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  • HP:0030075: Ductal carcinoma in situ
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    HP:0030075: Ductal carcinoma in situ

    Developed by Shray Alag, The Harker School
    Sections: Correlations, Clinical Trials, and HPO

    Correlations computed by analyzing all clinical trials.

    Navigate: Clinical Trials and HPO


    Correlated Drug Terms (2)


    Name (Synonyms) Correlation
    drug612 COVID-19 convalescent plasma treatment Wiki 1.00
    drug2687 Questionnaire Administration Wiki 0.29

    Correlated MeSH Terms (6)


    Name (Synonyms) Correlation
    D002285 Carcinoma, Intraductal, Noninfiltrating NIH 1.00
    D002278 Carcinoma in Situ NIH 1.00
    D044584 Carcinoma, Ductal NIH 1.00
    Name (Synonyms) Correlation
    D018270 Carcinoma, Ductal, Breast NIH 1.00
    D002277 Carcinoma NIH 0.50
    D001943 Breast Neoplasms NIH 0.45

    Correlated HPO Terms (2)


    Name (Synonyms) Correlation
    HP:0030731 Carcinoma HPO 0.50
    HP:0003002 Breast carcinoma HPO 0.45

    Clinical Trials

    Navigate: Correlations   HPO

    There is one clinical trial.


    1 Potential Impact of the COVID -19 Pandemic on Financial Toxicity in Breast Cancer Surgical Patients: The Impact on Out of Pocket Costs, Lost Wages and Economic Strain

    This study investigates the impact of COVID-19 pandemic on out-of-pocket costs, lost wages, and unemployment in patients with breast cancer undergoing breast surgery. Post-mastectomy reconstructive patients are at high risk for financial toxicity (adverse effects of escalating health care cost on well-being). The goal of this study is to collect information about financial costs patients may have as a result of surgical treatment for cancer with or without breast reconstruction and to learn if COVID-19 affects patient costs of breast reconstruction. This may help researchers demonstrate the financial consequences of undergoing breast surgery.

    NCT04169542
    Conditions
    1. Breast Ductal Carcinoma In Situ
    2. COVID-19 Infection
    3. Hereditary Breast Carcinoma
    4. Invasive Breast Carcinoma
    Interventions
    1. Other: Questionnaire Administration
    MeSH:Carcinoma Breast Neoplasms Carcinoma in Situ Carcinoma, Ductal Carcinoma, Intraductal, Noninfiltrating Carcinoma, Ductal, Breast
    HPO:Breast carcinoma Carcinoma Ductal carcinoma in situ Neoplasm of the breast

    Primary Outcomes

    Description: Will be measured by the Comprehensive Score for financial Toxicity questionnaire. Summary statistics including mean, standard deviation, median, and range for continuous variables, and frequency count and percentage for categorical variables will be provided. Various subgroup analyses may occur. In these cases, continuous variables will be compared using the two-sample t-test and categorical variables will be compared using chi-squared test or Fisher's exact test. Multivariate regression analysis will be performed to account for confounding and to increase the robustness of any causal inference.

    Measure: Prevalence of financial toxicity

    Time: Up to 1 year after completion of study

    Secondary Outcomes

    Description: Summary statistics including mean, standard deviation, median, and range for continuous variables, and frequency count and percentage for categorical variables will be provided. Various subgroup analyses may occur. In these cases, continuous variables will be compared using the two sample t-test and categorical variables will be compared using chi-squared test or Fisher's exact test. Multivariate regression analysis will be performed to account for confounding and to increase the robustness of any causal inference.

    Measure: Correlation between economic disruption from coronavirus disease 2019 (COVID-19) and financial toxicity

    Time: Up to 1 year after completion of study

    Description: Will be assessed using the Short Form-12 survey. Summary statistics including mean, standard deviation, median, and range for continuous variables, and frequency count and percentage for categorical variables will be provided. Various subgroup analyses may occur. In these cases, continuous variables will be compared using the two-sample t-test and categorical variables will be compared using chi-squared test or Fisher's exact test. Multivariate regression analysis will be performed to account for confounding and to increase the robustness of any causal inference.

    Measure: Relationship between financial toxicity and patient reported quality of life

    Time: Up to 1 year after completion of study

    Description: Will be assessed using the Breast-Q survey. Summary statistics including mean, standard deviation, median, and range for continuous variables, and frequency count and percentage for categorical variables will be provided. Various subgroup analyses may occur. In these cases, continuous variables will be compared using the two-sample t-test and categorical variables will be compared using chi-squared test or Fisher's exact test. Multivariate regression analysis will be performed to account for confounding and to increase the robustness of any causal inference.

    Measure: Relationship between financial toxicity and patient reported satisfaction with breast reconstruction

    Time: Up to 1 year after completion of study

    HPO Nodes


    Protein Mutations 0
    SNP 0

    HPO

    Alphabetical listing of all HPO terms. Navigate: Correlations   Clinical Trials


    HPO Nodes


    Protein Mutations 0
    SNP 0

    Reports

    Data processed on December 13, 2020.

    An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.

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    4,818 reports on interventions/drugs

    MeSH

    706 reports on MeSH terms

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    306 reports on HPO terms

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