Developed by Shray Alag, The Harker School
Sections: Correlations,
Clinical Trials, and HPO
Navigate: Clinical Trials and HPO
| Name (Synonyms) | Correlation | |
|---|---|---|
| drug2412 | Mobile Mental Health App - 9 Wiki | 0.71 |
| drug2403 | Mobile Mental Health App - 1 Wiki | 0.71 |
| drug2408 | Mobile Mental Health App - 5 Wiki | 0.71 |
| Name (Synonyms) | Correlation | |
|---|---|---|
| drug2410 | Mobile Mental Health App - 7 Wiki | 0.71 |
| drug2411 | Mobile Mental Health App - 8 Wiki | 0.71 |
| drug2404 | Mobile Mental Health App - 10 Wiki | 0.71 |
| drug2409 | Mobile Mental Health App - 6 Wiki | 0.71 |
| drug651 | Brief Skills for Safer Living Wiki | 0.71 |
| drug2407 | Mobile Mental Health App - 4 Wiki | 0.71 |
| drug2405 | Mobile Mental Health App - 2 Wiki | 0.71 |
| drug2406 | Mobile Mental Health App - 3 Wiki | 0.71 |
| drug4687 | questionnaire Wiki | 0.27 |
| Name (Synonyms) | Correlation | |
|---|---|---|
| D059020 | Suicidal Ideation NIH | 0.50 |
| D003863 | Depression, NIH | 0.08 |
| Name (Synonyms) | Correlation |
|---|
Navigate: Correlations HPO
There are 2 clinical trials
Mental health concerns have been on the rise since the onset of the COVID-19 pandemic. The pandemic has worsened risk factors for suicide, including job loss, anxiety, depression, and loneliness. Timely and easy access to mental health services is a dire need, and this study will test the efficacy and feasibility of a brief clinical intervention, Brief Skills for Safer Living (Brief-SfSL), at reducing suicide risk. The goal of this study is to investigate whether Brief-SfSL, delivered online, is a suitable, acceptable and effective method for reducing suicide risk and providing timely mental health services. The results from this study will provide vital insight into effective interventions for suicide risk that are accessible and can be widely distributed.
Description: Beck Scale for Suicide Ideation is a 21-item self-report scale that quantifies suicidal ideation. Items are scored 0 to 2 and yield a total score ranging from 0 to 38. Higher scores reflect greater severity of suicidal ideation.
Measure: Change in suicidal ideation using Beck Scale for Suicide Ideation Time: From baseline to 3 months; also administered at screening, 1 week and 1 monthDescription: The QIDS-SR is a 16-item validated self-report depression scale. Total scores range from 0 (none) to 27 (very severe).
Measure: Change in depression symptoms using the Quick Inventory of Depressive Symptoms self-report scale (QIDS-SR) Time: From baseline to 3 months; also administered at 1 week and 1 monthDescription: The GAD-7 is a brief 7-item self-report scale measuring anxiety symptoms. Total scores range from 0 to 21, with higher scores reflecting more severe anxiety.
Measure: Change in anxiety symptoms using the Generalized Anxiety Disorder 7-item scale (GAD-7) Time: From baseline to 3 months; also administered at 1 week and 1 monthDescription: The ACSS is a 20-item self-report instrument to assess the construct of acquired capability. Total scores range from 0 to 80, with higher scores reflecting greater acquired capability.
Measure: Change in Acquired Capability of Suicide Scale (ACSS) Time: From baseline to 3 months; also administered at 1 week and 1 monthDescription: The Interpersonal Needs Questionnaire is a 15-item self-report scale assessing connectedness to others and burdensomeness. Items are rated 1 to 7, with total scores ranging from 15 to 105. Higher scores reflect worse outcomes.
Measure: Change in Interpersonal Needs Questionnaire score Time: From baseline to 3 months; also administered at 1 week and 1 monthDescription: The DARS is a 26-item self-report scale measuring anhedonia across four domains. Items are scored on a 5-point Likert scale with lower total scores reflecting more severe anhedonia.
Measure: Change in Dimensional Anhedonia Rating Scale (DARS) score Time: From baseline to 3 months; also administered at 1 week and 1 monthDescription: The SDS is a brief 3-item self-report scale that probes work/school, social, and family/home functioning. Each item is scored from 0 to 10. Total scores range from 0 (unimpaired) to 30 (highly impaired).
Measure: Change in Sheehan Disability Scale (SDS) score Time: From baseline to 3 months; also administered at 1 monthDescription: Use of healthcare services will be assessed through four questions enquiring about the frequency and description of health care professional visits, use of mental health services, hospital admissions, and emergency room visits in the preceding specified time frame (1-3 months).
Measure: Change in Treatment Utilization Time: From screening to 3 months; also administered at 1 monthDescription: Feasibility and Acceptability survey and interview created in-house with questions designed to collect quantitative and qualitative feedback from participants with respect to the feasibility and acceptability of the Brief-SfSL intervention.
Measure: Participant feedback on their experiences with specific aspects of the Brief-SfSL intervention Time: 3 monthsAccess to mental health care by essential workers and the unemployed during the COVID19 pandemic has been challenging. Usual access to mental health care is limited by social distancing, and for many now unemployed due to closures of businesses, insurance is insufficient to cover the costs of mental health care. For these individuals who are at risk for suicide (isolation, unemployment, financial crisis plus past suicide attempts, significant mental health challenges), access to care is crucial and many maybe turning to online and accessible interventions, such as mental health apps and other online resources. Indeed, organizations such as the VA have already created free access mobile applications for mental health in anticipation of this need. Using Psyberguide, the investigators will identify the top ten free apps that address mental health issues and conduct a nation-wide evaluation of these apps with participants who are essential workers and unemployed with risk for suicide. Participants will first be surveyed about which strategies they have used to manage mental health issues, what apps and online tools they have used, and what usability challenges they have faced. The investigators will then ask a random sample of participant to engage in a randomized trial of these top-rated apps for 4 weeks. Apps will be rated on usability, acceptability, feasibility and effectiveness. Results from this trial will be quickly disseminated through several avenues: (1) the UWAC website and ALACRITY Centers network; (2) through CREATIV Lab's partnership with Mental Health America; (3) through the UW Center for Suicide Prevention and Recovery (CSPAR) and partnerships with other suicide focused organizations including Forefront, the American Foundation for Suicide Prevention, that American Association of Suicidology, the Rocky Mountain MIRECC, and the Defense Suicide Prevention Office and (4) through local partnership with King County and WA state contact tracers.
Description: The PHQ-9 consists of 9 depression items and one disability item. Each time is associated with a DSM symptom of depression, which the participant rates whether or not they have experienced the symptom over the last two weeks, with severity rating of 0-3. It is one of the few measures that is brief (it takes less than one minute to give) and has been found to have excellent sensitivity to change over time.
Measure: Patient Health Questionnaire (PHQ-9) Time: Change from baseline PHQ-9 at 4 weeksDescription: A 7- item screener for generalized anxiety. It consists of items related to GAD. Participants rate on a scale of 0-3 how much they have experienced in the last two weeks. The scale is a valid screener for GAD.
Measure: Generalized Anxiety Disorder (7-Item) Scale (GAD-7) Time: Change from baseline GAD-7 at 4 weeksDescription: The DERS is a brief, 36-item, self-report questionnaire designed to assess multiple aspects of emotion dysregulation.
Measure: Brief Difficulties with Emotional Regulation Scale (DERS) Time: Change from baseline DERS at 4 weeksDescription: This is a four item measure of intervention acceptability, where each item is rated on a 1-5 scale, with 1 = not at all acceptable and 5 = very acceptable. Participants will complete this measure after 4 weeks of using the mobile mental health app to which they are randomized.
Measure: Acceptability of Intervention Measure (AIM) Time: 4 weeksDescription: This is a four item measure of intervention appropriateness, where each item is rated on a 1-5 scale, with 1 = not at all acceptable and 5 = very acceptable. Participants will complete this measure after 4 weeks of using the mobile mental health app to which they are randomized.
Measure: Intervention Appropriateness Measure (IAM) Time: 4 weeksDescription: This is a four item measure of intervention feasibility, where each item is rated on a 1-5 scale, with 1 = not at all acceptable and 5 = very acceptable. Participants will complete this measure after 4 weeks of using the mobile mental health app to which they are randomized.
Measure: Feasibility of Intervention Measure (FIM) Time: 4 weeksDescription: A brief, 4 item screen for PTSD
Measure: Primary Care - Post-Traumatic Stress Disorder (PC-PTSD) Time: Change from baseline PC-PTSD at 4 weeksDescription: Self-report measure of describing one's responses to depressed mood, consists of 22 items and three factors (Depression, Brooding, and Reflection)
Measure: Ruminative Responses Scale (RRS) Time: Change from baseline RRS at 4 weeksDescription: Standardized measure of health status
Measure: PARS EQ-5D Time: Change from baseline PARS EQ-5D at 4 weeksDescription: Standardized measure of alcohol/drug use
Measure: PARS SIP-AD Time: Change from baseline PARS SIP-AD at 4 weeksDescription: A validated, brief, 11 item self-report measure of the amount of social support a person feels.
Measure: Duke University Social Support Scale Time: Change from baseline Duke Univ Social Support Scale at 4 weeksDescription: 6-item, self-reported measure of an individual's ability to bounce back, resist illness, adapt to stress, or thrive in the face of adversity
Measure: Brief Resilience Scale (BRS) Time: Change from baseline BRS at 4 weeksDescription: Gilbert and Allan (1998) designed the items on this scale in order to depict a sense of failed struggle and losing rank. This measure requests participants to respond to 16 items on a 5-point Likert scale (ranging from 0 = 'Never' to 4 = 'Always') asking them how much they had felt defeated in the previous seven days, for example item 1 'I feel that I have not made it in life'. This scale has very high internal consistency with Alpha coefficients of 0.94 for females and 0.93 for males in both groups, furthermore reliability of 0.94 for students and 0.93 for depressed group.
Measure: Defeat Scale Time: Change from baseline Defeat Scale at 4 weeksDescription: This 16-item scale asks participants to indicate on a 5-point scale the degree to which the items represent their thoughts and feelings. The response options are 0 = 'not at all like me', 1 = 'a little bit like me', 2 = 'moderately like me', 3= 'quite a bit like me' and 4 = 'extremely like me'. Gilbert and Allan (1998) reported high levels of internal consistency for both student and depressed groups, with Cronbach's alphas respectively of .93 and .86 in Internal Entrapment, and .88 and .89 in External Entrapment.
Measure: Entrapment Scale Time: Change from baseline Entrapment Scale at 4 weeksDescription: Brief measure of thwarted belongingness
Measure: Loneliness and Social Distress Scale Time: Change from baseline Loneliness and Social Distress Scale at 4 weeksDescription: Brief questionnaire that asks respondents to think about themselves and other people, based on the respondent's current beliefs and experiences.
Measure: Interpersonal Needs Questionnaire Time: Change from Interpersonal Needs Questionnaire at 4 weeksDescription: A measure that seeks to identify experiences that lead an individual to acquire the capability for suicide through an increased tolerance for pain and a decreased fear of death
Measure: Painful and Provocative Events (subscale of Acquired Capability for Suicide Scale) Time: Change from baseline at 4 weeksDescription: Self-report questionnaire designed to identify risk factors for suicide
Measure: Suicidal Behavioral Questionnaire-Revised (SBQ-R) Time: Change from baseline SBQ-R at 4 weeksAlphabetical listing of all HPO terms. Navigate: Correlations Clinical Trials
Data processed on September 26, 2020.
An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.
Drug Reports MeSH Reports HPO Reports