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  • HP:0001973: Autoimmune thrombocytopenia
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    HP:0001973: Autoimmune thrombocytopenia

    Developed by Shray Alag, The Harker School
    Sections: Correlations, Clinical Trials, and HPO

    Correlations computed by analyzing all clinical trials.

    Navigate: Clinical Trials and HPO


    Correlated Drug Terms (2)


    Name (Synonyms) Correlation
    drug1145 Eltrombopag Wiki 1.00
    drug3995 rhTPO Wiki 1.00

    Correlated MeSH Terms (2)


    Name (Synonyms) Correlation
    D013921 Thrombocytopenia NIH 1.00
    D016553 Purpura, Thrombocytopenic, Idiopathic NIH 1.00

    Correlated HPO Terms (1)


    Name (Synonyms) Correlation
    HP:0001873 Thrombocytopenia HPO 1.00

    Clinical Trials

    Navigate: Correlations   HPO

    There is one clinical trial.


    1 The Combination of Eltrombopag and Recombinant Human Thrombopoietin (rhTPO) Versus Eltrombopag Monotherapy as Subsequent Treatment for Immune Thrombocytopenia During the COVID-19 Pandemic

    This is a prospective, multicenter, randomized, open-label study to investigate the efficacy and safety of eltrombopag plus recombinant human thrombopoietin (rhTPO) versus eltrombopag as treatment for corticosteroid-resistant or relapsed immune thrombocytopenia (ITP) during the COVID-19 pandemic.

    NCT04516837
    Conditions
    1. Immune Thrombocytopenia
    Interventions
    1. Drug: Eltrombopag
    2. Drug: rhTPO
    MeSH:Thrombocytopenia Purpura, Thrombocytopenic, Idiopathic
    HPO:Autoimmune thrombocytopenia Thrombocytopenia

    Primary Outcomes

    Description: A complete response (CR) was defined as a sustained (≥ 3 months) platelet count ≥ 100×10^9/L.

    Measure: Complete response

    Time: 6 months

    Description: A response (R) was defined as a sustained (≥ 3 months) platelet count ≥ 30×10^9/L without recurrence of thrombocytopenia.

    Measure: Response

    Time: 6 months

    Description: No response (NR) was defined as platelet count < 30 × 10^9/L or a less than two fold increase in platelet count from baseline or the presence of bleeding. Platelet count must be measured on two occasions more than a day apart.

    Measure: No response

    Time: 6 months

    Description: A relapses was defined as platelet count falls below 30×10^9/L or bleeding accrues after achieving R or CR.

    Measure: Relapses

    Time: 6 months

    Secondary Outcomes

    Description: Early response was defined as the attainment of a platelet count ≥ 30 × 10⁹ and at least a doubling of baseline platelet count at 1 week.

    Measure: Early response

    Time: 7 days

    Description: Initial treatment was defined as the attainment of a platelet count ≥ 30 × 10⁹ and at least a doubling of baseline platelet count at 1 month.

    Measure: Initial response

    Time: 1 month

    Description: Durable response was defined as the attainment of a platelet count ≥ 30 × 10⁹ and at least a doubling of baseline platelet count at 6 months.

    Measure: Durable response

    Time: 6 months

    Description: The time to achieve platelet count ≥ 30×10^9/L and at least 2-fold increase of the baseline count and absence of bleeding since start of treatment.

    Measure: TOR (time to response)

    Time: 6 months

    Description: The duration of achieve platelet count ≥ 30×10^9/L and at least 2-fold increase of the baseline count and absence of bleeding since start of treatment.

    Measure: DOR (duration of response)

    Time: 6 months

    Description: All patients were assessed for safety every week during the first 8 weeks of treatment, and at 2-week intervals thereafter. Adverse events were scaled according to Common Terminology Criteria for Adverse Events (CTCAE) version 5.0.

    Measure: Treatments associated adverse events

    Time: 6 months

    Description: Changes of bleeding after treatment. Bleeding was defined in accordance with the WHO bleeding scale (0, no bleeding; 1, petechiae; 2, mild blood loss; 3, gross blood loss; and 4, debilitating blood loss).

    Measure: Reduction in bleeding symptoms

    Time: 6 months

    HPO Nodes


    Reports

    Data processed on December 13, 2020.

    An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.

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    MeSH

    706 reports on MeSH terms

    HPO

    306 reports on HPO terms

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