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    HP:0002516: Increased intracranial pressure

    Developed by Shray Alag, The Harker School
    Sections: Correlations, Clinical Trials, and HPO

    Correlations computed by analyzing all clinical trials.

    Navigate: Clinical Trials and HPO


    Correlated Drug Terms (1)


    Name (Synonyms) Correlation
    drug712 Cerebral compliance and hemodynamics monitoring Wiki 1.00

    Correlated MeSH Terms (2)


    Name (Synonyms) Correlation
    D019586 Intracranial Hypertension NIH 1.00
    D012769 Shock, NIH 0.38

    Correlated HPO Terms (0)


    Name (Synonyms) Correlation

    Clinical Trials

    Navigate: Correlations   HPO

    There is one clinical trial.


    1 Assessment of Cerebral Compliance and Hemodynamics in Severe COVID-19

    Several recent studies point to the possibility of the new coronavirus (SARS-Cov2), which currently causes pandemic COVID-19, to infiltrate the central nervous system (CNS) and cause primary damage to neural tissues, increasing the morbidity and mortality of these patients. A pathophysiological hypothesis for insulting the CNS would be the impairment of cerebral compliance (CC), because elevation of intracranial pressure (ICP), but due to the invasive nature of the methods available for ICP evaluation, this hypothesis has so far not been verified. Recently, a noninvasive technique was developed to evaluate CC (B4C sensor), making it possible to analyse CC in patients outside the neurosurgical environment. Therefore, the main objective of this study was to assess the presence of CC impairment in patients with COVID-19, and observe potential influences of this syndrome on cerebral hemodynamics.

    NCT04429477
    Conditions
    1. Intracranial Hypertension
    2. Cerebral Circulatory Failure
    Interventions
    1. Device: Cerebral compliance and hemodynamics monitoring
    MeSH:Intracranial Hypertension Shock
    HPO:Increased intracranial pressure

    Primary Outcomes

    Description: Observe alteration in cerebral compliance due to potential intracranial hypertension during severe COVID-19. This situation is indicated when the relation P2/P1 given by the B4C sensor is >1.

    Measure: Detection of cerebral compliance impairment by the B4C sensor

    Time: During critical care, around 15 days/patient

    Description: Observe disturbances in cerebral circulation during severe COVID-19, given by blood flow velocities in middle cerebral arteries (with normal range 40-70 cm/s) and the pulsatility index (normal <1.2) calculated by transcranial Doppler.

    Measure: Detection of cerebral hemodynamics impairment by transcranial Doppler

    Time: During critical care, around 15 days/patient

    Secondary Outcomes

    Description: Observe whether disturbances in cerebral compliance and hemodynamics assessed in this population is significantly associated with higher mortality.

    Measure: Calculate mortality in this population

    Time: 3 months

    HPO Nodes


    Reports

    Data processed on December 13, 2020.

    An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.

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