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  • HP:0012288: Neoplasm of head and neck
  • Pneumonia (361) Abnormality of the cardiovascular system (36) Respiratory tract infection (36) Neoplasm (29) Hypoxemia (28) Diabetes mellitus (25) Depressivity (24) Thromboembolism (23) Acute kidney injury (22) Abnormal lung morphology (21) Anosmia (19) Hypertension (18) Abnormality of coagulation (15) Pulmonary embolism (15) Pulmonary fibrosis (15) Stroke (14) Arthritis (14) Interstitial pneumonitis (14) Myocardial infarction (12) Type II diabetes mellitus (12) Deep venous thrombosis (11) Rheumatoid arthritis (10) Leukemia (10) Respiratory distress (10) Low levels of vitamin D (10) Behavioral abnormality (9) Mental deterioration (9) Chronic pain (9) Congestive heart failure (8) Myocarditis (8) Type I diabetes mellitus (8) Sepsis (8) Infertility (7) Abnormality of the liver (7) Lymphopenia (7) Inflammation of the large intestine (7) Pulmonary obstruction (7) Pulmonary insufficiency (7) Immunodeficiency (6) Systemic lupus erythematosus (6) Chronic pulmonary obstruction (6) Abnormality of the gastrointestinal tract (6) Neoplasm of the lung (6) Encephalopathy (5) Obesity (5) Lymphoma (5) Autoimmunity (5) Breast carcinoma (5) Disseminated intravascular coagulation (5) Fatigue (5) Abnormality of the kidney (4) Coronary artery atherosclerosis (4) Cardiac arrest (4) Headache (4) Colon cancer (4) Arrhythmia (4) Carcinoma (4) Hypercoagulability (4) Autistic behavior (3) Seizure (3) Cardiomyopathy (3) Dysphagia (3) Migraine (3) Pulmonary arterial hypertension (3) Asthma (3) Bronchiectasis (3) Neoplasm of the pancreas (3) Psoriasiform dermatitis (3) Attention deficit hyperactivity disorder (3) Cutaneous melanoma (3) Neoplasm of head and neck (3) Pulmonary edema (3) Insomnia (3) Neoplasm of the large intestine (3) Renal insufficiency (2) Hypogeusia (2) Hearing impairment (2) Abnormality of the eye (2) Visual impairment (2) Conjunctivitis (2) Psychosis (2) Autism (2) Dementia (2) Abnormality of the endocrine system (2) Abnormality of the thyroid gland (2) Jaundice (2) Hepatic fibrosis (2) Premature birth (2) Abnormal heart morphology (2) Abnormality of blood and blood-forming tissues (2) Fever (2) Diarrhea (2) Hypothermia (2) Neurodegeneration (2) Abnormal intestine morphology (2) Alopecia of scalp (2) Encephalitis (2) Obstructive sleep apnea (2) Male infertility (2) Stillbirth (2) Paroxysmal atrial fibrillation (2) Lymphoid leukemia (2) Myeloproliferative disorder (2) Chronic lymphatic leukemia (2) Renal cell carcinoma (2) Multiple myeloma (2) Abnormal anterior horn cell morphology (2) Amyotrophic lateral sclerosis (2) Sleep apnea (2) Cystoid macular edema (2) Hemeralopia (2) Arteritis (2) Chronic kidney disease (2) Cervix cancer (2) Cholangitis (2) Cholangiocarcinoma (2) Myositis (2) Neuroendocrine neoplasm (2) Neoplasm of the rectum (2) Mania (2) Nephritis (1) Menorrhagia (1) Conductive hearing impairment (1) Cataract (1) Amblyopia (1) Periodontitis (1) Abnormality of the nervous system (1) Oligospermia (1) Adrenal insufficiency (1) Hyperaldosteronism (1) Abnormality of the skin (1) Lymphedema (1) Cholecystitis (1) Keratoconjunctivitis (1) Intellectual disability (1) Spastic diplegia (1) Hemiparesis (1) Meningitis (1) Cerebral hemorrhage (1) Abnormal joint morphology (1) Hepatic failure (1) Hepatocellular carcinoma (1) Intrauterine growth retardation (1) Hoarse voice (1) Dysphonia (1) Weak voice (1) Sudden cardiac death (1) Cor pulmonale (1) Tachycardia (1) Aortic valve stenosis (1) Bradycardia (1) Torsade de pointes (1) Atrioventricular block (1) Angina pectoris (1) Pancreatitis (1) Premature rupture of membranes (1) Weight loss (1) Thrombocytopenia (1) Autoimmune thrombocytopenia (1) Gastroesophageal reflux (1) Anorexia (1) Esophageal varix (1) Apnea (1) Status epilepticus (1) Subarachnoid hemorrhage (1) Memory impairment (1) Difficulty walking (1) Hyperkinetic movements (1) Alzheimer disease (1) Increased intracranial pressure (1) Colitis (1) Biliary cirrhosis (1) Hypotension (1) Vascular dilatation (1) Atherosclerosis (1) Osteoarthritis (1) Tachypnea (1) Hypoventilation (1) Myelodysplasia (1) Neoplasm of the liver (1) Hypokalemia (1) Hyponatremia (1) Hyperphosphatemia (1) Reduced factor VIII activity (1) Skeletal muscle atrophy (1) Myalgia (1) Muscular dystrophy (1) Neonatal death (1) Increased body weight (1) Neoplasm of the nervous system (1) Malnutrition (1) Thrombophlebitis (1) Ventricular tachycardia (1) Acute myeloid leukemia (1) Dilatation of the cerebral artery (1) Knee osteoarthritis (1) Monoclonal immunoglobulin M proteinemia (1) Intraalveolar phospholipid accumulation (1) Neoplasm of the stomach (1) Neoplasm of the genitourinary tract (1) Neoplasm of the skin (1) Female infertility (1) Benign prostatic hyperplasia (1) Hip osteoarthritis (1) Renal neoplasm (1) Uterine neoplasm (1) Testicular neoplasm (1) Intestinal atresia (1) Tonsillitis (1) Inflammatory abnormality of the skin (1) Placental abruption (1) Postprandial hyperglycemia (1) Endometrial carcinoma (1) Erythroid hypoplasia (1) Asterixis (1) Glioblastoma multiforme (1) B-cell lymphoma (1) Ciliary dyskinesia (1) Morphea (1) Allergy (1) Non-Hodgkin lymphoma (1) Retinal vein occlusion (1) Heart block (1) Dyspareunia (1) Ductal carcinoma in situ (1) Endometriosis (1) Cardiogenic shock (1) Vulvar neoplasm (1) Addictive behavior (1) Femur fracture (1) Neonatal sepsis (1) Glue ear (1) Neoplasm of the central nervous system (1) Abnormality of movement (1) Ulcerative colitis (1) Crohn's disease (1) Endocarditis (1) Toxemia of pregnancy (1) Neoplasm of the larynx (1) Ovarian neoplasm (1) Vaginal neoplasm (1) Cellulitis (1) Bulimia (1) Atelectasis (1) Esophageal neoplasm (1) Lymphocytosis (1) Polymenorrhea (1)

    HP:0012288: Neoplasm of head and neck

    Developed by Shray Alag, The Harker School
    Sections: Correlations, Clinical Trials, and HPO

    Correlations computed by analyzing all clinical trials.

    Navigate: Clinical Trials and HPO


    Correlated Drug Terms (6)


    Name (Synonyms) Correlation
    drug2979 Screening test for covid ( RT PCR and CT Chest) Wiki 0.58
    drug4076 vitamin d Wiki 0.58
    drug765 Clinical Trial Matching Wiki 0.58
    Name (Synonyms) Correlation
    drug4084 zinc gluconate and ascorbic acid Wiki 0.58
    drug3903 non interventional study Wiki 0.58
    drug610 COVID-19 convalescent plasma Wiki 0.26

    Correlated MeSH Terms (22)


    Name (Synonyms) Correlation
    D006258 Head and Neck Neoplasms NIH 1.00
    D016889 Endometrial Neoplasms NIH 0.58
    D004938 Esophageal Neoplasms NIH 0.58
    Name (Synonyms) Correlation
    D013274 Stomach Neoplasms NIH 0.58
    D012878 Skin Neoplasms NIH 0.58
    D009423 Nervous System Neoplasms NIH 0.58
    D007680 Kidney Neoplasms NIH 0.58
    D016543 Central Nervous System Neoplasms NIH 0.58
    D005909 Glioblastoma NIH 0.58
    D008113 Liver Neoplasms NIH 0.58
    D007822 Laryngeal Neoplasms NIH 0.58
    D013736 Testicular Neoplasms NIH 0.58
    D002292 Carcinoma, Renal Cell NIH 0.41
    D002583 Uterine Cervical Neoplasms NIH 0.41
    D012004 Rectal Neoplasms NIH 0.41
    D018281 Cholangiocarcinoma NIH 0.41
    D018358 Neuroendocrine Tumors NIH 0.41
    D010190 Pancreatic Neoplasms NIH 0.33
    D002277 Carcinoma NIH 0.29
    D003110 Colonic Neoplasms NIH 0.29
    D001943 Breast Neoplasms NIH 0.26
    D008175 Lung Neoplasms NIH 0.24

    Correlated HPO Terms (21)


    Name (Synonyms) Correlation
    HP:0002896 Neoplasm of the liver HPO 0.58
    HP:0008069 Neoplasm of the skin HPO 0.58
    HP:0012114 Endometrial carcinoma HPO 0.58
    Name (Synonyms) Correlation
    HP:0100006 Neoplasm of the central nervous system HPO 0.58
    HP:0010788 Testicular neoplasm HPO 0.58
    HP:0009726 Renal neoplasm HPO 0.58
    HP:0012174 Glioblastoma multiforme HPO 0.58
    HP:0100751 Esophageal neoplasm HPO 0.58
    HP:0004375 Neoplasm of the nervous system HPO 0.58
    HP:0006753 Neoplasm of the stomach HPO 0.58
    HP:0100605 Neoplasm of the larynx HPO 0.58
    HP:0005584 Renal cell carcinoma HPO 0.41
    HP:0100634 Neuroendocrine neoplasm HPO 0.41
    HP:0100743 Neoplasm of the rectum HPO 0.41
    HP:0030153 Cholangiocarcinoma HPO 0.41
    HP:0030079 Cervix cancer HPO 0.41
    HP:0002894 Neoplasm of the pancreas HPO 0.33
    HP:0030731 Carcinoma HPO 0.29
    HP:0003003 Colon cancer HPO 0.29
    HP:0003002 Breast carcinoma HPO 0.26
    HP:0100526 Neoplasm of the lung HPO 0.24

    Clinical Trials

    Navigate: Correlations   HPO

    There are 3 clinical trials


    1 SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry

    International registry for cancer patients evaluating the feasibility and clinical utility of an Artificial Intelligence-based precision oncology clinical trial matching tool, powered by a virtual tumor boards (VTB) program, and its clinical impact on pts with advanced cancer to facilitate clinical trial enrollment (CTE), as well as the financial impact, and potential outcomes of the intervention.

    NCT03452774
    Conditions
    1. Cancer, Metastatic
    2. Cancer
    3. Cancer of Pancreas
    4. Cancer of Liver
    5. Cancer of Stomach
    6. Cancer Liver
    7. Cancer of Rectum
    8. Cancer of Kidney
    9. Cancer of Esophagus
    10. Cancer of Cervix
    11. Cancer of Colon
    12. Cancer of Larynx
    13. Cancer, Lung
    14. Cancer, Breast
    15. Cancer, Advanced
    16. Cancer Prostate
    17. Cancer of Neck
    18. Cancer of Skin
    19. Neuroendocrine Tumors
    20. Carcinoma
    21. Mismatch Repair Deficiency
    22. BRCA Gene Rearrangement
    23. Non Hodgkin Lymphoma
    24. Leukemia
    25. Non Small Cell Lung Cancer
    26. Cholangiocarcinoma
    27. Glioblastoma
    28. Central Nervous System Tumor
    29. Melanoma
    30. Urothelial Carcinoma
    31. Bladder Cancer
    32. Ovarian Cancer
    33. Endometrial Cancer
    34. Testicular Cancer
    35. Breast Cancer
    36. COVID
    Interventions
    1. Other: Clinical Trial Matching
    MeSH:Carcinoma Glioblastoma Endometrial Neoplasms Neuroendocrine Tumors Cholangiocarcinoma Nervous System Neoplasms Central Nervous System Neoplasms Testicular Neoplasms Pancreatic Neoplasms Breast Neoplasms Lung Neoplasms Esophageal Neoplasms Stomach Neoplasms Liver Neoplasms Colonic Neoplasms Uterine Cervical Neoplasms Rectal Neoplasms Kidney Neoplasms Carcinoma, Renal Cell Skin Neoplasms Head and Neck Neoplasms Laryngeal Neoplasms
    HPO:Breast carcinoma Carcinoma Cervical polyp Cervix cancer Cholangiocarcinoma Clear cell renal cell carcinoma Colon cancer Endometrial carcinoma Esophageal neoplasm Glioblastoma multiforme Neoplasm of head and neck Neoplasm of the breast Neoplasm of the central nervous system Neoplasm of the colon Neoplasm of the larynx Neoplasm of the liver Neoplasm of the lung Neoplasm of the nervous system Neoplasm of the pancreas Neoplasm of the rectum Neoplasm of the skin Neoplasm of the stomach Neuroendocrine neoplasm Papillary renal cell carcinoma Renal cell carcinoma Renal neoplasm Testicular neoplasm

    Primary Outcomes

    Description: CTE Accrual

    Measure: Proportion of patients Eligible for CTE versus Actual CTE

    Time: Through study completion, an average of 1 year

    Secondary Outcomes

    Description: OS

    Measure: Impact of CTE on Overall Survival (OS), estimated by Kaplan-Meier and Cox multivariable survival analysis

    Time: 4 years

    Description: PFS

    Measure: Impact of CTE on Progression-Free Survival (PFS), estimated by Kaplan-Meier and Cox multivariable survival analysis

    Time: 4 years

    Description: To identify barriers to accruals to clinical trials, as measured and reported by a questionnaire

    Measure: Identification of Barriers to CTE

    Time: Through study completion, an average of 1 year

    Description: To Analyze Individual Standard of Care Chemotherapy Utilization (nominal), across treatment lines (numeric); data will be combined and aggregated to report chemotherapy utilization rate (%).

    Measure: Real World Data Analytics

    Time: Through study completion, an average of 1 year

    Description: VTB Use Rate

    Measure: Virtual Tumor Board Utilization

    Time: Through study completion, an average of 1 year

    Description: Time to CTE

    Measure: Time from Intervention to Actual CTE (months)

    Time: Through study completion, an average of 1 year
    2 Surgical Activity During the Covid-19 Pandemic: Results for 112 Patients in a French Tertiary Care Center: A Retrospective Observational Cohort Study

    Background After the emergence of Covid-19 in China, Hubei Province, the epidemic quickly spread to Europe. France was quickly hit and the Croix-Rousse hospital at the Hospices Civils de Lyon was one of the first French university hospital to receive patients infected with Sars-COV2. The predicted massive influx of patients motivated the cancellation of all elective surgical procedures planned to free hospitalization beds and to free intensive care beds. Nevertheless, patients who had to be canceled had to be properly selected to avoid a life threatening. The retained surgical indications were surgical emergencies, oncologic surgery and organ transplantation. The objective was to describe the organization of the Croix-Rousse hospital to allow the continuation of these surgical activities while limiting the exposure of patients to the Sars Cov2.

    NCT04379232
    Conditions
    1. Digestive Cancer
    2. Gynaecological Cancer
    3. Head and Neck Cancer
    Interventions
    1. Biological: Screening test for covid ( RT PCR and CT Chest)
    MeSH:Head and Neck Neoplasms
    HPO:Neoplasm of head and neck

    Primary Outcomes

    Description: Patients are tested with RT PCR and CT Chest if they declare symptoms after surgery

    Measure: Symptoms of Covid after surgery

    Time: Screening test are performed if the patient becomes symptomatic up to 14 days after surgery. In case of symptoms patients are tested within 24 hours.
    3 HERODOTUS: Head and Neck cancERs International cOviD-19 collabOraTion

    To develop an International registry on head and neck cancer patients infected with COVID-19

    NCT04632173
    Conditions
    1. Head and Neck Cancer
    2. Covid19
    Interventions
    1. Other: non interventional study
    MeSH:Head and Neck Neoplasms
    HPO:Neoplasm of head and neck

    Primary Outcomes

    Description: age, performance status etc

    Measure: Demographic features

    Time: Nov 1 2019 to January 31 2021

    Measure: prevalence of comorbidities in head and neck cancer patients with COVID-19

    Time: Nov 1 2019 to January 31 2021

    Measure: proportion of head and neck cancer patients experiencing severe adverse events

    Time: Nov 1 2019 to January 31 2021

    Measure: proportion of head and neck cancer patients by COVID-19 clinical course severity

    Time: Nov 1 2019 to January 31 2021

    Measure: proportion of head and neck cancer patients with COVID-19 who received chemotherapy, surgery, radiotherapy, immune check point inhibitors in the last 3 months before, as well as during, COVID-19 infection

    Time: Nov 1 2019 to January 31 2021

    Measure: predictive factors of severe adverse events in head and neck cancer patients with COVID-19 including cancer-related treatment

    Time: Nov 1 2019 to January 31 2021

    Measure: prognostic factors of head and neck cancer patients with COVID-19 including cancer related treatment including Human papilloma virus(HPV).

    Time: Nov 1 2019 to January 31 2021

    HPO Nodes


    Reports

    Data processed on December 13, 2020.

    An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.

    Drug Reports   MeSH Reports   HPO Reports  

    Interventions

    4,818 reports on interventions/drugs

    MeSH

    706 reports on MeSH terms

    HPO

    306 reports on HPO terms

    All Terms

    Alphabetical index of all Terms

    Google Colab

    Python example via Google Colab Notebook