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    HP:0001678: Atrioventricular block

    Developed by Shray Alag, The Harker School
    Sections: Correlations, Clinical Trials, and HPO

    Correlations computed by analyzing all clinical trials.

    Navigate: Clinical Trials and HPO


    Correlated Drug Terms (2)


    Name (Synonyms) Correlation
    drug479 Blood samples (collection of 5 mL of blood in a dry tube) Wiki 1.00
    drug2115 Nasopharyngeal swabs Wiki 0.71

    Correlated MeSH Terms (5)


    Name (Synonyms) Correlation
    D016171 Torsades de Pointes NIH 1.00
    D001919 Bradycardia NIH 1.00
    D054537 Atrioventricular Block NIH 1.00
    Name (Synonyms) Correlation
    D001281 Atrial Fibrillation NIH 0.71
    D001145 Arrhythmias, Cardiac NIH 0.50

    Correlated HPO Terms (4)


    Name (Synonyms) Correlation
    HP:0001664 Torsade de pointes HPO 1.00
    HP:0001662 Bradycardia HPO 1.00
    HP:0004757 Paroxysmal atrial fibrillation HPO 0.71
    Name (Synonyms) Correlation
    HP:0011675 Arrhythmia HPO 0.50

    Clinical Trials

    Navigate: Correlations   HPO

    There is one clinical trial.


    1 COVIDAR - International Registry on Arrhythmias in COVID-19

    BACKGROUND AND RATIONALE: There is very limited literature available on the arrhythmia occurrence in the context of an infection by the SARS-CoV2 virus. On the other hand, treatment strategies against the SARS-CoV2 virus may carry a risk of QTc prolongation and pro-arrhythmia/sudden death which may be amplified by concomitant use of other QTc-prolonging drugs and/or ion disbalances. COVIDAR is an international initiative to monitor the occurrence of arrhythmic events in the context of the SARS-CoV2 infection, to identify potential modifiable predisposing factors to reduce their incidence and to inform the best arrhythmia management options in this patient population. MAIN OBJECTIVE: To describe the incidence and type of arrhythmic events in the context of the SARS-CoV2 infection. STUDY DESIGN: patient registry (observational). Patients will not undergo any additional investigations. Only data that is generated during routine clinical care will be collected. STUDY POPULATION: Patients admitted to the hospital highly suspected of or with confirmed COVID-19.

    NCT04437901
    Conditions
    1. COVID
    2. Arrhythmia
    3. Torsades de Pointe Caused by Drug
    4. Qt Interval, Variation in
    5. Atrioventricular Block
    6. Atrial Fibrillation
    7. Bradyarrhythmia
    8. Ventricular Arrythmia
    MeSH:Atrial Fibrillation Arrhythmias, Cardiac Atrioventricular Block Bradycardia Torsades de Pointes
    HPO:Arrhythmia Atrial fibrillation Atrioventricular block Bradycardia Paroxysmal atrial fibrillation Torsade de pointes

    Primary Outcomes

    Description: Any arrhythmic event occurring in COVID-19 patients during hospital admission: Monomorphic ventricular tachycardia Polymorphic ventricular tachycardia/Torsades de pointes (non-sustained) Ventricular fibrillation AV-block Severe bradycardia, symptomatic and/or requiring treatment New-onset atrial fibrillation Other

    Measure: Arrhythmia

    Time: From date of admission until the date of first documented arrhythmic adverse event or date of death from any cause, whichever came first, assessed up to 12 months

    Secondary Outcomes

    Description: Categorical variable collecting the patient's underlying rhythm at baseline, on treatment and in case of arrhythmic adverse events): sinus rhythm, atrial fibrillation/flutter, other

    Measure: Electrocardiographic changes - Underlying rhythm

    Time: From date of admission until the date of first documented arrhythmic adverse event or date of death from any cause, whichever came first, assessed up to 12 months

    Description: Collected as a categorical (normal, 1st-, 2nd- or 3rd degree AV block) and a continuous (PR duration in ms) at baseline, on treatment and in case of arrhythmic adverse events)

    Measure: Electrocardiographic changes - Atrioventricular conduction

    Time: From date of admission until the date of first documented arrhythmic adverse event or date of death from any cause, whichever came first, assessed up to 12 months

    Description: Collected as a continuous variable (ms) at baseline, on treatment and in case of arrhythmic adverse events)

    Measure: Electrocardiographic changes - QRS duration

    Time: From date of admission until the date of first documented arrhythmic adverse event or date of death from any cause, whichever came first, assessed up to 12 months

    Description: Collected as a categorical variable (not present, type 1 or type 2) at baseline, on treatment and in case of arrhythmic adverse events)

    Measure: Electrocardiographic changes - presence of Brugada QRS pattern

    Time: From date of admission until the date of first documented arrhythmic adverse event or date of death from any cause, whichever came first, assessed up to 12 months

    Description: Collected as a continuous variable (ms) at baseline, on treatment and in case of arrhythmic adverse events)

    Measure: Electrocardiographic changes - QTc duration

    Time: From date of admission until the date of first documented arrhythmic adverse event or date of death from any cause, whichever came first, assessed up to 12 months

    Description: Kalium, magnesium and calcium collected as continuous variables at baseline, on treatment and in case of arrhythmic adverse events). Will be reported as a categorical variable (presence/absence) of electrolyte misbalance

    Measure: Laboratory abnormalities - electrolyte misbalance

    Time: From date of admission until the date of first documented arrhythmic adverse event or date of death from any cause, whichever came first, assessed up to 12 months

    Description: Cardiac CK, troponin T and/or troponin I (where available) collected as a continuous variable at baseline, on treatment and in case of arrhythmic adverse events)

    Measure: Laboratory abnormalities - cardiac biomarkers

    Time: From date of admission until the date of first documented arrhythmic adverse event or date of death from any cause, whichever came first, assessed up to 12 months

    Description: Creatinine clearance at baseline, on treatment and in case of arrhythmic adverse events)

    Measure: Laboratory abnormalities - renal function

    Time: From date of admission until the date of first documented arrhythmic adverse event or date of death from any cause, whichever came first, assessed up to 12 months

    Description: Liver enzymes collected at at baseline, on treatment and in case of arrhythmic adverse events)

    Measure: Laboratory abnormalities - liver function

    Time: From date of admission until the date of first documented arrhythmic adverse event or date of death from any cause, whichever came first, assessed up to 12 months

    HPO Nodes


    Reports

    Data processed on December 13, 2020.

    An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.

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