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    HP:0000717: Autism

    Developed by Shray Alag, The Harker School
    Sections: Correlations, Clinical Trials, and HPO

    Correlations computed by analyzing all clinical trials.

    Navigate: Clinical Trials and HPO

    Correlated Drug Terms (7)

    Name (Synonyms) Correlation
    drug1153 Emotional Support Plan Wiki 0.71
    drug1672 Interview by psychologists Wiki 0.71
    drug3947 placebo rinse Wiki 0.71
    Name (Synonyms) Correlation
    drug544 CD24Fc Wiki 0.71
    drug550 CHX0.12+CPC0.05 oral rinse (PerioAidActive Control) Wiki 0.71
    drug958 Daily Monitoring Wiki 0.71
    drug2448 Placebo Wiki 0.03

    Correlated MeSH Terms (7)

    Name (Synonyms) Correlation
    D002659 Child Development Disorders, Pervasive NIH 1.00
    D001321 Autistic Disorder NIH 0.82
    D000067877 Autism Spectrum Disorder NIH 0.71
    Name (Synonyms) Correlation
    D006948 Hyperkinesis NIH 0.71
    D001289 Attention Deficit Disorder with Hyperactivity NIH 0.41
    D004194 Disease NIH 0.14
    D013315 Stress, Psychological NIH 0.13

    Correlated HPO Terms (3)

    Name (Synonyms) Correlation
    HP:0000729 Autistic behavior HPO 0.82
    HP:0002487 Hyperkinetic movements HPO 0.71
    HP:0007018 Attention deficit hyperactivity disorder HPO 0.41

    Clinical Trials

    Navigate: Correlations   HPO

    There are 2 clinical trials

    1 Clinical Evolution and Parenting in Children and Adolescents With Autism Spectrum Disorder or Attention Deficit Hyperactivity Disorder Quarantined Because of Covid-19 Outbreak

    In response to the coronavirus disease 2019 (covid-19) outbreak, the home confinement of the population ordered by governments in many countries raise questions about its impact on individuals' physical and mental health in the short and longer term. In children, reduced physical activity, changes in lifestyle, disturbances in sleep patterns, lack of in-person contact with peers, poor or inadequate understanding of health risks may be risk factors of anxiety, stress, fatigue, sleep disorders (Brooks et al, 2020; Wang et al, 2020; Sprang et al, 2013). These problematic effects could be modulated by social factors (housing in urban or rural areas, availability of personal space at home, parenting stress, etc.) (Cluver et al, 2020; Liu et al, 2020).

    1. Autism Spectrum Disorder
    2. Attention-deficit Hyperactivity Disorder
    1. Other: Interview by psychologists
    MeSH:Hyperkinesis Disease Autistic Disorder Attention Deficit Disorder with Hyperactivity Autism Spectrum Disorder Child Development Disorders, Pervasive
    HPO:Attention deficit hyperactivity disorder Autism Autistic behavior Hyperactivity Hyperkinetic movements

    Primary Outcomes

    Description: composition, home confinement, change in the environment, personal room at home, screens with internet access, parents' current professional status, teleworking, care, family concerns related to Covid-19, parenting stress, schooling, recurrent complaints.

    Measure: Interview of the parents : contextual data

    Time: Baseline

    Description: related to education; related to daily family life; related to leisure, related to care (children/adolescents, parents)

    Measure: Interview of the children/adolescents/ parents : Experience of the confinement in general

    Time: Baseline

    Description: related to education; related to daily family life; related to leisure, related to care (children/adolescents, parents)

    Measure: Interview of the children/adolescents/ parents : Experience of the confinement in general

    Time: 1 month

    Description: related to education; related to daily family life; related to leisure, related to care (children/adolescents, parents)

    Measure: Interview of the children/adolescents/ parents : Experience of the confinement in general

    Time: 3 months

    Description: Data relating to disease and management of care. Experience of the referring caregiver.

    Measure: Interview of the referring caregiver : data relating to disease and management of care

    Time: 3 months
    2 ASD (Autism Spectrum Disorder) Telehealth for Distress Related to COVID-19 (Coronavirus Disease)

    The purpose of this study is to evaluate the feasibility, acceptability and effectiveness of a brief, telehealth intervention (the Emotional Support Plan), intended to support autistic adults to cope with their negative emotions during and/or after the COVID-19 pandemic. The first objective is to develop and refine a brief telehealth-delivered treatment, the Emotional Support Plan (ESP), to help promote adults to cope during periods of acute distress, such as those experienced during the COVID-19 pandemic. The second objective is to assess the feasibility and effectiveness of the ESP to support autistic adults to implement emotion regulation strategies during periods of acute distress. The last objective is to yield preliminary data to apply for extramural grants to validate these methods to monitor and support mental health of autistic adults during key transitions (e.g., starting college).

    1. Psychological Distress
    2. Stress, Psychological
    3. Autism Spectrum Disorder
    1. Behavioral: Emotional Support Plan
    2. Behavioral: Daily Monitoring
    MeSH:Autistic Disorder Autism Spectrum D Autism Spectrum Disorder Child Development Disorders, Pervasive Stress, Psychological
    HPO:Autism Autistic behavior

    Primary Outcomes

    Description: The PHQ-9, assessed weekly, is a 9-item questionnaire of psychological function over the past week with all items on a "0" (not at all) to "3" (nearly every day) scale. Higher scores equal more distress.

    Measure: Decreased distress on Patient Health Questionnaire (PHQ-9)

    Time: 8 week study period

    Description: EMA (Ecological Momentary Assessment) reports of decreased distress (in ESP + daily monitoring group only). Higher scores on the item equal higher levels of distress.

    Measure: Decreased distress on EMA reports

    Time: 8 week study period

    Description: The GAD-7, assessed weekly, is a 7-item questionnaire of anxiety symptoms over the past week with all items on a "0" (not at all) to "3" (nearly every day) scale. Higher scores equal more anxiety.

    Measure: Decreased anxiety symptoms on the Generalized Anxiety Disorder Questionnaire (GAD-7)

    Time: 8 week study period

    Secondary Outcomes

    Description: The ASR is a measure of adaptive functioning and psychopathology (e.g., anxiety, depression symptoms). Most of the items are on a 3 point scale including: (0) Not true, (1) Somewhat or sometimes true, and (2) Very often or often true.

    Measure: Adult Self Report (ASR)

    Time: 8 week study period

    HPO Nodes


    Data processed on December 13, 2020.

    An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.

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