Report Sections

See All Reports

  • HP:0002014: Diarrhea
  • Pneumonia (361) Abnormality of the cardiovascular system (36) Respiratory tract infection (36) Neoplasm (29) Hypoxemia (28) Diabetes mellitus (25) Depressivity (24) Thromboembolism (23) Acute kidney injury (22) Abnormal lung morphology (21) Anosmia (19) Hypertension (18) Abnormality of coagulation (15) Pulmonary embolism (15) Pulmonary fibrosis (15) Stroke (14) Arthritis (14) Interstitial pneumonitis (14) Myocardial infarction (12) Type II diabetes mellitus (12) Deep venous thrombosis (11) Rheumatoid arthritis (10) Leukemia (10) Respiratory distress (10) Low levels of vitamin D (10) Behavioral abnormality (9) Mental deterioration (9) Chronic pain (9) Congestive heart failure (8) Myocarditis (8) Type I diabetes mellitus (8) Sepsis (8) Infertility (7) Abnormality of the liver (7) Lymphopenia (7) Inflammation of the large intestine (7) Pulmonary obstruction (7) Pulmonary insufficiency (7) Immunodeficiency (6) Systemic lupus erythematosus (6) Chronic pulmonary obstruction (6) Abnormality of the gastrointestinal tract (6) Neoplasm of the lung (6) Encephalopathy (5) Obesity (5) Lymphoma (5) Autoimmunity (5) Breast carcinoma (5) Disseminated intravascular coagulation (5) Fatigue (5) Abnormality of the kidney (4) Coronary artery atherosclerosis (4) Cardiac arrest (4) Headache (4) Colon cancer (4) Arrhythmia (4) Carcinoma (4) Hypercoagulability (4) Autistic behavior (3) Seizure (3) Cardiomyopathy (3) Dysphagia (3) Migraine (3) Pulmonary arterial hypertension (3) Asthma (3) Bronchiectasis (3) Neoplasm of the pancreas (3) Psoriasiform dermatitis (3) Attention deficit hyperactivity disorder (3) Cutaneous melanoma (3) Neoplasm of head and neck (3) Pulmonary edema (3) Insomnia (3) Neoplasm of the large intestine (3) Renal insufficiency (2) Hypogeusia (2) Hearing impairment (2) Abnormality of the eye (2) Visual impairment (2) Conjunctivitis (2) Psychosis (2) Autism (2) Dementia (2) Abnormality of the endocrine system (2) Abnormality of the thyroid gland (2) Jaundice (2) Hepatic fibrosis (2) Premature birth (2) Abnormal heart morphology (2) Abnormality of blood and blood-forming tissues (2) Fever (2) Diarrhea (2) Hypothermia (2) Neurodegeneration (2) Abnormal intestine morphology (2) Alopecia of scalp (2) Encephalitis (2) Obstructive sleep apnea (2) Male infertility (2) Stillbirth (2) Paroxysmal atrial fibrillation (2) Lymphoid leukemia (2) Myeloproliferative disorder (2) Chronic lymphatic leukemia (2) Renal cell carcinoma (2) Multiple myeloma (2) Abnormal anterior horn cell morphology (2) Amyotrophic lateral sclerosis (2) Sleep apnea (2) Cystoid macular edema (2) Hemeralopia (2) Arteritis (2) Chronic kidney disease (2) Cervix cancer (2) Cholangitis (2) Cholangiocarcinoma (2) Myositis (2) Neuroendocrine neoplasm (2) Neoplasm of the rectum (2) Mania (2) Nephritis (1) Menorrhagia (1) Conductive hearing impairment (1) Cataract (1) Amblyopia (1) Periodontitis (1) Abnormality of the nervous system (1) Oligospermia (1) Adrenal insufficiency (1) Hyperaldosteronism (1) Abnormality of the skin (1) Lymphedema (1) Cholecystitis (1) Keratoconjunctivitis (1) Intellectual disability (1) Spastic diplegia (1) Hemiparesis (1) Meningitis (1) Cerebral hemorrhage (1) Abnormal joint morphology (1) Hepatic failure (1) Hepatocellular carcinoma (1) Intrauterine growth retardation (1) Hoarse voice (1) Dysphonia (1) Weak voice (1) Sudden cardiac death (1) Cor pulmonale (1) Tachycardia (1) Aortic valve stenosis (1) Bradycardia (1) Torsade de pointes (1) Atrioventricular block (1) Angina pectoris (1) Pancreatitis (1) Premature rupture of membranes (1) Weight loss (1) Thrombocytopenia (1) Autoimmune thrombocytopenia (1) Gastroesophageal reflux (1) Anorexia (1) Esophageal varix (1) Apnea (1) Status epilepticus (1) Subarachnoid hemorrhage (1) Memory impairment (1) Difficulty walking (1) Hyperkinetic movements (1) Alzheimer disease (1) Increased intracranial pressure (1) Colitis (1) Biliary cirrhosis (1) Hypotension (1) Vascular dilatation (1) Atherosclerosis (1) Osteoarthritis (1) Tachypnea (1) Hypoventilation (1) Myelodysplasia (1) Neoplasm of the liver (1) Hypokalemia (1) Hyponatremia (1) Hyperphosphatemia (1) Reduced factor VIII activity (1) Skeletal muscle atrophy (1) Myalgia (1) Muscular dystrophy (1) Neonatal death (1) Increased body weight (1) Neoplasm of the nervous system (1) Malnutrition (1) Thrombophlebitis (1) Ventricular tachycardia (1) Acute myeloid leukemia (1) Dilatation of the cerebral artery (1) Knee osteoarthritis (1) Monoclonal immunoglobulin M proteinemia (1) Intraalveolar phospholipid accumulation (1) Neoplasm of the stomach (1) Neoplasm of the genitourinary tract (1) Neoplasm of the skin (1) Female infertility (1) Benign prostatic hyperplasia (1) Hip osteoarthritis (1) Renal neoplasm (1) Uterine neoplasm (1) Testicular neoplasm (1) Intestinal atresia (1) Tonsillitis (1) Inflammatory abnormality of the skin (1) Placental abruption (1) Postprandial hyperglycemia (1) Endometrial carcinoma (1) Erythroid hypoplasia (1) Asterixis (1) Glioblastoma multiforme (1) B-cell lymphoma (1) Ciliary dyskinesia (1) Morphea (1) Allergy (1) Non-Hodgkin lymphoma (1) Retinal vein occlusion (1) Heart block (1) Dyspareunia (1) Ductal carcinoma in situ (1) Endometriosis (1) Cardiogenic shock (1) Vulvar neoplasm (1) Addictive behavior (1) Femur fracture (1) Neonatal sepsis (1) Glue ear (1) Neoplasm of the central nervous system (1) Abnormality of movement (1) Ulcerative colitis (1) Crohn's disease (1) Endocarditis (1) Toxemia of pregnancy (1) Neoplasm of the larynx (1) Ovarian neoplasm (1) Vaginal neoplasm (1) Cellulitis (1) Bulimia (1) Atelectasis (1) Esophageal neoplasm (1) Lymphocytosis (1) Polymenorrhea (1)

    HP:0002014: Diarrhea

    Developed by Shray Alag, The Harker School
    Sections: Correlations, Clinical Trials, and HPO

    Correlations computed by analyzing all clinical trials.

    Navigate: Clinical Trials and HPO


    Correlated Drug Terms (7)


    Name (Synonyms) Correlation
    drug3591 WFI water nebulization Wiki 0.71
    drug3595 WJ-MSCs Wiki 0.71
    drug3831 inhaled type I interferon Wiki 0.71
    Name (Synonyms) Correlation
    drug1489 Hydroxychloroquine Pill Wiki 0.71
    drug3063 SivoMixx (200 billion) Wiki 0.50
    drug3810 hydroxychloroquine Wiki 0.32
    drug333 Azithromycin Wiki 0.11

    Correlated MeSH Terms (2)


    Name (Synonyms) Correlation
    D003967 Diarrhea NIH 1.00
    D011014 Pneumonia NIH 0.04

    Correlated HPO Terms (1)


    Name (Synonyms) Correlation
    HP:0002090 Pneumonia HPO 0.04

    Clinical Trials

    Navigate: Correlations   HPO

    There are 2 clinical trials


    1 Evaluation of the Impact of Bacteriotherapy in the Treatment of COVID-19

    In light of its high morbidity and mortality, COronaVIrus Disease 19 (COVID-19) pandemic spread is considered an unprecedented global health challenge. Given the very limited therapeutic options available against Severe Acute Respiratory Syndrome - CoronaVirus-2 (SARS-CoV-2) epidemic at this time, the evaluation of new resources, designed in the first instance for other pathologies but potentially active against COVID-19, represents a priority in clinical research. This is an observational, retrospective, non-profit study on the adjuvant use of bacteriotherapy in the early control of disease progression in patients affected by COVID-19 and treated with the current standard of care on the basis of the interim guidelines of the Italian Society of Infectious and Tropical Diseases. The main purpose of the study is to evaluate the effectiveness of bacteriotherapy in reducing the clinical impact of acute diarrhea, containing the progression of COVID-19 and preventing the need for hospitalization in intensive care units.

    NCT04368351
    Conditions
    1. COVID
    2. Pneumonia
    3. Diarrhea
    Interventions
    1. Dietary Supplement: SivoMixx (200 billion)
    2. Drug: Azithromycin
    3. Drug: hydroxychloroquine
    MeSH:Pneumonia Diarrhea
    HPO:Diarrhea Pneumonia

    Primary Outcomes

    Description: Comparison between the two groups. Acute diarrhea was defined as a stool with increased water content, volume, or frequency that lasts less than 14 days.

    Measure: delta of time of disappearance of acute diarrhea

    Time: 21 days

    Secondary Outcomes

    Description: Comparison between the two groups

    Measure: Delta in the number of patients requiring orotracheal intubation despite treatment

    Time: 21 days

    Description: Comparison between the two groups

    Measure: Delta of crude mortality

    Time: 21 days

    Description: Comparison between the two groups

    Measure: Delta of length of stay for patients in hospital

    Time: 21 days
    2 Corona Virus (COVID-19) Disease Duration and Gastrointestinal Tract (GIT) Manifestations; Can be New Disease Severity Classification. A Pilot Egyptian Single National Center Experience

    The present study conducted to correlate symptoms not only constitutional and respiratory, but GIT as a principle presentation, with laboratory markers and COVID-19 severe acute respiratory syndrome (SARS-COV2) disease outcomes, as the duration of symptoms varies substantially between patients; the investigators undertook this study to determine the optimal time to predict COVID-19 outcomes based on real-time experience.

    NCT04554979
    Conditions
    1. Covid19
    2. Diarrhea
    Interventions
    1. Drug: Hydroxychloroquine Pill
    MeSH:Diarrhea
    HPO:Diarrhea

    Primary Outcomes

    Description: The investigators tried to correlate disease severity with disease duration

    Measure: COVID-19 disease spectrum and duration

    Time: july 2020 to june 2020

    Description: spectrum of GIT manifestations in COVID-19 patients was investigated

    Measure: GIT manifestations among COVID-19 patients

    Time: july 2020 to june 2020

    Secondary Outcomes

    Description: The link between non-communicable disease (including diabetes, hypertension and Hypercholesterolemia) severity and COVID-19 prognosis

    Measure: Non-communicable disease and COVID-19

    Time: july 2020 to june 2020

    Description: the investigators studied the Impact of weather climate on COVID-19 presentations (higher incidence of diarrhea in COVID-19 patients in summer) and outcomes

    Measure: Seasonal change and COVID-19

    Time: july 2020 to june 2020

    Description: The investigators tried to find new Egyptian classification fro COVID-19 disease severity

    Measure: Possible region specific classification for COVID-19 disease

    Time: july 2020 to june 2020

    HPO Nodes


    HP:0002014: Diarrhea
    Genes 401
    SLC26A3 ACSF3 ND6 LCK CASP8 BMPR1A SCNN1G CD247 APC NHLRC2 IFNG EGFR RRM2B IKZF1 UCP2 SDHD ACSF3 JAK3 TTR BTK MYO5B PIK3CD SCNN1B KCNJ11 GALT RFX6 SI TP53 ZAP70 MPV17 LRRK2 CYP27A1 WAS PODXL VPS13C MAOA RAG1 AP1S1 TTC7A CYP27A1 HSD3B7 MEN1 COX1 TNFRSF13B TXNRD2 MYD88 ERCC8 SCN11A TERT TLK2 GNS CFHR1 FOXP3 CBL POLA1 MLYCD TTR SON TCF3 ARX GREM1 IL10RA ATP7A SLC9A3 TRNW FBP1 MRAP SLC7A7 TTC37 SMAD4 DAXX TNFRSF13C KNSTRN CD79A KCNJ1 RAG1 IL7R PKP1 DDC CIITA ACVRL1 HNF4A BACH2 LIG4 MADD DNMT3B PPP2R5D IL21 IL2RA ALDOB SLC35C1 PIK3R1 SP110 RFX5 NOD2 SEMA3D NBN TRNS1 TRNH SPINT2 RAG1 SI SKIV2L MVK ZAP70 STAR IFNGR1 BRCA1 DES CR2 SLC7A7 TFRC ITGA2B ITGB3 ND1 GATA6 TCIRG1 SLC19A2 ND4 BLNK CPT1A TKFC LIPA ACAT1 STAT1 SRP54 SUGCT ELP1 RMRP TRNQ HNF1A BMPR1A IGHM BTK CYP7B1 NEUROG3 SLC39A4 RET ADA PALLD LIPA SERPING1 SMAD4 SMAD4 SKIV2L RAG2 STAT1 HMBS GLA CD40LG ALG3 ABCC8 HBB SPP1 ITGA2 FOXP3 KIF1B TRNF WNT2B RAG1 CLMP HMGCL RET RNF113A RFXAP IL6ST TTC7A TRNS2 IL2RG BTK ETHE1 DNASE1L3 ATRX COG4 COG4 ETHE1 LRRC8A PINK1 ENG NNT TYMP CDKN1B KIF23 C5 MGME1 DNAJC6 ANAPC1 CR2 PPP2R5D ALAD CTLA4 GFI1 PRKN IL21R DBH SCNN1A SAR1B DGAT1 GDNF CD109 IDS CHD7 NSUN2 JAK3 SCN9A MC2R NAGS NCF4 MPI PLVAP CD79B CD19 CDKN2C SLC39A4 CCDC47 SNCA PMM2 TREH CPOX ENG TNFRSF1A LCT RAG2 SLC46A1 IL6 PLEC HYOU1 TSHR EDN3 ATP8B1 GINS1 AKR1D1 RFXANK WIPF1 B2M MCM6 PHKB AGA NR3C2 RAG2 MADD PCSK1 EPCAM CD3D IL2RB SMARCD2 NRTN CDKN2A DCLRE1C SAA1 IL7R CDKN2B HTRA2 BRCA2 POLG TTC37 STAT4 AVP IGLL1 PERCC1 IDS SRSF2 EDNRB IGHM ALG8 MEN1 CD79A PIK3R1 COG6 ADAM17 CD79B HEXB ECE1 SAR1B CD3E PTPRC COX2 TYMP RNF168 PARK7 SYNJ1 COX3 HADH SMAD4 IDUA HBB MTTP SERPING1 NBN ICOS SLC12A3 ADA ABCB11 CFH CD3D SLC46A1 HLA-B SREBF1 F5 PIGT RFX5 SLC25A13 SLC5A1 CLCNKB DCLRE1C ITGA6 SLC25A13 TCN2 IL2RG HMBS MEFV EGFR TSHR ITCH OTULIN PALB2 TET2 ASXL1 WAS SAMD9 DMPK CD247 ANTXR2 HPS1 RFXAP CARMIL2 MGME1 ASAH1 G6PC1 KRAS TNFRSF1A MEFV HGSNAT PTEN ACADM IRAK1 RUNX1 RIPK1 RECQL4 CIITA ABCB4 GP1BB IKBKB EFL1 IDS NLRC4 CFHR3 SLC10A2 ANTXR2 TGFB1 HMGCS2 NEUROG3 ERCC6 WDR1 NAGLU POLG TRNL1 BMPR1A ND5 ICOS RFXANK CDKN1B RECQL4 BMPR1A STX3 AIRE LIG4 GUCY2C AK2 OPLAH CD55 MVK ITGB4 SLC12A1 DCLRE1C NAXD TMPRSS15 ACTG2 LRBA ELANE SGSH MYO5B CYP11B2 ERCC4 NOD2 CDKN1A BLNK USP7 IGKC IL2RG IL7R ERCC2 RAG2 ADA GP1BA SERPING1 SEMA3C UCHL1 ADAM17 BTD MVK
    Protein Mutations 1
    R192G
    SNP 0

    HPO

    Alphabetical listing of all HPO terms. Navigate: Correlations   Clinical Trials


    HPO Nodes


    HP:0002014: Diarrhea
    Genes 401
    SLC26A3 ACSF3 ND6 LCK CASP8 BMPR1A SCNN1G CD247 APC NHLRC2 IFNG EGFR RRM2B IKZF1 UCP2 SDHD ACSF3 JAK3 TTR BTK MYO5B PIK3CD SCNN1B KCNJ11 GALT RFX6 SI TP53 ZAP70 MPV17 LRRK2 CYP27A1 WAS PODXL VPS13C MAOA RAG1 AP1S1 TTC7A CYP27A1 HSD3B7 MEN1 COX1 TNFRSF13B TXNRD2 MYD88 ERCC8 SCN11A TERT TLK2 GNS CFHR1 FOXP3 CBL POLA1 MLYCD TTR SON TCF3 ARX GREM1 IL10RA ATP7A SLC9A3 TRNW FBP1 MRAP SLC7A7 TTC37 SMAD4 DAXX TNFRSF13C KNSTRN CD79A KCNJ1 RAG1 IL7R PKP1 DDC CIITA ACVRL1 HNF4A BACH2 LIG4 MADD DNMT3B PPP2R5D IL21 IL2RA ALDOB SLC35C1 PIK3R1 SP110 RFX5 NOD2 SEMA3D NBN TRNS1 TRNH SPINT2 RAG1 SI SKIV2L MVK ZAP70 STAR IFNGR1 BRCA1 DES CR2 SLC7A7 TFRC ITGA2B ITGB3 ND1 GATA6 TCIRG1 SLC19A2 ND4 BLNK CPT1A TKFC LIPA ACAT1 STAT1 SRP54 SUGCT ELP1 RMRP TRNQ HNF1A BMPR1A IGHM BTK CYP7B1 NEUROG3 SLC39A4 RET ADA PALLD LIPA SERPING1 SMAD4 SMAD4 SKIV2L RAG2 STAT1 HMBS GLA CD40LG ALG3 ABCC8 HBB SPP1 ITGA2 FOXP3 KIF1B TRNF WNT2B RAG1 CLMP HMGCL RET RNF113A RFXAP IL6ST TTC7A TRNS2 IL2RG BTK ETHE1 DNASE1L3 ATRX COG4 COG4 ETHE1 LRRC8A PINK1 ENG NNT TYMP CDKN1B KIF23 C5 MGME1 DNAJC6 ANAPC1 CR2 PPP2R5D ALAD CTLA4 GFI1 PRKN IL21R DBH SCNN1A SAR1B DGAT1 GDNF CD109 IDS CHD7 NSUN2 JAK3 SCN9A MC2R NAGS NCF4 MPI PLVAP CD79B CD19 CDKN2C SLC39A4 CCDC47 SNCA PMM2 TREH CPOX ENG TNFRSF1A LCT RAG2 SLC46A1 IL6 PLEC HYOU1 TSHR EDN3 ATP8B1 GINS1 AKR1D1 RFXANK WIPF1 B2M MCM6 PHKB AGA NR3C2 RAG2 MADD PCSK1 EPCAM CD3D IL2RB SMARCD2 NRTN CDKN2A DCLRE1C SAA1 IL7R CDKN2B HTRA2 BRCA2 POLG TTC37 STAT4 AVP IGLL1 PERCC1 IDS SRSF2 EDNRB IGHM ALG8 MEN1 CD79A PIK3R1 COG6 ADAM17 CD79B HEXB ECE1 SAR1B CD3E PTPRC COX2 TYMP RNF168 PARK7 SYNJ1 COX3 HADH SMAD4 IDUA HBB MTTP SERPING1 NBN ICOS SLC12A3 ADA ABCB11 CFH CD3D SLC46A1 HLA-B SREBF1 F5 PIGT RFX5 SLC25A13 SLC5A1 CLCNKB DCLRE1C ITGA6 SLC25A13 TCN2 IL2RG HMBS MEFV EGFR TSHR ITCH OTULIN PALB2 TET2 ASXL1 WAS SAMD9 DMPK CD247 ANTXR2 HPS1 RFXAP CARMIL2 MGME1 ASAH1 G6PC1 KRAS TNFRSF1A MEFV HGSNAT PTEN ACADM IRAK1 RUNX1 RIPK1 RECQL4 CIITA ABCB4 GP1BB IKBKB EFL1 IDS NLRC4 CFHR3 SLC10A2 ANTXR2 TGFB1 HMGCS2 NEUROG3 ERCC6 WDR1 NAGLU POLG TRNL1 BMPR1A ND5 ICOS RFXANK CDKN1B RECQL4 BMPR1A STX3 AIRE LIG4 GUCY2C AK2 OPLAH CD55 MVK ITGB4 SLC12A1 DCLRE1C NAXD TMPRSS15 ACTG2 LRBA ELANE SGSH MYO5B CYP11B2 ERCC4 NOD2 CDKN1A BLNK USP7 IGKC IL2RG IL7R ERCC2 RAG2 ADA GP1BA SERPING1 SEMA3C UCHL1 ADAM17 BTD MVK
    Protein Mutations 1
    R192G
    SNP 0

    Reports

    Data processed on December 13, 2020.

    An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.

    Drug Reports   MeSH Reports   HPO Reports  

    Interventions

    4,818 reports on interventions/drugs

    MeSH

    706 reports on MeSH terms

    HPO

    306 reports on HPO terms

    All Terms

    Alphabetical index of all Terms

    Google Colab

    Python example via Google Colab Notebook