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    HP:0001873: Thrombocytopenia

    Developed by Shray Alag, The Harker School
    Sections: Correlations, Clinical Trials, and HPO

    Correlations computed by analyzing all clinical trials.

    Navigate: Clinical Trials and HPO


    Correlated Drug Terms (2)


    Name (Synonyms) Correlation
    drug1145 Eltrombopag Wiki 1.00
    drug3995 rhTPO Wiki 1.00

    Correlated MeSH Terms (2)


    Name (Synonyms) Correlation
    D013921 Thrombocytopenia NIH 1.00
    D016553 Purpura, Thrombocytopenic, Idiopathic NIH 1.00

    Correlated HPO Terms (1)


    Name (Synonyms) Correlation
    HP:0001973 Autoimmune thrombocytopenia HPO 1.00

    Clinical Trials

    Navigate: Correlations   HPO

    There is one clinical trial.


    1 The Combination of Eltrombopag and Recombinant Human Thrombopoietin (rhTPO) Versus Eltrombopag Monotherapy as Subsequent Treatment for Immune Thrombocytopenia During the COVID-19 Pandemic

    This is a prospective, multicenter, randomized, open-label study to investigate the efficacy and safety of eltrombopag plus recombinant human thrombopoietin (rhTPO) versus eltrombopag as treatment for corticosteroid-resistant or relapsed immune thrombocytopenia (ITP) during the COVID-19 pandemic.

    NCT04516837
    Conditions
    1. Immune Thrombocytopenia
    Interventions
    1. Drug: Eltrombopag
    2. Drug: rhTPO
    MeSH:Thrombocytopenia Purpura, Thrombocytopenic, Idiopathic
    HPO:Autoimmune thrombocytopenia Thrombocytopenia

    Primary Outcomes

    Description: A complete response (CR) was defined as a sustained (≥ 3 months) platelet count ≥ 100×10^9/L.

    Measure: Complete response

    Time: 6 months

    Description: A response (R) was defined as a sustained (≥ 3 months) platelet count ≥ 30×10^9/L without recurrence of thrombocytopenia.

    Measure: Response

    Time: 6 months

    Description: No response (NR) was defined as platelet count < 30 × 10^9/L or a less than two fold increase in platelet count from baseline or the presence of bleeding. Platelet count must be measured on two occasions more than a day apart.

    Measure: No response

    Time: 6 months

    Description: A relapses was defined as platelet count falls below 30×10^9/L or bleeding accrues after achieving R or CR.

    Measure: Relapses

    Time: 6 months

    Secondary Outcomes

    Description: Early response was defined as the attainment of a platelet count ≥ 30 × 10⁹ and at least a doubling of baseline platelet count at 1 week.

    Measure: Early response

    Time: 7 days

    Description: Initial treatment was defined as the attainment of a platelet count ≥ 30 × 10⁹ and at least a doubling of baseline platelet count at 1 month.

    Measure: Initial response

    Time: 1 month

    Description: Durable response was defined as the attainment of a platelet count ≥ 30 × 10⁹ and at least a doubling of baseline platelet count at 6 months.

    Measure: Durable response

    Time: 6 months

    Description: The time to achieve platelet count ≥ 30×10^9/L and at least 2-fold increase of the baseline count and absence of bleeding since start of treatment.

    Measure: TOR (time to response)

    Time: 6 months

    Description: The duration of achieve platelet count ≥ 30×10^9/L and at least 2-fold increase of the baseline count and absence of bleeding since start of treatment.

    Measure: DOR (duration of response)

    Time: 6 months

    Description: All patients were assessed for safety every week during the first 8 weeks of treatment, and at 2-week intervals thereafter. Adverse events were scaled according to Common Terminology Criteria for Adverse Events (CTCAE) version 5.0.

    Measure: Treatments associated adverse events

    Time: 6 months

    Description: Changes of bleeding after treatment. Bleeding was defined in accordance with the WHO bleeding scale (0, no bleeding; 1, petechiae; 2, mild blood loss; 3, gross blood loss; and 4, debilitating blood loss).

    Measure: Reduction in bleeding symptoms

    Time: 6 months

    HPO Nodes


    HP:0001873: Thrombocytopenia
    Genes 451
    PSMB4 GFI1B FANCG KMT2D RPS7 TREX1 ARHGAP31 MS4A1 SLFN14 GATA1 NPM1 ZBTB16 ERCC6L2 TINF2 GATA1 TERT HOXA11 VWF PLAU MTOR ARVCF FANCM IKZF1 RPS15A NBEAL2 RREB1 PSAP GATA1 SPATA5 TERT RAD51C CD81 PRDX1 WAS ANKRD11 FANCD2 RAG1 PRKACG HIRA SPATA5 FLI1 GP1BB RARA BRIP1 STT3B CD81 SEC24C UROS MECOM SLC19A2 HLCS ATRX FANCG TET2 TERT MPL NOTCH1 TERC CFHR1 FOXP3 RPL27 AP3B1 PKHD1 GFI1B CASP10 NIPBL CA2 LMBRD1 RPL11 PDGFRB STAT5B MYH9 STXBP2 ANKRD26 VPS45 SLC35A1 TET2 PHGDH PRKCD SLC7A7 PCCA DOCK6 LIG4 CD46 SF3B1 RPL15 TINF2 ADA2 TERT FANCD2 PTPN22 CFI USB1 SMARCAL1 STAT2 CR2 GBA G6PC3 GALC STX11 LIG4 DNAJC21 SH2D1A MADD PDGFB RPL35 SBDS FANCL FAS CTC1 GBA CALR PNP SP110 VPS33A MPL NHP2 NBN GP1BB FCGR2B ACD PTPN11 CTLA4 TREX1 TINF2 ZAP70 MAGT1 GATA2 C3 IFIH1 SLC7A7 TFRC NFKB1 ITGA2B FANCF APOE ITGB3 VWF ABCA1 SLC19A2 RPS19 FLI1 CASP10 STAT1 DLL4 DGKE TNFRSF13C UQCRFS1 RPL18 SALL4 MECOM SBDS TNFSF11 BTK KIF15 RNASEH2B SLC20A2 PSMB9 STIM1 TNFAIP3 CDC42 PRF1 ITGB3 FANCC ACAD9 GBA NUMA1 JAK2 TNFRSF11A CD40LG MMACHC GP1BB FANCI FAS SCARB2 SLC35A1 GBA MPIG6B SPP1 ITGA2 MMAA FOXP3 STIM1 FARS2 TPP2 RAG1 SBDS RFXAP FLNA HOXA11 ACP5 UROS RNASEH2A RASGRP1 FANCA ABCD4 COG4 DIAPH1 PRKCD GP1BA RPS19 RPL26 COG1 CYCS DHFR GP9 NHEJ1 ACTN1 NPM1 LBR CD36 IFNG CTLA4 MMUT TNFSF12 CFB POMP RPS28 MYSM1 CD109 HPS5 COL4A5 ERBB3 NSUN2 ACP5 NABP1 CFI DNAJC21 GUCY1A1 SRP54 HLCS WIPF1 LYST RBM8A FYB1 WFS1 ADAMTS13 RPS26 GATA1 RPS17 SCARB2 GBA APOE FANCF THBD SLC46A1 MMUT JMJD1C FANCE PALB2 HYOU1 TBX1 PNP SRC OCLN MYSM1 TNFSF12 JAK2 TBX1 FASLG FANCE RFXANK WIPF1 RUNX1 TINF2 GBA CORIN PARN BCOR NBEAL2 RAG2 TMEM165 RNASEH2C SAMD9L GNA14 MADD FANCC SALL4 MAD2L2 WAS PEPD NOP10 FLT1 CD19 SMPD1 SMARCD2 BRCA1 MPL PSMB8 MYH9 CDC42 RNASEH2A RPS10 STAT4 TUBB1 SAMHD1 KRAS BRCA2 MMACHC BRAF ALG8 FASLG NOP10 NOS3 COG6 ETV6 STOX1 SC5D CFH TALDO1 STAT3 TERC PRKAR1A SNX10 RTEL1 ESCO2 AGK RASGRP1 ACAD9 TREX1 XPR1 NBN STT3B NRAS MAD2L2 CLCN7 GATA1 ADA CFH FANCB EOGT STAT3 SLC46A1 ICOS HLA-B SLX4 RFX5 RPL31 BCR TNFRSF13B IRF2BP2 WAS SAMD9 RPL5 USP18 RPS27 RPS24 WRAP53 RPL35A FAS SAMHD1 UFD1 TET2 ASAH1 UBE2T SRP54 GBA WARS2 DKC1 DGUOK ITGA2B MMAB NHP2 NFKB1 SMARCAL1 IRAK1 IFIH1 TERT RNASEH2C CIITA TALDO1 GP1BB NFKB2 EFL1 LAT TBXAS1 RBM8A NLRC4 MAP2K1 CFHR3 PCCB GP1BA ERCC4 ARHGEF1 LARS2 RAD51 OCRL PRF1 DZIP1L MMUT JAM2 ARPC1B XRCC2 DKC1 GATA1 ITK GATA1 WDR1 CTC1 RBPJ TSR2 TET2 LYST PML GBA ADAR SARS2 TCN2 FIP1L1 ELANE RFWD3 TBL1XR1 EFL1 TERC DNASE1 RRAS2 HLA-DRB1 PARN NFKB2 ATP7B DKC1 RPS29 DCLRE1C HELLPAR ABL1 LRBA FANCA GP9 NHP2 BLOC1S6 RUNX1 FANCB COMT PRKCD MYORG FCGR2C UBE2T GP1BA OSTM1 IL7R RTEL1 RAG2 CD46 FCGR2A GP1BA VPS33A IVD KDM6A BTNL2 XIAP MVK
    Protein Mutations 2
    G20210A V617F
    SNP 0

    HPO

    Alphabetical listing of all HPO terms. Navigate: Correlations   Clinical Trials


    HPO Nodes


    HP:0001873: Thrombocytopenia
    Genes 451
    PSMB4 GFI1B FANCG KMT2D RPS7 TREX1 ARHGAP31 MS4A1 SLFN14 GATA1 NPM1 ZBTB16 ERCC6L2 TINF2 GATA1 TERT HOXA11 VWF PLAU MTOR ARVCF FANCM IKZF1 RPS15A NBEAL2 RREB1 PSAP GATA1 SPATA5 TERT RAD51C CD81 PRDX1 WAS ANKRD11 FANCD2 RAG1 PRKACG HIRA SPATA5 FLI1 GP1BB RARA BRIP1 STT3B CD81 SEC24C UROS MECOM SLC19A2 HLCS ATRX FANCG TET2 TERT MPL NOTCH1 TERC CFHR1 FOXP3 RPL27 AP3B1 PKHD1 GFI1B CASP10 NIPBL CA2 LMBRD1 RPL11 PDGFRB STAT5B MYH9 STXBP2 ANKRD26 VPS45 SLC35A1 TET2 PHGDH PRKCD SLC7A7 PCCA DOCK6 LIG4 CD46 SF3B1 RPL15 TINF2 ADA2 TERT FANCD2 PTPN22 CFI USB1 SMARCAL1 STAT2 CR2 GBA G6PC3 GALC STX11 LIG4 DNAJC21 SH2D1A MADD PDGFB RPL35 SBDS FANCL FAS CTC1 GBA CALR PNP SP110 VPS33A MPL NHP2 NBN GP1BB FCGR2B ACD PTPN11 CTLA4 TREX1 TINF2 ZAP70 MAGT1 GATA2 C3 IFIH1 SLC7A7 TFRC NFKB1 ITGA2B FANCF APOE ITGB3 VWF ABCA1 SLC19A2 RPS19 FLI1 CASP10 STAT1 DLL4 DGKE TNFRSF13C UQCRFS1 RPL18 SALL4 MECOM SBDS TNFSF11 BTK KIF15 RNASEH2B SLC20A2 PSMB9 STIM1 TNFAIP3 CDC42 PRF1 ITGB3 FANCC ACAD9 GBA NUMA1 JAK2 TNFRSF11A CD40LG MMACHC GP1BB FANCI FAS SCARB2 SLC35A1 GBA MPIG6B SPP1 ITGA2 MMAA FOXP3 STIM1 FARS2 TPP2 RAG1 SBDS RFXAP FLNA HOXA11 ACP5 UROS RNASEH2A RASGRP1 FANCA ABCD4 COG4 DIAPH1 PRKCD GP1BA RPS19 RPL26 COG1 CYCS DHFR GP9 NHEJ1 ACTN1 NPM1 LBR CD36 IFNG CTLA4 MMUT TNFSF12 CFB POMP RPS28 MYSM1 CD109 HPS5 COL4A5 ERBB3 NSUN2 ACP5 NABP1 CFI DNAJC21 GUCY1A1 SRP54 HLCS WIPF1 LYST RBM8A FYB1 WFS1 ADAMTS13 RPS26 GATA1 RPS17 SCARB2 GBA APOE FANCF THBD SLC46A1 MMUT JMJD1C FANCE PALB2 HYOU1 TBX1 PNP SRC OCLN MYSM1 TNFSF12 JAK2 TBX1 FASLG FANCE RFXANK WIPF1 RUNX1 TINF2 GBA CORIN PARN BCOR NBEAL2 RAG2 TMEM165 RNASEH2C SAMD9L GNA14 MADD FANCC SALL4 MAD2L2 WAS PEPD NOP10 FLT1 CD19 SMPD1 SMARCD2 BRCA1 MPL PSMB8 MYH9 CDC42 RNASEH2A RPS10 STAT4 TUBB1 SAMHD1 KRAS BRCA2 MMACHC BRAF ALG8 FASLG NOP10 NOS3 COG6 ETV6 STOX1 SC5D CFH TALDO1 STAT3 TERC PRKAR1A SNX10 RTEL1 ESCO2 AGK RASGRP1 ACAD9 TREX1 XPR1 NBN STT3B NRAS MAD2L2 CLCN7 GATA1 ADA CFH FANCB EOGT STAT3 SLC46A1 ICOS HLA-B SLX4 RFX5 RPL31 BCR TNFRSF13B IRF2BP2 WAS SAMD9 RPL5 USP18 RPS27 RPS24 WRAP53 RPL35A FAS SAMHD1 UFD1 TET2 ASAH1 UBE2T SRP54 GBA WARS2 DKC1 DGUOK ITGA2B MMAB NHP2 NFKB1 SMARCAL1 IRAK1 IFIH1 TERT RNASEH2C CIITA TALDO1 GP1BB NFKB2 EFL1 LAT TBXAS1 RBM8A NLRC4 MAP2K1 CFHR3 PCCB GP1BA ERCC4 ARHGEF1 LARS2 RAD51 OCRL PRF1 DZIP1L MMUT JAM2 ARPC1B XRCC2 DKC1 GATA1 ITK GATA1 WDR1 CTC1 RBPJ TSR2 TET2 LYST PML GBA ADAR SARS2 TCN2 FIP1L1 ELANE RFWD3 TBL1XR1 EFL1 TERC DNASE1 RRAS2 HLA-DRB1 PARN NFKB2 ATP7B DKC1 RPS29 DCLRE1C HELLPAR ABL1 LRBA FANCA GP9 NHP2 BLOC1S6 RUNX1 FANCB COMT PRKCD MYORG FCGR2C UBE2T GP1BA OSTM1 IL7R RTEL1 RAG2 CD46 FCGR2A GP1BA VPS33A IVD KDM6A BTNL2 XIAP MVK
    Protein Mutations 2
    G20210A V617F
    SNP 0

    Reports

    Data processed on December 13, 2020.

    An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.

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