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    HP:0002617: Vascular dilatation

    Developed by Shray Alag, The Harker School
    Sections: Correlations, Clinical Trials, and HPO

    Correlations computed by analyzing all clinical trials.

    Navigate: Clinical Trials and HPO


    Correlated Drug Terms (3)


    Name (Synonyms) Correlation
    drug381 BRII-198 Wiki 1.00
    drug3589 WEB embolization Wiki 1.00
    drug2448 Placebo Wiki 0.05

    Correlated MeSH Terms (2)


    Name (Synonyms) Correlation
    D002532 Intracranial Aneurysm NIH 1.00
    D000783 Aneurysm, NIH 1.00

    Correlated HPO Terms (1)


    Name (Synonyms) Correlation
    HP:0004944 Dilatation of the cerebral artery HPO 1.00

    Clinical Trials

    Navigate: Correlations   HPO

    There is one clinical trial.


    1 Comparison of Woven EndoBridge Device Sizing With Conventional Measurements and Virtual Simulation Using the Sim&Size Software: A Multi-Center Experience

    Selection of the appropriate size of the device is mandatory during aneurysm treatment with a WEB. The Investigators aimed to investigate if virtual simulation with Sim&Size software may have an impact on technical, angiographic, and clinical outcomes after WEB treatment. Data from two large-volume centers were collected and compared (January 2017-January 2020). Virtual simulation was systematically adopted in one center, while conventional sizing was used in the other one. Outcomes were the duration of intervention, the radiation dose (mGy), the number of corrective interventions for inappropriate WEB size, the number of WEBs not deployed, angiographic occlusion, and complications. Univariate and multivariate linear models were adopted.

    NCT04621552
    Conditions
    1. Aneurysm
    2. Intracranial Aneurysm
    Interventions
    1. Device: WEB embolization
    MeSH:Intracranial Aneurysm Aneurysm
    HPO:Cerebral berry aneurysm Dilatation of the cerebral artery Vascular dilatation

    Primary Outcomes

    Description: the median duration of the intervention

    Measure: Median duration of the intervention

    Time: 1day

    Description: the median radiation dose

    Measure: Median radiation dose

    Time: 1 day

    Description: the need of corrective interventions

    Measure: Need of corrective interventions

    Time: 1 day

    Description: the number of WEBs opened but finally not deployed because of the inappropriate size of the device.

    Measure: number of WEBs opened

    Time: 1 day

    Secondary Outcomes

    Description: the overall rate of complications (peri-procedural and long-term adverse events)

    Measure: Overall rate of complications

    Time: 1 day

    Description: the morbidity rate (complications associated with permanent change of the clinical and neurological status of the patient)

    Measure: morbidity rate

    Time: 1 day

    Description: short-term (6 months) and long-term (12 months or more) aneurysm occlusion

    Measure: Rate of Aneurysm occlusion

    Time: 6 months and 12 months

    Description: WEB-shape change ("compaction") (decrease in height of the device or a deepening of the proximal and distal concave recesses during follow-up9 based on non-subtracted images).

    Measure: WEB-shape change

    Time: 6 months and 12 months

    HPO Nodes


    HPO

    Alphabetical listing of all HPO terms. Navigate: Correlations   Clinical Trials


    HPO Nodes


    Reports

    Data processed on December 13, 2020.

    An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.

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