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D005759: Gastroenteritis

Developed by Shray Alag, The Harker School
Sections: Correlations, Clinical Trials, and HPO

Correlations computed by analyzing all clinical trials.

Navigate: Clinical Trials and HPO


Correlated Drug Terms (10)


Name (Synonyms) Correlation
drug1622 Gamification Wiki 0.71
drug1010 Completion of survey after peak of pandemic Wiki 0.71
drug2628 Norovirus Bivalent (GI.1 / GII.4) Vaccine(low) Wiki 0.71
Name (Synonyms) Correlation
drug1009 Completion of pre-pandemic survey Wiki 0.71
drug2627 Norovirus Bivalent (GI.1 / GII.4) Vaccine(high) Wiki 0.71
drug1008 Completion of post telemedicine encounter survey Wiki 0.71
drug2538 Newsfeed function Wiki 0.71
drug2629 Norovirus Bivalent (GI.1 / GII.4) Vaccine(middle) Wiki 0.71
drug263 Aluminum adjuvant Wiki 0.71
drug2620 Normal saline Wiki 0.29

Correlated MeSH Terms (1)


Name (Synonyms) Correlation
D017250 Caliciviridae Infections NIH 0.50

Correlated HPO Terms (0)


Name (Synonyms) Correlation

Clinical Trials

Navigate: Correlations   HPO

There are 2 clinical trials


1 A Randomized, Blind, Placebo-controlled Phase I Clinical Trial to Evaluate the Safety and Immunogenicity of Recombinant Norovirus Bivalent (GI. 1 / GII. 4) Vaccine (Hansenulapolymorpha) in Healthy People Aged 6 Months to 59 Years

A total of 450 subjects were enrolled, divided into four age groups, including 18-59 years, 6-17 years, 3-5 years, and 6-35 months. There are three types of the test vaccine component in each age group. A total of 30 people in each dose group were vaccinated with the test vaccine or placebo 1 or placebo 2, respectively, in a ratio of 3: 1: 1. The 18-59-year-old, 6-17-year-old, and 3-5-year-old age groups were vaccinated 2 times at a time interval of 28 days. The 6-35 month age group is divided into two groups, Group 1 is inoculated with 2 doses interval of 28 days each, and Group 2 is inoculated with 3 doses interval of 28 days.

NCT04188691
Conditions
  1. Norwalk Gastroenteritis
  2. Norovirus Infections
Interventions
  1. Biological: Norovirus Bivalent (GI.1 / GII.4) Vaccine(low)
  2. Biological: Norovirus Bivalent (GI.1 / GII.4) Vaccine(middle)
  3. Biological: Norovirus Bivalent (GI.1 / GII.4) Vaccine(high)
  4. Biological: Normal saline
  5. Biological: Aluminum adjuvant
MeSH:Caliciviridae Infections Gastroenteritis

Primary Outcomes

Measure: AE of local and systemic reactions within 30 minutes after each dose

Time: 30 minutes

Description: Active AE: Local and systemic adverse reactions occurring within 0-7 days after each dose of vaccination

Measure: All active AEs within 0-7 days after each dose

Time: 7 days

Description: Adverse events other than active AE include solicitation adverse events reported in addition to the specified solicitation time window

Measure: All non-active collection AEs within 0-28(30) days after each dose

Time: 28(30) days

Measure: All SAEs within 6 months after the last dose is vaccinated

Time: 6 months

Secondary Outcomes

Measure: Calculate geometric mean titer (GMT) of NoV GI.1 and GII.4 IgG antibodies

Time: 28 days after the full vaccination

Measure: Calculate positive rate of NoV GI.1 and GII.4 IgG antibodies

Time: 28 days after the full vaccination

Measure: Calculate NoV GI.1 and GII.4 HBGA-blocking antibody titers

Time: 28 days after the full vaccination

Measure: Calculate NoV GI.1 and GII.4 HBGA-blocking antibody positive rates

Time: 28 days after the full vaccination
2 Innovative Tool to Limit Spread of SARS-CoV-2(COVID 19) in Residential Aged Care

This project is a randomised trial in order to determine if "gamification" can result in behaviour change for healthcare workers in the residential aged care setting. The app is for Age Care and care workers at the front line who are working to protect those most vulnerable to COVID-19. There are 2 groups in this trial on group will receive current and accurate information from an app. The other group will receives the app with the addition of a gamification competent, this will include rewarding experiences for staff doing safety behaviours and wellbeing behaviours. The purpose of the gamification is to create a calming and reassuring experience that injects positivity and joy where possible during this stressful time.

NCT04377165
Conditions
  1. COVID
  2. Influenza
  3. Gastroenteritis
Interventions
  1. Behavioral: Gamification
  2. Behavioral: Newsfeed function
MeSH:Gastroenteritis

Primary Outcomes

Description: Compare the number of sick leave prior to users utilising the app and at the end of the 4 weeks between the arms

Measure: To compare the hours of sick leave used over the course of the 4-week period post randomisation for each group

Time: 4 weeks

Secondary Outcomes

Description: Compare the amount of soap/sanitiser used between the arms

Measure: To compare handwashing behaviour

Time: 4 weeks

Description: Compare the number of self tests between the two arms

Measure: To compare self-testing rates

Time: 4 weeks

Description: Compare the amount of wipes/disinfectant used between the two arms

Measure: To compare the level of surface wipe down

Time: 4 weeks

Description: Compare the number of COVID-19 tests between the two arms

Measure: To compare number of COVID-19 tests completed in Facilities

Time: 4 weeks

Description: Compare the number of COVID-19 infections between the arms

Measure: To compare the number of COVID 19 infections in facilities

Time: 4 weeks

Description: Compare the number of flu and gastroenteritis outbreaks between the arms

Measure: To compare the other types of outbreaks (Flu, gastroenteritis)

Time: 4 weeks

Description: Compare the COVID 19 training between the two arms, this is via a self reported survey

Measure: To compare the awareness of COVID 19 training available to workers in the facilities

Time: 4 weeks

Description: Compare the awareness of PPE training of the workers in the two arms, this is captured in self reported survey

Measure: To compare the awareness of PPE training available to workers in the facilities

Time: 4 weeks

Description: Compare the amount of PPE used between the arms

Measure: To compare the levels of PPE material used in

Time: 4 weeks

Description: Compare the wellbeing and self-efficacy between the two arms, this is captured in a self reported survey.

Measure: To compare the wellbeing and self-efficacy of the two groups

Time: 4 weeks

HPO Nodes


HPO

Alphabetical listing of all HPO terms. Navigate: Correlations   Clinical Trials


HPO Nodes


Reports

Data processed on September 26, 2020.

An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.

Drug Reports   MeSH Reports   HPO Reports  

Interventions

4,180 reports on interventions/drugs

MeSH

691 reports on MeSH terms

HPO

263 reports on HPO terms

All Terms

Alphabetical index of all Terms

Google Colab

Python example via Google Colab Notebook