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    HP:0000405: Conductive hearing impairment

    Developed by Shray Alag, The Harker School
    Sections: Correlations, Clinical Trials, and HPO

    Correlations computed by analyzing all clinical trials.

    Navigate: Clinical Trials and HPO


    Correlated Drug Terms (2)


    Name (Synonyms) Correlation
    drug3173 Standardized crisis management and coping protocol plan toward Coronavirus disease 2019 (COVID-19) Wiki 1.00
    drug492 Bone conduction headphones Wiki 1.00

    Correlated MeSH Terms (4)


    Name (Synonyms) Correlation
    D003638 Deafness NIH 1.00
    D010034 Otitis Media with Effusion NIH 1.00
    D034381 Hearing Loss NIH 1.00
    Name (Synonyms) Correlation
    D006314 Hearing Loss, Conductive NIH 1.00

    Correlated HPO Terms (2)


    Name (Synonyms) Correlation
    HP:0040262 Glue ear HPO 1.00
    HP:0000365 Hearing impairment HPO 0.71

    Clinical Trials

    Navigate: Correlations   HPO

    There is one clinical trial.


    1 Exploring Interventions for Children With Chronic Otitis Media With Effusion ('Glue Ear') When Services Are Reduced During Covid-19

    During the Coronavirus pandemic children's hearing services are closed or reduced and grommet operations are part of the lowest priority group. In the absence of management options, this research study aims to see if bone conduction headphones either paired (via bluetooth) to a microphone or an app will help children with a hearing loss during this period of waiting. The child's quality of life is measured with validated questionnaires The study is over 3 months, and delivered remotely, with the product being sent to the family home and support offered via telephone/ video consulattion.

    NCT04427631
    Conditions
    1. Hearing Impaired Children
    2. Glue Ear
    3. Hearing Loss, Conductive
    Interventions
    1. Device: Bone conduction headphones
    MeSH:Hearing Loss Deafness Otitis Media with Effusion Hearing Loss, Conductive
    HPO:Conductive hearing impairment Glue ear Hearing impairment

    Primary Outcomes

    Description: questionnaire based accpetability question. A higher acceptability score will be positive for the intervention.

    Measure: acceptability of management strategy, questionnaire

    Time: Acceptability will be measured on a Likert scale pre-assessment and the end of 3 months of using the intervention

    Secondary Outcomes

    Description: validated questionnaire assessing quality of life in children with glue ear. The questionnaire assess disease- related hearing difficulty and treatment-related improvements in hearing. Improved (lower) scores will indicate a more positive response from the intervention.

    Measure: quality of life questionnaire OMQ-14

    Time: Questionnaires at beginning of study (as a baseline assessment and after 3 months of using the intervention. The sc

    HPO Nodes


    HP:0000405: Conductive hearing impairment
    Genes 436
    MERTK COL2A1 DNAH1 LMNA DNAAF1 FAT4 LRRC56 TCOF1 SLC7A14 RP1 ERCC6 EFTUD2 SLC25A24 PDE6A CNGB1 ARVCF ZNF408 TP63 NOG RSPH9 NOTCH2 RREB1 TOPORS PIK3C2A GATA1 CTBP1 SNRPB RBP3 ELMO2 MCIDAS SAG EFTUD2 DNAH11 ANKH ARHGAP29 B3GLCT CFAP221 CPLANE1 FGFR2 MYT1L HIRA GP1BB DRC1 SVBP EYA1 ACTL6B FRAS1 OFD1 SEC24C FGFR3 TULP1 SPAG1 PRDM5 SNRNP200 DLST FLNB NIPBL DNMT3A EYA1 COL2A1 GJA1 GMNN ALX1 FAM20C GJB2 EPAS1 STK36 ADAMTS3 SLC25A24 COL2A1 SPECC1L GJA1 RP9 IFT88 FAT4 FGFR2 RHO CFAP300 POLR1D LRRC6 KMT2E ARL3 RPGR GRIP1 TNFRSF11A TMEM67 SNRPB PDE6B TANC2 COL11A2 AMMECR1 ZNF513 NF1 CCNO ERCC8 TSR2 HYDIN SDHAF2 FGFR2 CNOT3 CPLX1 ERF RLBP1 RAB23 FLNA SLC35C1 TMEM216 FAM161A MED13 FRAS1 SDHD MYCN ROM1 FLNB ODAD4 CCDC40 TTC8 FANCI DDR2 KIAA0753 IDH3B CCBE1 FGFRL1 HOXA2 KIF1B BEST1 KMT2A ZNF469 MASP1 RP2 KMT2D PAX1 CTNND1 DCHS1 UBB IMPDH1 FGFR3 RPS28 DCHS1 DHDDS CNOT1 ARID2 CFAP300 EYA1 ZMPSTE24 RAI1 MAX RPE65 LONP1 EXT1 DNAI2 EYA1 RSPH1 CHRNG SPATA7 CCBE1 WDFY3 MSX1 GJA1 ARHGEF18 DNAH9 NECTIN1 TCOF1 SC5D FOXJ1 DLG1 SDHC AMER1 CREBBP KIF7 FLNA PTPN22 CFAP298 SKI SALL4 DDX6 PORCN GALNT2 KLHL7 RAD21 TBX22 SEMA4A USH2A CERKL CPLANE1 TCTN3 SIX1 TWIST1 BCORL1 SDHB CDCA7 OFD1 PRPF8 TTC12 PAX1 GSC KDM6A FBXW11 MAP3K7 MAN2B1 CDHR1 FGF9 GAS2L2 EYS TP63 IRF6 MAP3K7 GAS8 CLRN1 NIPBL DLX4 GJB6 NOTCH3 DHODH IDS RPGR DNAAF3 TCF20 DNAL1 PCGF2 MYCN DHX38 IFT172 ANKH VHL FKBP14 EDN1 ARL2BP NOG PRCD APC2 PRPH2 NEK2 FBN1 ACVR1 PIGL STAC3 GJA1 TP63 NSD1 PGM3 SPEF2 REEP6 DNAJB13 JMJD1C COL2A1 CREBBP AGBL5 NECTIN1 PDE6D PROM1 TBX1 NEK1 TBX1 BBS2 ZBTB20 ODAD2 DNAI1 SDHD FLNB DNAI1 IFT140 CDH11 PSMD12 TP63 NSD2 LRP5 CCDC103 MYT1L OFD1 DNAAF5 ABCA4 IDH3A EP300 TRPS1 NOG POLR1D KIZ SRCAP COL1A2 SIX1 FAM149B1 ALX3 MAP3K7 IMPG2 MEOX1 BPTF DNAH5 ODAD3 MSX1 SEMA3E EDNRA IDS HNRNPK GRHL3 IQSEC2 SDHB TUB PRDM16 RPS23 ACTL6A DEAF1 AFF4 TXNL4A PSMD12 STAC3 TFAP2A CDH1 BPTF NOG GNPTAB FGFR2 SIX1 RERE FGF10 POLR1B SMCHD1 TSHZ1 SKI POR PGM3 ANKRD11 POMGNT1 PRRX1 TCTN3 ZMIZ1 PDE6G HDAC4 POLR1C GDF5 POU3F4 RSPH3 RECQL4 AHI1 B3GALT6 RPS26 GABRD RP1L1 SDHA SGMS2 NEK10 CRB1 CNGA1 DHODH DOCK3 TFAP2A FGFR2 RET UFD1 HGSNAT CREB3L1 CHRNG DNAAF2 SF3B4 PRPF3 GUCA1B TMEM127 FAT4 AMER1 SETD5 DNAAF4 MDH2 RAI1 HNRNPK NR2E3 PCARE FREM2 MAK SMC1A EYA1 ALX3 SETD2 SLITRK6 SKI TELO2 SMC3 FSCN2 RECQL4 FLNA CA4 ODAD1 TRMT1 NME8 RGR AHR PRPF4 LETM1 GDF6 BMP2 HDAC8 CHD7 POLR1C SDHD NFIX CCDC39 LRAT WHCR FH SCAPER CRX NSD1 FGFR3 KIAA1549 PRPF31 MYH3 PRPF6 DVL1 MAP3K7 DNAAF6 VHL GAS8 NRL NOTCH3 TRAPPC4 RDH12 ARL6 RSPH4A MAN2B1 COMT ZMYND10 CCDC65 SLC25A11 RET FLII NTNG1 CDH1 BMP4 TNFRSF11A IRF6 KCNAB2 C8ORF37 POU3F4 SOST RLIM FGFR3 OSTM1
    Protein Mutations 0
    SNP 0

    HPO

    Alphabetical listing of all HPO terms. Navigate: Correlations   Clinical Trials


    HPO Nodes


    HP:0000405: Conductive hearing impairment
    Genes 436
    MERTK COL2A1 DNAH1 LMNA DNAAF1 FAT4 LRRC56 TCOF1 SLC7A14 RP1 ERCC6 EFTUD2 SLC25A24 PDE6A CNGB1 ARVCF ZNF408 TP63 NOG RSPH9 NOTCH2 RREB1 TOPORS PIK3C2A GATA1 CTBP1 SNRPB RBP3 ELMO2 MCIDAS SAG EFTUD2 DNAH11 ANKH ARHGAP29 B3GLCT CFAP221 CPLANE1 FGFR2 MYT1L HIRA GP1BB DRC1 SVBP EYA1 ACTL6B FRAS1 OFD1 SEC24C FGFR3 TULP1 SPAG1 PRDM5 SNRNP200 DLST FLNB NIPBL DNMT3A EYA1 COL2A1 GJA1 GMNN ALX1 FAM20C GJB2 EPAS1 STK36 ADAMTS3 SLC25A24 COL2A1 SPECC1L GJA1 RP9 IFT88 FAT4 FGFR2 RHO CFAP300 POLR1D LRRC6 KMT2E ARL3 RPGR GRIP1 TNFRSF11A TMEM67 SNRPB PDE6B TANC2 COL11A2 AMMECR1 ZNF513 NF1 CCNO ERCC8 TSR2 HYDIN SDHAF2 FGFR2 CNOT3 CPLX1 ERF RLBP1 RAB23 FLNA SLC35C1 TMEM216 FAM161A MED13 FRAS1 SDHD MYCN ROM1 FLNB ODAD4 CCDC40 TTC8 FANCI DDR2 KIAA0753 IDH3B CCBE1 FGFRL1 HOXA2 KIF1B BEST1 KMT2A ZNF469 MASP1 RP2 KMT2D PAX1 CTNND1 DCHS1 UBB IMPDH1 FGFR3 RPS28 DCHS1 DHDDS CNOT1 ARID2 CFAP300 EYA1 ZMPSTE24 RAI1 MAX RPE65 LONP1 EXT1 DNAI2 EYA1 RSPH1 CHRNG SPATA7 CCBE1 WDFY3 MSX1 GJA1 ARHGEF18 DNAH9 NECTIN1 TCOF1 SC5D FOXJ1 DLG1 SDHC AMER1 CREBBP KIF7 FLNA PTPN22 CFAP298 SKI SALL4 DDX6 PORCN GALNT2 KLHL7 RAD21 TBX22 SEMA4A USH2A CERKL CPLANE1 TCTN3 SIX1 TWIST1 BCORL1 SDHB CDCA7 OFD1 PRPF8 TTC12 PAX1 GSC KDM6A FBXW11 MAP3K7 MAN2B1 CDHR1 FGF9 GAS2L2 EYS TP63 IRF6 MAP3K7 GAS8 CLRN1 NIPBL DLX4 GJB6 NOTCH3 DHODH IDS RPGR DNAAF3 TCF20 DNAL1 PCGF2 MYCN DHX38 IFT172 ANKH VHL FKBP14 EDN1 ARL2BP NOG PRCD APC2 PRPH2 NEK2 FBN1 ACVR1 PIGL STAC3 GJA1 TP63 NSD1 PGM3 SPEF2 REEP6 DNAJB13 JMJD1C COL2A1 CREBBP AGBL5 NECTIN1 PDE6D PROM1 TBX1 NEK1 TBX1 BBS2 ZBTB20 ODAD2 DNAI1 SDHD FLNB DNAI1 IFT140 CDH11 PSMD12 TP63 NSD2 LRP5 CCDC103 MYT1L OFD1 DNAAF5 ABCA4 IDH3A EP300 TRPS1 NOG POLR1D KIZ SRCAP COL1A2 SIX1 FAM149B1 ALX3 MAP3K7 IMPG2 MEOX1 BPTF DNAH5 ODAD3 MSX1 SEMA3E EDNRA IDS HNRNPK GRHL3 IQSEC2 SDHB TUB PRDM16 RPS23 ACTL6A DEAF1 AFF4 TXNL4A PSMD12 STAC3 TFAP2A CDH1 BPTF NOG GNPTAB FGFR2 SIX1 RERE FGF10 POLR1B SMCHD1 TSHZ1 SKI POR PGM3 ANKRD11 POMGNT1 PRRX1 TCTN3 ZMIZ1 PDE6G HDAC4 POLR1C GDF5 POU3F4 RSPH3 RECQL4 AHI1 B3GALT6 RPS26 GABRD RP1L1 SDHA SGMS2 NEK10 CRB1 CNGA1 DHODH DOCK3 TFAP2A FGFR2 RET UFD1 HGSNAT CREB3L1 CHRNG DNAAF2 SF3B4 PRPF3 GUCA1B TMEM127 FAT4 AMER1 SETD5 DNAAF4 MDH2 RAI1 HNRNPK NR2E3 PCARE FREM2 MAK SMC1A EYA1 ALX3 SETD2 SLITRK6 SKI TELO2 SMC3 FSCN2 RECQL4 FLNA CA4 ODAD1 TRMT1 NME8 RGR AHR PRPF4 LETM1 GDF6 BMP2 HDAC8 CHD7 POLR1C SDHD NFIX CCDC39 LRAT WHCR FH SCAPER CRX NSD1 FGFR3 KIAA1549 PRPF31 MYH3 PRPF6 DVL1 MAP3K7 DNAAF6 VHL GAS8 NRL NOTCH3 TRAPPC4 RDH12 ARL6 RSPH4A MAN2B1 COMT ZMYND10 CCDC65 SLC25A11 RET FLII NTNG1 CDH1 BMP4 TNFRSF11A IRF6 KCNAB2 C8ORF37 POU3F4 SOST RLIM FGFR3 OSTM1
    Protein Mutations 0
    SNP 0

    Reports

    Data processed on December 13, 2020.

    An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.

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