Developed by Shray Alag, The Harker School
Sections: Correlations,
Clinical Trials, and HPO
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Name (Synonyms) | Correlation | |
---|---|---|
drug1061 | Collection of tears and saliva. Wiki | 0.58 |
drug378 | Artificial tear MDI - 101 Wiki | 0.58 |
drug2975 | Ophthalmologic exam Wiki | 0.58 |
Navigate: Correlations HPO
There are 3 clinical trials
Ophthalmologic damages secondary to COVID-19 coronavirus infection are little described. The ocular involvement is probably multiple, ranging from pathologies of the anterior segment such as conjunctivitis and anterior uveitis to disorders that threaten vision such as retinitis or optic neuropathy. On the other hand, in addition to this impairment, when patients are hospitalized for acute respiratory failure, complications related to possible resuscitation, medication prescriptions, positioning and oxygenation. COVID-19 itself, has several components: - An apoptotic action of the viral attack which will generate cellular destruction, whether pulmonary, cardiac or renal or maybe ocular - A secondary autoimmune action with the development of major vascular inflammation, possibly reaching the retinal, choroidal, and optic nerve vessels. A secondary "hyper" inflammatory syndrome with flashing hypercytokinemia and multi-organ decompensation is described in 3,7% to 4 ,3% of severe cases. - A thromboembolic action
Description: Multimodal ophthalmologic imaging
Measure: Description of the ophthalmological problems observed Time: 6 months after discharge of hospitalizationTo assess the co-relation of COVID-19 in nasopharyngeal swabs and tears or saliva, and to determine duration of COVID-19 activity in ocular fluid and saliva by serial tests over 3 months.
Description: Patients will receive a Schirmer's strip to place in both eyes without topical proparacaine, and a tube to collect saliva. The co-relation of COVID-19 in nasopharyngeal swabs and tears or saliva will be measured and reported by serial tests over 3 months.
Measure: Co-relation of COVID-19 activity Time: 3 monthsThis is post-market study to evaluate the safety and efficacy of MDI - 101 a novel tear substitute for the treatment of dry eye (DE) in subjects with evidence of inflammation of the ocular surface. In particular, this study intends to evaluate, in a cohort of 25 patients, the anti-inflammatory properties of the product under study over a period of 10 weeks
Description: Change of OSDI score versus baseline at any study time-point. The main goal of the study is to gather information about the efficacy, assessed by OSDI (Ocular Surface Disease Index) questionnaire, of artificial tear containing AG, trehalose and HA (MDI - 101) used in the treatment of symptoms of DE of various aetiology, with evidence of inflammation of the ocular surface. The OSDI score ranges from 0 (better outcome) to 100 (worst outcome)
Measure: Efficacy - Ocular Surface Disease Index (OSDI) Time: 1 week - 2 weeks - 4 weeks - 6 weeks - 8 weeksDescription: Change of tear matrix metalloproteinase(MMP)-9 at T0 vs final assessment. The result of the MMP test could be NEGATIVE if the level of MMP-9 is < 40 ng/ml (better outcome) or POSITIVE if the level of MMP-9 is ≥ 40 ng/ml (worst outcome)
Measure: Additional efficacy parameters: Matrix Metalloproteinase 9 (MMP-9) Time: 8 weeksDescription: Change of Efron Grading Scales at T0 vs final assessment. The Efron grading scale range from 0 (cornea surface normale) to 4 (severe corneal damage)
Measure: Additional Efficacy parameters: EFRON SCALE Time: 8 weeksDescription: Change of Corneal and Conjunctival Staining at T0 vs final assessment. The Staining scale ranges from 0 (better outcome) to 3 (worst outcome)
Measure: Additional Efficacy parameters: Corneal and Conjunctival Staining Time: 8 weeksDescription: Change of NIBUT at T0 vs final assessment. The result of the Non-Invasive Break-Up Time (NIBUT) test could be >10 seconds (better outcome) or ≤10 seconds (worst outcome)
Measure: Additional Efficacy parameters: NIBUT Time: 8 weeksDescription: Change of Osmolarity at T0 vs final assessment. The higher the tear film osmolarity, the greater the severity of the ocular surface damage.
Measure: Additional Efficacy parameters: Osmolarity Time: 8 weeksDescription: Change of Ocular Protection Index (OPI) at T0 vs final assessment The principle of the test is that when BUT is shorter than the blink interval, the eyes are exposed to the risk of focal ocular surface damage.
Measure: Additional Efficacy parameters: Ocular Protection Index Time: 8 weeksDescription: Change of meniscometry at T0 vs final assessment. The lowest tear meniscus radius, the higher the severity of the ocular surface health
Measure: Additional Efficacy parameters: meniscometry Time: 8 weeksDescription: Safety Adverse Event (AE) experienced with the artificial tear assessed by the patient, before the ocular examination or reported by the patient at any time during the study.
Measure: Incidence of Treatment-Emergent Adverse Events [Safety and Tolerability] Time: 8 weeksDescription: Unaided and corrected visual acuity Snellen test will be performed to evaluate change in the unaided and corrected visual acuity at T0 vs final assessment.
Measure: Incidence of change in the unaided and corrected visual acuity Time: 8 weeksDescription: Change of Intraocular pressure at T0 vs final assessment.
Measure: Incidence of change in the Intraocular pressure Time: 8 weeksDescription: Treatment adherence assessed by the patient at any study time-point (number of instillations in the past 24 hours).
Measure: Evaluation of the Tolerability Signs and symptoms of discomfort Time: 8 weeksDescription: Treatment adherence assessed by the patient at any study time-point (number of instillations in the past 24 hours)
Measure: Treatment adherence (24 hours) Time: 8 weeksDescription: Treatment adherence assessed by the patient at any study time-point (number of days of product usage).
Measure: Treatment adherence (total days) Time: 8 weeksAlphabetical listing of all HPO terms. Navigate: Correlations Clinical Trials
Data processed on December 13, 2020.
An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.
Drug Reports MeSH Reports HPO Reports