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  • HP:0000083: Renal insufficiency
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    HP:0000083: Renal insufficiency

    Developed by Shray Alag, The Harker School
    Sections: Correlations, Clinical Trials, and HPO

    Correlations computed by analyzing all clinical trials.

    Navigate: Clinical Trials and HPO


    Correlated Drug Terms (0)


    Name (Synonyms) Correlation

    Correlated MeSH Terms (3)


    Name (Synonyms) Correlation
    D051437 Renal Insufficiency, NIH 1.00
    D051436 Renal Insufficiency, Chronic NIH 0.41
    D007674 Kidney Diseases NIH 0.32

    Correlated HPO Terms (2)


    Name (Synonyms) Correlation
    HP:0012622 Chronic kidney disease HPO 0.50
    HP:0000077 Abnormality of the kidney HPO 0.35

    Clinical Trials

    Navigate: Correlations   HPO

    There are 2 clinical trials


    1 Antistof Respons Mod SARS-CoV-2 Hos Dialysepatienter i Forbindelse Med COVID-19

    Determination of IgM and IgG antibodies against SARS-CoV-2 in dialysis patients by continous monitoring in the period from March 2020 to december 2020

    NCT04367714
    Conditions
    1. COVID
    2. Terminal Renal Insufficiency
    MeSH:Renal Insufficiency
    HPO:Renal insufficiency

    Primary Outcomes

    Description: IgM and IgG against SARS-CoV-2

    Measure: AAntibody response

    Time: 1 year
    2 Global Assessment of Acute and Chronic Kidney Disease Incidence and Outcomes in Patients With COVID-19 Infection

    The coronavirus (COVID-19) pandemic has created a significant strain on health care resources across the world for managing critically ill patients. Emerging reports from China, South Korea and Italy have reported varying incidence of acute kidney (AKI) ranging from 5-15% with a mortality of 60-80% however there is no systematic assessment of the risk factors, recognition, course and outcomes in patients with and without kidney disease whose course is complicated by AKI1-4. Patients with underlying CKD, immunosuppressed patients with renal transplants and ESKD patients are at high risk for COVID-19 infection and there is limited information on the effect of COVID-19 on the course and outcomes of these patients. The requirement for renal support including IHD, CRRT and sorbent based therapies has been variable and has contributed to the intense pressure on the nephrology and critical care providers for delivering these therapies. As the COVID-19 pandemic expands in the USA and abroad, there is an intense need to understand the epidemiology of the disease and the resources needed for renal support to inform clinical management and public health interventions. In this study, the investigators aim to investigate health care facilities across the world (hospital wards, ICU, outpatient clinics, nursing homes, healthcare centers) to draw a global picture of incidence, risk factors, resources available for treatment and prognosis of acute and chronic kidney disease in patient with COVID 19 confirmed infection. The aim is to identify trends in patients with acute and chronic kidney disease, determine its incidence, treatment and outcomes in different settings across the world. This information will be used to develop and implement educational tools and resources to prevent deaths from AKI and progression of CKD in this and following pandemics.

    NCT04491227
    Conditions
    1. Covid19
    2. AKI
    3. CKD
    4. ESRD
    5. Transplant;Failure,Kidney
    MeSH:Kidney Diseases Renal Insufficiency, Chronic Renal Insufficiency
    HPO:Abnormality of the kidney Chronic kidney disease Nephropathy Renal insufficiency

    Primary Outcomes

    Description: Meeting of at least one of the modified KDIGO Criteria Increase or decrease in serum creatinine >0.3 mg/dl from reference in 48 hours Increase or decrease in serum creatinine > 50% from reference in 7 days Urine output < 400 ml/day

    Measure: AKI incidence

    Time: from hospital admission through hospital discharge upto 24 weeks

    Description: initiation of intermittent hemodialysis, continuous hemodialysis or peritoneal dialysis during the hospital stay

    Measure: Dialysis requirement

    Time: through study completion upto 1 year from enrollment

    Description: Deaths during primary hospitalization

    Measure: hospital mortality

    Time: through study completion within 1 year

    Secondary Outcomes

    Description: C-Complete: SCr < 0.3 mg/dL from reference P-Partial: Requires no dialysis but not complete recovery N-No recovery: Dialysis dependent C-Complete: SCr < 0.3 mg/dL from reference P-Partial: Requires no dialysis but not complete recovery N-No recovery: Dialysis dependent Percentage of patinets with renal functioanl recovery based on serum creatinien levels classfied as C-Complete: SCr < 0.3 mg/dL from reference P-Partial: Requires no dialysis but not complete recovery N-No recovery: Dialysis dependent

    Measure: Renal functional recovery

    Time: Assessed at at 3, 6 and 12 months from enrollment at hospital admission

    Description: EQL5D scale and SH8 scales completed at 3, 6 and 12 months post enrollment

    Measure: Functional status

    Time: questionnaires to be completed at 3, 6 and 12 months from enrollment at hospital admission

    Description: Number of days patient is in the hospital and ICU and is managed with ventilators, dialysis or other extracorporeal organ support e.g. ECMO during the hospital stay

    Measure: Resource utilization

    Time: Within 1 year of enrollment for primary hospitalization

    HPO Nodes


    HP:0000083: Renal insufficiency
    Genes 451
    LHX1 LCAT ALOXE3 SH2B1 WT1 PGAM2 FN1 COL7A1 GTF2IRD1 MME GSN ERCC6 NTRK1 OSGEP FANCM TBX18 IKZF1 CTNS GRHPR IFT140 CACNA1S PAX2 IFT172 FXYD2 NPHP3 TCF4 SHPK HLA-DPA1 SCNN1G CEP164 RAD51C SLC30A9 FUZ TMEM67 OCRL PRDX1 ABCA12 MUC1 KYNU ARHGDIA NLRP3 DYNC2H1 CLIP2 ELN PKD1 NPHP1 CEP290 BRIP1 IRF5 LMX1B WT1 TGM1 ELN MYD88 CLCNKB NPHP1 ERCC8 FANCG HLA-DPB1 CFHR5 CFHR1 WDR19 SDCCAG8 LIPN CRB2 PKHD1 UMOD COQ8B PPOX SIX5 ACTN4 CC2D2A NOD2 SCNN1B AP2S1 CEP83 PAX2 HNF1B CTLA4 IFT122 CLCNKA PRKCD SLC7A7 CPT2 CCR6 DNAJB11 CLCN5 DACT1 CD46 WT1 PKD2 GLA TTC21B PKD2 FANCD2 CFI TMEM67 MYOCD SMARCAL1 MEN1 RMND1 PUS3 STAT2 FAH CEP290 PYGM FAN1 TMEM67 UMOD ERCC8 TPRKB OCRL SLC7A9 BBS10 FANCL MAGI2 FAS ALDOB GSN IQCB1 PRTN3 MEFV HRAS HPSE2 MYCN NUP160 AGXT NUP85 DZIP1L CAV1 ALOX12B C3 TMEM260 BBIP1 RYR1 ELP1 UMOD KMT2A FANCF WDR73 NPHP3 IFT80 SPRY2 CASP10 GATA3 DGKE SCNN1A IFT140 DSTYK C4A NPHP4 GATM LRIG2 CHRNA3 AGXT PGK1 GATA3 LDHA CYP4F22 ERCC8 CHRM3 MEFV NPHP3 TRNE WT1 CD2AP KCTD1 TRAF3IP1 TTC21B TMEM231 HMBS GLA MMACHC KIAA0586 FANCI NUP107 SPP1 XPNPEP3 PTPN22 PKD1 RAD21 ALMS1 CHD4 CDC73 IFT43 COL4A1 MAFB FN1 PTPN22 ACP5 DHDDS SLC3A1 ERCC4 LEMD3 HNF4A CLDN10 DNASE1L3 RASGRP1 FANCA STS MOCOS PRKCD LRIG2 NPHP4 IL12A-AS1 COG1 BICC1 PEX7 CCN2 TTC21B GANAB VANGL1 IL12A LAMB2 TSC2 WDR19 MMUT CLDN16 CFB HNF1B NIPBL HOXA13 PHYH COL4A5 SLC37A4 CFI NPHP4 MYCN SOX18 FAM20A INVS DYNC2LI1 NPHP3 COL4A3 EIF2AK3 APC2 RPGRIP1L SCARB2 LMX1B ZNF423 THBD GLIS2 CLCN5 WDR73 NSD1 SULT2B1 DYNC2I1 MMUT SDR9C7 TMEM237 PBX1 PALB2 TMEM231 TRNK OCLN TBL2 GRHPR IL10 WDR19 SDCCAG8 FANCE IFT172 EHMT1 CTNS CORIN CCNQ SLC34A1 CEP120 RFC2 SLC22A12 NPHS2 HPRT1 SGPL1 GCDH FANCC LIMK1 ZNF592 ITGA3 APOE NPHP1 FLT1 TRNT BRCA1 MYH9 SAA1 MYO1E CCND1 IQCB1 MAPKBP1 STAT4 PKHD1 CD151 MST1 ANKS6 BRCA2 NPHP1 MMACHC LPIN1 NUP107 PRPS1 FASLG NDUFAF6 AVPR2 TRAF3IP1 TMEM216 STOX1 CFH LAMB2 C3 NPHS1 IL23R CLCN5 APRT OFD1 TMEM126B MAD2L2 AMMECR1 DCDC2 NUP205 PNPLA6 TMEM237 CFH FANCB ANLN CLCN5 HLA-B SIX5 SLX4 TSC1 ALMS1 GCM2 TLR4 WT1 PAX6 RPGRIP1L AQP2 CFH TBC1D8B COL4A1 SIX1 PKDCC MEFV NEK8 HBB BSND LAGE3 CFI FAS HPS1 HNF1B APRT NOTCH2 UBE2T SCNN1B GTF2I SLC26A1 STAT4 LMX1B ERCC6 IRAK1 EIF2AK3 CLPB HPRT1 SETD5 AHI1 CSPP1 CCR1 UBAC2 PAX2 COL4A3 WDR35 TMEM138 SALL1 FAS SMC1A CFHR3 SETD2 ERCC4 RAD51 OCRL DZIP1L MMUT NPHP1 CDC73 SMC3 BNC2 XRCC2 TP53RK BICC1 ERAP1 ERCC6 CDC73 INF2 WDR19 APOL1 INF2 HLA-DRB1 IFT27 CPT2 PRPS1 CEP290 JAG1 CPT2 TMEM67 SARS2 PGK1 TCN2 HDAC8 RFWD3 COL4A4 CEP290 AVIL ACSL4 EYA1 HPRT1 KLRC4 RAD51C TRPC6 PLCE1 MMP1 MLXIPL CC2D2A FAM20A LZTFL1 MDM2 HLA-DRB1 WDR19 INPP5E AMMECR1 REN DYNC2I2 HELLPAR NUP133 NUP93 GPR35 BAZ1B ERCC4 KCNE5 SEC61A1 CPT2 HSD11B2 NIPAL4 TMEM67 CD46 CTNS SALL1 CLDN19 BTNL2 INVS HLA-B TRNL1
    Protein Mutations 2
    L31F Y93H
    SNP 0

    HPO

    Alphabetical listing of all HPO terms. Navigate: Correlations   Clinical Trials


    HPO Nodes


    HP:0000083: Renal insufficiency
    Genes 451
    LHX1 LCAT ALOXE3 SH2B1 WT1 PGAM2 FN1 COL7A1 GTF2IRD1 MME GSN ERCC6 NTRK1 OSGEP FANCM TBX18 IKZF1 CTNS GRHPR IFT140 CACNA1S PAX2 IFT172 FXYD2 NPHP3 TCF4 SHPK HLA-DPA1 SCNN1G CEP164 RAD51C SLC30A9 FUZ TMEM67 OCRL PRDX1 ABCA12 MUC1 KYNU ARHGDIA NLRP3 DYNC2H1 CLIP2 ELN PKD1 NPHP1 CEP290 BRIP1 IRF5 LMX1B WT1 TGM1 ELN MYD88 CLCNKB NPHP1 ERCC8 FANCG HLA-DPB1 CFHR5 CFHR1 WDR19 SDCCAG8 LIPN CRB2 PKHD1 UMOD COQ8B PPOX SIX5 ACTN4 CC2D2A NOD2 SCNN1B AP2S1 CEP83 PAX2 HNF1B CTLA4 IFT122 CLCNKA PRKCD SLC7A7 CPT2 CCR6 DNAJB11 CLCN5 DACT1 CD46 WT1 PKD2 GLA TTC21B PKD2 FANCD2 CFI TMEM67 MYOCD SMARCAL1 MEN1 RMND1 PUS3 STAT2 FAH CEP290 PYGM FAN1 TMEM67 UMOD ERCC8 TPRKB OCRL SLC7A9 BBS10 FANCL MAGI2 FAS ALDOB GSN IQCB1 PRTN3 MEFV HRAS HPSE2 MYCN NUP160 AGXT NUP85 DZIP1L CAV1 ALOX12B C3 TMEM260 BBIP1 RYR1 ELP1 UMOD KMT2A FANCF WDR73 NPHP3 IFT80 SPRY2 CASP10 GATA3 DGKE SCNN1A IFT140 DSTYK C4A NPHP4 GATM LRIG2 CHRNA3 AGXT PGK1 GATA3 LDHA CYP4F22 ERCC8 CHRM3 MEFV NPHP3 TRNE WT1 CD2AP KCTD1 TRAF3IP1 TTC21B TMEM231 HMBS GLA MMACHC KIAA0586 FANCI NUP107 SPP1 XPNPEP3 PTPN22 PKD1 RAD21 ALMS1 CHD4 CDC73 IFT43 COL4A1 MAFB FN1 PTPN22 ACP5 DHDDS SLC3A1 ERCC4 LEMD3 HNF4A CLDN10 DNASE1L3 RASGRP1 FANCA STS MOCOS PRKCD LRIG2 NPHP4 IL12A-AS1 COG1 BICC1 PEX7 CCN2 TTC21B GANAB VANGL1 IL12A LAMB2 TSC2 WDR19 MMUT CLDN16 CFB HNF1B NIPBL HOXA13 PHYH COL4A5 SLC37A4 CFI NPHP4 MYCN SOX18 FAM20A INVS DYNC2LI1 NPHP3 COL4A3 EIF2AK3 APC2 RPGRIP1L SCARB2 LMX1B ZNF423 THBD GLIS2 CLCN5 WDR73 NSD1 SULT2B1 DYNC2I1 MMUT SDR9C7 TMEM237 PBX1 PALB2 TMEM231 TRNK OCLN TBL2 GRHPR IL10 WDR19 SDCCAG8 FANCE IFT172 EHMT1 CTNS CORIN CCNQ SLC34A1 CEP120 RFC2 SLC22A12 NPHS2 HPRT1 SGPL1 GCDH FANCC LIMK1 ZNF592 ITGA3 APOE NPHP1 FLT1 TRNT BRCA1 MYH9 SAA1 MYO1E CCND1 IQCB1 MAPKBP1 STAT4 PKHD1 CD151 MST1 ANKS6 BRCA2 NPHP1 MMACHC LPIN1 NUP107 PRPS1 FASLG NDUFAF6 AVPR2 TRAF3IP1 TMEM216 STOX1 CFH LAMB2 C3 NPHS1 IL23R CLCN5 APRT OFD1 TMEM126B MAD2L2 AMMECR1 DCDC2 NUP205 PNPLA6 TMEM237 CFH FANCB ANLN CLCN5 HLA-B SIX5 SLX4 TSC1 ALMS1 GCM2 TLR4 WT1 PAX6 RPGRIP1L AQP2 CFH TBC1D8B COL4A1 SIX1 PKDCC MEFV NEK8 HBB BSND LAGE3 CFI FAS HPS1 HNF1B APRT NOTCH2 UBE2T SCNN1B GTF2I SLC26A1 STAT4 LMX1B ERCC6 IRAK1 EIF2AK3 CLPB HPRT1 SETD5 AHI1 CSPP1 CCR1 UBAC2 PAX2 COL4A3 WDR35 TMEM138 SALL1 FAS SMC1A CFHR3 SETD2 ERCC4 RAD51 OCRL DZIP1L MMUT NPHP1 CDC73 SMC3 BNC2 XRCC2 TP53RK BICC1 ERAP1 ERCC6 CDC73 INF2 WDR19 APOL1 INF2 HLA-DRB1 IFT27 CPT2 PRPS1 CEP290 JAG1 CPT2 TMEM67 SARS2 PGK1 TCN2 HDAC8 RFWD3 COL4A4 CEP290 AVIL ACSL4 EYA1 HPRT1 KLRC4 RAD51C TRPC6 PLCE1 MMP1 MLXIPL CC2D2A FAM20A LZTFL1 MDM2 HLA-DRB1 WDR19 INPP5E AMMECR1 REN DYNC2I2 HELLPAR NUP133 NUP93 GPR35 BAZ1B ERCC4 KCNE5 SEC61A1 CPT2 HSD11B2 NIPAL4 TMEM67 CD46 CTNS SALL1 CLDN19 BTNL2 INVS HLA-B TRNL1
    Protein Mutations 2
    L31F Y93H
    SNP 0

    Reports

    Data processed on December 13, 2020.

    An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.

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