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    HP:0001609: Hoarse voice

    Developed by Shray Alag, The Harker School
    Sections: Correlations, Clinical Trials, and HPO

    Correlations computed by analyzing all clinical trials.

    Navigate: Clinical Trials and HPO


    Correlated Drug Terms (6)


    Name (Synonyms) Correlation
    drug1276 Fibreoptic Endoscopic Evaluation of Swallowing (FEES) Wiki 1.00
    drug1083 Dysphagia Handicap Index (DHI) Wiki 1.00
    drug2719 RESP301, a Nitric Oxide generating solution Wiki 1.00
    Name (Synonyms) Correlation
    drug3552 Videofluoroscopy Wiki 1.00
    drug3586 Voice Symptom Scale (VoiSS) Wiki 1.00
    drug3138 Standard of Care Wiki 0.16

    Correlated MeSH Terms (8)


    Name (Synonyms) Correlation
    D006685 Hoarseness NIH 1.00
    D055154 Dysphonia NIH 1.00
    D014832 Voice Disorders NIH 1.00
    Name (Synonyms) Correlation
    D003680 Deglutition Disorders NIH 0.58
    D004194 Disease NIH 0.20
    D007239 Infection NIH 0.05
    D045169 Severe Acute Respiratory Syndrome NIH 0.04
    D018352 Coronavirus Infections NIH 0.04

    Correlated HPO Terms (3)


    Name (Synonyms) Correlation
    HP:0001618 Dysphonia HPO 1.00
    HP:0001621 Weak voice HPO 1.00
    HP:0002015 Dysphagia HPO 0.58

    Clinical Trials

    Navigate: Correlations   HPO

    There is one clinical trial.


    1 Dysphagia and Dysphonia Outcomes in SARS CoV-2 (COVID-19): A Prospective Observational Cohort Study.

    This study examines the presence, severity and natural history of dysphagia and dysphonia in the post-extubation and severely unwell COVID-19 patient.

    NCT04584658
    Conditions
    1. Dysphagia
    2. Dysphonia
    3. Subglottic Stenosis
    4. Voice Disorders
    5. Swallowing Disorder
    6. Covid19
    7. SARS (Severe Acute Respiratory Syndrome)
    8. SARS Pneumonia
    9. Quality of Life
    10. SARS-CoV-2 Infection
    Interventions
    1. Diagnostic Test: Fibreoptic Endoscopic Evaluation of Swallowing (FEES)
    2. Diagnostic Test: Videofluoroscopy
    3. Other: Dysphagia Handicap Index (DHI)
    4. Other: Voice Symptom Scale (VoiSS)
    MeSH:Infection Severe Acute Respiratory Syndrome Coronavirus Infections Deglutition Disorders Dysphonia Hoarseness Voice Disorders Disease
    HPO:Dysphagia Dysphonia Hoarse voice Oral-pharyngeal dysphagia Weak voice

    Primary Outcomes

    Description: Based on therapy outcome measures from FEES, VoiS

    Measure: Primary endpoint is severity of dysphonia and dysphagia at the time of initial assessment t = day 0 (for ITU patients: Day 0 = 24 hours after extubation or decannulation).

    Time: t = day 0 (for ITU patients: Day 0 = 24 hours after extubation or decannulation).

    Secondary Outcomes

    Description: Clinical assessment including outcome measures, FEES and/or Videofluoroscopy

    Measure: The severity of dysphonia and/or dysphagia over an initial 12 month period (at t = 14 days, 1 month, 3 months, 6 months, 9 months, 12 months)

    Time: t = 14 days, 1 month, 3 months, 6 months, 9 months, 12 months

    Description: Clinical assessment including outcome measures, FEES and/or Videofluoroscopy

    Measure: The severity of dysphonia and/or dysphagia at t = day 5, day 10, day 14, day 21 - For in-patients only.

    Time: t = day 5, day 10, day 14, day 21 - For in-patients only.

    Description: Clinical assessment including outcome measures, FEES and/or Videofluoroscopy

    Measure: Relationship between severity of dysphonia and/or dysphagia with grade of ARDS

    Time: t = day 0 and 9 months

    Description: Clinical assessment including outcome measures, FEES and/or Videofluoroscopy

    Measure: Relationship between severity of dysphonia and/or dysphagia with length of intubation

    Time: t = day 0 and 9 months

    Description: Clinical assessment including outcome measures, FEES and/or Videofluoroscopy

    Measure: Relationship between severity of dysphonia and/or dysphagia with duration of mechanical ventilation

    Time: t = day 0 and 9 months

    Description: Questionnaire assessment: This is a 30-item validated quality of life tool that is also a self-reporting tool. It appraises the impact of the patient's abnormal voice from an emotional perspective, related physical symptoms and stratifies the impairment itself in context of day to day activities. VoiSS is currently the most psychometrically robust voice outcome measure. Each item is scored 0 - 4 on the frequency responses: never, occasionally, some of the time, most of the time, always. The total score of 120 measures general voice pathology which is made up of Impairment = maximum score of 60; Emotional = maximum score of 32; Physical = maximum score of 28

    Measure: Relationship between severity of dysphonia on quality of life using Voice Symptom Scale (VoiSS) questionnaire over time at day 0, 1 month and 9 months.

    Time: t = day 0, 1 month and 9 months.

    Description: Questionnaire assessment: This is a 25-item questionnaire assessing three domains: physical (9 items), functional (9 items), and emotional aspects (7 items) of the Quality of Life (QOL) in patients suffering with dysphagia. For each statement the patient checks if it applies to him/her all the time, some of the time or never. The suggested scores are 0, 2 and 4, respectively. Using this scoring system amounts to a DHI score range of 0 - 100. The higher the score, the worse the dysphagia related QOL. The patient is also asked to provide a rating of their own impression of the severity of the dysphagia experienced on a scale from 1 (normal) to 7 (severe problem).

    Measure: Relationship between severity of dysphagia on quality of life using Dysphagia Handicap Index (DHI) questionnaire over time at day 0, 1 month and 9 months

    Time: t = day 0, 1 month and 9 months

    HPO Nodes


    Reports

    Data processed on December 13, 2020.

    An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.

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