentage of the patients to differentiate complicated and uncomplciated acute appendicitisMeasure: Preoperative IG percentage of the patients to differentiate complicated and uncomplciated acute appendicitis Time: Preoperative
Description: Preoperative IG percentage of the patients to select medically treatment patients of noncomplicated acute appendicitisMeasure: Preoperative IG percentage for selection of medical treatment patients of noncomplicated acute appendicitis Time: Preoperative
Appendicitis is one of the most common clinical conditions in general surgery. The diagnosis is usually made from clinical examination, imaging (sonography or CT) and laboratory parameters. The laparoscopic appendectomy without drainage has established as the gold standard. Patients usually leave the hospital two days after surgery. In times of corona crisis, patients are unsure to visit the hospital because of fear of infection with SARS-CoV-2. A higher incidence of perforated appendicitis could be an indicator for fear-related delay of going to the hospital. Methods: Investigators performed a retrospective analysis on the incidence of perforated appendicitis in a 10-week interval (mid-March to end of May) of the years 2018, 2019 and 2020 to evaluate possible changes in times of corona crisis. Intraoperative findings, procedures, complications and the length of hospital stay were considered.
During the Covid-19 pandemic, non-operative management for acute appendicitis (AA) was implemented in the UK. The aim of this study was to determine the efficacy and outcomes of conservative versus surgical management of AA during the pandemic.
Description: Death secondary to acute appendicitisMeasure: Mortality Time: within 90 days of a patient's initial presentation
Description: failure of conservative management and need to undergo surgeryMeasure: Failure of primary proposed treatment Time: within 90 days of a patient's initial presentation
Description: length of stay in hospital from admission date till discharge date or deathMeasure: length of stay Time: within 90 days of a patient's initial presentation
Description: Re-attendance to hospital after patient's discharge whether planned or unplannedMeasure: Re-attendance Time: within 90 days of a patient's initial presentation
Description: imaging modality obtained and findings to confirm the diagnosis of acute appendicitisMeasure: Imaging Time: within 90 days of a patient's initial presentation
Description: Intra-operative findings of pus or free fluid during appendicectomyMeasure: Intra-operative findings during surgery Time: within 90 days of a patient's initial presentation
Data processed on September 26, 2020.
An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.Drug Reports MeSH Reports HPO Reports