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Sections: Correlations,
Clinical Trials, and HPO
Navigate: Clinical Trials and HPO
| Name (Synonyms) | Correlation | |
|---|---|---|
| drug457 | BCG-Denmark Wiki | 0.58 |
| drug246 | Alcohol brief intervention Wiki | 0.41 |
| drug3308 | Regular messages through Instant Messaging (IM) Wiki | 0.41 |
| Name (Synonyms) | Correlation | |
|---|---|---|
| drug1394 | Enhanced linkage Wiki | 0.41 |
| drug1488 | FITSTART+ PBI Wiki | 0.41 |
| drug150 | AUDIT score interpretation sheet adapted from the Department of Health of Hong Kong Wiki | 0.41 |
| drug1630 | General Parenting Advice Wiki | 0.41 |
| drug2497 | Naltrexone 380 MG Wiki | 0.41 |
| drug456 | BCG vaccine (Freeze-dried) Wiki | 0.41 |
| drug27 | 12-page health warning leaflet Wiki | 0.41 |
| drug1689 | HaRTC Wiki | 0.41 |
| drug2068 | Ketamine Hydrochloride Wiki | 0.41 |
| drug4381 | attendance by ambulance crew Wiki | 0.41 |
| drug1633 | General health through IM Apps Wiki | 0.41 |
| drug3282 | Real-time chat-based support through IM Apps Wiki | 0.41 |
| drug459 | BGB DXP593 Wiki | 0.41 |
| drug3502 | Saline Wiki | 0.26 |
| drug455 | BCG vaccine Wiki | 0.24 |
| drug454 | BCG Vaccine Wiki | 0.20 |
| drug2916 | Placebo Wiki | 0.05 |
| Name (Synonyms) | Correlation | |
|---|---|---|
| D000437 | Alcoholism NIH | 0.46 |
| D019973 | Alcohol-Related Disorders NIH | 0.41 |
| D000435 | Alcoholic Intoxication NIH | 0.41 |
| Name (Synonyms) | Correlation |
|---|
Navigate: Correlations HPO
There are 6 clinical trials
This study aims to assess the effect of personalized support using instant messaging application on alcohol drinking reduction in university students proactively recruited from universities in Hong Kong.
Description: Assessed by unit in gram and compare the alcohol consumption between intervention and control group at 6-month after baseline.
Measure: Amount of alcohol consumption per week (gram/week) at 6-month follow-up Time: 6-month after baselineDescription: To estimate large, moderate and null (same as the control) treatment effects and check whether ITT, AP and PP analysis estimates are biased compared with CACE estimates (alcohol consumption per week at 6-month follow-up)
Measure: Compare the primary outcome using intention-to-treat (ITT), per-protocol (PP) and as-treated (AP) analysis with Compliance Average Causal Effect (CACE) analysis Time: 6-month after baselineDescription: Assessed by unit in gram and compare the alcohol consumption between intervention and control group at 12-month after baseline.
Measure: Amount of alcohol consumption per week (gram/week) at 12-month follow-up Time: 12-month after baselineDescription: Assessed by Alcohol Use Disorders Identification Test (ranged 0-40 with higher score indicating problematic alcohol use) and compare the AUDIT between intervention and control group at 6-month after baseline.
Measure: AUDIT scores at 6-month follow-up Time: 6-month after baselineDescription: Assessed by Alcohol Use Disorders Identification Test (ranged 0-40 with higher score indicating problematic alcohol use) and compare the AUDIT between intervention and control group at 12-month after baseline.
Measure: AUDIT scores at 12-month follow-up Time: 12-month after baselineDescription: Assessed by either increase or decrease in standard drinks number and compared between intervention and control group at 6-month
Measure: Number of standard drinks (10g of alcohol) per week at 6-month follow-up Time: 6-month after baselineDescription: Assessed by either increase or decrease in standard drinks number and compared between intervention and control group at 12-month
Measure: Number of standard drinks (10g of alcohol) per week at 12-month follow-up Time: 12-month after baselineDescription: Defined by 5 standard drink [male] or 4 standard drink [female] in one occasion for binge drinking and compare the episode of binge drinking between intervention group and control at baseline and 6-month follow-up questionnaires
Measure: Episode of binge drinking in the past 30-day at 6-month follow up Time: at 6-month after baselineDescription: Defined by 5 standard drink [male] or 4 standard drink [female] in one occasion for binge drinking and compare the episode of binge drinking between intervention group and control at baseline and 12-month follow-up questionnaires
Measure: Episode of binge drinking in the past 30-day at 12-month follow up Time: at 12-month after baselineDescription: Defined by 15 standard drink [male] or 8 standard drink[female] in a week for heavy drinking and compare the episode of heavy drinking between intervention group and control at baseline and 6-month follow-up questionnaires
Measure: Episode of heavy drinking in the past 30-day at 6-month follow up Time: at 6 -month after baselineDescription: Defined by 15 standard drink [male] or 8 standard drink [female] in a week for heavy drinking and compare the episode of heavy drinking between intervention group and control at baseline and 12-month follow-up questionnaires
Measure: Episode of heavy drinking in the past 30-day at 12-month follow up Time: at 12-month after baselineDescription: Compare the number of planned drinking (yes or no) between intervention group and control group at baseline and 6-month follow-up questionnaires
Measure: Planned drinking measured in the coming 30-day at 6-month follow up Time: at 6-month after baselineDescription: Compare the number of planned drinking (yes or no) between intervention group and control group at baseline and 12-month follow-up questionnaires
Measure: Planned drinking measured in the coming 30-day at 12-month follow up Time: at 12-month after baselineDescription: The four items in this scale addressed the number of times the student had been 'late to class', 'missed class', was 'unable to concentrate' and 'failed to complete assignment' (score range 0-16). The responses included 'not at all', 'once', 'twice', 'three times' and 'four times or more'. The score will be compared between intervention group and control group at baseline and 6-month follow-up questionnaires
Measure: Academic Role Expectation and Alcohol Scale at 6-month follow-up Time: at 6-month after baselineDescription: The four items in this scale addressed the number of times the student had been 'late to class', 'missed class', was 'unable to concentrate' and 'failed to complete assignment' (score range 0-16). The responses included 'not at all', 'once', 'twice', 'three times' and 'four times or more'. The score will be compared between intervention group and control group at baseline and 12-month follow-up questionnaires
Measure: Academic Role Expectation and Alcohol Scale at 12-month follow-up Time: at 12-month after baselineDescription: The 14-item measure of alcohol-related personal, social, sexual, and legal problems (eg, being physically aggressive toward someone while under the influence of alcohol).The score will be compared between intervention group and control group at baseline and 6-month follow-up questionnaires
Measure: Alcohol Problems Scale at 6-month follow-up Time: at 6-month after baselineDescription: The 14-item measure of alcohol-related personal, social, sexual, and legal problems (eg, being physically aggressive toward someone while under the influence of alcohol).The score will be compared between intervention group and control group at baseline and 12-month follow-up questionnaires
Measure: Alcohol Problems Scale at 12-month follow-up Time: at 12- month after baselineDescription: Mediation analysis of 6-month factors (knowledge of alcohol drinking, perception of alcohol drinking, intention to quit drinking, mental health) on weekly amount of alcohol consumption at 12-month
Measure: Mediation analysis of variables at 6-month on weekly amount of alcohol consumption at 12-month Time: at 12- month after baselineDescription: Subgroup analysis to check whether the intervention is more effective with participants with intention to quit/reduce drinking on outcomes
Measure: Subgroup analysis of baseline intention to quit/reduce drinking Time: at 12- month after baselineDescription: The conversations between the participants and the nurse will be analyzed and categorized into different sub-type of BCT taxonomy
Measure: Content analysis of IM Apps conversation using alcohol BCT taxonomy Time: at 12- month after baselineDescription: Total score is determined by adding together the scores of each of the 4 items. Scores are rated as normal (0-2), mild (3-5), moderate (6-8), and severe (9-12). Total score ≥3 for first 2 questions suggests anxiety. Total score ≥3 for last 2 questions suggests depression. The score will be compared between intervention group and control group at baseline and 6-month follow-up questionnaires
Measure: Patient Health Questionnaire 4-item (PHQ-4) at 6-month Time: at 6-month after baselineDescription: Total score is determined by adding together the scores of each of the 4 items. Scores are rated as normal (0-2), mild (3-5), moderate (6-8), and severe (9-12). Total score ≥3 for first 2 questions suggests anxiety. Total score ≥3 for last 2 questions suggests depression. The score will be compared between intervention group and control group at baseline and 12-month follow-up questionnaires
Measure: Patient Health Questionnaire 4-item (PHQ-4) at 12-month Time: at 12-month after baselineDescription: Subjects' responses are measured on a five-point scale (0 = never, 1 = almost never, 2 =sometimes, 3 = fairly often, 4 = very often). Scoring: PSS-4 scores are obtained by summing across all four items. Scoring items 2 and 3 require reverse coding. This involves assigning the opposite score. For example, a score of 0=4, 1=3, 2=2, 3=1, and 4=0. The higher the score, the more perceived stress. The score will be compared between intervention group and control group at baseline and 6-month follow-up questionnaires
Measure: Perceived Stress Scale 4-item (PSS-4) at 6-month Time: at 6-month after baselineDescription: Subjects' responses are measured on a five-point scale (0 = never, 1 = almost never, 2 =sometimes, 3 = fairly often, 4 = very often). Scoring: PSS-4 scores are obtained by summing across all four items. Scoring items 2 and 3 require reverse coding. This involves assigning the opposite score. For example, a score of 0=4, 1=3, 2=2, 3=1, and 4=0. The higher the score, the more perceived stress. The score will be compared between intervention group and control group at baseline and 12-month follow-up questionnaires
Measure: Perceived Stress Scale 4-item (PSS-4) at 12-month Time: at 12-month after baselineDescription: Score ranges from 0 to 10 with higher score indicates a higher level of usefulness of our intervention.
Measure: Perceived usefulness of IM app intervention at 12-month Time: at 12-month after baselineDescription: Ask for intention to use (yes/no) IM app intervention to reduce/quit drinking at 12-month
Measure: Intention to continue using IM app intervention at 12-month Time: at 12-month after baselineDescription: Perceived difficulty, confidence and importance of quitting/reducing to drink will be asked. Score ranges from 0 to 10 with higher score indicates a high level. The score will be compared between intervention group and control group at baseline and 6-month follow-up questionnaires
Measure: Self-efficacy to reduce/quit drinking at 6-month Time: at 6-month after baselineDescription: Perceived difficulty, confidence and importance of quitting/reducing to drink will be asked. Score ranges from 0 to 10 with higher score indicates a high level. The score will be compared between intervention group and control group at baseline and 12-month follow-up questionnaires
Measure: Self-efficacy to reduce/quit drinking at 12-month Time: at 12-month after baselineDescription: Assessed by stop drinking, increase (+50%), slight increase, decrease (-50%), slight decrease or no change of drinking after the start of pandemic
Measure: Covid-19 related drinking behavioral changes at baseline Time: at baselineDescription: Assessed by stop drinking, increase (+50%), slight increase, decrease (-50%), slight decrease or no change of drinking after the start of pandemic. The changes will be compared between the intervention group and control group at 6-month
Measure: Covid-19 related drinking behavioral changes at 6-month Time: at 6-monthDescription: Assessed by stop drinking, increase (+50%), slight increase, decrease (-50%), slight decrease or no change of drinking after the start of pandemic. The changes will be compared between the intervention group and control group at 12-month
Measure: Covid-19 related drinking behavioral changes at 12-month Time: at 12-monthThis randomized clinical trial will compare participants who receive HaRTC versus the nontreatment control arm to see if HaRTC helps urban American Indians and Alaska Natives who meet criteria for an alcohol use disorder to increase their engagement in cultural practices, enhance their quality of life, and reduce their alcohol-related harm.
Description: Alcohol and Substance Use Frequency Assessment items were adapted from the Addiction Severity Index-Fifth Edition (ASI-5th Ed) and will be used to assess frequency of alcohol use in the past 30 days. Scores range from 0 to 30 with higher scores indicating more frequent drinking.
Measure: Change in Alcohol frequency Time: Pre-intervention, mid-, immediate post-intervention, 1 month post-intervention, 3 months post intervention, and 6 months post-intervention.Description: The Alcohol Quantity and Use Assessment was created by the research team for previous studies with a similar population and will be used to record the quantity of alcohol consumed on participants' heaviest, typical, and lightest drinking days in the past month. Scores are expressed in number of standard drinks with higher numbers indicating heavier drinking.
Measure: Change in Peak alcohol use Time: Pre-intervention, mid-, immediate post-intervention, 1 month post-intervention, 3 months post intervention, and 6 months post-intervention.Description: The Short Inventory of Problems-2nd Revision (SIP-2R), a psychometrically reliable and valid 15-item, Likert-scale questionnaire, measures social, occupational, and psychological problems related to alcohol use. Scores range from 0 to 45 with higher scores indicating more severe alcohol-related harm.
Measure: Change in Alcohol-related harm Time: Pre-intervention, mid-, immediate post-intervention, 1 month post-intervention, 3 months post intervention, and 6 months post-intervention.Description: The EuroQoL-5 Dimensional-5 Level is a widely used generic measure of health status consisting of two parts. The first part (the descriptive system) assesses health in five dimensions (MOBILITY, SELF-CARE, USUAL ACTIVITIES, PAIN / DISCOMFORT, ANXIETY / DEPRESSION), each of which has five levels of response (no problems, slight problems, moderate problems, severe problems, extreme problems/unable to). Each domain is rated on a 5 point likert scale. Scores range from 5-25, with higher scores indicating poorer health related quality of life.
Measure: Change in EuroQoL-5 Dimensional-5 Level Time: Pre-intervention, mid-, immediately post-intervention, 1 month post-intervention, 3 months post intervention, and 6 months post-intervention.Description: **Self-report data for cost-effectiveness analyses -The Non-Study Resources Form: documents change in medical and nonmedical resources used by participants.
Measure: Change in Cost effectiveness Time: 6 months before study participation compared to 6 months after enrollment.Description: Ethyl glucuronide (EtG) urine tests will be used to validate self-reported alcohol use at each assessment. EtG, a metabolite of ethyl alcohol formed in the body after ethanol exposure, reflects alcohol consumption over the previous 72 hours. EtG (cutoff 300 mg/nl) will serve as a secondary outcome in analyses.
Measure: Change in Ethyl glucuronide Time: Pre-intervention, mid-, immediately post-intervention, 1 month post-intervention, 3 months post intervention, and 6 months post-intervention.Description: The Cultural Connectedness Scale is a 29-item Likert type measure consisting of 3 dimensions: identity, traditions, and spirituality. Scores can range from 29-145, with higher scores indicating a greater degree of cultural connectedness. Criterion validity was demonstrated with cultural connectedness dimensions adequately correlating with other indicators of wellness. The resulting scale scores will represent the proposed mediator in this study.
Measure: Change in Cultural connectedness Time: Pre-intervention, mid-, immediately post-intervention, 1 month post-intervention, 3 months post intervention, and 6 months post-intervention.Background: The SARS-CoV-2 virus has caused a pandemic infection called COVID-19. It is a global threat to people, communities, and health systems. Researchers are concerned about the mental health effects of the pandemic. They want to learn more about how it is affecting people s alcohol use and problems, and how it may continue to affect them over time. Objective: To study the impact of the COVID-19 pandemic on alcohol use and consequences in individuals across the spectrum of alcohol use and those with alcohol use disorder. Eligibility: Participants who have been screened under the NIAAA Screening, Assessment and Management Protocol (14-AA-0181) Design: Participants will complete a baseline survey by phone. It will ask about alcohol use, alcohol dependence, and stress. It covers 2 time periods: the 12 months before the pandemic started and the time since it started. Participants will get an ID code and a link to an online survey. They will complete the online survey within a week of the phone survey. Participants will complete a series of online surveys over 24 months. For the first year, surveys will be completed weekly for the first 4 weeks, then biweekly for the next 8 weeks, and then every 1-2 months for the rest of the year. For the second year, surveys will be completed every 6 months. Surveys will cover the following topics: - Alcohol use and its consequences - Other substance use - Stress - Impact of the COVID-19 pandemic - Pain - Physical health - Sleep - Quality of life. Because the course of the pandemic may change, the frequency of the surveys may change. Participation lasts 2 years.
Description: Alcohol Use Disorder Identification Test (AUDIT): This is a 10-item questionnaire designed to screen for AUD. The first 3 questions constitute the AUDIT-C and provides a measure of alcohol consumption. The total score provides a continuous quantification of AUD severity.
Measure: AUDIT Score Time: 24 monthsDescription: Alcohol Dependence Scale (ADS): This 25-item scale will be used to measure severity of alcohol dependence. This scale covers alcohol withdrawal symptoms, impaired control over drinking, awareness of a compulsion to drink, increased tolerance to alcohol, and salience of drink-seeking behavior.
Measure: ADS Score Time: 24 monthsDescription: Life Events Questionnaire (LEQ): This questionnaire assesses positive and negative life events and their impact on participants
Measure: Life Events Questionnaire (LEQ) Score Time: 24 monhtsDescription: UCLA Loneliness Scale (UCLALS): This is a 20-item scale designed to measure a person s subjective feeling of loneliness and social isolation in the last month
Measure: UCLA Loneliness Scale (UCLALS) Score Time: 24 monthsDescription: Perceived stress scale (PSS): This is a 10-item scale to measure perception of stress
Measure: Perceived Stress Scale (PSS) Score Time: 24 monthsThe Primary objective is to explore ambulance service attendance at incidents involving alcohol and/or substance use over the period of the pandemic lockdown, and the following months. This will be to determine prevalence and explore factors such as patient gender, age, ethnicity or location. Analysis will examine the calls over the course of the year prior to the lockdown, and then compare this to the period of lockdown and following months.
Description: Counts of attendances for alcohol and drug use by the East Midland's Ambulance Service over the time period. This will be a number per day of people attended.
Measure: Attendances for alcohol and drug use Time: Full data set 23/03/2019 compared to 22/03/2021 to look at interruption (lockdown) in the time series.FITSTART (Feedback Intervention Targeting Student Transitions and Risk Trajectories) is a parent-based social norms intervention that has been shown to reduce risky drinking in incoming first year students.This program uses normative feedback to correct parents overestimation of other parents negative alcohol-related parenting practices (e.g., number of drinks parents would permit their college student to consume). Theory and research suggests that correcting those common misperceptions can motivate parents to adjust their own behaviors (e.g., reducing the number of drinks they would permit), which, in turn, can impact college student drinking. Despite FITSTARTs success, the design of the program limits participation to only students who have parents who can attend on-campus orientation sessions during the summer months before the start of the Fall semester. To address this limitation and extend the previous work, the proposed randomized clinical trial (RCT) will evaluate the efficacy of an online adaptation of the FITSTART(+) PBI program. To examine the efficacy of the newly developed FITSTART+ PBI web app, the proposed RCT will use a longitudinal design to examine if students self-report drinking and related negative consequences during their first semester in college significantly differed between FITSTART+ PBI (intervention app) and a control version of the app. Self-reported drinking and consequences are expected to be lower amongst students with parents randomized to FITSTART+ PBI relative to those with parents randomized to the control app.
Description: Assesses number of drinks consumed during an average week over the past month
Measure: Change from Baseline Daily Drinking at 1 Month Time: baseline, 1 monthDescription: Assesses number of drinks consumed during an average week over the past month.
Measure: Change from Baseline Daily Drinking at 3 Months Time: baseline, 3 monthsDescription: Assesses reported frequency of negative alcohol outcomes over the past month
Measure: Change from Baseline Frequency of Alcohol Consequences at 1 Month Time: baseline, 1 monthDescription: Assesses reported frequency of negative alcohol outcomes over the past month
Measure: Change from Baseline Frequency of Alcohol Consequences at 3 Months Time: baseline, 3 monthsDescription: Assesses frequency and quantity of alcohol consumption over the past month
Measure: Change from Baseline Quantity/Frequency/Peak Alcohol Use at 1 Month Time: baseline, 1 monthDescription: Assesses frequency and quantity of alcohol consumption over the past month
Measure: Change from Baseline Quantity/Frequency/Peak Alcohol Use at 3 Months Time: baseline, 3 monthsDescription: Assesses frequency heavy episodic drinking events over the past month
Measure: Change from Baseline heavy episodic drinking at 1 Month Time: baseline, 1 monthDescription: Assesses frequency heavy episodic drinking events over the past month
Measure: Change from Baseline heavy episodic drinking at 3 Months Time: baseline, 3 monthsEvery year, alcohol use disorder (AUD) generates millions of emergency department (ED) visits and hospital admissions, costing the U.S. health sector over $90 billion. These hospital admissions are critical opportunities to start patients on addiction pharmacotherapy, but factors like medication non-adherence and post-discharge relapse contribute to frequent re-admissions. Two single-dose interventions are well suited to facilitate treatment retention and prevent re-admissions due to their prolonged, adherence-independent effects: extended-release (XR) naltrexone injection and intravenous (IV) ketamine infusion. These have not been thoroughly investigated in the hospital setting among high-utilizer, safety-net populations. Therefore, the investigators aim to: 1. Test the feasibility of randomizing hospitalized patients (n=45-60, age 18-65) with multiple AUD-related admissions to treatment with either extended-release (XR) naltrexone, intravenous (IV) ketamine, or no single-dose medication, all with enhanced linkage to care. Feasibility outcomes such as recruitment rate, patient acceptability, post-discharge follow-up rate, and adverse events will help to identify key lessons for a future comparative effectiveness study. 2. Estimate the 30-day re-admission rate for patients randomized to treatment with XR naltrexone, with IV ketamine, or no single-dose medication, all with enhanced linkage to care. The investigators hypothesize that the re-admission rate will be lower for each of the two single-dose medication groups than for the "linkage-alone" group.
Description: Binary outcome: any all-cause hospitalization ascertained by chart review (our EHR includes records from several local hospitals)
Measure: Rate (%) of 30-day hospital re-admission Time: Within 30 days of index hospital discharge. The enrollment period is 5 months.Description: Number of participants recruited per month during the enrollment period
Measure: Feasibility - recruitment rate (# per month) Time: The enrollment period is 5 monthsDescription: Percentage of patients who presented to 1 week follow-up appointment
Measure: Feasibility - follow-up rate (%) Time: The enrollment period is 5 monthsDescription: Within-subject differences in readiness to change between inpatient enrollment and outpatient follow-up.
Measure: Average within-subject difference in readiness-to-change (SOCRATES-8A score) Time: Follow-up planned to be within one week of dischargeDescription: Binary outcome: any all-cause ED visit ascertained by chart review
Measure: Rate (%) of 30-day emergency department visit Time: Within 30 days of index hospital discharge. The enrollment period is 5 months.Description: Obtained by urine EtG at outpatient follow-up
Measure: Rate (%) of urine Ethyl Glucuronide (EtG) at follow-up Time: Follow-up planned to be within one week of discharge. The enrollment period is 5 months.Description: Self reported at outpatient follow-up, ascertained by Timeline Follow-Back Method.
Measure: Rate (%) of self-reported binge drinking since discharge Time: Follow-up planned to be within one week of discharge. The enrollment period is 5 months.Alphabetical listing of all HPO terms. Navigate: Correlations Clinical Trials
Data processed on September 26, 2020.
An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.
Drug Reports MeSH Reports HPO Reports