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    HP:0001622: Premature birth

    Developed by Shray Alag, The Harker School
    Sections: Correlations, Clinical Trials, and HPO

    Correlations computed by analyzing all clinical trials.

    Navigate: Clinical Trials and HPO

    Correlated Drug Terms (1)

    Name (Synonyms) Correlation
    drug3803 hospitalization for premature birth Wiki 0.71

    Correlated MeSH Terms (2)

    Name (Synonyms) Correlation
    D047928 Premature Birth NIH 1.00
    D007752 Obstetric Labor, Premature NIH 0.50

    Correlated HPO Terms (0)

    Name (Synonyms) Correlation

    Clinical Trials

    Navigate: Correlations   HPO

    There are 2 clinical trials

    1 Extremely Premature Births During the Peak of the COVID-19 Pandemic: an International Study of the Active SafeBoosC III Departments

    This is a retrospective, observational study based on the consortium of the SafeBoosC-III randomised clinical trial. This study will evaluate if the number of admitted extremely preterm infants has decreased in the SafeBoosC-III departments during the global lockdown, and whether there is an association between the level of lockdown restrictions and change in the number of ELGAN admissions.

    1. Extreme Prematurity
    2. Covid19
    MeSH:Premature Birth
    HPO:Premature birth

    Primary Outcomes

    Description: The primary outcome will be the difference in the total number of ELGAN admissions in SafeBoosC-III departments during the peak three months of the COVID-19 pandemic in 2020 compared to the same three months period in 2019. The most rigorous three months of the COVID-19 pandemic will be a subjective definition by the local investigator, based on when the lockdown restrictions were strictest.

    Measure: Number of ELGAN admissions during peak three months of COVID-19 compared to corresponding months in 2019

    Time: 3 months

    Secondary Outcomes

    Description: The difference in the number of ELGAN admissions during the peak three months of the COVID-19 pandemic versus the same three months in 2019, within the following regions: North America: USA Northern Europe: Denmark, Norway Eastern Europe: Austria, Poland, Czech Republic, Ukraine, Turkey Western Europe: Germany, UK, Ireland, Switzerland, Belgium Southern Europe: Spain, Portugal, Italy, Greece Asia: India, China

    Measure: Regional difference in ELGAN admissions during peak three months of COVID-19 compared to corresponding months in 2019

    Time: 3 months

    Description: Investigators will be asked to clarify how and where the information has been obtained from. Furthermore, investigators will be asked to classify the level of restrictions imposed upon the public, during the lockdown period, in a Likert scale format from 1-5.

    Measure: Correlation between the level of lockdown restrictions and number of ELGAN admissions during peak three months of COVID-19 compared to corresponding months in 2019

    Time: 3 months

    Other Outcomes

    Description: For the purpose of an exploratory analysis, we will ask investigators to rate the likelihood that restrictions outside or inside health institutions in their country/region, have led to non-admittance of ELGAN. Causes could be intrauterine death, or no transfer from place of birth

    Measure: Likelihood of restrictions leading to non-admittance of ELGAN

    Time: 3 months
    2 The Impact of the SARS CoV-2 Lockdown Policy on Spontaneous Premature Birth at the Regional University Maternity Hospital of Nancy

    Preterm labor (PL) is the leading cause of hospitalization during pregnancy and premature birth the leading cause of fetal morbidity and mortality in France. PL is defined by regular and painful uterine contractions associated with a change in the cervix, between 22 and 36 weeks of gestation. It has been shown that the risk of spontaneous prematurity increases particularly in case of working over 40 hours per week, hard physically conditions, or prolonged daily transport time. Rest is one of the most efficient measure to prevent PL and should be proposed to all pregnant women, and combined with other therapies such as tocolysis or cerclage when needed. The very particular period of lockdown during the COVID-19 pandemic had pregnant women to drastically reduce their activity. They suspended their work and stayed home for various reasons such as pregnancy in progress, children at home, and also collective reasons such as teleworking or workplace closure. During the lockdown period from March 17th to May 11th 2020, fewer preterm labor and less spontaneous prematurity have been suspected by the neonatology and obstetrics teams throughout the Lorraine region. Our study aims to objectively confirm this observation. In this investigation we aim to find a relationship between lockdown, PL and spontaneous prematurity which would need to re-evaluate public health recommendations for pregnant women outside the lockdown.

    1. Premature Birth
    2. Preterm Labor
    1. Other: hospitalization for premature birth
    MeSH:Premature Birth Obstetric Labor, Premature
    HPO:Premature birth

    Primary Outcomes

    Description: Number of prematurely born infants

    Measure: Evaluate the impact of confinement on the rate of spontaneous prematurity at the Regional University Maternity Hospital of Nancy (MRUN)

    Time: baseline

    Secondary Outcomes

    Description: Number of infants born by vaginal delivery or cesarean section

    Measure: Evaluate the impact of confinement on the type of prematurity rate: spontaneous or not

    Time: baseline

    Description: Number of infants transferred from referring hospitals to the level III NICU for prematurity

    Measure: Evaluate the impact of confinement on the outborn rate managed by the Regional Neonatal transport team for prematurity

    Time: baseline

    Description: Diagnosis evaluation of prematurely born infants during lockdown period

    Measure: Evaluate the type of prematurity over the period of confinement

    Time: baseline

    HPO Nodes


    Data processed on December 13, 2020.

    An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.

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