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    HP:0030149: Cardiogenic shock

    Developed by Shray Alag, The Harker School
    Sections: Correlations, Clinical Trials, and HPO

    Correlations computed by analyzing all clinical trials.

    Navigate: Clinical Trials and HPO


    Correlated Drug Terms (0)


    Name (Synonyms) Correlation

    Correlated MeSH Terms (4)


    Name (Synonyms) Correlation
    D012770 Shock, Cardiogenic NIH 1.00
    D012769 Shock, NIH 0.38
    D000860 Hypoxia NIH 0.18
    Name (Synonyms) Correlation
    D012128 Respiratory Distress Syndrome, Adult NIH 0.07

    Correlated HPO Terms (1)


    Name (Synonyms) Correlation
    HP:0012418 Hypoxemia HPO 0.18

    Clinical Trials

    Navigate: Correlations   HPO

    There is one clinical trial.


    1 European/Euro-ELSO Survey on Adult and Neonatal/ Pediatric COVID Patients in ECMO

    In the last 10 years, severe acute respiratory infection (SARI) was responsible of multiple outbreaks putting a strain on the public health worldwide. Indeed, SARI had a relevant role in the development of pandemic and epidemic with terrible consequences such as the 2009 H1N1 pandemic which led to more than 200.000 respiratory deaths globally. In late December 2019, in Wuhan, Hubei, China, a new respiratory syndrome emerged with clinical signs of viral pneumonia and person-to-person transmission. Tests showed the appearance of a novel coronavirus, namely the 2019 novel coronavirus (COVID-19). Two other strains, the severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV) have caused severe respiratory illnesses, sometimes fatal. In particular, the mortality rate associated with SARS-CoV and MERS-CoV, was of 10% and 37% respectively. Even though COVID-19 appeared from the first time in China, quickly it spread worldwide and cases have been described in other countries such as Thailand, Japan, South Korea, Germany, Italy, France, Iran, USA and many other countries. An early paper reported 41 patients with laboratory-confirmed COVID-19 infection in Wuhan. The median age of the patients was 49 years and mostly men (73%). Among those, 32% were admitted to the ICU because of the severe hypoxemia. The most associated comorbidities were diabetes (20%), hypertension (15%), and cardiovascular diseases (15%). On admission, 98% of the patients had bilateral multiple lobular and sub-segmental areas of consolidation. Importantly, acute respiratory distress syndrome (ARDS) developed in 29% of the patients, while acute cardiac injury in 12%, and secondary infection in 10%. Invasive mechanical ventilation was required in 10% of those patients, and two of these patients (5%) had refractory hypoxemia and received extracorporeal membrane oxygenation (ECMO). In a later retrospective report by Wang and collaborators, clinical characteristics of 138 patients with COVID-19 infection were described. ICU admission was required in 26.1% of the patients for acute respiratory distress syndrome (61.1%), arrhythmia (44.4%), and shock (30.6%). ECMO support was needed in 11% of the patients admitted to the ICU. During the period of follow-up, overall mortality was 4.3%. The use of ECMO in COVID-19 infection is increasing due to the high transmission rate of the infection and the respiratory-related mortality. Therefore, the investigators believe that ECMO in case of severe interstitial pneumonia caused by COVID could represent a valid solution in order to avoid lung injuries related to prolonged treatment with non-invasive and invasive mechanical ventilation. In addition, ECMO could have a role for the systemic complications such as septic and cardiogenic shock as well myocarditis scenarios. Potential clinical effects and outcomes of the ECMO support in the novel coronavirus pandemic will be recorded and analyzed in our project. The researchers hypothesize that a significant percentage of patients with COVID-19 infection will require the utilize of ECMO for refactory hypoxemia, cardiogenic shock or septic shock. This study seeks to prove this hypothesis by conducting an observational retrospective/prospective study of patients in the ICU who underwent ECMO support and describe clinical features, severity of pulmonary dysfunction and risk factors of COVID-patients who need ECMO support, the incidence of ECMO use, ECMO technical characteristics, duration of ECMO, complications and outcomes of COVID-patients requiring ECMO support.

    NCT04366921
    Conditions
    1. COVID
    2. SARS-CoV-2
    3. ARDS, Human
    4. Refractory Hypoxemia
    5. Cardiogenic Shock
    6. Septic Shock
    7. Extracorporeal Membrane Oxygenation
    MeSH:Respiratory Distress Syndrome, Adult Shock, Cardiogenic Shock Hypoxia
    HPO:Cardiogenic shock Hypoxemia

    Primary Outcomes

    Description: age in years

    Measure: Age

    Time: at baseline

    Description: male/female

    Measure: Gender

    Time: at baseline

    Description: in kilograms

    Measure: Weight

    Time: at baseline

    Description: in meters

    Measure: Height

    Time: at baseline

    Description: weight and height combined to calculate BMI in kg/m^2

    Measure: BMI

    Time: at baseline

    Description: Asthma y/n, cystic fibrosis y/n, chronic obstructive pulmonary disease y/n, pulmonary hypertension y/n, pulmonary fibrosis y/n, chronic restrictive lung disease y/n

    Measure: Pre-existing pulmonary disease y/n

    Time: at baseline

    Description: diabetes mellitus y/n, chronic renal failure y/n, ischemic heart disease y/n, heart failure y/n, chronic liver failure y/n, neurological impairment y/n

    Measure: Main co-morbidities y/n

    Time: at baseline

    Description: in dd-mm-yyyy or mm-dd-yyyy

    Measure: Date of signs of COVID-19 infection

    Time: at baseline or date of occurence

    Description: in dd-mm-yyyy or mm-dd-yyyy

    Measure: Date of positive swab

    Time: at baseline or date of occurence

    Description: in days

    Measure: Pre-ECMO length of hospital stay

    Time: at or during ECMO-implant

    Description: in days

    Measure: Pre-ECMO length of ICU stay

    Time: at or during ECMO-implant

    Description: in days

    Measure: Pre-ECMO length of mechanical ventilation days

    Time: at or during ECMO-implant

    Description: y/n, what kind

    Measure: Use of antibiotics

    Time: up to 6 months

    Description: y/n, what kind

    Measure: Use of anti-viral treatment

    Time: up to 6 months

    Description: y/n, what kind (eg prone-position, recruitment manoeuvers, neuromuscular blockade etc)

    Measure: Use of second line treatment

    Time: up to 6 months

    Description: respiratory or cardiac

    Measure: Indications for ECMO-implant

    Time: at ECMO-implant

    Description: veno-venous, veno-arterial or veno-venoarterial

    Measure: Type of ECMO-implant

    Time: at ECMO-implant

    Description: peripheral or central

    Measure: Type of access

    Time: at ECMO-implant

    Description: in dd-mm-yyyy or mm-dd-yyyy

    Measure: Date of ECMO implant

    Time: at ECMO-implant

    Description: l/min

    Measure: ECMO blood flow rate

    Time: from day of ECMO-implant for every 24 hours until date of weaning or death, up to 6 months

    Description: l/min

    Measure: ECMO gas flow rate

    Time: from day of ECMO-implant for every 24 hours until date of weaning or death, up to 6 months

    Description: y/n

    Measure: ECMO configuration change

    Time: up to 6 months

    Description: in dd-mm-yyyy or mm-dd-yyyy

    Measure: Date of ECMO configuration change

    Time: up to 6 months

    Description: veno-venous, veno-arterial, veno-venoarterial, other

    Measure: New ECMO configuration

    Time: up to 6 months

    Description: right ventricular failure, left ventricular failure, refractory hypoxemia

    Measure: Indications for ECMO configuration change

    Time: up to 6 months

    Description: settings of ventilator

    Measure: Ventilator setting on ECMO

    Time: from day of ECMO-implant for every 24 hours until date of weaning or death, up to 6 months

    Description: heparin, bivalirudin, nothing

    Measure: Anticoagulation during ECMO

    Time: from day of ECMO-implant for every 24 hours until date of weaning or death, up to 6 months

    Description: amount of ECMO circuit changes (1, 2, 3 etc.)

    Measure: Frequency of ECMO circuit change

    Time: up to 6 months

    Description: Hemorrhagic, infection, other complications

    Measure: ECMO complications

    Time: up to 6 months

    Description: y/n

    Measure: ECMO Weaning

    Time: from day of ECMO-implant for every 24 hours until date of weaning or death, up to 6 months

    Description: y/n, date

    Measure: ICU discharge

    Time: from day of ICU-admission for every 24 hours until date of discharge or death, up to 6 months

    Measure: Main cause of death

    Time: 6 months

    Description: Ward, another ICU, rehabilitation center, home

    Measure: Type of discharge

    Time: up to 6 months

    Measure: Alive/deceased

    Time: 6 months

    HPO Nodes


    Protein Mutations 0
    SNP 0

    HPO

    Alphabetical listing of all HPO terms. Navigate: Correlations   Clinical Trials


    HPO Nodes


    Protein Mutations 0
    SNP 0

    Reports

    Data processed on December 13, 2020.

    An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.

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