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Name (Synonyms) | Correlation | |
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drug1908 | MagPro X100 Stimulator, B70 Fluid-Cooled Coil Wiki | 0.29 |
drug547 | CHAMindWell Wiki | 0.20 |
drug1655 | Internet Cognitive Behavioral Therapy plus CHAMindWell Wiki | 0.20 |
Name (Synonyms) | Correlation | |
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drug2640 | Psychoeducation Wiki | 0.20 |
drug3449 | Two doses of high-dose recombinant SARS-CoV-2 vaccine (CHO Cell) at the schedule of day 0, 14 Wiki | 0.20 |
drug1104 | EPDS (Edinburgh Postnatal Depression Scale) Wiki | 0.20 |
drug3309 | Test for SARS-CoV-2 Wiki | 0.20 |
drug403 | Behavioral Activation SSI Wiki | 0.20 |
drug3618 | Written Information Wiki | 0.20 |
drug3350 | Three doses of high-dose recombinant SARS-CoV-2 vaccine (CHO Cell) at the schedule of day 0, 14, 28 Wiki | 0.20 |
drug3467 | Typical surgical covered mask Wiki | 0.20 |
drug2631 | Prospective study across two time-points examining the impact of viral mitigation protocols on mental health Wiki | 0.20 |
drug1788 | Lifestyle change promotion program Wiki | 0.20 |
drug1370 | Growth Mindset SSI Wiki | 0.20 |
drug1934 | Maternal attachment, Edinburgh depression scoring and postpartum anxiety scale scores Wiki | 0.20 |
drug635 | COVID-surgRES questionaire Wiki | 0.20 |
drug3381 | Tocilizumab 20 MG/ML Intravenous Solution [ACTEMRA]_#1 (2 doses) Wiki | 0.20 |
drug4046 | test Wiki | 0.20 |
drug3424 | Travelan OTC Wiki | 0.20 |
drug3417 | Transplant patient Wiki | 0.20 |
drug3380 | Tocilizumab 20 MG/ML Intravenous Solution [ACTEMRA]_#1 Wiki | 0.20 |
drug1319 | GAD-7 (General Anxiety Disorder) scale Wiki | 0.20 |
drug2005 | Mindfullness based cognitive program Wiki | 0.20 |
drug4004 | self-care tools Wiki | 0.20 |
drug3352 | Three doses of middle-dose recombinant SARS-CoV-2 vaccine (CHO Cell) at the schedule of day 0, 14, 28 Wiki | 0.20 |
drug3455 | Two doses of middle-dose recombinant SARS-CoV-2 vaccine (CHO Cell) at the schedule of day 0, 14 Wiki | 0.20 |
drug461 | Blood collection Wiki | 0.20 |
drug429 | Biobehavioral Tele-rehabilitation Sessions Wiki | 0.20 |
drug3399 | Training clinicians in basic critical care and the management of severe COVID-19 cases Wiki | 0.20 |
drug293 | Assessment of postnatal depression using the the Edinburgh questionnaire between 4 and 6 weeks after delivery Wiki | 0.20 |
drug3207 | Supportive Therapy SSI Wiki | 0.20 |
drug3462 | Two doses of placebo at the schedule of day 0, 14 #middle-dose group# Wiki | 0.20 |
drug2273 | Online Intervention Mental Health COVID-19 Wiki | 0.20 |
drug3848 | lay telephone coaching Wiki | 0.20 |
drug3416 | Transparent mask Wiki | 0.20 |
drug3329 | The study does not required Wiki | 0.20 |
drug4013 | service of questionnaire Wiki | 0.20 |
drug49 | 38 questions questionnaire Wiki | 0.20 |
drug1790 | Limbix Spark Wiki | 0.20 |
drug770 | Clinical interview Wiki | 0.20 |
drug2009 | Mindfulness Based Cognitive Therapy for Resilience During COVID-19 plus CHAMindWell Wiki | 0.20 |
drug3222 | Survey and Questionnaire Wiki | 0.20 |
drug3353 | Three doses of placebo at the schedule of day 0, 14, 28 #High-dose group# Wiki | 0.20 |
drug3402 | Training of youth, community health assistants and community health workers. Wiki | 0.20 |
drug1273 | Feeling Good Digital App Wiki | 0.20 |
drug3252 | TCM prescriptions Wiki | 0.20 |
drug3461 | Two doses of placebo at the schedule of day 0, 14 #High-dose group# Wiki | 0.20 |
drug2363 | Pandemic control measures Wiki | 0.20 |
drug3314 | Testing for SARS-CoV-2 Wiki | 0.20 |
drug439 | Biological sampling Wiki | 0.20 |
drug2337 | PHQ-9 (Patient Health Questionnaire) Depression Scale Wiki | 0.20 |
drug3354 | Three doses of placebo at the schedule of day 0, 14, 28 #middle-dose group# Wiki | 0.20 |
drug3401 | Training load Wiki | 0.20 |
drug1101 | EMDR Wiki | 0.20 |
drug3281 | Telehealth Wiki | 0.20 |
drug3324 | The demographic, clinical, laboratory, and instrumental data Wiki | 0.20 |
drug406 | Behaviour Change Technique Intervention to Improve Quality of Life Wiki | 0.20 |
drug425 | Bicalutamide 150 Mg Oral Tablet Wiki | 0.14 |
drug577 | COVID Convalescent Plasma Wiki | 0.14 |
drug466 | Blood draw Wiki | 0.12 |
drug2284 | Online survey Wiki | 0.09 |
drug2951 | Saliva collection Wiki | 0.08 |
drug391 | Baricitinib Wiki | 0.07 |
drug1000 | Dexamethasone Wiki | 0.06 |
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drug2782 | Remdesivir Wiki | 0.04 |
drug3375 | Tocilizumab Wiki | 0.03 |
drug2448 | Placebo Wiki | 0.01 |
Name (Synonyms) | Correlation | |
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D003866 | Depressive Disorder NIH | 1.00 |
D003863 | Depression, NIH | 0.51 |
D019052 | Depression, Postpartum NIH | 0.31 |
Name (Synonyms) | Correlation | |
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D003865 | Depressive Disorder, Major NIH | 0.29 |
D001008 | Anxiety Disorders NIH | 0.23 |
D061218 | Depressive Disorder, Treatment-Resistant NIH | 0.20 |
D001714 | Bipolar Disorder NIH | 0.14 |
D040921 | Stress Disorders, Traumatic NIH | 0.08 |
D020920 | Dyssomnias NIH | 0.08 |
D013313 | Stress Disorders, Post-Traumatic NIH | 0.08 |
D013315 | Stress, Psychological NIH | 0.07 |
D020447 | Parasomnias NIH | 0.07 |
D002055 | Burnout, Professional NIH | 0.07 |
D020521 | Stroke NIH | 0.05 |
D000077062 | Burnout, Psychological NIH | 0.05 |
D004194 | Disease NIH | 0.04 |
Name (Synonyms) | Correlation | |
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HP:0100754 | Mania HPO | 0.14 |
HP:0001297 | Stroke HPO | 0.05 |
Navigate: Correlations HPO
There are 24 clinical trials
Postnatal depression is an important problematic in French population with approximatively 10 -20% of women who suffer from postnatal depression. This pathology may have strong negative impact on both women and neonate's health. The women's satisfaction degree in front of childbirth is an important factor associated with postnatal depression since women unsatisfied of their childbirth and/or women with a complicated childbirth are more encline to suffer from postnatal depression. It is likely that the actual context of Covid 19 pandemia and the change in obstetrical cares organization may have a negative impact on women's satisfaction about their childbirth and so a negative impact on the risk of postnatal depression.
Description: proportion of women with an Edinburgh score higher than 12 between 4 and 6 weeks postpartum
Measure: Report postnatal depression between 4 of 6 weeks during the covid 19 pandemia Time: 4-6 weeks postpartumDescription: Existence of an association with postnatal depression and these factors: socio demographic women's characteristics, modalities of pregnancy management, satisfaction and experience about delivery, postnatal pelvic floor disorders, self rated health for the woman and the child, modalities of delivery, prenatal anxiety
Measure: Report factors associated with postnatal depression between 4 of 6 weeks during the covid 19 pandemia Time: 4-6 weeks postpartumDescription: Scale from 0 to 10 of satisfaction ; answers to the WOMBLSQ4 questionnaire about childbirth experience and satisfaction
Measure: Describe the experience and the satisfaction about delivery during the covid 19 pandemia Time: within the week after deliveryThis study seeks to investigate the levels of parental stress across different demographic subgroups in the general parental population during the strict social distancing government-initiated non-pharmacological interventions (NPI's) related to the COVID-19 pandemic. The study also seeks to examine the predictors of parental stress rates related to these non-pharmacological interventions (NPI's). In addition, the research will investigate the association between parental stress associated and psychopathology symptoms (i.e., depression and generalized anxiety). The aim of the project is to: - Inform the policymakers, the general public, scientists, and health practitioners about the psychological associations of the COVID-19-related government-initiated measures on parental stress, with special focus on the school and kindergarten lockdowns. - Provide a foundation for policymakers and health-care professionals to employ interventions that protect families against possibly increased psychological stressors. - Help policymakers and healthcare professionals to better understand the association of demographic variables and other predictors on parental stress and parent-child dysfunction, which information necessary for evaluating the psychological impact of NPIs on parental stress and thus the framework under which decisions about school/kindergarten lockdowns are made.
Description: Three items from the Danish Parental Stress Scale (PSS) was selected, which intends to be a short measure of perceived stress resulting from being a parent (Pontoppidan et al., 2018). The scale consists of nine items measuring parental stress where each is measured on a five-point Likert scale (1-5), with the scores ranging from 3 to 15. Higher scores indicate higher parental stress. The following three were chosen in this large-scale investigation: 1) I feel overwhelmed by the responsibility of being a parent. 2) The major source of stress in my life is my child(ren), and 3) It is difficult to balance different responsibilities because of my child(ren) (Pontoppidan et al., 2018).
Measure: Measure of parental stress Time: All data was collected between March 31st 2020 and April 7th 2020, a period where the NPIs (nonpharmacological interventions) against the COVID-19 pandemic were identical and constant in NorwayDescription: The Patient Health Questionnaire 9 (PHQ-9; Kroenke, Spitzer & Williams, 2001) is used to measure symptoms of depression in accordance with the diagnostic criteria for major depressive disorder. The questionnaire consists of nine items where each is scored on a four-point Likert scale (0-3), with the range of scores from 0 to 27. Higher scores indicate greater depression severity, and scores above 10 are considered as the cut-off that indicating that the patient is within the depressive area.
Measure: Patient Health Questionnaire 9 Time: All data was collected between March 31st 2020 and April 7th 2020, a period where the NPIs (nonpharmacological interventions) against the COVID-19 pandemic were identical and constant in NorwayDescription: The Generalized Anxiety Disorder 7 (GAD-7; Spitzer, Kroenke, Williams & Löwe, 2006) is a questionnaire consisting of seven items measuring symptoms of anxiety and worry. The items are scored on a four-point Likert scale (0-3), with the scores ranging from 0 to 21. Higher scores indicate greater anxiety severity, and scores that are above the cutoff of 10 are considered to be in the clinical range (Spitzer et al., 2006). Specific cut-off for Norwegian samples have been found yielding a cut-off of 8 and above for high sensitivity and specificity (Johnson, Ulvenes, Øktedalen & Hoffart, 2019).
Measure: Generalized Anxiety Disorder 7 Time: All data was collected between March 31st 2020 and April 7th 2020, a period where the NPIs (nonpharmacological interventions) against the COVID-19 pandemic were identical and constant in NorwayThe article presents a protocol of a cross-sectional study of mental health of pregnant women in relation to the COVID 19 pandemic. The primary aim is to compare differences in anxiety and depression scores of pregnant women between countries affected by the COVID-19 pandemic. The secondary aim is to assess demographic, economic, and social aspects affecting maternal anxiety and depression scores among pregnant women worldwide in the time of the COVID-19 pandemic. Finally, investigators will be able to compare differences in perception of the different aspects of the COVID-19 pandemic (social distancing, restrictions related to delivery) between countries and according to the epidemic status (number of infected patients, number of reported deaths). The comparisons will also be done according to COVID-19 status of the participants.
Description: Anxiety measured by General Anxiety Disorder-7 (GAD-7) scale. Scoring:5-9 mild; 10-14 moderate; >15 severe. Minimum 0, maximum 21 points
Measure: Anxiety Time: 4 monthsDescription: Depression measured by Patient Health Questionnaire-9 (PHQ-9) scale. Scoring: 5-9 mild;10-14 moderate; 15-19 moderately severe; >20 severe. Minimum 0 maximum 27 points
Measure: Depression Time: 4 monthsThe current study aims to assess the feasibility, acceptance and clinical outcomes of a practical high-dose aiTBS protocol, including tapering treatments and symptom-based relapse prevention treatments, in patients with unipolar depression previously responsive to ECT and patients needing urgent treatment due to symptom severity during the COVID-19 pandemic.
Description: Less than or equal to 10
Measure: Proportion achieving remission on Hamilton Rating Scale for Depresion 24-it (HRSD-24) Time: Up to 10 days (From screening/baseline to end of the acute treatment)Description: changes in scores
Measure: Change in HRSD-24 Time: Up to 10 days (From screening/baseline to end of the acute treatment)Description: 50% Reduction in score
Measure: Response on HRSD-24 Time: Up to 10 days (From screening/baseline to end of the acute treatment)Description: Less than or equal to 4
Measure: Remission on Patient Health Questionnaire (PHQ-9) Time: Up to 10 days (From screening/baseline to end of the acute treatment)Description: 50% Reduction in score
Measure: Response on PHQ-9 Time: Up to 10 days (From screening/baseline to end of the acute treatment)Description: changes in scores
Measure: Change in PHQ-9 Time: Up to 10 days (From screening/baseline to end of the acute treatment)Description: Less than or equal to 4
Measure: Remission on General Anxiety Disorder 7 item (GAD-7) Time: Up to 10 days (From screening/baseline to end of the acute treatment)Description: 50% Reduction in score
Measure: Response on GAD-7 Time: Up to 10 days (From screening/baseline to end of the acute treatment)Description: changes in scores
Measure: Change in GAD-7 Time: Up to 10 days (From screening/baseline to end of the acute treatment)Description: Less than or equal to 12
Measure: Remission on Beck Depression Inventory (BDI-II) Time: Up to 10 days (From screening/baseline to end of the acute treatment)Description: 50% Reduction in Score
Measure: Response on BDI-II Time: Up to 10 days (From screening/baseline to end of the acute treatment)Description: changes in scores
Measure: Change on BDI-II Time: Up to 10 days (From screening/baseline to end of the acute treatment)Description: Score of 0
Measure: Remission on Beck Scale for Suicidal Ideation (SSI) Time: Up to 10 days (From screening/baseline to end of the acute treatment)Description: changes in scores
Measure: Change on SSI Time: Up to 10 days (From screening/baseline to end of the acute treatment)Description: changes in scores
Measure: Change in WHO Disability Assessment Schedule (WHODAS) Time: Up to 10 days (From screening/baseline to end of the acute treatment)Description: Includes number of treatment days needed and number going on to receive ECT
Measure: Proportion of Patients Maintaining Response During Relapse Prevention Time: 24 weeks (Tapering and Relapse prevention phase)It is aimed to investigate the depression and quality of life of Turkish society caused by Covid-19 pandemic and reveal the relationship between them
Description: Participants are asked to give information about: age, gender, educational status, height, weight, occupation, working status, city inhabited, whether they live alone or with someone, whether they have a chronic disease, have a pet, do physical activity, eat healthy and sufficient, have qualified sleep, whether they are supported economically.
Measure: Sociodemographic information form Time: two months after Covid 19 recognised as pandemicDescription: Zung depression scale, developed by Zung (Zung, 1965), is patient rating depression scale, was used to asses four domains related to depression; somatic, mood disorders, psychomotor and psychological disorders. Each question is rated on a 4-point Likert scale (0- never, 1- sometimes, 2- frequently, 3- always). Scale contains 10 straight 10 reverse questions. The total score is calculated from the raw score obtained (total score = (raw score / 80) * 100). Accordingly, scores less than 50 are normal or no psychopathology; between 50 and 59 points indicates mild level, between 60 and 69 points indicate moderate level and 70 and above points indicate severe level depression (Thurber et al., 2002). The validity reliability of the scale was studied on Turkish society (Gencdogan & Nihal, 2011)
Measure: Zung Depression Scale Time: two months after Covid 19 recognised as pandemicDescription: World Health Organization Quality of Life Bref is the short version of the WHOQOL-100 to assess the health-related quality of life (Harper et al., 1998), which has efficient psychometric properties, valid and reliable for Turkish society (Eser et al., 1999). It is essential for epidemiological survey and international report has built for psychometric properties for 26 country where Turkey within (Skevington et al., 2004). It has 4 domains; physical health, psychology, social relations and environment. Each question is answered on a 5-point Likert scale. The raw score is converted into a percentage system. The quality of life is interpreted as good as it gets closer to 100% (Akvardar et al., 2006).
Measure: World Health Organization Quality of Life - Bref Time: two months after Covid 19 recognised as pandemicThis study aims to identify the preference of the class modalities (classroom or online) in undergraduate and graduate students. Additionally, to explore if the presence of any mental state alterations such as depression or anxiety due to the COVID-19 pandemic can alter their perception of academic performance.
Description: This scale will explore the effort and confidence of the participants. The minimum score for each facet is 10, and the maximum score is 70.
Measure: Academic Self-Concept Scale Score Time: up to 3 monthsDescription: This inventory will be used to identify the presence and intensity of depressive disorders. The minimum score is 0, and the maximum score is 27.
Measure: PHQ-9 Score Time: up to 3 monthsDescription: This questionnaire will be used to evaluate the presence and intensity of anxiety disorders. The minimum score is 0, and the maximum score is 21.
Measure: GAD-7 Score Time: up to 3 monthsDescription: Students' preference of classroom or online classes.
Measure: Preference of teaching method Time: up to 3 monthsDescription: Students' perception of changes in their academic performance: got better, worse, or stayed the same.
Measure: Self perceived academic performance Time: up to 3 monthsDescription: Students' perception of changes in their grades: got better, worse, or stayed the same.
Measure: Academic grades changes Time: up to 3 monthsThe current study aims to assess the feasibility, acceptance and clinical outcomes of a practical high-dose LFR protocol, including tapering treatments and symptom-based relapse prevention treatments, in patients with bipolar depression previously responsive to ECT and patients needing urgent treatment due to symptom severity during the COVID-19 pandemic.
Description: Less than or equal to 10 This scale is used to quantify the severity of symptoms of depression Scale range: 0-76 (total score) Lower scores indicate lower severity of depressive symptoms (i.e., better outcome) Higher scores indicate higher severity of depressive symptoms (i.e., worse outcome)
Measure: Proportion achieving remission on Hamilton Rating Scale for Depresion 24-it (HRSD-24) Time: Up to 10 days (From screening/baseline to end of the acute treatment)Description: changes in scores This scale is used to quantify the severity of symptoms of depression Scale range: 0-76 (total score) Lower scores indicate lower severity of depressive symptoms (i.e., better outcome) Higher scores indicate higher severity of depressive symptoms (i.e., worse outcome)
Measure: Change in Hamilton Rating Scale for Depresion 24-it (HRSD-24) Time: Up to 10 days (From screening/baseline to end of the acute treatment)Description: 50% Reduction in score This scale is used to quantify the severity of symptoms of depression Scale range: 0-76 (total score) Lower scores indicate lower severity of depressive symptoms (i.e., better outcome) Higher scores indicate higher severity of depressive symptoms (i.e., worse outcome)
Measure: Response on Hamilton Rating Scale for Depresion 24-it (HRSD-24) Time: Up to 10 days (From screening/baseline to end of the acute treatment)Description: changes in scores This scale is used to quantify the severity of symptoms of mania Scale range: 0-60 (total score) Lower scores indicate lower severity of manic symptoms (i.e., better outcome) Higher scores indicate higher severity of manic symptoms (i.e., worse outcome)
Measure: Change in Young Mania Rating Scale (YMRS) Time: Up to 10 days (From screening/baseline to end of the acute treatment)Description: Less than or equal to 4 This scale is used to quantify the severity of symptoms of depression Scale range: 0-27 (total score) Lower scores indicate lower severity of depressive symptoms (i.e., better outcome) Higher scores indicate higher severity of depressive symptoms (i.e., worse outcome)
Measure: Remission on Patient Health Questionnaire (PHQ-9) Time: Up to 10 days (From screening/baseline to end of the acute treatment)Description: 50% Reduction in score This scale is used to quantify the severity of symptoms of depression Scale range: 0-27 (total score) Lower scores indicate lower severity of depressive symptoms (i.e., better outcome) Higher scores indicate higher severity of depressive symptoms (i.e., worse outcome)
Measure: Response on Patient Health Questionnaire (PHQ-9) Time: Up to 10 days (From screening/baseline to end of the acute treatment)Description: changes in scores This scale is used to quantify the severity of symptoms of depression Scale range: 0-27 (total score) Lower scores indicate lower severity of depressive symptoms (i.e., better outcome) Higher scores indicate higher severity of depressive symptoms (i.e., worse outcome)
Measure: Change in Patient Health Questionnaire (PHQ-9) Time: Up to 10 days (From screening/baseline to end of the acute treatment)Description: Less than or equal to 4 This scale is used to quantify the severity of symptoms of anxiety Scale range: 0-21 (total score) Lower scores indicate lower severity of anxiety symptoms (i.e., better outcome) Higher scores indicate higher severity of anxiety symptoms (i.e., worse outcome)
Measure: Remission on General Anxiety Disorder 7 item (GAD-7) Time: Up to 10 days (From screening/baseline to end of the acute treatment)Description: 50% Reduction in score This scale is used to quantify the severity of symptoms of anxiety Scale range: 0-21 (total score) Lower scores indicate lower severity of anxiety symptoms (i.e., better outcome) Higher scores indicate higher severity of anxiety symptoms (i.e., worse outcome)
Measure: Response on General Anxiety Disorder 7 item (GAD-7) Time: Up to 10 days (From screening/baseline to end of the acute treatment)Description: changes in scores This scale is used to quantify the severity of symptoms of anxiety Scale range: 0-21 (total score) Lower scores indicate lower severity of anxiety symptoms (i.e., better outcome) Higher scores indicate higher severity of anxiety symptoms (i.e., worse outcome)
Measure: Change in General Anxiety Disorder 7 item (GAD-7) Time: Up to 10 days (From screening/baseline to end of the acute treatment)Description: Less than or equal to 12 This scale is used to quantify the severity of symptoms of depression Scale range: 0-63 (total score) Lower scores indicate lower severity of depressive symptoms (i.e., better outcome) Higher scores indicate higher severity of depressive symptoms (i.e., worse outcome)
Measure: Remission on Beck Depression Inventory (BDI-II) Time: Up to 10 days (From screening/baseline to end of the acute treatment)Description: 50% Reduction in Score This scale is used to quantify the severity of symptoms of depression Scale range: 0-63 (total score) Lower scores indicate lower severity of depressive symptoms (i.e., better outcome) Higher scores indicate higher severity of depressive symptoms (i.e., worse outcome)
Measure: Response on Beck Depression Inventory (BDI-II) Time: Up to 10 days (From screening/baseline to end of the acute treatment)Description: changes in scores This scale is used to quantify the severity of symptoms of depression Scale range: 0-63 (total score) Lower scores indicate lower severity of depressive symptoms (i.e., better outcome) Higher scores indicate higher severity of depressive symptoms (i.e., worse outcome)
Measure: Change on Beck Depression Inventory (BDI-II) Time: Up to 10 days (From screening/baseline to end of the acute treatment)Description: Score of 0 This scale is used to assess the presence or absence of suicidal ideation and the degree of severity of suicidal ideas Scale range: 0 - 38 (total score) Lower scores indicate lower severity of suicidal ideation (i.e., better outcome) Higher scores indicate higher severity of suicidal ideation (i.e., worse outcome)
Measure: Remission on Beck Scale for Suicidal Ideation (SSI) Time: Up to 10 days (From screening/baseline to end of the acute treatment)Description: changes in scores This scale is used to assess the presence or absence of suicidal ideation and the degree of severity of suicidal ideas Scale range: 0 - 38 (total score) Lower scores indicate lower severity of suicidal ideation (i.e., better outcome) Higher scores indicate higher severity of suicidal ideation (i.e., worse outcome)
Measure: Change on Beck Scale for Suicidal Ideation (SSI) Time: Up to 10 days (From screening/baseline to end of the acute treatment)Description: changes in scores
Measure: Change in WHO Disability Assessment Schedule (WHODAS) Range 0-38 Time: Up to 10 days (From screening/baseline to end of the acute treatment)Description: Includes number of treatment days needed and number going on to receive ECT
Measure: Proportion of Patients Maintaining Response During Relapse Prevention Time: 24 weeks (Tapering and Relapse prevention phase)The main objective of the study will be to evaluate the effectiveness of an adjuvant lifestyle-based intervention for treatment-resistant patients with major depressive disorder. Patients will be allocated to one of these three groups: 1)Treatment prescribed by their mental health team plus written lifestyle change suggestions 2)Treatment prescribed by their mental health team plus written lifestyle change suggestions plus 8-week Mindfulness-based cognitive therapy (MBCT) program 3) Treatment prescribed by their mental health team plus written lifestyle change suggestions plus 8-week lifestyle change promotion program. We will collect patient data using the questionnaires administered at baseline, immediately after the intervention, and at six and 12-month follow-up. The primary outcome will be depression severity and secondary outcomes will include health-related quality of life.
Description: Beck Depression Inventory-II (BDI-II)
Measure: Depression severity Time: 12 monthDescription: Questionnaire (EQ-5D)
Measure: Health-related quality of life Time: 12 monthThe aim of this multicenter prospective study is to evaluate the association between the Covid-19 pandemic maternal psychological distress with the postpartum depression, demographic and anaesthesiologic variables
Description: Prevalence of postpartum depression during the Covid-19 pandemic with EPDS scale (Edinburgh postnatal depression scale)
Measure: Correlation between the Covid-19 pandemic and postpartum depression with EPDS scale (Edinburgh postnatal depression scale) Time: 40 days postpartumDescription: Association between the Covid-19 pandemic, postpartum depression and type of anaesthesia (general, epidural, spinal, combined, epidural analgesia for vaginal delivery)
Measure: Correlation between the Covid-19 pandemic, postpartum depression and type of anaesthesia (general, epidural, spinal, combined, epidural analgesia for vaginal delivery) Time: 10 minutes postpartumDescription: Association between the Covid-19 pandemic, postpartum depression and postpartum pain assessed during postanesthesia care unit stay assessed by Numeric Pain Rating Scale (Scale 0-10 where 0 equals no pain and 10 maximum possible pain)
Measure: Correlation between the Covid-19 pandemic, postpartum depression and postpartum pain Time: 2 minutes prior to discharge from the Postanaesthesia care unitDescription: Association between the Covid-19 pandemic, postpartum depression and postpartum pain assessed during postanesthesia care unit stay assessed by Numeric Pain Rating Scale (Scale 0-10 where 0 equals no pain and 10 maximum possible pain)
Measure: Correlation between the Covid-19 pandemic, postpartum depression and postpartum pain Time: 2 minutes after admission to the Postanaesthesia care unitStudy description: The present study seeks to investigate the predictors and maintaining mechanisms of depression and anxiety symptoms during the COVID-19 pandemic, exactly 3 months following the strictest viral mitigation strategies initiated in Norway in response to the pandemic. This is the time period where the major pandemic protocols are lifted in Norway, following three months of strict pandemic mitigation protocols. The study further aims to identify subgroups with highest levels of depressive and anxiety symptoms during the measurement period, to identify vulnerable subgroups with maintained symptoms three months following the pandemic. Hypotheses and research questions: Research Question 1: What is the level of depressive and anxiety symptoms three months following the employment of the strict viral mitigation protocols (i.e., physical distancing protocols) in the general adult population? What are the proportion above the validated cut-offs for depression and general anxiety? Hypothesis 1: There will be a significant decrease in the levels of depression and anxiety symptoms from the baseline (T1) with the strictest mitigation protocols to measurement the measurement period three months into pandemic (T2) where major pandemic mitigation protocols are lifted. Additionally, there will be a significant decrease in the proportion of the sample meeting validated cut-offs for depression and anxiety from T1 to T2. Hypothesis 2: Higher level at T1 and less reduction from T1 to T2 in positive metacognitions, negative metacognitions, and unhelpful coping strategies all measured with CAS-1, will be related to less reduction in depression and anxiety, above and beyond age, gender, and education. Higher level at T1 and increases from T1 to T2 in physical activity and perceived competence will be related to greater reduction in depression and anxiety, above and beyond, age, gender, and education. Exploratory: The investigators will further explore the proportion showing reliable change in depression and anxiety and investigate the differences in changes in depression and anxiety across different demographic subgroups in the sample
Description: • The Patient Health Questionnaire 9 (PHQ-9; Kroenke, Spitzer & Williams, 2001) is used to measure symptoms of depression in accordance with the diagnostic criteria for major depressive disorder. The questionnaire consists of nine items where each is scored on a four-point Likert scale (0-3), with the range of scores from 0 to 27. Higher scores indicate greater depression severity, and scores above 10 are considered as the cut-off that indicating that the patient is within the depressive area.
Measure: Patient Health Questionnaire 9 Time: Data is set to be collected starting from 22nd of June until enough data has been collected.The data collection period will last no longer than three weeks.Description: • The Generalized Anxiety Disorder 7 (GAD-7; Spitzer, Kroenke, Williams & Löwe, 2006) is a questionnaire consisting of seven items measuring symptoms of anxiety and worry. The items are scored on a four-point Likert scale (0-3), with the scores ranging from 0 to 21. Specific cut-off for Norwegian samples have been found yielding a cut-off of 8 and above for high sensitivity and specificity (Johnson, Ulvenes, Øktedalen & Hoffart, 2019).
Measure: Generalized Anxiety Disorder 7 Time: Data is set to be collected starting from 22nd of June until enough data has been collected.The data collection period will last no longer than three weeks.Studies have shown that admission to hospital during a coronavirus epidemic is associated with increased levels of anxiety, depression and panic disorder. During the SARS-CoV-2 pandemic in North London the Royal Free Hospital admitted over 500 patients with Covid-19. As part of the standard of care, these patients are screened at 8 weeks post discharge for signs of anxiety and depression. The Feeling Good app is a NHS approved digital application which utilises applied relaxation, mindfulness based cognitive therapy and positive visualisation through audio tracks for the treatment of anxiety and depression. This is a naturalistic cohort study aimed to track the post illness psychological symptoms of those who have been admitted with Covid-19 to the Royal Free hospital up to 5-7 months after discharge. The study population is those who are exhibiting anxiety or depressive symptoms as measure by the PHQ-2 or TSQ questionnaires. All those with symptoms will be offered free access to a NHS approved app for anxiety and depression, and followed up for 3 months after recruitment to track changes to their symptoms.
Description: Generalised anxiety disorder score (GAD-7) scale. Score 0-21, with a higher score associated with greater anxiety symptoms. Scores of 5, 10, and 15 represent cut-points for mild, moderate, and severe anxiety, respectively. GAD-7 score at baseline will be controlled for.
Measure: Anxiety as measured by generalised anxiety disorder score (GAD-7) scale Time: Day 14Description: The Patient Health Questionnaire (PHQ-9) is a screening tool for the identification of depressive disorders, which has been validated for use in primary care. Each of the nine items in the questionnaire is based on the DSM diagnostic criteria for clinical depression. The PHQ-9 is scored out of 27 according to severity, where score of 5-9 indicates mild depression, 10-14 moderate, 15-19 moderately severe, and 20 or above severe depression.
Measure: Depression as measured by the patient health questionnaire 9 (PHQ-9) Time: 14 days and week 12Description: The Trauma screening questionnaire (TSQ) is a 10 point scale used to identify symptoms of post traumatic stress disorder (PTSD), with a score between 0 and 10, with a score of 6 or higher scored as positive.
Measure: Trauma as measured by Trauma screening questionnaire (TSQ) Time: 12 weeksDescription: Generalised anxiety disorder score (GAD-7) scale. Score 0-21, with a higher score associated with greater anxiety symptoms. Scores of 5, 10, and 15 represent cut-points for mild, moderate, and severe anxiety, respectively. GAD-7 score at baseline will be controlled for.
Measure: Anxiety as measured by generalised anxiety disorder score (GAD-7) scale Time: Week 12Description: Risk factors for psychological distress from admission with Covid-19 will be collected, these will include, age, gender, ethnicity, length of hospital stay, oxygen requirement, co-morbidites, years of education, smoking status, occupation.
Measure: Risk associated with distress Time: Baseline analysisDescription: Framework analysis. Qualitative feedback of patient experience. Semi structured interviews of a subset of patients will be performed to gain further insight into the patient experience. These will be analysed using a framework thematic analysis, to identify themes which will then be used to code the text.
Measure: Qualitative analysis Time: BaselineThis study evaluates the effectiveness of a Positive Psychology intervention, that is focused on increasing the positive emotions and strengths of human beings. It is compared to the effectiveness of an online treatment with the change of the same participants before and after receiving the treatment accompanied by a chat support service vs. the treatment solely. The changes are being assessed through worldwide validated measures such as psychometrics.
Description: The State/Trait Anxiety Inventory consists of two subscales of 20 items each that measure anxiety as a transient state of tension (Scale A-State), and as a characteristic of the personality relatively stable over time (Scale B -trait). The items are composed by an assertion to which the subject responds indicating their degree of identification. In the case of state anxiety, the scale goes from 1 (not at all), 2 (somewhat), 3 (moderately), 4 (very much), while in the trait anxiety it ranges from 1 (almost never), 2 (sometimes), 3 (often), 4 (almost always). In both, a percentage of the items evaluate well-being or absence of anxiety, while the rest of the items to the presence of anxiety. Scores range from 20 to 80, in each subscale, with higher scores correlating with greater anxiety. It is expected a statistically significant decrease (P < 0.05) in the anxiety symptoms.
Measure: Decrease in the score of Anxiety symptoms Time: [Time Frame: 2 weeks to one month, depending on the development of the patient and the completion of the 15 modules.]Description: The Beck Depression Inventory is a self-report that provides a measure of the presence and severity of depression. Contains 21 items indicative of symptoms such as sadness, crying, loss of pleasure, feelings of failure and guilt, suicidal thoughts or desires, pessimism, etc. Each item is answered on a 4-point scale, from 0 to 3, where each number is identified differently for each item, in all of them 0 means absence and 3 full presence (e.g. sadness), except for items 16 (changes in the sleep pattern) and 18 (changes in appetite) that contain 7 categories. The minimum and maximum scores in the test are 0 and 63. Cut-off points ha that allow classifying those evaluated in one of the following four groups: 0-13, minimum depression; 14-19, mild depression; 20-28, moderate depression; and 29-63, severe depression. It is expected a statistically significant decrease (P < 0.05) in the depression symptoms.
Measure: Change in the symptoms of depression Time: [Time Frame: 2 weeks to one month, depending on the development of the patient and the completion of the 15 modules.]Description: On the Generalized Anxiety Disorder 7-item (GAD-7) scale subjects are asked how often, during the last 2 weeks, they have been bothered by each of the 7 core symptoms of generalized anxiety disorder. Response options are "not at all," "several days," "more than half the days," and "nearly every day," scored as 0, 1, 2, and 3, respectively. Therefore, GAD-7 scores range from 0 to 21, with scores of ≥5, ≥10, and ≥15 represent mild, moderate, and severe anxiety symptom levels, respectively. It is expected a statistically significant decrease (P < 0.05) in the General Anxiety symptoms.
Measure: Change in the symptoms of General Anxiety Disorder Time: [Time Frame: 2 weeks to one month, depending on the development of the patient and the completion of the 15 modules.]Description: The Scale of Post-traumatic Stress Traits in the Mexican Youth Exposed to Social Violence It is a brief scale with 24 symptoms corresponding to the diagnosis of PTSD, to respond by self-report, and a scale was used discretely from 1 (strongly disagree) to 4 (strongly agree). The total score was obtained by arithmetic sum. The minimum possible is 24 and the maximum 96. It is expected a statistically significant decrease (P < 0.05) in the posttraumatic stress symptoms.
Measure: Change in the score of Posttraumatic stress symptoms Time: [Time Frame: 2 weeks to one month, depending on the development of the patient and the completion of the 15 modules.]Description: It is composed of seven items with options of 0 = nothing, 3 = a lot, and measures the fear in its emotional component, that is, the fear to adversities in the context and the feelings it disseminates, as well as others economic and social fears, in this case, adapted for the Sars-Cov2 pandemic. In previous studies, an acceptable internal consistency of .95 was reached. It consists of several items about the fear of being a SARS Cov2 victim in diverse contexts. In the present study, a Cronbach alpha coefficient of 0.96 was obtained. It is expected a statistically significant decrease (P < 0.05) in the widespread fear symptoms.
Measure: Changes in the Widespread fear Scale Time: [Time Frame: 2 weeks to one month, depending on the development of the patient and the completion of the 15 modules.]Description: This instrument assesses the quality patterns of sleep. It differentiates the "poor" and "good" sleep by measuring seven areas, where the range score of answers are from 0 to 3, the global sum of this scale can be a value between 0 to 60, and the cutoff point is "5" that indicates a "poor" sleep quality. It is expected a statistically significant increase (P < 0.05) in the Sleep Quality Index.
Measure: Change in the score of The Pittsburgh Sleep Quality Index. Time: [Time Frame: 2 weeks to one month, depending on the development of the patient and the completion of the 15 modules.]Description: This scale aims to assess the frequency of attitudes, behaviors and plans to commit suicide. It is divided into 19 items with a response option of 0 to 2, giving a total of 0 to 38 where a score equal to or greater than 10 indicates an existing risk of suicide. This scale has been validated in the Mexican population (González-Macip & Díaz-Martínez, 2000).
Measure: Change on the Suicidal Thoughts Scale Time: [Time Frame: 2 weeks to one month, depending on the development of the patient and the completion of the 15 modules.]Postpartum depression (PPD) represent around 15% of birth in developed countries. The context of the COVID-19 epidemy represents a possible source of additional emotional distress. The objective of this study is to determine the screening prevalence and risk factors of postpartum depression, among women who deliver in fourth hospital in the North of France in the context of the COVID epidemy.
Description: Variation of prevalence of clinically-significant post-partum depressive symptoms
Measure: Variation of prevalence of clinically-significant post-partum depressive symptoms Time: up to 35 days after deliveryThis study aims to advance research on group sessions for mental health. The first-of-its-kind study measuring various features in a group setting, combining rich metadata in creating state-of-the-art machine learning models, and developing workflows for mental health that are both scalable and personalized.
Description: A repeated measures, within-subject design using exploratory techniques will identify the best group session features or combination of features that correlate with or predict change on the PHQ-9.
Measure: Patient Health Questionnaire (PHQ-9) Time: March 30, 2021Description: A repeated measures, within-subject design using exploratory techniques will identify the best group session features or combination of features that correlate with or predict change on the GAD-7.
Measure: Generalized Anxiety Disorder (GAD-7) Time: June 20, 2021Women who were able to benefit from psychiatric follow-up during the quarantine by tele-consultation have a lower risk of anxious and depressive symptoms than those who did not receive follow-up.
Description: To compare depression and anxiety HAD score of women who have a medical history ofpost-partum depression according to a follow-up or not during the quarantine by tele-consultation Score less than or egal to 7 = no case Score between 8 and 10 = uncertain case Score higher than or equal to 11 = confirmed case
Measure: Evaluation of Hospital anxiety and depression scale (HAD) Time: 15 minutesDescription: To compare the result of EPDS in women who have a child of less 2 years old according to a follow-up or not by tele-consultation during the quarantine
Measure: Evaluation of Edinburgh Postpartum Depression Scale (EPDS) Time: 15 minutesDescription: Anxiety and depression of fathers will be assessed with HAD scale
Measure: Evaluation of HAD score in fathers Time: 15 minutesDescription: EPDS will be assessed in fathers who have a child of less than 2 years old
Measure: Evaluation of EPDS in fathers Time: 15 minutesDescription: The aim is to show that maternals anxious and depressive symptoms would be correlated to paternals positively symptoms
Measure: Study of the relationship between maternals and paternals symptoms Time: 15 minutesDescription: Look for a correlation between the difficulties in child during the quarantine describe by parents and anxiety and depression symptoms in parents The difficulties in child will be illustrated with the rate of children with difficulties describe by the parents
Measure: Study of difficuties in child during the quarantine Time: 15 minutesDescription: Description of risk factors and protection factors setting up by the family during this quarantine period
Measure: Risk and protection factors Time: 15 minutesOver 3 million teenagers in the USA have depression, and rates of depression and suicide are sharply increasing. Teenage depression has far-reaching consequences including impairments in academic and work performance and social and family relationships, substance abuse, and worsening of other health conditions, which can persist into adulthood. Access to mental health care for teenagers is limited due to a shortage of mental health providers and many teenagers and parents are reluctant to take antidepressants. COVID-19 and mandated physical and social distancing is expected to increase rates of teenage depression, and further limit access to traditional methods of care (e.g. psychotherapy). This highlights an urgent need to develop accessible, digital treatments for teenage depression to address the serious mental health impacts of the COVID-19 pandemic. This fully virtual study (https://www.limbix.com/spark) will compare the relative safety, effectiveness, and engagement of a mobile application based on cognitive behavioral therapy and behavioral activation (Limbix Spark), focusing on the idea that engaging in behaviors that are rewarding or provide a sense of mastery can be effective in reducing symptoms of depression. Limbix Spark will be compared to a mobile app containing educational material about depression (Psychoeducation).
Description: Change in depressive symptoms measured by Personal Health Questionnaire (PHQ-8) (min: 0; max: 24, with higher score indicating more severe depression).
Measure: Change in depressive symptoms Time: Change from Baseline to Post treatment (5 weeks)Description: Change in anxiety symptoms measured by the Generalized Anxiety Disorder (GAD-7) scale (min: 0; max: 21, with higher score indicating more severe anxiety).
Measure: Change in anxiety symptoms Time: Change from Baseline to Post treatment (5 weeks)Description: Change in parent report of child depressive symptoms measured by the Mood and Feelings Questionnaire (MFQ) (min: 0; max: 26, with higher score indicating more severe depression)
Measure: Change in parent report of child depressive symptoms Time: Change from Baseline to Post treatment (5 weeks)Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has begun, first in Wuhan, China, and then became a pandemic. The first SARS-CoV-2 case in Turkey was reported on March 11, 2020. People older than 65 years old became subject to lock down measures beginning on March 21, while people younger than 20 years old became subject to lock down measures beginning on April 03. A total lock down has been implemented a few times lasting between 3 to 4 days, especially at weekends. Several studies show that mental health problems could occur in public during the SARS-CoV-2 pandemic. Depression and anxiety are a commonly known mental health issue in post-stroke patients. This patient population, who usually have to spend most of their time at home, remained completely at home and socially isolated due to the precautions required by the pandemic. Based on the above research evidence; depression, anxiety and phobia of SARS-CoV-2 may increase in the post stroke patients due to being in risk group and effects of measures taken against SARS-CoV-2 pandemic. Therefore, we aimed to assess the depression, anxiety and SARS-CoV-2 phobia in post stroke patients during SARS-CoV-2 outbreak, and to explore the potential influence factors.
Description: The Hospital Anxiety and Depression Scale evaluation includes a total of 14 questions (score range 0-3), which are scored to separately estimate anxiety and depressive status (7 questions each). The individual score for the anxiety and depression subscales may vary from 0 to 21. The aim of this scoring system is not to make an objective diagnosis, but to determine the current presence and tendency to anxiety or depression at the time of diagnosis. A HADS score of 8 to 10 is broadly accepted as indicating mild symptoms, a score between 11-16 suggests moderate anxiety or depression, and a score of 16 or more indicates severe anxiety or depressive symptoms
Measure: Hospital Anxiety and Depression Scale Time: 3 monthsDescription: The Covid 19 Phobia Scale is a self-report instrument with a five-point Likert-type scale to assess the levels of SARS-CoV-2 phobia. All items are rated on a 5-point scale from "strongly disagree (1)" to "strongly agree (5)." The scores on the scale can range between 20 and 100 and a higher score indicates a greater phobia in the respected subscales and total scale. In the present study total scale scores ranged from 20 to 100. The scale examines four main factors: psychological, psycho-somatic, economic and social
Measure: Covid 19 Phobia Scale Time: 3 monthsHospital health workers involved in the coronavirus epidemic are facing several challenges such as direct exposure and involvement in the resolution of major public health emergencies, exposure to potentially fatal contamination, physical exhaustion , unadjusted work organizations, the unusual number of deaths among patients, colleagues and close relatives, and significant ethical challenges in decision-making. Preliminary data suggests that frontline and lay professionals suffer from different types of psychological distress. These data highlight the importance of screening for psychological distress in response to the scale of the pandemic and the provision of targeted psychological interventions, such as Eye Movement Desensitization and Reprocessing (EMDR, desensitization and neuro-emotional integration by eye movements), to improve the psychological well-being of healthcare workers exposed to COVID-19. This project is both a cohort study with the proposal of a randomized trial to evaluate an intervention adapted to the exceptional circumstances of the crisis. As such, it is designed as Trial(s) Within Cohort design (TWIC).
Description: This study is investigating three different conditions (PTSD, Depression and Burnout) each assessed with its own primary endpoint. Thus, the trial will have three primary endpoints. Change over a 6 months period in symptoms of PTSD measured by the Post-Traumatic Stress Disorder Checklist Scale for Diagnostic and Statistical Manual of mental disorders fifth edition ((DSM-5), PCL-5). The PCL-5 score is on a scale from 0 to 80. The higher the score, the higher the level of PTSD symptoms are.
Measure: Efficacy on symptoms of Post-Traumatic Stress Disorder Time: From inclusion to 6 months after inclusionDescription: Change over a 6 months period in symptoms of Burnout measured by the Professional Quality Of Life questionnaire (ProQOL). The ProQOL score is on a scale from 30 to 150. The higher the score, the higher the level of Burnout symptoms are.
Measure: Efficacy on symptoms of Burnout Time: From inclusion to 6 months after inclusionDescription: Change over a 6 months period in symptoms of depression measured by the Patient Health Questionnaire (PHQ-9). The PHQ-9 score is on a scale from 0 to 27. The higher the score, the higher the level of depression symptoms are.
Measure: Efficacy on symptoms of Depression Time: From inclusion to 6 months after inclusionDescription: Change over a 3 months period in symptoms of PTSD measured by the Post-Traumatic Stress Disorder Checklist Scale for Diagnostic and Statistical Manual of mental disorders fifth edition ((DSM-5), PCL-5). The PCL-5 score is on a scale from 0 to 80. The higher the score, the higher the level of PTSD symptoms are.
Measure: Short-term efficacy on symptoms of PTSD Time: From inclusion to 3 months after inclusionDescription: Change over a 3 months period in symptoms of Burnout measured by the Professional Quality Of Life questionnaire (ProQOL). The ProQOL score is on a scale from 30 to 150. The higher the score, the higher the level of Burnout symptoms are.
Measure: Short-term efficacy on symptoms of Burnout Time: From inclusion to 3 months after inclusionDescription: Change over a 3 months period in symptoms of depression measured by the Patient Health Questionnaire (PHQ-9). The PHQ-9 score is on a scale from 0 to 27. The higher the score, the higher the level of depression symptoms are.
Measure: Short-term efficacy on symptoms of Depression Time: From inclusion to 3 months after inclusionDescription: Change over a 12 months period in symptoms of PTSD measured by the Post-Traumatic Stress Disorder Checklist Scale for Diagnostic and Statistical Manual of mental disorders fifth edition ((DSM-5), PCL-5) for the participants who will be enrolled in the trial at M0 of the cohort. The PCL-5 score is on a scale from 0 to 80. The higher the score, the higher the level of PTSD symptoms are.
Measure: Long-term efficacy on symptoms of PTSD Time: From inclusion to 12 months after inclusionDescription: Change over a 12 months period in symptoms of Burnout measured by the Professional Quality Of Life questionnaire (ProQOL) for the participants who will be enrolled in the trial at M0 of the cohort. The ProQOL score is on a scale from 30 to 150. The higher the score, the higher the level of Burnout symptoms are.
Measure: Long-term efficacy on symptoms of Burnout Time: From inclusion to 12 months after inclusionDescription: Change over a 12 months period in symptoms of depression measured by the Patient Health Questionnaire (PHQ-9) for the participants who will be enrolled in the trial at M0 of the cohort. The PHQ-9 score is on a scale from 0 to 27. The higher the score, the higher the level of depression symptoms are.
Measure: Long-term efficacy on symptoms of Depression Time: From inclusion to 12 months after inclusionDescription: Change over a 6 months period in anxiety measured by the Generalized Anxiety Disorder-7 questionnaire (GAD-7). The GAD-7 score is on a scale from 0 to 21. The higher the score, the higher the level of anxiety symptoms are.
Measure: Efficacy on symptoms of Anxiety Time: From inclusion to 6 months after inclusionDescription: Change over a 12 months period in anxiety measured by the Generalized Anxiety Disorder-7 questionnaire (GAD-7) for the participants who will be enrolled in the trial at M0 of the cohort. The GAD-7 score is on a scale from 0 to 21. The higher the score, the higher the level of anxiety symptoms are.
Measure: Long-term efficacy on symptoms of Anxiety Time: From inclusion to 12 months after inclusionDescription: Number of suicide attempts over a 6-month period from baseline
Measure: Efficacy on suicide attempts Time: From inclusion to 6 months after inclusionDescription: Changes in the level of suicidal ideation over a 6 months period from baseline measured by Visual Analog Scale (VAS). The VAS is on a scale from 0 to 10. The higher the VAS score, the higher suicidal ideation level is.
Measure: Efficacy on suicidal ideation Time: From inclusion to 6 months after inclusionDescription: Changes in the level of suicidal ideation over a 12 months period from baseline measured by Visual Analog Scale (VAS) for the participants who are enrolled in the trial at M0 of the cohort. The VAS is on a scale from 0 to 10. The higher the VAS score, the higher suicidal ideation level is.
Measure: Long-term efficacy on suicidal ideation Time: From inclusion to 12 months after inclusionDescription: Change in the impact of health on functioning (Role Emotional (RE) subdomain of the MOS Short Form-36 health survey v1.3 (SF-36)) over a 6 months period from baseline. The RE score is on a scale from 0 to 100. The higher the score, the better Role Emotional is.
Measure: Efficacy on the impact of health on functioning: Role Emotional Time: From inclusion to 6 months after inclusionDescription: Change in the impact of health on functioning (Role Emotional (RE) subdomain of the MOS Short Form-36 health survey v1.3 (SF-36)) over a 12 months period from baseline for the participants who are enrolled in the trial at M0 of the cohort. The RE score is on a scale from 0 to 100. The higher the score, the better Role Emotional is.
Measure: Long-term efficacy on the impact of health on functioning: Role Emotional Time: From inclusion to 12 months after inclusionDescription: Change in the impact of health on functioning (Role Physical (RP) subdomain of the MOS Short Form-36 health survey v1.3 (SF-36)) over a 6 months period from baseline. The RP score is on a scale from 0 to 100. The higher the score, the better Role Physical is.
Measure: Efficacy on the impact of health on functioning: Role Physical Time: From inclusion to 6 months after inclusionDescription: Change in the impact of health on functioning (Role Physical (RP) subdomain of the MOS Short Form-36 health survey v1.3 (SF-36)) over a 12 months period from baseline for the participants who are enrolled in the trial at M0 of the cohort. The RP score is on a scale from 0 to 100. The higher the score, the better Role Physical is.
Measure: Long-term efficacy on the impact of health on functioning: Role Physical Time: From inclusion to 12 months after inclusionDescription: Evolution of substance use over 6 months
Measure: Substance use Time: From inclusion to 6 months after inclusionDescription: Evolution of substance use over 12 months for the participants who are enrolled in the trial at M0 of the cohort
Measure: Long-term substance use Time: From inclusion to 12 months after inclusionDescription: Evolution of medication use over 6 months
Measure: Medication use Time: From inclusion to 6 months after inclusionDescription: Evolution of medication use over 12 months for the participants who are enrolled in the trial at M0 of the cohort
Measure: Long-term medication use Time: From inclusion to 12 months after inclusionDescription: Number of consultations of health professionals within the period of follow-up (general practitioner, psychiatrist, psychotherapist, psychologist, professionals who are practicing alternative medicines); Occurrence of EMDR therapy within the control group; Number of visits at the emergency unit of a hospital; Number of nights spent in hospital as a patient (short-term); Number of nights spent in rehabilitation facilities as a patient.
Measure: Health care utilization Time: From inclusion to 6 months after inclusionDescription: Number of consultations of health professionals within the period of follow-up (general practitioner, psychiatrist, psychotherapist, psychologist, professionals who are practicing alternative medicines); Occurrence of EMDR therapy within the control group; Number of visits at the emergency unit of a hospital; Number of nights spent in hospital as a patient (short-term); Number of nights spent in rehabilitation facilities as a patient. For the participants who are enrolled in the trial at M0 of the cohort
Measure: Long-term health care utilization Time: From inclusion to 12 months after inclusionDescription: Proportion of those who will be offered EMDR and will actually receive EMDR
Measure: Acceptability of EMDR in the EMDR group Time: From inclusion to 12 months after inclusionDescription: Number of sessions attended over the total planned number
Measure: Compliance in the EMDR group Time: From inclusion to 12 months after inclusionThis 3-arm study compares the effectiveness of an (1) 8-week mindfulness-based intervention, MBCT-R (Mindfulness-Based Cognitive Therapy for Resilience During COVID-19)+CHA MindWell vs. (2) iCBT (internet based Cognitive Behavioral Therapy)+ CHA MindWell vs. (3) CHA MindWell remote monitoring and telephone coaching alone on depressive symptoms as measured over the course of 24-weeks by the computerized adaptive mental health (CAT-MH) interview for depression (CAT-DI). Secondary outcomes include rates and levels of alcohol and drug use, as well as the number of required mental health clinician visits (televisits and in-person visits). Exploratory outcomes include stress-related affect reactivity and salivary inflammatory markers (e.g., interleukin-6).
Description: Change in depression symptom severity as measured by CAT-MH Depression Inventory (DI) scores completed at baseline and every 4 weeks during the 24 weeks after randomization. Difference between MBCT-R arm and CHA-MW monitoring alone arm is primary outcome. Difference between iCBT arm and CHA-MW monitoring alone arm is secondary outcome. Difference between iCBT arm and MBCT-R is an exploratory outcome.
Measure: Depression Severity (CAT-DI) Time: Baseline, Weeks 4, 8, 12, 16, 20, 24Description: Rates of positive toxicology screens for illicit drugs or unprescribed controlled substances at 24 weeks. Rates of positive toxicology for illicit drug use or controlled substances (non prescribed) at week 24 is the secondary outcome.
Measure: Drug Use Rates Time: Week 24Description: We will conduct an Alcohol Use History at Week 24. We will conduct 30-day alcohol and substance use history using the TimeLine Follow Back (TLFB) Method at Week 24 visit by telephone or video conference. Heavy Drinking Days in past 30 days is the secondary outcome.
Measure: Heavy Drinking Days Time: Week 24Description: Number of mental health clinician televisits during 24 weeks
Measure: Televisits Time: Randomization through Week 24Description: Participants report the frequency of emotions using a 5-point scale: 0 = none of the time, 1 = a little of the time, 2 = some of the time, 3 = most of the time, 4 = all of the time. The NA scale consists of 14 items: restless or fidgety, nervous, worthless, so sad nothing could cheer you up, everything is an effort, hopeless, lonely, afraid, jittery, irritable, ashamed, upset, angry, and frustrated. The PA scale consists of 13 items: in good spirits, cheerful, extremely happy, calm and peaceful, satisfied, full of life, close to others, like you belong, enthusiastic, attentive, proud, active, and confident. Daily NA and PA are calculated by averaging the items within each subscale, and then aggregating scores across interview days.
Measure: Positive and Negative Affect Reactivity Scales Time: Weeks -4, -3, -2, -1, 0, 9, 10, 11Description: The Daily Inventory of Stressful Events is used to assess whether each of 7 types of stressors occurred in the past 24 hours: argument, avoided an argument, stressor at work or school, stressor at home, discrimination, network stressor (i.e., stressful event that happened to a close friend or family member), and any other stressor. A day is categorized as a "stressor day" if the participant endorsed at least one stressor, or a "nonstressor day" if the participant indicated that no stressors occurred. Stressor frequency is defined as the percentage of interview days during which at least one stressor occurred. Salivary Cytokine Panels will be collected on two of these stressor and non stressor days respectively.
Measure: Daily Inventory of Stressful Events Time: Weeks -4, -3, -2, -1, 9, 10, 11, 12Description: Difference between mean level of salivary Interleukin-6 during 2 low stressor and 2 high stressor days is exploratory outcome. Evening salivary passive drool samples (which assess TNF-a, IL-1b and IL-8 in addition to IL-6) will be collected 4 times during weeks -4-0 and 4 times during weeks 9-12 during diary collection. They will be primed with REDCAP branching logic activated by 2 multi-stressor (high) stressor days and 2 no stressor days. REDCAP will specifically tell them to select a color/letter coded sampling contained and they will collect that sample that evening. They will place samples immediately in the freezer.
Measure: Inflammatory Cytokines (IL-6, IL-1b, IL-8, TNF-a) Time: Weeks -4, -3, -2, -1, 9, 10, 11, 12Description: A 15-item scale with content from six dimensions of experiential avoidance.
Measure: Brief Experiential Avoidance Questionnaire (BEAQ) Time: Baseline, Weeks 4, 8, 12Description: The Difficulties in Emotion Regulation (DERS) Scale is a 36-item self-report scale designed to assess emotional dysregulation using a 5 point Likert scale. The scale assesses 6 aspects of emotional dysregulation: non-acceptance of emotional responses, difficulties engaging in goal directed behavior, impulse control difficulties, lack of emotional awareness, limited access to emotion regulation strategies, and lack of emotional clarity. Subscales are summed and a lower total score represents a better outcome. Individual subscales will also be assessed.
Measure: Difficulties in Emotion Regulation Scale (DERS) Time: Baseline, Weeks 4, 8, 12Description: The Perceived Stress Scale (PSS-14) (14 items) measures the degree to which situations in life are stressful. Items are designed to evaluate how overloaded, unpredictable, and uncontrollable one finds one's life. Each item is scored on a 5 point Likert scale from 0 (Never) to 4 (Very often).
Measure: Perceived Stress Scale (PSS-14) Time: Baseline, Weeks 4, 8, 12, 24Description: The short-form Self-Compassion Scale (SCS-SF) is an abbreviated 12-item form of the original 26-item Self-Compassion Scale. The scale is scored on a 5 point Likert scale (1 = Almost never; 5 = Almost always), and negative subscale items are reverse scored.
Measure: Self-Compassion Scale Short Form (SCS-SF) Time: Baseline, Weeks 4, 8, 12Description: The Multidimensional Assessment of Interoceptive Awareness (MAIA-2) is a 37 item self-report scale designed to assess multiple aspects of interoception and interoceptive awareness. The scale assesses 8 aspects of interoceptive awareness: noticing, not-distracting, not-worrying, attention regulation, emotional awareness, self-regulation, body listening, and trusting. Subscales are summed and a higher total score represents a better outcome. Individual subscales will also be assessed, especially Body Listen, Body Trust, and Self-Regulation.
Measure: Multidimensional Assessment of Interoceptive Awareness (MAIA-2) Time: Baseline, Weeks 4, 8, 12Description: The adult self-report COVID-19 Responses to Stress Questionnaire is a 72-item survey. Responses are recorded on a 4-point Likert scale (1 = Not at All, 4 = Very/A lot). Items in the RSQ cover 5 factors of coping and stress responses: primary control engagement coping (i.e., problem solving, emotional expression, emotional modulation), secondary control engagement coping (i.e., positive thinking, cognitive restructuring, acceptance, distraction), disengagement coping (i.e., avoidance, denial, wishful thinking); involuntary engagement (e.g., physiological arousal, rumination), and involuntary disengagement (e.g., emotional numbing).
Measure: Responses to Stress Questionnaire - COVID -19 (RSQ-COVID-19) Stress coping style (disengagement, involuntary engagement) Time: Baseline, Weeks 12, 24Description: This is a 20-item self-report measure of decentering and is conceptualized as a protective factor and capable of measuring resilience to depressive relapse. The EQ uses a 5-point Likert scale with responses from "never" to "all the time". A sample item from the decentering subscale is "I can observe unpleasant feelings without being drawn into them."
Measure: Experiences Questionnaire (EQ) (Rumination and Decentering) Time: Baseline, Weeks 4, 8, 12Description: Computer Adaptive Testing for Mental Health (CAT-MH) interviews are diagnostic interviews designed to be completed online using a computer, tablet or phone. Items from each of the modules for depression (CAT-DI), anxiety (ANX-CAT), mania and hypomania (M/HM-CAT), PTSD (PTSD-CAT), psychosis (PSY-S-CAT), suicidality (SS-CAT), and substance abuse (SUD-CAT) are chosen from large item banks based on multidimensional item response theory, adapting each item presented to the individual's severity so that different individuals are tested with different items depending on their severity level.
Measure: Computerized Adaptive Testing for Mental Health (CAT-MH) Interviews Time: Screening, Baseline, Weeks 1, 2, 3, 4, 5, 6, 7, 8, 12, 16, 20, 24Description: The Beck Depression Inventory (BDI-II) is a 21-item self-report scale designed to assess depression severity over the past 2 weeks with well-established internal consistency, reliability and validity.
Measure: Beck Depression Inventory (BDI-II) Time: BaselineDescription: Rank Desire for each intervention option will be assessed at baseline.
Measure: Rank Desire Time: BaselineDescription: Credibility/Expectancy for the assigned option will be assessed at Week 2. Treatment expectancy and credibility for each arm will be assessed with the 4-item Credibility/ Expectancy Questionnaire (CEQ)
Measure: Credibility and Expectancy Time: Week 2Description: The COVID-19 Fear scale is a 7-item questionnaire recorded on a 5-point Likert scale (1 = Strongly Disagree to 5 = Strongly Agree). Responses to scale items were found to positively correlate with perceived vulnerability, hospital anxiety, and depression. Sample questions include "I am most afraid of coronavirus-19," and "It makes me uncomfortable to think about coronavirus-19."
Measure: COVID-19 Fear Time: Baseline, Week 12Description: Participants will be asked to self-report on REDCap.
Measure: COVID-19 status (self-report) Time: Week 0, 4, 8, 12, 16, 20, 24Description: Participants will be asked to complete a salivary sample to assess COVID-19 status. COVID-19 IgG samples: Antibodies for COVID-19 will be sampled at week 12 among all participants to establish whether they were exposed to COVID-19 during the study. They will place samples immediately in the freezer.
Measure: COVID-19 status (salivary IgG) Time: Week 12Description: The UCI Oral Health Questionnaire is an 12-item survey that asks sociodemographic questions, questions about oral and physical health, as well as additional oral health questions drawn from the WHO Oral Health Survey. The questionnaire includes basic questions about dental health characteristics of participants to be used as an exclusion criteria for the salivary collection portion of the study and to track changes in oral health that might impact salivary data collection.
Measure: UCI Oral Health Questionnaire Time: Screening and at Week 12Description: The Home Skills Use Diary will be completed for the 8 weeks during the intervention period and will come in two types (1: weekly mindfulness practice and resource use diary for the MBCT-R group and 2: General CBT coping skills use diary card for both the iCBT and CHA MindWell arms).
Measure: Home Skills Use Diary Time: Weeks 1, 2, 3, 4, 5, 6, 7, 8Description: The Adverse Event Patient Participant Self-Report Form will be systematically assessed at assessment timepoints (baseline, 4-weeks, 8-weeks, 12-weeks, 16-weeks, 20-weeks and 24-weeks). In addition, group leaders and research coordinators will be trained to identify and report any adverse events that occur or are reported during weekly group visits.
Measure: Adverse Event Patient Participant Self-Report Form Time: Baseline, Weeks 4, 8, 12, 16, 20, 24To assess the depression in adults especially in post COVID-19 duration in the rural and urban settings.
Description: % prevalence of depression in adult population of south punjab will be assessed
Measure: Prevalence estimation of depression in adults Time: study will be completed in 15 days maximumDuring pandemics older adults with chronic physical conditions are a particularly vulnerable population for unmet mental health needs. This is a consequence of a number of factors which include decreased access to their doctors because of restrictions in visits in order to decrease risk of disease transmission and because doctors are seconded to provide medical services in areas of high priority. Since Public Health authorities worry that pandemics may be a reality of the future, this study is being operationalized during the present COVID-19 pandemic in order to see what can be learned about different ways to provide mental health care under such constraints. The study offers evidence-based approaches to managing feelings of anxiety or depression that may have existed prior to the onset of a pandemic, or that have arisen during a pandemic. It uses principles of cognitive behavioural therapy in which participants are offered self-care tools to help them develop strategies for dealing with their various symptoms. These tools have already been shown by the team to be effective in other contexts in studies DIRECT-sc (Effectiveness of a supported self-care intervention for depression compared to an unsupported intervention in older adults with chronic physical illnesses) and CanDIRECT (Effectiveness of a telephone-supported depression self-care intervention for cancer survivors). The present study, PanDIRECT (Assisting Family Physicians with Gaps in Mental Health Care Generated by the COVID-19 Pandemic), aims to answer the following questions: 1. Can these tools be used in the community care of mental health problems during pandemics? 2. Are they acceptable to patients? 3. Using a randomized control trial, does lay-coaching of use of these tools improve their use and patient outcomes? 4. Do family practitioners value patient information sent to them at the end of the trial
Description: Number of consenting participants out of total number contacted over the recruitment period
Measure: Consent rate Time: At recruitmentDescription: Investigators will report on rates of missing data from baseline and follow-up questionnaires
Measure: Data completion rate Time: From recruitment launch to completion of follow-up (4 months)Description: Logs and checklists will be used to evaluate completion of intervention, as per protocol
Measure: Fidelity of intervention completion Time: A 8 week follow-upDescription: Using the validated 9 item Patient Health Questionnaire (PHQ-9). Scores range from 0 to 27 - higher score indicates more severe depression
Measure: Severity of depression symptoms Time: At baselineDescription: Using the validated 9 item Patient Health Questionnaire (PHQ-9). Scores range from 0 to 27 - higher score indicates more severe depression
Measure: Severity of depression symptoms Time: At 8 week follow-upDescription: Using the validated 7 item General Anxiety Disorder (GAD-7) instrument. Scores range from 0 to 21 - higher score indicates more severe anxiety
Measure: Severity of anxiety symptoms Time: At baselineDescription: Using the validated 7 item General Anxiety Disorder (GAD-7) instrument. Scores range from 0 to 21 - higher score indicates more severe anxiety
Measure: Severity of anxiety symptoms Time: At 8 week follow-upDescription: Using questions developed by the team and administrative databases to assess use of hospital and mental health care services
Measure: Use of health care services Time: At baselineDescription: Using questions developed by the team and administrative databases to assess use of hospital and mental health care services
Measure: Use of health care services Time: At 8 week follow-upDescription: Using adherence questions developed by the team, not scored
Measure: Use of the self-care materials Time: At 8 week follow-upMaternal attachment, Edinburgh depression scoring, and postpartum anxiety scale are evaluated in patients with covid-positive pregnancies in the 3rd month after birth.
Description: Maternal attachment scores evaluated in 250 covid-positive pregnant women in the 3rd month after birth. The results will be compared with the results of covid-negative pregnant women who gave birth in the same period. High scores from the scale indicate high maternal attachment.
Measure: Maternal attachment in SARS- cov2 positive and negative pregnant women Time: 3 monthsDescription: Edinburgh depression scores evaluated in 250 covid-positive pregnant women in the 3rd month after birth. The results will be compared with the results of covid-negative pregnant women who gave birth in the same period. All questions are scored between 0 and 3 and the highest possible score on the scale is 30. and shows advanced depression.
Measure: Edinburgh depression scores in in SARS- cov2 positive and negative pregnant women Time: 3 monthsDescription: Postpartum anxiety scale scores evaluated in 250 covid-positive pregnant women in the 3rd month after birth. The results will be compared with the results of covid-negative pregnant women who gave birth in the same period. It can be said that the postpartum anxiety levels of those who score 73 and below on the scale are low, those who score between 74 and 100 are medium, and those who score 101 and above are high.
Measure: Postpartum anxiety scale scores in in SARS- cov2 positive and negative pregnant women Time: 3 monthsMedical personnel working in the Intensive Care Unit will be examined by means of tests. Their aim is to check how work-related stress in a potentially lethal threat affects the occurrence of depression, stress, anxiety and sleep disorders. We also want to check whether people working in such extremely difficult conditions show no greater interest in death.
Description: Beck's test the BDI-II contains 21 questions, each answer being scored on a scale value of 0 to 3. Higher total scores indicate more severe depressive symptoms. The standardized cutoffs used differ from the original: 0-13: minimal depression 14-19: mild depression 20-28: moderate depression 29-63: severe depression
Measure: Depression Time: 1 monthDescription: Perceived Stress Scale (PSS) The PSS predicts both objective biological markers of stress and increased risk for disease among persons with higher perceived stress levels. For example, those with higher scores (suggestive of chronic stress) on the PSS fend worse on biological markers of aging, cortisol levels, immune markers, depression, infectious disease,wound healing, and prostate-specific antigen levels in men. PSS scores are obtained by reversing responses (e.g., 0 = 4, 1 = 3, 2 = 2, 3 = 1 & 4 = 0) to the four positivelystated items (items 4, 5, 7, & 8) and then summing across all scale items. A short 4 item scale can be made fromquestions 2, 4, 5 and 10 of the PSS 10 item scale.
Measure: Stress Time: 1 monthDescription: COPE test It is a self-written tool consisting of 60 statements, to which the respondent responds on a 4-point scale. It allows the assessment of 15 strategies for responding to stressful situations.
Measure: Deal with Stress Time: 1 monthDescription: the scale of the fascination with death The Death Obsession Scale (DOS) was made by Abdel-Khalek. It was intended to be a main component in the death distress const.ruct: death anxiety, death depression, and death obsession. The DOS assesses a multidimensional trait. It is responded to on a five-point Likert-type rating scale as follows: No (1), A little (2), A fair amount (3), Much (4) and Very much (5). The total score can range from 15 to 75.
Measure: Stress 2 Time: 1 monthMost mental health problems emerge by age 14, often leading to chronic impairments and adverse impacts for individuals, families, and societies. Any action-focused path to reducing the need-to-access gap will require moving beyond the dominant settings, formats, and systems that have constrained intervention delivery to date. In a fully-online trial, youths ages 13-16 will be randomized to 1 of 3 self-administered single-session interventions (SSIs): a behavioral activation SSI, targeting behavioral MD symptoms; an SSI teaching growth mindset, targeting cognitive MD symptoms; or a control SSI. The investigators will test each SSI's relative benefits, versus the control, on depressive symptoms and proximal outcomes such as hopelessness. Results will reveal whether SSIs that were designed to address behavioral versus cognitive symptoms differentially benefit adolescents with elevated depressive symptoms.
Description: The Children's Depression Inventory (CDI) 2 - short form (CDI-SF) is a reliable, valid measure of youth depression severity, normed for youth age and sex and yielding raw and T scores.
Measure: Change in adolescent depressive symptom severity Time: Pre-SSI to 3-month follow-upDescription: Four items from a self-report version of the SITBI-SF were used to assess lifetime history of suicide ideation, suicide attempts, and deliberate self-harm. The SITBI-SF is a widely used measure of the continuum of suicidality and self-harm and has demonstrated high test-retest reliability, high internal consistency, and moderate-to-high concurrent validity. Score range for this measure can range widely (per wide variation in instances of self-harming behaviors across one's lifetime); thus, we anticipate a minimum score of 0 and are unable to predict the top (maximum) score.
Measure: Change in Self-Injurious Thoughts and Behaviors Interview-Short Form (SITBI-SF) Time: Pre-SSI to 3-month follow-upDescription: Youths' approach versus disengagement from rewarding activities will be assessed via the BADS-SF, a 9-item self-report questionnaire with strong reliability, predictive validity, and sensitivity to change following BA for adolescent depression symptoms. The BADS-SF has two subscales, both of relevance to this study: Activation (goal-directed engagement in rewarding activities) and Avoidance (engagement in rumination and avoidance rather than active coping).
Measure: Change in Behavioral Activation for Depression Scale - Short Form Time: Pre-SSI to 3-month follow-upDescription: The State Hope Scale asks participants to rate 6 statements based on how they think about themselves right now. Participants rate the 6 statements on an 8 point scale ranging from 0 (Definitely False) to 8 (Definitely True). Total score ranges from 6 to 48 (3 to 24 for each of two subscales). There are two subscales for pathway thinking and agency thinking, respectively with higher scores representing higher total hope, pathway thinking, and agency thinking, respectively.
Measure: Change in State Hope Scale Time: Pre-SSI to Immediately Post-SSI; Pre-SSI to 3-month follow-upDescription: 4 item version (BHS-4; referenced as 'How I Think Scale' in appended materials): This scale asks participants to rate 4 statements based on their sense of hopelessness. Participants rate the 4 statements on a 4 point scale ranging from 0 (Absolutely Disagree) to 3 (Absolutely Agree). Total score ranges from 0 to 12, with a higher score indicating greater levels of hopelessness.
Measure: Change in Beck Hopelessness Scale - 4 Item Version Time: Pre-SSI to Immediately Post-SSI; Pre-SSI to 3-month follow-upDescription: The IPTQ asks youth to rate the extent of their agreement with three statements linked to the malleability of personality, using a 1-to-7 Likert scale (e.g. "Your personality is something about you that you can't change very much.") Higher mean scores (range: 1-7) on these three items indicate a stronger fixed personality mindset, lower scores, a stronger growth personality mindset.
Measure: Change in Implicit Personality Theory Questionnaire Time: Pre-SSI, Immediately Post-SSIDescription: The PFS asks youth to rate agreement with 7 statements indicating perceived acceptability of an SSI (e.g. "I enjoyed the program") on a 5-point Likert scale (1="really disagree"; 5="totally agree"). The PFS also assesses youths' open-response feedback on each SSI. A score of 3.5/5 or above on any given PFS item is interpreted as an "acceptable" rating on that item.
Measure: Program Feedback Scale Time: Immediately Post-SSI onlyDescription: Participants will be asked to report demographic information including age, sex assigned at birth, gender identity, primary language, school grade, race/ethnicity, sexual/romantic attraction, experiences, and orientation, and zip code. This measure will also assess mental health treatment history and pubertal status.
Measure: Demographic Questions Time: Pre-SSI onlyDescription: Immediately pre-intervention, participants will be asked to rate their perceived socioeconomic and social status using the two items from the MacArthur Scale of Subjective Social Status-Youth Version. Respondents indicate where they see themselves on a ladder with 10 rungs (range: 1 to 10 for both items, where 1 = families with most money/education/jobs and youth with highest respect/grades/social standing; 10 = families with least money/education/jobs and youth with lowest respect/grades/social standing).
Measure: Perceived Socioeconomic and Social Status Time: Pre-SSI onlyDescription: The MVPS is a self-report scale assessing adolescents' experiences of peer victimization. This study will include the social manipulation, verbal victimization, and physical victimization scales, totaling 12 items (4 items per subscale). Higher scores on any given subscale indicate more frequent victimization of specific type. Adolescents rate how often peers have victimized them in various ways in the past year (e.g. "called me names"; "tried to turn my friends against me").
Measure: Multidimensional Peer Victimization Scale Time: Pre-SSI onlyDescription: The ULS is a widely used self-report scale of loneliness in adolescents. The brief 8-item version will be used here. Adolescents rate agreement with 8 items reflecting loneliness (e.g. "I feel left out"; "I feel isolated from others"). Higher summed-scores across all 8 items reflect higher levels of loneliness. The ULS has shown adequate reliability and validity in adolescent samples.
Measure: UCLA Loneliness Scale Time: Pre-SSI onlyDescription: The SRET is a web-based behavioral measure of self-referent information processing biases that assesses judgements of self-descriptiveness, response latencies and free recall of emotionally valanced stimuli. Participants make decisions about whether positive and negative adjectives are self-descriptive. Participants view various adjectives (26 positive adjectives, 26 negative adjectives) one at a time and make rapid judgments about whether or not each word presented described themselves following word offset. Participants will be told to use the Q or P keys on their keyboard to answer whether the word described them or not. Each trial will be followed by a 1,500 ms intertrial interval.
Measure: Self-Referential Encoding Task (SRET) Time: Pre-SSIDescription: The Expanded Everyday Discrimination Scale will be measured pre-intervention to gauge the levels of relatively minor, every-day, chronic discrimination experienced by participants. The original scale (Williams et al., 1997) asks participants, "In your day-to-day life, how often do any of the following things happen to you?" for 9 items (e.g. "you are treated with less courtesy than other people are") on a 5-point Likert scale (1= "never"; 6 = "almost every day"). These items assess the participant's observations about how others treat and act around them on a daily basis. The expanded version of this scale includes a 10th item, "You are followed around in stores." Scores on the Expanded Everyday Discrimination Scale range from 10-60, with higher scores indicating higher levels of chronic discrimination experienced by participants. Respondents are also asked to identify what they believe to be the main reason(s) for these experiences (e.g. gender, race, age, etc.).
Measure: Discrimination Time: Pre-SSIDescription: The GAD-7 measures the severity of clinical anxiety symptoms, based on diagnostic criteria for generalized anxiety disorder. The GAD-7 includes 7 items asking respondents how often, during the last 2 weeks, they were bothered by each of 7 anxiety symptoms. Response options are "not at all," "several days," "more than half the days," and "nearly every day," scored as 0, 1, 2, and 3, respectively; thus total sum-scores may range from 0-21 and average scores from 0 to 3.
Measure: Generalized Anxiety Disorder 7 (GAD-7) Time: Pre-SSIDescription: Youths will self-report perceived family social status related to the COVID-19 pandemic began (ie current perceived family social status), along with which among several COVID-19-related challenges they have faced (e.g., parent has lost job; school has closed; less contact with friends; know someone who was sick with COVID-19; more conflict at home; feel bored/restless; other [free response]). Item choices will be adapted from those included in the CDC's publicly-available item bank for research on COVID-19.
Measure: COVID-19-related stressors Time: Pre-SSI onlyDescription: The Child Trauma Screen-Reaction Scale (CTS-RS) is a reliable, valid self-report measure of youth traumatic stress symptom severity, including event-related somatic symptoms, intrusive memories, avoidance, sleep problems, and mood and behavioral changes. For this study, instructions will read: "For many kids and teens, the COVID-19 (or 'coronavirus') pandemic has been scary or very upsetting. Sometimes, events that are scary or upsetting can affect how people think, feel, and act. The next questions ask how you have been feeling and thinking recently." Youth will rate 6 statements describing traumatic stress symptoms (e.g., 'strong feelings in your body when you think about COVID-19 (sweating, heart beats fast, feel sick)') according to their frequency over the past 30 days (Never/Rarely; 1-2 times in the past month; 1-2 times in the past week; 3+ times per week).
Measure: Change in COVID-19-related Trauma Symptoms Time: Pre-SSI to 3-month follow-upDescription: Disordered eating behaviors will be measured at pre-intervention and 3-month follow-up using The Dietary Restriction Screener. The DRS-2 is a 9-item measure evaluating restrictive eating, bingeing, and purging behaviors in participants. 6 items ask participants whether or not they have engaged in restrictive eating, bingeing, or purging behaviors in the past year or in the past 3 months (0 = no; 1 = yes). The other 3 items assess the frequency of these behaviors over the past 28 days.
Measure: Disordered Eating Time: Pre-SSI to 3-month follow-upDescription: The ACEs questionnaire asks about exposure to violence, childhood emotional, physical, or sexual abuse, and household dysfunction during childhood. ACEs have shown robust associations with a range of adverse health and behavioral outcomes across the lifespan [yes/no]. Questions asked in this measure include: At any point since you were born… Did you often or very often feel that… No one in your family loved you or thought you were important or special? or Your family didn't look out for each other, feel close to each other, or support each other? Were your parents ever separated or divorced? Did you live with anyone who was a problem drinker or alcoholic, or who used street drugs? Was a household member depressed or mentally ill, or did a household member attempt suicide? Did a household member go to prison?
Measure: Adverse Childhood Experiences (ACEs) scale Time: Pre-SSI onlyDescription: The BSTAD questionnaire asks respondents to report retrospectively on their personal and friends' tobacco and drug use over the past year the past year (yes/no), including questions about how frequently (in days) the respondent recalls using alcohol, tobacco, and other drugs.
Measure: Brief Screener for Tobacco, Alcohol, and Other Drugs (BSTAD) Time: Pre-SSI onlyDescription: Participants rate their perceived changes in levels of pre- to post-SSI hopelessness and ability to solve problems. The questions are: Compared to before doing this activity, to what extent are you feeling hopeless right now? (Response options: much more hopeless = -2; a little more hopeless = -1; the same amount of hopeless = 0; a little less hopeless = 1; a lot less hopeless = 2). Compared to before doing this activity, to what extent are you able to solve the problems facing you right now? (Response options: Much less able to solve problems = -2; a little less able to solve problems = -1; the same amount able to solve problems = 0; a little more able to solve problems = 1; a lot more able to solve problems = 2)
Measure: Perceived pre-to-post SSI change items Time: Immediately Post-SSI onlyAlphabetical listing of all HPO terms. Navigate: Correlations Clinical Trials
Data processed on December 13, 2020.
An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.
Drug Reports MeSH Reports HPO Reports