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  • HP:0004375: Neoplasm of the nervous system
  • Pneumonia (361) Abnormality of the cardiovascular system (36) Respiratory tract infection (36) Neoplasm (29) Hypoxemia (28) Diabetes mellitus (25) Depressivity (24) Thromboembolism (23) Acute kidney injury (22) Abnormal lung morphology (21) Anosmia (19) Hypertension (18) Abnormality of coagulation (15) Pulmonary embolism (15) Pulmonary fibrosis (15) Stroke (14) Arthritis (14) Interstitial pneumonitis (14) Myocardial infarction (12) Type II diabetes mellitus (12) Deep venous thrombosis (11) Rheumatoid arthritis (10) Leukemia (10) Respiratory distress (10) Low levels of vitamin D (10) Behavioral abnormality (9) Mental deterioration (9) Chronic pain (9) Congestive heart failure (8) Myocarditis (8) Type I diabetes mellitus (8) Sepsis (8) Infertility (7) Abnormality of the liver (7) Lymphopenia (7) Inflammation of the large intestine (7) Pulmonary obstruction (7) Pulmonary insufficiency (7) Immunodeficiency (6) Systemic lupus erythematosus (6) Chronic pulmonary obstruction (6) Abnormality of the gastrointestinal tract (6) Neoplasm of the lung (6) Encephalopathy (5) Obesity (5) Lymphoma (5) Autoimmunity (5) Breast carcinoma (5) Disseminated intravascular coagulation (5) Fatigue (5) Abnormality of the kidney (4) Coronary artery atherosclerosis (4) Cardiac arrest (4) Headache (4) Colon cancer (4) Arrhythmia (4) Carcinoma (4) Hypercoagulability (4) Autistic behavior (3) Seizure (3) Cardiomyopathy (3) Dysphagia (3) Migraine (3) Pulmonary arterial hypertension (3) Asthma (3) Bronchiectasis (3) Neoplasm of the pancreas (3) Psoriasiform dermatitis (3) Attention deficit hyperactivity disorder (3) Cutaneous melanoma (3) Neoplasm of head and neck (3) Pulmonary edema (3) Insomnia (3) Neoplasm of the large intestine (3) Renal insufficiency (2) Hypogeusia (2) Hearing impairment (2) Abnormality of the eye (2) Visual impairment (2) Conjunctivitis (2) Psychosis (2) Autism (2) Dementia (2) Abnormality of the endocrine system (2) Abnormality of the thyroid gland (2) Jaundice (2) Hepatic fibrosis (2) Premature birth (2) Abnormal heart morphology (2) Abnormality of blood and blood-forming tissues (2) Fever (2) Diarrhea (2) Hypothermia (2) Neurodegeneration (2) Abnormal intestine morphology (2) Alopecia of scalp (2) Encephalitis (2) Obstructive sleep apnea (2) Male infertility (2) Stillbirth (2) Paroxysmal atrial fibrillation (2) Lymphoid leukemia (2) Myeloproliferative disorder (2) Chronic lymphatic leukemia (2) Renal cell carcinoma (2) Multiple myeloma (2) Abnormal anterior horn cell morphology (2) Amyotrophic lateral sclerosis (2) Sleep apnea (2) Cystoid macular edema (2) Hemeralopia (2) Arteritis (2) Chronic kidney disease (2) Cervix cancer (2) Cholangitis (2) Cholangiocarcinoma (2) Myositis (2) Neuroendocrine neoplasm (2) Neoplasm of the rectum (2) Mania (2) Nephritis (1) Menorrhagia (1) Conductive hearing impairment (1) Cataract (1) Amblyopia (1) Periodontitis (1) Abnormality of the nervous system (1) Oligospermia (1) Adrenal insufficiency (1) Hyperaldosteronism (1) Abnormality of the skin (1) Lymphedema (1) Cholecystitis (1) Keratoconjunctivitis (1) Intellectual disability (1) Spastic diplegia (1) Hemiparesis (1) Meningitis (1) Cerebral hemorrhage (1) Abnormal joint morphology (1) Hepatic failure (1) Hepatocellular carcinoma (1) Intrauterine growth retardation (1) Hoarse voice (1) Dysphonia (1) Weak voice (1) Sudden cardiac death (1) Cor pulmonale (1) Tachycardia (1) Aortic valve stenosis (1) Bradycardia (1) Torsade de pointes (1) Atrioventricular block (1) Angina pectoris (1) Pancreatitis (1) Premature rupture of membranes (1) Weight loss (1) Thrombocytopenia (1) Autoimmune thrombocytopenia (1) Gastroesophageal reflux (1) Anorexia (1) Esophageal varix (1) Apnea (1) Status epilepticus (1) Subarachnoid hemorrhage (1) Memory impairment (1) Difficulty walking (1) Hyperkinetic movements (1) Alzheimer disease (1) Increased intracranial pressure (1) Colitis (1) Biliary cirrhosis (1) Hypotension (1) Vascular dilatation (1) Atherosclerosis (1) Osteoarthritis (1) Tachypnea (1) Hypoventilation (1) Myelodysplasia (1) Neoplasm of the liver (1) Hypokalemia (1) Hyponatremia (1) Hyperphosphatemia (1) Reduced factor VIII activity (1) Skeletal muscle atrophy (1) Myalgia (1) Muscular dystrophy (1) Neonatal death (1) Increased body weight (1) Neoplasm of the nervous system (1) Malnutrition (1) Thrombophlebitis (1) Ventricular tachycardia (1) Acute myeloid leukemia (1) Dilatation of the cerebral artery (1) Knee osteoarthritis (1) Monoclonal immunoglobulin M proteinemia (1) Intraalveolar phospholipid accumulation (1) Neoplasm of the stomach (1) Neoplasm of the genitourinary tract (1) Neoplasm of the skin (1) Female infertility (1) Benign prostatic hyperplasia (1) Hip osteoarthritis (1) Renal neoplasm (1) Uterine neoplasm (1) Testicular neoplasm (1) Intestinal atresia (1) Tonsillitis (1) Inflammatory abnormality of the skin (1) Placental abruption (1) Postprandial hyperglycemia (1) Endometrial carcinoma (1) Erythroid hypoplasia (1) Asterixis (1) Glioblastoma multiforme (1) B-cell lymphoma (1) Ciliary dyskinesia (1) Morphea (1) Allergy (1) Non-Hodgkin lymphoma (1) Retinal vein occlusion (1) Heart block (1) Dyspareunia (1) Ductal carcinoma in situ (1) Endometriosis (1) Cardiogenic shock (1) Vulvar neoplasm (1) Addictive behavior (1) Femur fracture (1) Neonatal sepsis (1) Glue ear (1) Neoplasm of the central nervous system (1) Abnormality of movement (1) Ulcerative colitis (1) Crohn's disease (1) Endocarditis (1) Toxemia of pregnancy (1) Neoplasm of the larynx (1) Ovarian neoplasm (1) Vaginal neoplasm (1) Cellulitis (1) Bulimia (1) Atelectasis (1) Esophageal neoplasm (1) Lymphocytosis (1) Polymenorrhea (1)

    HP:0004375: Neoplasm of the nervous system

    Developed by Shray Alag, The Harker School
    Sections: Correlations, Clinical Trials, and HPO

    Correlations computed by analyzing all clinical trials.

    Navigate: Clinical Trials and HPO


    Correlated Drug Terms (2)


    Name (Synonyms) Correlation
    drug765 Clinical Trial Matching Wiki 1.00
    drug610 COVID-19 convalescent plasma Wiki 0.45

    Correlated MeSH Terms (22)


    Name (Synonyms) Correlation
    D016889 Endometrial Neoplasms NIH 1.00
    D004938 Esophageal Neoplasms NIH 1.00
    D013274 Stomach Neoplasms NIH 1.00
    Name (Synonyms) Correlation
    D012878 Skin Neoplasms NIH 1.00
    D009423 Nervous System Neoplasms NIH 1.00
    D007680 Kidney Neoplasms NIH 1.00
    D016543 Central Nervous System Neoplasms NIH 1.00
    D005909 Glioblastoma NIH 1.00
    D008113 Liver Neoplasms NIH 1.00
    D007822 Laryngeal Neoplasms NIH 1.00
    D013736 Testicular Neoplasms NIH 1.00
    D002292 Carcinoma, Renal Cell NIH 0.71
    D002583 Uterine Cervical Neoplasms NIH 0.71
    D012004 Rectal Neoplasms NIH 0.71
    D018281 Cholangiocarcinoma NIH 0.71
    D018358 Neuroendocrine Tumors NIH 0.71
    D010190 Pancreatic Neoplasms NIH 0.58
    D006258 Head and Neck Neoplasms NIH 0.58
    D002277 Carcinoma NIH 0.50
    D003110 Colonic Neoplasms NIH 0.50
    D001943 Breast Neoplasms NIH 0.45
    D008175 Lung Neoplasms NIH 0.41

    Correlated HPO Terms (21)


    Name (Synonyms) Correlation
    HP:0002896 Neoplasm of the liver HPO 1.00
    HP:0008069 Neoplasm of the skin HPO 1.00
    HP:0012114 Endometrial carcinoma HPO 1.00
    Name (Synonyms) Correlation
    HP:0100006 Neoplasm of the central nervous system HPO 1.00
    HP:0010788 Testicular neoplasm HPO 1.00
    HP:0009726 Renal neoplasm HPO 1.00
    HP:0012174 Glioblastoma multiforme HPO 1.00
    HP:0100751 Esophageal neoplasm HPO 1.00
    HP:0006753 Neoplasm of the stomach HPO 1.00
    HP:0100605 Neoplasm of the larynx HPO 1.00
    HP:0005584 Renal cell carcinoma HPO 0.71
    HP:0100634 Neuroendocrine neoplasm HPO 0.71
    HP:0100743 Neoplasm of the rectum HPO 0.71
    HP:0030153 Cholangiocarcinoma HPO 0.71
    HP:0030079 Cervix cancer HPO 0.71
    HP:0002894 Neoplasm of the pancreas HPO 0.58
    HP:0012288 Neoplasm of head and neck HPO 0.58
    HP:0030731 Carcinoma HPO 0.50
    HP:0003003 Colon cancer HPO 0.50
    HP:0003002 Breast carcinoma HPO 0.45
    HP:0100526 Neoplasm of the lung HPO 0.41

    Clinical Trials

    Navigate: Correlations   HPO

    There is one clinical trial.


    1 SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry

    International registry for cancer patients evaluating the feasibility and clinical utility of an Artificial Intelligence-based precision oncology clinical trial matching tool, powered by a virtual tumor boards (VTB) program, and its clinical impact on pts with advanced cancer to facilitate clinical trial enrollment (CTE), as well as the financial impact, and potential outcomes of the intervention.

    NCT03452774
    Conditions
    1. Cancer, Metastatic
    2. Cancer
    3. Cancer of Pancreas
    4. Cancer of Liver
    5. Cancer of Stomach
    6. Cancer Liver
    7. Cancer of Rectum
    8. Cancer of Kidney
    9. Cancer of Esophagus
    10. Cancer of Cervix
    11. Cancer of Colon
    12. Cancer of Larynx
    13. Cancer, Lung
    14. Cancer, Breast
    15. Cancer, Advanced
    16. Cancer Prostate
    17. Cancer of Neck
    18. Cancer of Skin
    19. Neuroendocrine Tumors
    20. Carcinoma
    21. Mismatch Repair Deficiency
    22. BRCA Gene Rearrangement
    23. Non Hodgkin Lymphoma
    24. Leukemia
    25. Non Small Cell Lung Cancer
    26. Cholangiocarcinoma
    27. Glioblastoma
    28. Central Nervous System Tumor
    29. Melanoma
    30. Urothelial Carcinoma
    31. Bladder Cancer
    32. Ovarian Cancer
    33. Endometrial Cancer
    34. Testicular Cancer
    35. Breast Cancer
    36. COVID
    Interventions
    1. Other: Clinical Trial Matching
    MeSH:Carcinoma Glioblastoma Endometrial Neoplasms Neuroendocrine Tumors Cholangiocarcinoma Nervous System Neoplasms Central Nervous System Neoplasms Testicular Neoplasms Pancreatic Neoplasms Breast Neoplasms Lung Neoplasms Esophageal Neoplasms Stomach Neoplasms Liver Neoplasms Colonic Neoplasms Uterine Cervical Neoplasms Rectal Neoplasms Kidney Neoplasms Carcinoma, Renal Cell Skin Neoplasms Head and Neck Neoplasms Laryngeal Neoplasms
    HPO:Breast carcinoma Carcinoma Cervical polyp Cervix cancer Cholangiocarcinoma Clear cell renal cell carcinoma Colon cancer Endometrial carcinoma Esophageal neoplasm Glioblastoma multiforme Neoplasm of head and neck Neoplasm of the breast Neoplasm of the central nervous system Neoplasm of the colon Neoplasm of the larynx Neoplasm of the liver Neoplasm of the lung Neoplasm of the nervous system Neoplasm of the pancreas Neoplasm of the rectum Neoplasm of the skin Neoplasm of the stomach Neuroendocrine neoplasm Papillary renal cell carcinoma Renal cell carcinoma Renal neoplasm Testicular neoplasm

    Primary Outcomes

    Description: CTE Accrual

    Measure: Proportion of patients Eligible for CTE versus Actual CTE

    Time: Through study completion, an average of 1 year

    Secondary Outcomes

    Description: OS

    Measure: Impact of CTE on Overall Survival (OS), estimated by Kaplan-Meier and Cox multivariable survival analysis

    Time: 4 years

    Description: PFS

    Measure: Impact of CTE on Progression-Free Survival (PFS), estimated by Kaplan-Meier and Cox multivariable survival analysis

    Time: 4 years

    Description: To identify barriers to accruals to clinical trials, as measured and reported by a questionnaire

    Measure: Identification of Barriers to CTE

    Time: Through study completion, an average of 1 year

    Description: To Analyze Individual Standard of Care Chemotherapy Utilization (nominal), across treatment lines (numeric); data will be combined and aggregated to report chemotherapy utilization rate (%).

    Measure: Real World Data Analytics

    Time: Through study completion, an average of 1 year

    Description: VTB Use Rate

    Measure: Virtual Tumor Board Utilization

    Time: Through study completion, an average of 1 year

    Description: Time to CTE

    Measure: Time from Intervention to Actual CTE (months)

    Time: Through study completion, an average of 1 year

    HPO Nodes


    HP:0004375: Neoplasm of the nervous system
    Genes 281
    BAP1 POLD1 SMARCE1 TUBB RET MEN1 RPS20 WRN SMO WRN CDKN2C EWSR1 VHL GCGR SDHD APC RET APC2 CDKN2A ASCL1 APC SDHD LMNA YY1 KIF1B EDN3 AKT1 MSH3 NSD1 PTEN CREBBP LRP5 PDGFB PDE6D SDHC EPCAM PTEN SMARCB1 NAB2 SUFU SDHB TGFBR2 NF2 RUNX1 SDHD CDKN2A CPLANE1 MDM2 TP53 WDPCP RET NF1 GCDH NF1 KARS1 KRIT1 GNAS TP53 GLI3 NTHL1 CCM2 SMARCB1 SMARCE1 APC BAP1 MEN1 EP300 PTEN DICER1 PIK3CA PMS1 CDKN2B FAM149B1 ALX3 NUTM1 PHOX2B DLST PMS2 IDH1 SEC23B MAPRE2 DLST AKT1 TSC1 PTCH1 DNMT3A PDGFRB RAF1 MEN1 MN1 TUBB CHEK2 ALX1 SDHB ALK GDNF SDHC EPAS1 PRDM16 ADAMTS3 PTCH1 BRCA2 DNMT3A DAXX MLH1 PALB2 EDN3 KRAS SDHD CDKN1B PHOX2B NF1 LMO1 TSC2 GPC4 USF3 POT1 RERE NBN TMEM127 PDCD10 NF1 NF1 NTHL1 POLE SKI SDHAF2 SDHC PRKAR1A SETBP1 KIT PIK3CA LMNA SDHA SDHB VHL FAN1 TCTN3 TMEM216 BRD4 SMARCB1 GLI3 SDHD HRAS SUFU NBN TSC1 TP53 SDHC SDHD SIX6 MYO1H C11ORF95 TERT FLI1 PIK3CA KIAA0753 ERBB2 GABRD SOX2 SDHC SEMA4A SDHA IDH2 DMPK CTNNB1 PDGFB NF2 KIF1B SMARCA4 NF2 SLC25A11 RET MLH1 PTEN GDNF PIK3CA ASCL1 ARMC5 SUFU NF2 NRAS PTEN NF2 PTCH2 GLI3 BAP1 TMEM127 FAT4 MAX BDNF SMARCB1 SDHAF2 MDH2 FGFR1 MSH6 NOTCH3 OFD1 CCBE1 TOP2A RET PHOX2B BMPR1A MAX CCND1 RNF43 ALX3 SETD2 PTCH2 SMO OCRL MSH3 EPHB2 PHOX2B MSH2 BRAF SDHB VHL LIN28B SDHC MYCN CREBBP KIF7 RET PIK3CA SDHB PHOX2B PHOX2B AKT1 KIF1B KEAP1 RELA AKT1 SDHB MLH3 STAT6 APC SDHD ZSWIM6 MAFA FH ALK CDKN1B CPLANE1 GPC3 TRAF7 DICER1 PRKAR1A BMPR1A NF1 SDHB ATRX BRCA2 NF1 OFD1 VHL SPRED1 PTPN11 SDHD CHEK2 KLLN HACE1 CDKN1B GDNF LZTR1 PTEN VHL CDKN1A SLC25A11 RET RB1 SDHB IDH1 SUFU WT1 TSC2 L2HGDH KCNAB2 IFNG APC TP53
    Protein Mutations 3
    G156A G20210A K27M
    SNP 0

    HPO

    Alphabetical listing of all HPO terms. Navigate: Correlations   Clinical Trials


    HPO Nodes


    HP:0004375: Neoplasm of the nervous system
    Genes 281
    BAP1 POLD1 SMARCE1 TUBB RET MEN1 RPS20 WRN SMO WRN CDKN2C EWSR1 VHL GCGR SDHD APC RET APC2 CDKN2A ASCL1 APC SDHD LMNA YY1 KIF1B EDN3 AKT1 MSH3 NSD1 PTEN CREBBP LRP5 PDGFB PDE6D SDHC EPCAM PTEN SMARCB1 NAB2 SUFU SDHB TGFBR2 NF2 RUNX1 SDHD CDKN2A CPLANE1 MDM2 TP53 WDPCP RET NF1 GCDH NF1 KARS1 KRIT1 GNAS TP53 GLI3 NTHL1 CCM2 SMARCB1 SMARCE1 APC BAP1 MEN1 EP300 PTEN DICER1 PIK3CA PMS1 CDKN2B FAM149B1 ALX3 NUTM1 PHOX2B DLST PMS2 IDH1 SEC23B MAPRE2 DLST AKT1 TSC1 PTCH1 DNMT3A PDGFRB RAF1 MEN1 MN1 TUBB CHEK2 ALX1 SDHB ALK GDNF SDHC EPAS1 PRDM16 ADAMTS3 PTCH1 BRCA2 DNMT3A DAXX MLH1 PALB2 EDN3 KRAS SDHD CDKN1B PHOX2B NF1 LMO1 TSC2 GPC4 USF3 POT1 RERE NBN TMEM127 PDCD10 NF1 NF1 NTHL1 POLE SKI SDHAF2 SDHC PRKAR1A SETBP1 KIT PIK3CA LMNA SDHA SDHB VHL FAN1 TCTN3 TMEM216 BRD4 SMARCB1 GLI3 SDHD HRAS SUFU NBN TSC1 TP53 SDHC SDHD SIX6 MYO1H C11ORF95 TERT FLI1 PIK3CA KIAA0753 ERBB2 GABRD SOX2 SDHC SEMA4A SDHA IDH2 DMPK CTNNB1 PDGFB NF2 KIF1B SMARCA4 NF2 SLC25A11 RET MLH1 PTEN GDNF PIK3CA ASCL1 ARMC5 SUFU NF2 NRAS PTEN NF2 PTCH2 GLI3 BAP1 TMEM127 FAT4 MAX BDNF SMARCB1 SDHAF2 MDH2 FGFR1 MSH6 NOTCH3 OFD1 CCBE1 TOP2A RET PHOX2B BMPR1A MAX CCND1 RNF43 ALX3 SETD2 PTCH2 SMO OCRL MSH3 EPHB2 PHOX2B MSH2 BRAF SDHB VHL LIN28B SDHC MYCN CREBBP KIF7 RET PIK3CA SDHB PHOX2B PHOX2B AKT1 KIF1B KEAP1 RELA AKT1 SDHB MLH3 STAT6 APC SDHD ZSWIM6 MAFA FH ALK CDKN1B CPLANE1 GPC3 TRAF7 DICER1 PRKAR1A BMPR1A NF1 SDHB ATRX BRCA2 NF1 OFD1 VHL SPRED1 PTPN11 SDHD CHEK2 KLLN HACE1 CDKN1B GDNF LZTR1 PTEN VHL CDKN1A SLC25A11 RET RB1 SDHB IDH1 SUFU WT1 TSC2 L2HGDH KCNAB2 IFNG APC TP53
    Protein Mutations 3
    G156A G20210A K27M
    SNP 0

    Reports

    Data processed on December 13, 2020.

    An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.

    Drug Reports   MeSH Reports   HPO Reports  

    Interventions

    4,818 reports on interventions/drugs

    MeSH

    706 reports on MeSH terms

    HPO

    306 reports on HPO terms

    All Terms

    Alphabetical index of all Terms

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