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  • HP:0004808: Acute myeloid leukemia
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    HP:0004808: Acute myeloid leukemia

    Developed by Shray Alag, The Harker School
    Sections: Correlations, Clinical Trials, and HPO

    Correlations computed by analyzing all clinical trials.

    Navigate: Clinical Trials and HPO


    Correlated Drug Terms (0)


    Name (Synonyms) Correlation

    Correlated MeSH Terms (3)


    Name (Synonyms) Correlation
    D015470 Leukemia, Myeloid, Acute NIH 1.00
    D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma NIH 0.71
    D007938 Leukemia, NIH 0.50

    Correlated HPO Terms (1)


    Name (Synonyms) Correlation
    HP:0001909 Leukemia HPO 0.32

    Clinical Trials

    Navigate: Correlations   HPO

    There is one clinical trial.


    1 National Retrospective Monitoring of Patients With Acute Leukemia Infected by COronaVirus Disease 2019 (COVID-19)

    The COVID-19 epidemic (Coronavirus Disease 2019) currently raging in France is an emerging infectious disease linked to a virus of the genus coronavirus (SARS-CoV-2). Epidemiologically, acute myeloblastic leukemias (AML) are the most common of acute leukemias. The incidence of acute lymphoblastic leukemia (ALL) is 900 new cases in France in 2018, of which 57% in humans. The treatments administered to AML and ALL patients induce variable immunosuppression: neutropenia, neuropathy, deficits in humoral or cellular immunity or combinations of these deficits. Patients with AML or ALL therefore represent a population at high risk of developing a serious form in the event of infection with SARS-CoV-2. To date, no data is available in the literature to assess the impact of the COVID-19 epidemic in the population of patients with acute leukemia. The main objective of the study is to determine the clinical and biological prognostic factors during SARS-CoV-2 infection in patients with acute leukemia.

    NCT04452604
    Conditions
    1. Acute Myeloblastic Leukemia
    2. Acute Lymphoblastic Leukemia
    3. SARS-CoV-2
    MeSH:Leukemia Precursor Cell Lymphoblastic Leukemia-Lymphoma Leukemia, Myeloid, Acute
    HPO:Acute megakaryocytic leukemia Acute myeloid leukemia Leukemia

    Primary Outcomes

    Description: Factors associated with overall survival will be analyzed : center, sex, leukemia subtype, previous treatment by corticosteroids, and comorbidities (respiratory, renal, cardiac, weight, diabetes)

    Measure: Clinical prognostic factors for infection with COVID-19

    Time: Day 0

    Description: neutrophils and lymphocytes count at the time of SARS-COV2 infection

    Measure: Biological prognostic factors for infection with COVID-19

    Time: Day 0

    Description: Describe the management carried out concerning coronavirus infection and its impact of the treatment of acute leukemia (non-invasive ventilation, orotracheal intubation, vasopressor requiring, treatments used, cause of death

    Measure: Medical care of Coronavirus infection

    Time: within 12 months after diagnosis

    HPO Nodes


    Reports

    Data processed on December 13, 2020.

    An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.

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