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D014029: Tobacco Use Disorder

Developed by Shray Alag, The Harker School
Sections: Correlations, Clinical Trials, and HPO

Correlations computed by analyzing all clinical trials.

Navigate: Clinical Trials and HPO


Correlated Drug Terms (17)


Name (Synonyms) Correlation
drug1819 Hydroxychloroquine, Azithromycin Wiki 0.50
drug3610 Sham cTBS to the vmPFC Wiki 0.50
drug1820 Hydroxychloroquine, Clindamycin Wiki 0.50
Name (Synonyms) Correlation
drug3611 Sham iTBS to the dlPFC Wiki 0.50
drug796 CRI management Wiki 0.50
drug3280 Real cTBS to the vmPFC Wiki 0.50
drug1821 Hydroxychloroquine, Clindamycin, Primaquine - high dose. Wiki 0.50
drug1964 Interferon-Alpha2B Wiki 0.50
drug1057 Convalescent Serum Wiki 0.50
drug1822 Hydroxychloroquine, Clindamycin, Primaquine - low dose. Wiki 0.50
drug1823 Hydroxychloroquine, Doxycycline Wiki 0.50
drug3281 Real iTBS to the dlPFC Wiki 0.50
drug4289 Web + text smoking cessation intervention Wiki 0.50
drug2176 Losartan Wiki 0.17
drug2365 Methylprednisolone Wiki 0.13
drug3319 Remdesivir Wiki 0.09
drug4025 Tocilizumab Wiki 0.08

Correlated MeSH Terms (3)


Name (Synonyms) Correlation
D016739 Behavior, Addictive NIH 0.25
D019966 Substance-Related Disorders NIH 0.14
D002318 Cardiovascular Diseases NIH 0.09

Correlated HPO Terms (2)


Name (Synonyms) Correlation
HP:0030858 Addictive behavior HPO 0.25
HP:0001626 Abnormality of the cardiovascular system HPO 0.09

Clinical Trials

Navigate: Correlations   HPO

There are 4 clinical trials


1 Cognitive Task Development and Implementation for Functional MRI Studies

Background: - Drugs of abuse have effects on mood, behavior, thinking, and decision making that may encourage people to continue using them and make it difficult for them to stop. Researchers who study these effects are interested in developing new tests to evaluate how drugs and drug use affect different areas of the brain. - Magnetic resonance imaging (MRI) scans allow researchers to study brain activity and changes to brain function. When specific psychological tests are performed during functional MRI (fMRI) scans, researchers can examine the effects of drug use on the brain. By developing and testing new procedures for fMRI studies, more information can be obtained on brain function and activity in drug-using and non-drug-using individuals, and this information can help develop new treatments and therapies for substance abuse. Objectives: - To evaluate the effects of newly developed psychological procedures to be performed during fMRI scans. Eligibility: - Healthy volunteers between 13 and 55 years of age who are willing to undergo MRI scanning. - Both drug-using and non-drug-using individuals will be selected for this study. Design: - Before the start of the study, participants will complete questionnaires about medical and psychological history, and provide information about past or current drug use. Researchers will introduce the tasks to be performed during the scanning session(s), and will allow participants to practice the test either on a separate computer or on the computer used during the MRI scan. - During the study, participants will be asked to do one or more tasks selected by the researchers. The tasks will be performed on a computer in an MRI machine, and may involve receiving rewards (such as money or sips of juice) for actions, memory and reaction-time tests, or other tests that involve responding to instructions on the screen. - Participants will receive compensation for their participation in the study, including hourly compensation for individual visits and lump-sum compensation for each MRI scan.

NCT01036685
Conditions
  1. Drug Abuse
  2. Nicotine Dependence
MeSH:Tobacco Use Disorder Substance-Related Disorders

Primary Outcomes

Description: yield measurable and interpretable fMRI results, and/or if they are able to be combined with the application of tDCS

Measure: To determine if the tasks reliably and appropriately measure specific cognitive constructs and behaviors thought to be associated with specific brain systems and, also if they yield measurable and interpretable fMRI results.

Time: each visit
2 QuitFast: Evaluating Transcranial Magnetic Stimulation as a Tool to Reduce Smoking Directly Following a Quit Attempt

Cigarette smoking constitutes the greatest preventable cause of mortality and morbidity in the US. The most critical period for long term success of smoking cessation appears to be in the first 7 days after the quit date. A metaanalysis of 3 pharmacotherapy trials revealed that abstinence during the first 7 days was the strongest predictor of 6 month outcomes (n=1649; Odds ratio: 1.4, P <0.0001; Ashare et al. 2013). Prodigious relapse rates during this first week of smoking cessation are likely due to behavioral and neurobiological factors that contribute to high cue-associated craving and low executive control over smoking. The long term goal of the research is to develop evidence-based transcranial magnetic stimulation protocols to facilitate abstinence during this critical period.

NCT04159571
Conditions
  1. Smoking
  2. Smoking Cessation
  3. Craving
  4. Addiction
  5. Addiction Nicotine
  6. Nicotine Dependence
  7. Cigarette Smoking
Interventions
  1. Device: Real cTBS to the vmPFC
  2. Device: Sham cTBS to the vmPFC
  3. Device: Real iTBS to the dlPFC
  4. Device: Sham iTBS to the dlPFC
MeSH:Tobacco Use Disorder Behavior, Addictive
HPO:Addictive behavior

Primary Outcomes

Description: The effect of real vs. sham iTBS to the left DLPFC vs. real vs. sham cTBS to the left MPFC as a tool to modulate the brain response to cigarette cravings will be assessed by comparing the brain activity in the executive circuit and limbic circuit before and after TMS. Participants will receive an MRI brain scan before their first TMS treatment, and at the end of their 10th days of TMS. At each MRI scan, participants will be subjected to a cigarette craving "cue" task within the scanner where elevated brain activity (BOLD signal) will be measured using an fMRI sequence. During each scan, they will see pictures of cigarette cues, neutral cues, and blurred images. The task is meant to induce craving and see how the brain responds to these craving cues.

Measure: Neuroimaging outcomes: changes in drug cue reactivity as specified by changes in BOLD signal

Time: Through study completion, an average of 8 weeks

Description: Participants will be asked to choose between two conditions in which varying amounts and delays to behavioral outcomes (e.g., $50 now or $100 later) are presented. We will use magnitudes of $100 and $1000 which are the most thoroughly documented among the literature. Across consecutive choices, the delay to the larger outcome will be titrated until reaching the participant's indifference delay (i.e., the delay at which s/he equally values both options). This indifference delay indexes individual participants' rates of delay discounting. Monetary delay discounting has been documented to be predictive to treatment success for smokers.

Measure: Changes in Delayed Discounting Cognitive Behavioral Task

Time: Through study completion, an average of 8 weeks

Description: This 10-item questionnaire assesses cigarette craving. Participants will be asked to rate from 1 (strongly disagree) to 100 (strongly agree) their agreement with several statements (e.g., "I have a desire for a cigarette right now," and "Nothing would be better than smoking a cigarette right now."). Factor analyses support two factors: one that reflects a strong desire and intention to smoke and one that reflects relief from negative affect associated with an urgent desire to smoke.

Measure: Questionnaire on Smoking Urges administered daily both pre/post TMS to measure craving

Time: Through study completion, an average of 8 weeks

Description: The hypothetical purchase task (HPT), a validated measure for cigarette demand, will assess cigarette purchases at various price conditions. Participants will hypothetically purchase quantities of cigarettes to use over a 24-hour period across ascending prices (e.g., $0, 0.12, $0.25, $0.50, $1.00, and $2.00 per cigarette). The HPT has been shown to be predictive of treatment outcomes. It will measure how participants value cigarettes throughout the course of the study visits.

Measure: Hypothetical Purchase Task to measure tobacco product value and sensitivity

Time: Through study completion, an average of 8 weeks

Secondary Outcomes

Description: Changes in cigarette use as detected by quantitative cotinine urine screens collected at visits 1, 6, 10, and all follow-ups

Measure: Biochemical assessment of tobacco use via quantitative urine screens to detect cotenine level

Time: Through study completion, an average of 8 weeks

Description: This self-reported tobacco product use interview asks participants to retrospectively estimate the number of tobacco products they've used each day for the past 30 days or since the previous assessment, whichever is fewer.

Measure: Self- report assessment of tobacco use through Timeline Follow-Back (TLFB) Interview

Time: Through study completion, an average of 8 weeks

Description: Breath CO provides an accurate measure of recent exposure to CO, including from smoking combustible tobacco products (95). The CO measurement will be used to determine recency of smoking.

Measure: Biochemical assessment of recent tobacco use via breath Carbon Monoxide (CO) sample

Time: Through study completion, an average of 8 weeks
3 Improving Smoking Cessation in Socioeconomically-Disadvantaged Young Adults

The purpose of this study is to understand how to develop and deliver a better smoking cessation program for lower-income young adult smokers.

NCT04379388
Conditions
  1. Nicotine Dependence, Cigarettes
Interventions
  1. Behavioral: Web + text smoking cessation intervention
MeSH:Tobacco Use Disorder

Primary Outcomes

Description: Self-reported smoking abstinence and biochemical validation (saliva cotinine)

Measure: 30-day point prevalence smoking abstinence

Time: Assessed at 3-month follow-up

Description: Confidence to quit within the next month (7days) on 0-10 scale

Measure: Self-efficacy to quit smoking

Time: Assessed at 3-month follow-up

Description: Completing 75% or more of 12 weekly check-ins

Measure: Intervention engagement

Time: 12 weeks

Secondary Outcomes

Description: Self-reported smoking abstinence

Measure: 7-day point prevalence smoking abstinence

Time: Assessed at 3-month follow-up

Description: Number of times intentionally stopped smoking cigarettes for 24 hours or longer because trying to quit

Measure: Number of 24-hour quit attempts

Time: Assessed at 3-month follow-up

Description: 4 items pertaining to quit support from the text messages

Measure: Perceived support to quit smoking

Time: Assessed 3-month follow-up

Description: Past 30 (90 day) use of tobacco or nicotine products such as cigars, e-cigarettes, chewing tobacco, and nicotine replacement products

Measure: Pattern and rate of tobacco/e-cigarette use

Time: Assessed at 3-month follow-up
4 Investigating the Association Between Smoking Status and COVID-19 Outcomes: Collecting Data From Health Systems Affiliated With the National Cancer Institute's Cancer Center Cessation Initiative (C3I)

This cohort study will obtain electronic health record (EHR) de-identified data from 21 health systems affiliated with the Cancer Center Cessation Initiative (C3I) network or health systems with large numbers of COVID-19 patients to explore whether smoking status, cancer history, and other risk factors among patients diagnosed with COVID-19 are associated with mortality and/or COVID-19 disease severity/complications. Each site will provide de-identified data from their health system EHR on a monthly basis that includes all patients identified as having COVID-19 at some point in the interval from February 1, 2020, through December 31, 2020.

NCT04506528
Conditions
  1. Covid19
  2. Cancer
  3. Nicotine Dependence
  4. Pulmonary Disease
  5. Cardiovascular Diseases
  6. Immunosuppression Disorders
MeSH:Cardiovascular Diseases Tobacco Use Disorder
HPO:Abnormality of the cardiovascular system

Primary Outcomes

Description: Death resulting from COVID-19 illness in inpatients vs discharge from hospital (binary outcome)

Measure: Mortality due to COVID-19

Time: February 1, 2020, through December 31, 2020

Description: COVID-19 severity as measured by intubation for respiratory support (i.e., patient required intubation during hospitalization) - binary variable

Measure: COVID-19 Severity

Time: February 1, 2020, through December 31, 2020

HPO Nodes


HPO

Alphabetical listing of all HPO terms. Navigate: Correlations   Clinical Trials


HPO Nodes


Reports

Data processed on September 26, 2020.

An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.

Drug Reports   MeSH Reports   HPO Reports  

Interventions

4,180 reports on interventions/drugs

MeSH

691 reports on MeSH terms

HPO

263 reports on HPO terms

All Terms

Alphabetical index of all Terms

Google Colab

Python example via Google Colab Notebook